Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1173	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 9430 (nM), Ref: 20185318 Ki: 9430 (nM), Ref: 26498394
TCMC1173	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 9780 (nM), Ref: 20185318 Ki: 9780 (nM), Ref: 26498394
TCMC1173	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 9870 (nM), Ref: 20185318
TCMC1173	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 7410 (nM), Ref: 20185318
TCMC1173	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 8450 (nM), Ref: 20185318
TCMC1173	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 7040 (nM), Ref: 20185318
TCMC1173	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 2400 (nM), Ref: 20185318
TCMC1173	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 2890 (nM), Ref: 20185318
TCMC1495	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 1000 (nM), Ref: 20471252 IC50: 1000 (nM), Ref: 25461324 IC50: 1000 (nM), Ref: 25461324 Ki: 9300 (nM), Ref: 27460668
TCMC1495	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 1000 (nM), Ref: 20471252 Ki: 6800 (nM), Ref: 27460668
TCMC1495	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1100 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 10000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495	TCMT67	Peroxisome proliferator-activated receptor gamma	Homo sapiens	IC50: 6200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1956	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 1080 (nM), Ref: 21282059
TCMC1956	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 470 (nM), Ref: 21282059
TCMC1956	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 4450 (nM), Ref: 21282059
TCMC1956	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 4090 (nM), Ref: 21282059
TCMC1956	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 4720 (nM), Ref: 21669522 Ki: 4720 (nM), Ref: 22687439
TCMC1956	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 2450 (nM), Ref: 22687439
TCMC1956	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 690 (nM), Ref: 22668600
TCMC1956	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 7870 (nM), Ref: 22668600
TCMC1741	TCMT161	Hydroxycarboxylic acid receptor 2	Homo sapiens	IC50: 140 (nM), Ref: 17994679 IC50: 140 (nM), Ref: 18029181 Ki: 50 (nM), Ref: 18665582 IC50: 150 (nM), Ref: 18752940 IC50: 140 (nM), Ref: 19307116 IC50: 130 (nM), Ref: 18760600 IC50: 140 (nM), Ref: 19309152 IC50: 140 (nM), Ref: 19592242 IC50: 140 (nM), Ref: 19592242 Ki: 82 (nM), Ref: 20184326 Ki: 104 (nM), Ref: 20184326 IC50: 140 (nM), Ref: 20444602 IC50: 140 (nM), Ref: 20615702 IC50: 249 (nM), Ref: 25737085
TCMC1830	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 930 (nM), Ref: 15357969
TCMC1830	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 2600 (nM), Ref: 15357969
TCMC1830	TCMT808	Fatty acid binding protein epidermal	Homo sapiens	IC50: 1200 (nM), Ref: 15357969
TCMC1830	TCMT809	Fatty acid binding protein intestinal	Homo sapiens	IC50: 1700 (nM), Ref: 15357969
TCMC1830	TCMT810	Toll-like receptor 2	Homo sapiens	IC50: 5000 (nM), Ref: 16509590
TCMC1830	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC846	TCMT207	Beta-secretase 1	Homo sapiens	Ki: 6200 (nM), Ref: 22222157
TCMC1118	TCMT304	Matrix metalloproteinase 14	Homo sapiens	IC50: 6800 (nM), Ref: 19524436
TCMC1118	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 9600 (nM), Ref: 19524436
TCMC1118	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 757 (nM), Ref: 22225636
TCMC1118	TCMT126	Telomerase reverse transcriptase	Homo sapiens	IC50: 1000 (nM), Ref: 22413845 IC50: 1080 (nM), Ref: 22413845 IC50: 1180 (nM), Ref: 22413845 IC50: 1000 (nM), Ref: 10.1039/C0MD00241K
TCMC1118	TCMT47	Apoptosis regulator Bcl-2	Homo sapiens	Ki: 335 (nM), Ref: 10.1007/s00044-009-9233-5
TCMC1118	TCMT2	Microtubule-associated protein tau	Homo sapiens	IC50: 1800 (nM), Ref: 23484434
TCMC1118	TCMT751	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	IC50: 330 (nM), Ref: 24188002
TCMC1118	TCMT45	Beta amyloid A4 protein	Homo sapiens	IC50: 4600 (nM), Ref: 24878198 IC50: 3000 (nM), Ref: 24878198 IC50: 500 (nM), Ref: 25978520
TCMC1118	TCMT567	DNA (cytosine-5)-methyltransferase 1	Homo sapiens	IC50: 500 (nM), Ref: 25406944
TCMC1118	TCMT232	P-glycoprotein 1	Homo sapiens	IC50: 124.1 (nM), Ref: 25985195 IC50: 122.6 (nM), Ref: 25985195
TCMC1788	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 600 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 600 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 5300 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788	TCMT67	Peroxisome proliferator-activated receptor gamma	Homo sapiens	IC50: 4100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788	TCMT126	Telomerase reverse transcriptase	Homo sapiens	IC50: 8600 (nM), Ref: 10.1039/C0MD00241K
TCMC1788	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	Ki: 1500 (nM), Ref: 27460668
TCMC341	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 510 (nM), Ref: 19231207
TCMC847	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 8710 (nM), Ref: 20185318 Ki: 8710 (nM), Ref: 26498394
TCMC847	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 9060 (nM), Ref: 20185318 Ki: 9060 (nM), Ref: 26498394
TCMC847	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 7870 (nM), Ref: 20185318
TCMC847	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 6420 (nM), Ref: 20185318
TCMC847	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 7330 (nM), Ref: 20185318
TCMC847	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 9080 (nM), Ref: 20185318
TCMC847	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 6490 (nM), Ref: 20185318
TCMC847	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 10000 (nM), Ref: 20185318
TCMC847	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 1610 (nM), Ref: 20185318
TCMC847	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 2380 (nM), Ref: 20185318
TCMC847	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3060 (nM), Ref: 19476336
TCMC847	TCMT321	Matrix metalloproteinase 9	Homo sapiens	IC50: 21.22 (nM), Ref: 23375794 IC50: 10 (nM), Ref: 23375794
TCMC847	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 24.26 (nM), Ref: 23375794
TCMC847	TCMT295	Matrix metalloproteinase-1	Homo sapiens	IC50: 238.91 (nM), Ref: 23375794
TCMC847	TCMT130	Arachidonate 5-lipoxygenase	Homo sapiens	IC50: 8500 (nM), Ref: 26197161
TCMC897	TCMT223	Aldose reductase	Homo sapiens	IC50: 300 (nM), Ref: 22236472 IC50: 1800 (nM), Ref: 22261024
TCMC897	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 7900 (nM), Ref: 22236472
TCMC273	TCMT332	Amine oxidase, copper containing	Homo sapiens	IC50: 4100 (nM), Ref: 23664164

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1866	TCMT1112	Quinolone resistance protein norA	Staphylococcus aureus	MIC: 4 (ug/ml), Ref: 10.1039/C4MD00196F
TCMC1118	TCMT1092	Fatty acid synthase	Plasmodium falciparum	IC50: 0.03 (ug/ml), Ref: 20855214 IC50: 30 (nM), Ref: 24063369
TCMC1118	TCMT1094	3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	IC50: 0.32 (ug/ml), Ref: 20855214
TCMC2354	TCMT1251	Candida albicans	Candida albicans	IC50: 81.47 (ug/ml), Ref: 25686593
TCMC2539	TCMT1462	Streptococcus mutans	Streptococcus mutans	MIC: 100 (ug/ml), Ref: 1517735
TCMC1830	TCMT1361	Neisseria meningitidis	Neisseria meningitidis	MIC: 50 (ug/ml), Ref: 19884363
TCMC1830	TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50: 3.8 (ug/ml), Ref: 20855214 IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 14.5 (ug/ml), Ref: 20855214
TCMC924	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 64 (ug/ml), Ref: 24641242
TCMC2166	TCMT1211	Fusobacterium nucleatum	Fusobacterium nucleatum	MIC: 50 (ug/ml), Ref: 8864235
TCMC2166	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 64 (ug/ml), Ref: 19651906
TCMC2166	TCMT1321	Staphylococcus hominis	Staphylococcus hominis	MIC: 32 (ug/ml), Ref: 19651906 MIC50: 64 (ug/ml), Ref: 19651906 MBC: 64 (ug/ml), Ref: 19651906 MIC: 4 (ug/ml), Ref: 19651906 MIC90: 64 (ug/ml), Ref: 19651906
TCMC2166	TCMT1223	Staphylococcus epidermidis	Staphylococcus epidermidis	MIC: 32 (ug/ml), Ref: 19651906 MIC50: 64 (ug/ml), Ref: 19651906 MBC: 64 (ug/ml), Ref: 19651906 MIC: 4 (ug/ml), Ref: 19651906 MIC90: 64 (ug/ml), Ref: 19651906 MIC: 32.25 (ug/ml), Ref: 10.1007/s00044-013-0809-8
TCMC2166	TCMT1209	Staphylococcus haemolyticus	Staphylococcus haemolyticus	MIC: 32 (ug/ml), Ref: 19651906 MIC50: 64 (ug/ml), Ref: 19651906 MBC: 64 (ug/ml), Ref: 19651906 MIC: 4 (ug/ml), Ref: 19651906 MIC90: 64 (ug/ml), Ref: 19651906
TCMC2166	TCMT1343	Staphylococcus simulans	Staphylococcus simulans	MIC: 32 (ug/ml), Ref: 19651906 MIC50: 64 (ug/ml), Ref: 19651906 MBC: 64 (ug/ml), Ref: 19651906 MIC: 4 (ug/ml), Ref: 19651906 MIC90: 64 (ug/ml), Ref: 19651906
TCMC2166	TCMT1344	Staphylococcus sciuri	Staphylococcus sciuri	MIC: 32 (ug/ml), Ref: 19651906 MIC50: 64 (ug/ml), Ref: 19651906 MBC: 64 (ug/ml), Ref: 19651906 MIC: 4 (ug/ml), Ref: 19651906 MIC90: 64 (ug/ml), Ref: 19651906
TCMC2166	TCMT1251	Candida albicans	Candida albicans	MIC: 100 (ug/ml), Ref: 10.1007/s00044-013-0809-8
TCMC2166	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 62.5 (ug/ml), Ref: 10.1007/s00044-013-0809-8
TCMC2166	TCMT1246	Escherichia coli	Escherichia coli	MIC: 100 (ug/ml), Ref: 10.1007/s00044-013-0809-8
TCMC2166	TCMT1462	Streptococcus mutans	Streptococcus mutans	MIC: 62.5 (ug/ml), Ref: 10.1007/s00044-013-0809-8
TCMC1788	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 100 (ug/ml), Ref: 24103427
TCMC912	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 6.21 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1578	TCMT1408	Colletotrichum gloeosporioides	Colletotrichum gloeosporioides	IC50: 0.09 (ug/ml), Ref: 10.1016/j.cropro.2009.12.007
TCMC1578	TCMT1245	Phytophthora cactorum	Phytophthora cactorum	IC50: 0.052 (ug/ml), Ref: 10.1016/j.cropro.2009.12.007
TCMC1776	TCMT1253	Penicillium chrysogenum	Penicillium chrysogenum	MIC: 100 (ug/ml), Ref: 10.1021/np50124a013
TCMC897	TCMT1346	Helicobacter pylori	Helicobacter pylori	MIC: 6.25 (ug/ml), Ref: 12762812
TCMC2822	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC: 6.25 (ug/ml), Ref: 17845001
TCMC1118	TCMT1093	Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Ki: 79 (nM), Ref: 17263522 Ki: 8 (nM), Ref: 17263522
TCMC791	TCMT1221	Human herpesvirus 4	Human herpesvirus 4	IC50: 12.7 (nM), Ref: 17503850
TCMC1118	TCMT1222	Plasmodium falciparum D6	Plasmodium falciparum D6	IC50: 73 (nM), Ref: 25488841