Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC948	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 6680 (nM), Ref: 20185318 Ki: 6680 (nM), Ref: 26498394
TCMC948	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 8010 (nM), Ref: 20185318 Ki: 8010 (nM), Ref: 26498394
TCMC948	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 5330 (nM), Ref: 20185318
TCMC948	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 5230 (nM), Ref: 20185318
TCMC948	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 6720 (nM), Ref: 20185318
TCMC948	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 7760 (nM), Ref: 20185318
TCMC948	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 5960 (nM), Ref: 20185318
TCMC948	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 9600 (nM), Ref: 20185318
TCMC948	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 7570 (nM), Ref: 20185318
TCMC948	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 980 (nM), Ref: 20185318
TCMC948	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 1070 (nM), Ref: 20185318
TCMC948	TCMT223	Aldose reductase	Homo sapiens	IC50: 140 (nM), Ref: 10.1007/s00044-010-9412-4
TCMC1957	TCMT34	Cytochrome P450 2D6	Homo sapiens	Ki: 78 (nM), Ref: 26125082
TCMC2001	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 6.9 (nM), Ref: 19027293 Ki: 3.9 (nM), Ref: 20055417
TCMC2001	TCMT113	Delta opioid receptor	Homo sapiens	Ki: 180 (nM), Ref: 19027293 Ki: 49 (nM), Ref: 20055417
TCMC2001	TCMT117	Kappa opioid receptor	Homo sapiens	Ki: 3 (nM), Ref: 19027293 Ki: 2.2 (nM), Ref: 20055417
TCMC1258	TCMT37	Serotonin 2a (5-HT2a) receptor	Homo sapiens	Ki: 966 (nM), Ref: 25695425
TCMC1258	TCMT160	Serotonin 7 (5-HT7) receptor	Homo sapiens	Ki: 43 (nM), Ref: 25695425
TCMC1258	TCMT36	Serotonin 1a (5-HT1a) receptor	Homo sapiens	Ki: 171 (nM), Ref: 25695425
TCMC1339	TCMT117	Kappa opioid receptor	Homo sapiens	Ki: 260 (nM), Ref: 22439881
TCMC1339	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 9.5 (nM), Ref: 22439881
TCMC1795	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 286 (nM), Ref: 17616524
TCMC130	TCMT615	Sentrin-specific protease 8	Homo sapiens	IC50: 2470 (nM), Ref:
TCMC130	TCMT616	Sentrin-specific protease 7	Homo sapiens	IC50: 1670 (nM), Ref:
TCMC130	TCMT617	Sentrin-specific protease 6	Homo sapiens	IC50: 805 (nM), Ref:
TCMC2155	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 7400 (nM), Ref: 17616524
TCMC2053	TCMT27	Dopamine D1 receptor	Homo sapiens	Ki: 22 (nM), Ref: 23332346
TCMC2053	TCMT38	Dopamine D2 receptor	Homo sapiens	Ki: 214 (nM), Ref: 23332346
TCMC1837	TCMT789	Phosphodiesterase 3A	Homo sapiens	Ki: 279 (nM), Ref: 17228859
TCMC1837	TCMT790	Phosphodiesterase 3B	Homo sapiens	Ki: 417 (nM), Ref: 17228859
TCMC1837	TCMT792	Phosphodiesterase 10A	Homo sapiens	IC50: 56.9 (nM), Ref: 20450197 IC50: 76 (nM), Ref: 20450197 IC50: 17 (nM), Ref: 21087867 IC50: 21 (nM), Ref: 21705115 IC50: 36 (nM), Ref: 22321214 IC50: 210 (nM), Ref: 23978358 IC50: 36 (nM), Ref: 24721831 IC50: 36 (nM), Ref: 25592707 IC50: 92.3 (nM), Ref: 10.1039/C5MD00419E
TCMC1837	TCMT307	HERG	Homo sapiens	IC50: 7244.36 (nM), Ref: 21185626
TCMC1724	TCMT113	Delta opioid receptor	Homo sapiens	Ki: 41 (nM), Ref: 10741545 Ki: 33 (nM), Ref: 14643346 Ki: 33 (nM), Ref: 17149859 Ki: 33 (nM), Ref: 17149858 Ki: 76 (nM), Ref: 17407276 IC50: 138 (nM), Ref: 17388627 IC50: 138 (nM), Ref: 17451272 IC50: 138 (nM), Ref: 18039010 Ki: 33 (nM), Ref: 18313920 Ki: 120 (nM), Ref: 19027293 IC50: 138 (nM), Ref: 16989522 Ki: 51 (nM), Ref: 20055417 Ki: 38 (nM), Ref: 21482470 Ki: 21.38 (nM), Ref: 19527931 Ki: 103 (nM), Ref: 25062506 Ki: 1516 (nM), Ref: 25268943 Ki: 30 (nM), Ref: 26035635 Ki: 103 (nM), Ref: 10.1039/C5MD00414D
TCMC1724	TCMT117	Kappa opioid receptor	Homo sapiens	Ki: 1.2 (nM), Ref: 10741545 Ki: 9.2 (nM), Ref: 17149859 Ki: 9.2 (nM), Ref: 17149858 Ki: 1.1 (nM), Ref: 17407276 IC50: 320 (nM), Ref: 17407276 Ki: 9.2 (nM), Ref: 18313920 Ki: 1.2 (nM), Ref: 19027293 Ki: 3 (nM), Ref: 20055417 Ki: 14.7 (nM), Ref: 20441176 Ki: 0.25 (nM), Ref: 21482470 Ki: 4.467 (nM), Ref: 19527931 Ki: 362 (nM), Ref: 25268943 Ki: 15 (nM), Ref: 10.1039/C5MD00414D
TCMC1724	TCMT116	Mu opioid receptor	Homo sapiens	IC50: 7.3 (nM), Ref: 14643346 Ki: 3.7 (nM), Ref: 17149859 IC50: 7.3 (nM), Ref: 17149859 Ki: 3.7 (nM), Ref: 17149858 IC50: 7.3 (nM), Ref: 17149858 Ki: 0.79 (nM), Ref: 17407276 IC50: 23 (nM), Ref: 17407276 Ki: 3.7 (nM), Ref: 18313920 IC50: 7.3 (nM), Ref: 18313920 Ki: 0.66 (nM), Ref: 19027293 Ki: 0.98 (nM), Ref: 20055417 Ki: 0.23 (nM), Ref: 21482470 Ki: 0.5623 (nM), Ref: 19527931 IC50: 1.87 (nM), Ref: 24171469 Ki: 2.3 (nM), Ref: 25062506 Ki: 354 (nM), Ref: 25268943 Ki: 1.148 (nM), Ref: 26632862 Ki: 1.259 (nM), Ref: 26632862 Ki: 2.3 (nM), Ref: 10.1039/C5MD00414D
TCMC1724	TCMT112	Adenosine A3 receptor	Homo sapiens	IC50: 1.6 (nM), Ref: 16250647
TCMC1763	TCMT309	Solute carrier family 22 member 2	Homo sapiens	IC50: 2600 (nM), Ref: 23241029
TCMC264	TCMT38	Dopamine D2 receptor	Homo sapiens	Ki: 105 (nM), Ref: 23332346
TCMC264	TCMT27	Dopamine D1 receptor	Homo sapiens	Ki: 6.6 (nM), Ref: 23332346
TCMC930	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 459 (nM), Ref: 17616524
TCMC1600	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 3.96 (nM), Ref: 12372519 Ki: 0.88 (nM), Ref: 16392810 Ki: 1.1 (nM), Ref: 16913723 Ki: 1.1 (nM), Ref: 17887741 Ki: 4 (nM), Ref: 17616524 Ki: 2.55 (nM), Ref: 19627147 Ki: 2.55 (nM), Ref: 21684752 Ki: 2.6 (nM), Ref: 21570305 Ki: 2.6 (nM), Ref: 22341895 Ki: 2.2 (nM), Ref: 24900459 Ki: 0.88 (nM), Ref: 22439881 IC50: 4.3 (nM), Ref: 22995061 Ki: 2.6 (nM), Ref: 23618710 Ki: 2.6 (nM), Ref: 23880358 IC50: 2.5 (nM), Ref: 24171469 Ki: 5.2 (nM), Ref: 25062506 Ki: 2.6 (nM), Ref: 25599950 Ki: 22 (nM), Ref: 25494650 IC50: 6.3 (nM), Ref: 26789491 Ki: 0.53 (nM), Ref: 26390077 Ki: 5.2 (nM), Ref: 10.1039/C5MD00414D
TCMC1600	TCMT113	Delta opioid receptor	Homo sapiens	Ki: 140 (nM), Ref: 16392810 Ki: 140 (nM), Ref: 16913723 Ki: 140 (nM), Ref: 17887741 Ki: 605 (nM), Ref: 22341895 Ki: 140 (nM), Ref: 22439881 Ki: 605 (nM), Ref: 23618710 Ki: 605 (nM), Ref: 23880358 Ki: 605 (nM), Ref: 25599950
TCMC1600	TCMT117	Kappa opioid receptor	Homo sapiens	Ki: 24 (nM), Ref: 16392810 Ki: 46.9 (nM), Ref: 16913723 Ki: 46.9 (nM), Ref: 17887741 Ki: 6.9 (nM), Ref: 19932964 Ki: 299 (nM), Ref: 22341895 Ki: 24 (nM), Ref: 22439881 Ki: 60.9 (nM), Ref: 23419026 Ki: 299 (nM), Ref: 23618710 Ki: 299 (nM), Ref: 23880358 Ki: 299 (nM), Ref: 25599950 Ki: 120 (nM), Ref: 26390077
TCMC1329	TCMT239	Serine/threonine-protein kinase PIM1	Homo sapiens	IC50: 2710 (nM), Ref: 26275107
TCMC1723	TCMT117	Kappa opioid receptor	Homo sapiens	Ki: 0.38 (nM), Ref: 19027293 Ki: 2 (nM), Ref: 26390077
TCMC1723	TCMT113	Delta opioid receptor	Homo sapiens	Ki: 120 (nM), Ref: 19027293
TCMC1723	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 0.19 (nM), Ref: 19027293 Ki: 0.36 (nM), Ref: 26390077
TCMC38	TCMT27	Dopamine D1 receptor	Homo sapiens	Ki: 529 (nM), Ref: 23332346
TCMC1839	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 9800 (nM), Ref: 18501600 Ki: 9800 (nM), Ref: 18579385 Ki: 920 (nM), Ref: 20185318
TCMC1839	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 4800 (nM), Ref: 18579385 Ki: 6270 (nM), Ref: 20185318
TCMC1839	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 9200 (nM), Ref: 18579385 Ki: 3670 (nM), Ref: 20185318
TCMC1839	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 6160 (nM), Ref: 20185318
TCMC1839	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 3730 (nM), Ref: 20185318
TCMC1839	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 4080 (nM), Ref: 20185318
TCMC1839	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 5700 (nM), Ref: 20185318
TCMC1839	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 7130 (nM), Ref: 20185318
TCMC1839	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 7780 (nM), Ref: 20185318
TCMC1839	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 6610 (nM), Ref: 20185318
TCMC1839	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 870 (nM), Ref: 20185318
TCMC28	TCMT853	Sigma opioid receptor	Homo sapiens	Ki: 36 (nM), Ref: 24617836 IC50: 8.24 (nM), Ref: 26717207 IC50: 7.59 (nM), Ref: 26717207
TCMC847	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 8710 (nM), Ref: 20185318 Ki: 8710 (nM), Ref: 26498394
TCMC847	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 9060 (nM), Ref: 20185318 Ki: 9060 (nM), Ref: 26498394
TCMC847	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 7870 (nM), Ref: 20185318
TCMC847	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 6420 (nM), Ref: 20185318
TCMC847	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 7330 (nM), Ref: 20185318
TCMC847	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 9080 (nM), Ref: 20185318
TCMC847	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 6490 (nM), Ref: 20185318
TCMC847	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 10000 (nM), Ref: 20185318
TCMC847	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 1610 (nM), Ref: 20185318
TCMC847	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 2380 (nM), Ref: 20185318
TCMC847	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3060 (nM), Ref: 19476336
TCMC847	TCMT321	Matrix metalloproteinase 9	Homo sapiens	IC50: 21.22 (nM), Ref: 23375794 IC50: 10 (nM), Ref: 23375794
TCMC847	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 24.26 (nM), Ref: 23375794
TCMC847	TCMT295	Matrix metalloproteinase-1	Homo sapiens	IC50: 238.91 (nM), Ref: 23375794
TCMC847	TCMT130	Arachidonate 5-lipoxygenase	Homo sapiens	IC50: 8500 (nM), Ref: 26197161
TCMC1657	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 1.585 (nM), Ref: 26632862
TCMC234	TCMT615	Sentrin-specific protease 8	Homo sapiens	IC50: 5470 (nM), Ref:
TCMC234	TCMT616	Sentrin-specific protease 7	Homo sapiens	IC50: 4630 (nM), Ref:
TCMC234	TCMT617	Sentrin-specific protease 6	Homo sapiens	IC50: 1860 (nM), Ref:
TCMC929	TCMT116	Mu opioid receptor	Homo sapiens	Ki: 6300 (nM), Ref: 17616524
TCMC265	TCMT38	Dopamine D2 receptor	Homo sapiens	Ki: 91 (nM), Ref: 23332346
TCMC265	TCMT27	Dopamine D1 receptor	Homo sapiens	Ki: 4.5 (nM), Ref: 23332346
TCMC1857	TCMT853	Sigma opioid receptor	Homo sapiens	Ki: 36 (nM), Ref: 27156565

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1329	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 13.9 (ug/ml), Ref: 20116898
TCMC995	TCMT1104	Sortase	Staphylococcus aureus	IC50: 18.3 (ug/ml), Ref: 16154746
TCMC1957	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 50.13 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC2444	TCMT1438	Plasmodium falciparum	Plasmodium falciparum D6	IC50: 5.8 (ug/ml), Ref: 8786363 IC50: 3.65 (ug/ml), Ref: 8786363
TCMC2444	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 5.8 (ug/ml), Ref: 8786363 IC50: 3.65 (ug/ml), Ref: 8786363
TCMC2444	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 32 (ug/ml), Ref: 25372601
TCMC495	TCMT1438	Plasmodium falciparum	Plasmodium falciparum D6	IC50: 7.33 (ug/ml), Ref: 8759172 IC50: 5.56 (ug/ml), Ref: 8759172
TCMC495	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 7.33 (ug/ml), Ref: 8759172 IC50: 5.56 (ug/ml), Ref: 8759172
TCMC2565	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 7 (ug/ml), Ref: 17845001
TCMC1329	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC2596	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 4.2 (ug/ml), Ref: 17845001
TCMC2040	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 50.03 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC2044	TCMT1462	Streptococcus mutans	Streptococcus mutans	MIC: 15 (ug/ml), Ref: 9644074 MIC: 15 (ug/ml), Ref: 8904847
TCMC2044	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MIC: 15 (ug/ml), Ref: 8904847
TCMC2044	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC90: 16 (ug/ml), Ref: 23127490 MIC90: 8 (ug/ml), Ref: 23127490 MIC: 16 (ug/ml), Ref: 23314053 MIC: 8 (ug/ml), Ref: 23314053
TCMC2044	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC90: 2 (ug/ml), Ref: 23127490 MIC: 2 (ug/ml), Ref: 23314053 MBC: 0.034 (nM), Ref: 22182580
TCMC2338	TCMT1221	Human herpesvirus 4	Human herpesvirus 4	IC50: 8.8 (nM), Ref: 17503850
TCMC2514	TCMT1221	Human herpesvirus 4	Human herpesvirus 4	IC50: 8.9 (nM), Ref: 17503850
TCMC2542	TCMT1221	Human herpesvirus 4	Human herpesvirus 4	IC50: 8.8 (nM), Ref: 17503850
TCMC2044	TCMT1223	Staphylococcus epidermidis	Staphylococcus epidermidis	MBC: 0.034 (nM), Ref: 22182580