Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC2093	TCMT82	Estrogen receptor alpha	Homo sapiens	IC50: 57 (nM), Ref: 17149865
TCMC2093	TCMT236	Estrogen receptor beta	Homo sapiens	IC50: 68 (nM), Ref: 17149865
TCMC758	TCMT67	Peroxisome proliferator-activated receptor gamma	Homo sapiens	Ki: 175.5 (nM), Ref: 25978962 IC50: 488.8 (nM), Ref: 25978962
TCMC1480	TCMT107	Glutamate receptor ionotropic kainate 2	Homo sapiens	Ki: 1106 (nM), Ref: 10821708
TCMC1480	TCMT108	Glutamate receptor ionotropic, AMPA 1	Homo sapiens	Ki: 1360 (nM), Ref: 9357531
TCMC1480	TCMT109	Glutamate receptor ionotropic, AMPA 2	Homo sapiens	Ki: 940 (nM), Ref: 9357531
TCMC1480	TCMT110	Glutamate receptor ionotropic, AMPA 4	Homo sapiens	Ki: 868 (nM), Ref: 9357531
TCMC1480	TCMT111	Glutamate receptor ionotropic kainate 5	Homo sapiens	Ki: 701 (nM), Ref: 9357531
TCMC1480	TCMT660	Metabotropic glutamate receptor 8	Homo sapiens	IC50: 5.7 (nM), Ref: 15603952
TCMC1480	TCMT112	Adenosine A3 receptor	Homo sapiens	IC50: 613 (nM), Ref: 16250647
TCMC1480	TCMT653	Metabotropic glutamate receptor 1	Homo sapiens	Ki: 250 (nM), Ref: 17725337 Ki: 570 (nM), Ref: 19042134 Ki: 1584.89 (nM), Ref: 10.1039/C1MD00186H
TCMC1480	TCMT654	Metabotropic glutamate receptor 5	Homo sapiens	Ki: 390 (nM), Ref: 17725337 Ki: 1160 (nM), Ref: 19042134 Ki: 4677.35 (nM), Ref: 10.1039/C1MD00186H
TCMC1480	TCMT657	Metabotropic glutamate receptor 4	Homo sapiens	Ki: 2400 (nM), Ref: 17725337 Ki: 1400 (nM), Ref: 19042134 Ki: 3235.94 (nM), Ref: 10.1039/C1MD00186H
TCMC1480	TCMT655	Metabotropic glutamate receptor 2	Homo sapiens	Ki: 6400 (nM), Ref: 19042134 Ki: 1819.7 (nM), Ref: 10.1039/C1MD00186H
TCMC1480	TCMT664	Excitatory amino acid transporter 3	Homo sapiens	Ki: 51 (nM), Ref: 18578477
TCMC1480	TCMT656	Metabotropic glutamate receptor 3	Homo sapiens	Ki: 57.54 (nM), Ref: 10.1039/C1MD00186H
TCMC1786	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3900 (nM), Ref: 16580200 IC50: 7600 (nM), Ref: 18798681 IC50: 4200 (nM), Ref: 19702283 IC50: 3840 (nM), Ref: 22044245 IC50: 5600 (nM), Ref: 22690646 IC50: 9500 (nM), Ref: 21453996 Ki: 6000 (nM), Ref: 21453996 IC50: 5050.1 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3370 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2600 (nM), Ref: 23357636 IC50: 1100 (nM), Ref: 23434422 IC50: 3020 (nM), Ref: 23942421 IC50: 2010 (nM), Ref: 24090912 IC50: 1900 (nM), Ref: 24684845 IC50: 3020 (nM), Ref: 25497963 IC50: 9500 (nM), Ref: 25264584 Ki: 6000 (nM), Ref: 25264584 IC50: 1030 (nM), Ref: 25595683 IC50: 1170 (nM), Ref: 25600405 IC50: 3020 (nM), Ref: 25872983 IC50: 1000 (nM), Ref: 26083682 IC50: 1536 (nM), Ref: 26100442 IC50: 700 (nM), Ref: 26115570 IC50: 700 (nM), Ref: 26253631 IC50: 1536 (nM), Ref: 26481657 IC50: 730 (nM), Ref: 26711144 IC50: 3020 (nM), Ref: 26774579 IC50: 1536 (nM), Ref: 27123900
TCMC1786	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 4000 (nM), Ref: 21561086 Ki: 3560 (nM), Ref: 21561086 Ki: 660 (nM), Ref: 21561086 Ki: 940 (nM), Ref: 21561086 Ki: 160 (nM), Ref: 21561086 Ki: 72 (nM), Ref: 21561086 IC50: 90 (nM), Ref: 21561086
TCMC1786	TCMT190	T-cell protein-tyrosine phosphatase	Homo sapiens	IC50: 4230 (nM), Ref: 24684845 IC50: 4440 (nM), Ref: 25497963 IC50: 5460 (nM), Ref: 26100442 IC50: 5460 (nM), Ref: 26481657 IC50: 5460 (nM), Ref: 27123900
TCMC1786	TCMT563	Dual specificity phosphatase Cdc25B	Homo sapiens	IC50: 980 (nM), Ref: 25497963
TCMC1199	TCMT320	Matrix metalloproteinase 3	Homo sapiens	IC50: 1000 (nM), Ref: 10.1016/0960-894X(95)00282-X
TCMC2105	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2105	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 930 (nM), Ref: 15357969
TCMC1830	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 2600 (nM), Ref: 15357969
TCMC1830	TCMT808	Fatty acid binding protein epidermal	Homo sapiens	IC50: 1200 (nM), Ref: 15357969
TCMC1830	TCMT809	Fatty acid binding protein intestinal	Homo sapiens	IC50: 1700 (nM), Ref: 15357969
TCMC1830	TCMT810	Toll-like receptor 2	Homo sapiens	IC50: 5000 (nM), Ref: 16509590
TCMC1830	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1551	TCMT206	Cytochrome P450 2A6	Homo sapiens	Ki: 1900 (nM), Ref: 16248836 Ki: 1900 (nM), Ref: 16248836 Ki: 800 (nM), Ref: 16248836 Ki: 250 (nM), Ref: 22696418
TCMC1551	TCMT131	Acetylcholinesterase	Homo sapiens	IC50: 760 (nM), Ref: 23746477
TCMC1551	TCMT268	Cytochrome P450 2A13	Homo sapiens	Ki: 40 (nM), Ref: 22696418
TCMC679	TCMT624	Heat shock protein HSP 90-beta	Homo sapiens	IC50: 930 (nM), Ref: 7853008 IC50: 1410 (nM), Ref: IC50: 24 (nM), Ref: 10.1007/s00044-012-0301-x IC50: 90 (nM), Ref: 19734910
TCMC679	TCMT619	Heat shock protein HSP 90-alpha	Homo sapiens	Ki: 680 (nM), Ref:
TCMC1961	TCMT206	Cytochrome P450 2A6	Homo sapiens	Ki: 600 (nM), Ref: 16248836
TCMC1961	TCMT131	Acetylcholinesterase	Homo sapiens	IC50: 6480 (nM), Ref: 23746477
TCMC1343	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 90 (nM), Ref: 18501600 Ki: 90 (nM), Ref: 18579385
TCMC1343	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 7800 (nM), Ref: 18579385
TCMC1343	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 8200 (nM), Ref: 18579385

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1786	TCMT1107	Protease	Human immunodeficiency virus 1	IC50: 10 (ug/ml), Ref: 10691716
TCMC995	TCMT1104	Sortase	Staphylococcus aureus	IC50: 18.3 (ug/ml), Ref: 16154746
TCMC1381	TCMT1251	Candida albicans	Candida albicans	IC50: 3 (ug/ml), Ref: 17112640 IC50: 2 (ug/ml), Ref: 12502337
TCMC1381	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 7 (ug/ml), Ref: 17112640 IC50: 45 (ug/ml), Ref: 12502337
TCMC1381	TCMT1286	Bacillus cereus	Bacillus cereus	MIC: 31.2 (ug/ml), Ref: 18951808
TCMC1381	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 31.2 (ug/ml), Ref: 18951808 MIC: 31.25 (ug/ml), Ref: 22169259 MIC: 62.5 (ug/ml), Ref: 22169259 MIC: 15.62 (ug/ml), Ref: 22169259
TCMC1381	TCMT1246	Escherichia coli	Escherichia coli	MIC: 2 (ug/ml), Ref: 20160051 MIC: 64 (ug/ml), Ref: 20160051 MIC: 0.5 (ug/ml), Ref: 20160051 MIC: 16 (ug/ml), Ref: 20160051 MIC: 0.25 (ug/ml), Ref: 20160051 MIC: 8 (ug/ml), Ref: 20160051
TCMC1381	TCMT1179	Escherichia coli ATCC 8739	Escherichia coli ATCC 8739	MIC: 8 (ug/ml), Ref: 20160051
TCMC1381	TCMT1448	Enterobacter aerogenes	Enterobacter aerogenes	MIC: 16 (ug/ml), Ref: 20160051 MIC: 32 (ug/ml), Ref: 20160051 MIC: 0.5 (ug/ml), Ref: 20160051 MIC: 8 (ug/ml), Ref: 20160051 MIC: 64 (ug/ml), Ref: 20160051
TCMC1381	TCMT1226	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC: 32 (ug/ml), Ref: 20160051 MIC: 4 (ug/ml), Ref: 20160051 MIC: 16 (ug/ml), Ref: 20160051 MIC: 0.5 (ug/ml), Ref: 20160051
TCMC1381	TCMT1215	Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa PAO1	MIC: 64 (ug/ml), Ref: 20160051 MIC: 16 (ug/ml), Ref: 20160051
TCMC1381	TCMT1232	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC: 64 (ug/ml), Ref: 20160051 MIC: 4 (ug/ml), Ref: 20160051
TCMC1381	TCMT1170	Enterobacter cloacae	Enterobacter cloacae	MIC: 8 (ug/ml), Ref: 20160051 MIC: 64 (ug/ml), Ref: 20160051 MIC: 1 (ug/ml), Ref: 20160051
TCMC1381	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 18 (ug/ml), Ref: 22280816
TCMC2362	TCMT1211	Fusobacterium nucleatum	Fusobacterium nucleatum	MIC: 32 (ug/ml), Ref: 20427099
TCMC2362	TCMT1182	Streptococcus sanguinis	Streptococcus sanguinis	MIC: 1 (ug/ml), Ref: 20427099
TCMC2362	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MIC: 1 (ug/ml), Ref: 20427099
TCMC2362	TCMT1462	Streptococcus mutans	Streptococcus mutans	MIC: 1 (ug/ml), Ref: 20427099
TCMC2374	TCMT1251	Candida albicans	Candida albicans	IC50: 5 (ug/ml), Ref: 12502337
TCMC2374	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 7.5 (ug/ml), Ref: 12502337
TCMC553	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0032-z
TCMC2093	TCMT1251	Candida albicans	Candida albicans	MIC: 64 (ug/ml), Ref: 12932139
TCMC2093	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	MIC: 64 (ug/ml), Ref: 12932139
TCMC2411	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 16 (ug/ml), Ref: 11141098
TCMC2411	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 64 (ug/ml), Ref: 12608857
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC1786	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 21.8 (ug/ml), Ref: 9748372
TCMC1786	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 21288041
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC2491	TCMT1251	Candida albicans	Candida albicans	MIC: 3.2 (ug/ml), Ref: 9873584
TCMC1515	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 100 (ug/ml), Ref: 20542692
TCMC2544	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 3.2 (ug/ml), Ref: 7964799
TCMC2544	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	MIC: 50 (ug/ml), Ref: 7964799
TCMC1830	TCMT1361	Neisseria meningitidis	Neisseria meningitidis	MIC: 50 (ug/ml), Ref: 19884363
TCMC1830	TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50: 3.8 (ug/ml), Ref: 20855214 IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 14.5 (ug/ml), Ref: 20855214
TCMC495	TCMT1438	Plasmodium falciparum	Plasmodium falciparum D6	IC50: 7.33 (ug/ml), Ref: 8759172 IC50: 5.56 (ug/ml), Ref: 8759172
TCMC495	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 7.33 (ug/ml), Ref: 8759172 IC50: 5.56 (ug/ml), Ref: 8759172
TCMC801	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 32 (ug/ml), Ref: 15844943
TCMC801	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 52.3 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC724	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 20 (ug/ml), Ref: 12502337
TCMC724	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 8 (ug/ml), Ref: 9748372 IC50: 36 (ug/ml), Ref: 9748372
TCMC724	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 64 (ug/ml), Ref: 21288041
TCMC724	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 64 (ug/ml), Ref: 21288041
TCMC348	TCMT1232	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC: 62 (ug/ml), Ref: 25813159
TCMC1955	TCMT1464	Hepatitis B virus	Hepatitis B virus	IC50: 4.17 (ug/ml), Ref: 24549242
TCMC912	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 6.21 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC2667	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 64 (ug/ml), Ref: 15104489 MIC: 100 (ug/ml), Ref: 20542692
TCMC1551	TCMT1349	Helicobacter pylori SS1	Helicobacter pylori SS1	MIC: 25 (ug/ml), Ref: 20832915
TCMC2747	TCMT1182	Streptococcus sanguinis	Streptococcus sanguinis	MBC: 16 (ug/ml), Ref: 15958589 MIC: 16 (ug/ml), Ref: 15958589
TCMC2747	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MBC: 64 (ug/ml), Ref: 15958589 MIC: 32 (ug/ml), Ref: 15958589
TCMC1961	TCMT1349	Helicobacter pylori SS1	Helicobacter pylori SS1	MIC: 6.25 (ug/ml), Ref: 20832915
TCMC2809	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 0.59 (ug/ml), Ref: 18553924
TCMC2818	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MIC: 64 (ug/ml), Ref: 20427099