Targeted Human Proteins by the Ingredients of Prescription
References are linked to referred publications via PubMed ID or DOI.There may be multiple activity records for a specific ingredient-target pair.
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| Ingredient ID & Structure | Target ID | Target Name | Target Organism | Activity Records & Reference |
|---|---|---|---|---|
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TCMT142 | Carbonic anhydrase IV | Homo sapiens |
Ki: 2330 (nM), Ref: 22245047 |
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TCMT139 | Carbonic anhydrase VI | Homo sapiens |
Ki: 3630 (nM), Ref: 22245047 |
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TCMT207 | Beta-secretase 1 | Homo sapiens |
IC50: 1800 (nM), Ref: 14592472 |
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TCMT223 | Aldose reductase | Homo sapiens |
IC50: 2030 (nM), Ref: 10.1007/s00044-010-9412-4 |
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TCMT23 | Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens | IC50: 407 (nM), Ref: |
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TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3900 (nM), Ref: 16580200 IC50: 7600 (nM), Ref: 18798681 IC50: 4200 (nM), Ref: 19702283 IC50: 3840 (nM), Ref: 22044245 IC50: 5600 (nM), Ref: 22690646 IC50: 9500 (nM), Ref: 21453996 Ki: 6000 (nM), Ref: 21453996 IC50: 5050.1 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3370 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2600 (nM), Ref: 23357636 IC50: 1100 (nM), Ref: 23434422 IC50: 3020 (nM), Ref: 23942421 IC50: 2010 (nM), Ref: 24090912 IC50: 1900 (nM), Ref: 24684845 IC50: 3020 (nM), Ref: 25497963 IC50: 9500 (nM), Ref: 25264584 Ki: 6000 (nM), Ref: 25264584 IC50: 1030 (nM), Ref: 25595683 IC50: 1170 (nM), Ref: 25600405 IC50: 3020 (nM), Ref: 25872983 IC50: 1000 (nM), Ref: 26083682 IC50: 1536 (nM), Ref: 26100442 IC50: 700 (nM), Ref: 26115570 IC50: 700 (nM), Ref: 26253631 IC50: 1536 (nM), Ref: 26481657 IC50: 730 (nM), Ref: 26711144 IC50: 3020 (nM), Ref: 26774579 IC50: 1536 (nM), Ref: 27123900 |
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TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
IC50: 4000 (nM), Ref: 21561086 Ki: 3560 (nM), Ref: 21561086 Ki: 660 (nM), Ref: 21561086 Ki: 940 (nM), Ref: 21561086 Ki: 160 (nM), Ref: 21561086 Ki: 72 (nM), Ref: 21561086 IC50: 90 (nM), Ref: 21561086 |
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TCMT190 | T-cell protein-tyrosine phosphatase | Homo sapiens |
IC50: 4230 (nM), Ref: 24684845 IC50: 4440 (nM), Ref: 25497963 IC50: 5460 (nM), Ref: 26100442 IC50: 5460 (nM), Ref: 26481657 IC50: 5460 (nM), Ref: 27123900 |
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TCMT563 | Dual specificity phosphatase Cdc25B | Homo sapiens |
IC50: 980 (nM), Ref: 25497963 |
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TCMT47 | Apoptosis regulator Bcl-2 | Homo sapiens |
Ki: 400 (nM), Ref: 10.1007/s00044-009-9233-5 |
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TCMT161 | Hydroxycarboxylic acid receptor 2 | Homo sapiens |
IC50: 140 (nM), Ref: 17994679 IC50: 140 (nM), Ref: 18029181 Ki: 50 (nM), Ref: 18665582 IC50: 150 (nM), Ref: 18752940 IC50: 140 (nM), Ref: 19307116 IC50: 130 (nM), Ref: 18760600 IC50: 140 (nM), Ref: 19309152 IC50: 140 (nM), Ref: 19592242 IC50: 140 (nM), Ref: 19592242 Ki: 82 (nM), Ref: 20184326 Ki: 104 (nM), Ref: 20184326 IC50: 140 (nM), Ref: 20444602 IC50: 140 (nM), Ref: 20615702 IC50: 249 (nM), Ref: 25737085 |
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TCMT781 | Cytochrome P450 2E1 | Homo sapiens |
Ki: 9980 (nM), Ref: 16248836 |
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TCMT683 | Macrophage migration inhibitory factor | Homo sapiens |
IC50: 1600 (nM), Ref: 25743213 |
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TCMT206 | Cytochrome P450 2A6 | Homo sapiens |
Ki: 1700 (nM), Ref: 22696418 |
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TCMT268 | Cytochrome P450 2A13 | Homo sapiens |
Ki: 3800 (nM), Ref: 22696418 |
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TCMT304 | Matrix metalloproteinase 14 | Homo sapiens |
IC50: 6800 (nM), Ref: 19524436 |
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TCMT306 | Matrix metalloproteinase-2 | Homo sapiens |
IC50: 9600 (nM), Ref: 19524436 |
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TCMT207 | Beta-secretase 1 | Homo sapiens |
IC50: 757 (nM), Ref: 22225636 |
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TCMT126 | Telomerase reverse transcriptase | Homo sapiens |
IC50: 1000 (nM), Ref: 22413845 IC50: 1080 (nM), Ref: 22413845 IC50: 1180 (nM), Ref: 22413845 IC50: 1000 (nM), Ref: 10.1039/C0MD00241K |
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TCMT47 | Apoptosis regulator Bcl-2 | Homo sapiens |
Ki: 335 (nM), Ref: 10.1007/s00044-009-9233-5 |
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TCMT2 | Microtubule-associated protein tau | Homo sapiens |
IC50: 1800 (nM), Ref: 23484434 |
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TCMT751 | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Homo sapiens |
IC50: 330 (nM), Ref: 24188002 |
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TCMT45 | Beta amyloid A4 protein | Homo sapiens |
IC50: 4600 (nM), Ref: 24878198 IC50: 3000 (nM), Ref: 24878198 IC50: 500 (nM), Ref: 25978520 |
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TCMT567 | DNA (cytosine-5)-methyltransferase 1 | Homo sapiens |
IC50: 500 (nM), Ref: 25406944 |
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TCMT232 | P-glycoprotein 1 | Homo sapiens |
IC50: 124.1 (nM), Ref: 25985195 IC50: 122.6 (nM), Ref: 25985195 |
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TCMT296 | Adenosine A1 receptor | Homo sapiens |
Ki: 6200 (nM), Ref: 15214785 Ki: 0.6 (nM), Ref: 15664822 Ki: 6200 (nM), Ref: 16335918 Ki: 6920 (nM), Ref: 16759111 Ki: 6200 (nM), Ref: 16789747 Ki: 6200 (nM), Ref: 17665891 Ki: 6200 (nM), Ref: 19301821 Ki: 6200 (nM), Ref: 18468446 Ki: 6200 (nM), Ref: 19569717 Ki: 6770 (nM), Ref: 20188574 Ki: 6770 (nM), Ref: 24139167 Ki: 6770 (nM), Ref: 10.1039/C5MD00573F |
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TCMT571 | Adenosine A2b receptor | Homo sapiens |
Ki: 7059 (nM), Ref: 15664822 Ki: 9070 (nM), Ref: 16250640 Ki: 9070 (nM), Ref: 16759111 Ki: 7850 (nM), Ref: 19569717 Ki: 9070 (nM), Ref: 20188574 Ki: 2700 (nM), Ref: 20202853 Ki: 9070 (nM), Ref: 20537438 Ki: 9070 (nM), Ref: 24139167 Ki: 9070 (nM), Ref: 26824742 |
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TCMT707 | Adenosine A2a receptor | Homo sapiens |
Ki: 0.6 (nM), Ref: 15664822 Ki: 7900 (nM), Ref: 16335918 Ki: 6700 (nM), Ref: 16759111 Ki: 7900 (nM), Ref: 16789747 Ki: 7900 (nM), Ref: 17665891 Ki: 7900 (nM), Ref: 19301821 Ki: 7900 (nM), Ref: 18468446 Ki: 4200 (nM), Ref: 19569717 Ki: 6700 (nM), Ref: 20188574 Ki: 1700 (nM), Ref: 23200243 Ki: 2030 (nM), Ref: 23200243 Ki: 6700 (nM), Ref: 24139167 Ki: 1710 (nM), Ref: 10.1039/C5MD00573F |
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TCMT112 | Adenosine A3 receptor | Homo sapiens |
Ki: 14 (nM), Ref: 15664822 |
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TCMT307 | HERG | Homo sapiens |
IC50: 4897.79 (nM), Ref: 21185626 |
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TCMT707 | Adenosine A2a receptor | Homo sapiens |
Ki: 5011.87 (nM), Ref: 21661720 Ki: 9560 (nM), Ref: 23200243 Ki: 2480 (nM), Ref: 23200243 |
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TCMT131 | Acetylcholinesterase | Homo sapiens |
IC50: 7250 (nM), Ref: 23791077 |
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TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
IC50: 2000 (nM), Ref: 21561086 |
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TCMT207 | Beta-secretase 1 | Homo sapiens |
IC50: 2500 (nM), Ref: 14592472 |
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TCMT131 | Acetylcholinesterase | Homo sapiens |
IC50: 9000 (nM), Ref: 23791077 |
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TCMT223 | Aldose reductase | Homo sapiens |
IC50: 300 (nM), Ref: 22236472 IC50: 1800 (nM), Ref: 22261024 |
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TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
IC50: 7900 (nM), Ref: 22236472 |
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TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3600 (nM), Ref: 17489632 IC50: 3100 (nM), Ref: 18798681 IC50: 3600 (nM), Ref: 19008110 IC50: 3600 (nM), Ref: 17125223 IC50: 3800 (nM), Ref: 19846295 IC50: 3900 (nM), Ref: 19632832 IC50: 3600 (nM), Ref: 19836230 IC50: 3100 (nM), Ref: 21555221 IC50: 3600 (nM), Ref: 21571537 IC50: 3100 (nM), Ref: 22940448 IC50: 2300 (nM), Ref: 21453996 Ki: 3400 (nM), Ref: 21453996 IC50: 3600 (nM), Ref: 23022281 IC50: 3080 (nM), Ref: 23141910 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2750 (nM), Ref: 23387824 IC50: 4120 (nM), Ref: 24224843 IC50: 4000 (nM), Ref: 24953600 IC50: 3500 (nM), Ref: 25559759 IC50: 3400 (nM), Ref: 25907369 Ki: 6400 (nM), Ref: 25907369 IC50: 5200 (nM), Ref: 26841168 |
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TCMT174 | 11-beta-hydroxysteroid dehydrogenase 1 | Homo sapiens |
IC50: 1900 (nM), Ref: 20100662 |
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TCMT102 | Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens |
IC50: 7200 (nM), Ref: 21453996 |
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TCMT103 | Receptor-type tyrosine-protein phosphatase F (LAR) | Homo sapiens |
IC50: 3800 (nM), Ref: 21453996 |
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TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
Ki: 6000 (nM), Ref: 21561086 Ki: 3700 (nM), Ref: 21561086 Ki: 2100 (nM), Ref: 21561086 Ki: 2800 (nM), Ref: 21561086 Ki: 2000 (nM), Ref: 21561086 IC50: 4000 (nM), Ref: 21561086 |
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TCMT190 | T-cell protein-tyrosine phosphatase | Homo sapiens |
IC50: 2400 (nM), Ref: 23387824 |
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TCMT150 | Nuclear receptor ROR-gamma | Homo sapiens |
IC50: 680 (nM), Ref: 10.1039/C3MD00005B IC50: 130 (nM), Ref: 24704616 IC50: 1060 (nM), Ref: 24704616 IC50: 9410 (nM), Ref: 24704616 |
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TCMT219 | Cytochrome P450 1A2 | Homo sapiens |
IC50: 2437 (nM), Ref: 20696580 |
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TCMT215 | Cytochrome P450 1A1 | Homo sapiens |
IC50: 140 (nM), Ref: 20696580 |
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TCMT257 | Cytochrome P450 1B1 | Homo sapiens |
IC50: 29 (nM), Ref: 20696580 |
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TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 7400 (nM), Ref: 22940448 |
