TCM Putative Target References: TCMFx4618


Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC2051
TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 8710 (nM), Ref: 22892213
TCMC2051
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 4050 (nM), Ref: 22892213
TCMC2051
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 960 (nM), Ref: 22892213
TCMC1372
TCMT142 Carbonic anhydrase IV Homo sapiens Ki: 2330 (nM), Ref: 22245047
TCMC1372
TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 3630 (nM), Ref: 22245047
TCMC1480
TCMT107 Glutamate receptor ionotropic kainate 2 Homo sapiens Ki: 1106 (nM), Ref: 10821708
TCMC1480
TCMT108 Glutamate receptor ionotropic, AMPA 1 Homo sapiens Ki: 1360 (nM), Ref: 9357531
TCMC1480
TCMT109 Glutamate receptor ionotropic, AMPA 2 Homo sapiens Ki: 940 (nM), Ref: 9357531
TCMC1480
TCMT110 Glutamate receptor ionotropic, AMPA 4 Homo sapiens Ki: 868 (nM), Ref: 9357531
TCMC1480
TCMT111 Glutamate receptor ionotropic kainate 5 Homo sapiens Ki: 701 (nM), Ref: 9357531
TCMC1480
TCMT660 Metabotropic glutamate receptor 8 Homo sapiens IC50: 5.7 (nM), Ref: 15603952
TCMC1480
TCMT112 Adenosine A3 receptor Homo sapiens IC50: 613 (nM), Ref: 16250647
TCMC1480
TCMT653 Metabotropic glutamate receptor 1 Homo sapiens Ki: 250 (nM), Ref: 17725337
Ki: 570 (nM), Ref: 19042134
Ki: 1584.89 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
TCMT654 Metabotropic glutamate receptor 5 Homo sapiens Ki: 390 (nM), Ref: 17725337
Ki: 1160 (nM), Ref: 19042134
Ki: 4677.35 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
TCMT657 Metabotropic glutamate receptor 4 Homo sapiens Ki: 2400 (nM), Ref: 17725337
Ki: 1400 (nM), Ref: 19042134
Ki: 3235.94 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
TCMT655 Metabotropic glutamate receptor 2 Homo sapiens Ki: 6400 (nM), Ref: 19042134
Ki: 1819.7 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
TCMT664 Excitatory amino acid transporter 3 Homo sapiens Ki: 51 (nM), Ref: 18578477
TCMC1480
TCMT656 Metabotropic glutamate receptor 3 Homo sapiens Ki: 57.54 (nM), Ref: 10.1039/C1MD00186H
TCMC498
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 410 (nM), Ref: 26688270
TCMC498
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 6300 (nM), Ref: 26688270
TCMC1396
TCMT689 Protein-glutamine gamma-glutamyltransferase Homo sapiens IC50: 8000 (nM), Ref: 21215619
TCMC1743
TCMT206 Cytochrome P450 2A6 Homo sapiens Ki: 4400 (nM), Ref: 15634016
TCMC1743
TCMT241 Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki: 7200 (nM), Ref: 15686879
Ki: 6300 (nM), Ref: 15908213
Ki: 630 (nM), Ref: 16171993
Ki: 10000 (nM), Ref: 17722904
Ki: 1000 (nM), Ref: 19331415
Ki: 1023.29 (nM), Ref: 20828128
Ki: 1000 (nM), Ref: 21920761
Ki: 1000 (nM), Ref: 22243960
Ki: 3000 (nM), Ref: 22793665
Ki: 3000 (nM), Ref: 23126648
Ki: 3800 (nM), Ref: 23561269
IC50: 7600 (nM), Ref: 23561269
Ki: 3000 (nM), Ref: 23692872
TCMC1743
TCMT552 Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens IC50: 45 (nM), Ref: 11312774
TCMC2196
TCMT30 Cyclooxygenase-2 Homo sapiens IC50: 64 (nM), Ref: 22819942
IC50: 64 (nM), Ref: 23146282
TCMC2196
TCMT130 Arachidonate 5-lipoxygenase Homo sapiens IC50: 150 (nM), Ref: 22819942
TCMC2196
TCMT336 Indoleamine 2,3-dioxygenase Homo sapiens IC50: 53.7 (nM), Ref: 24099220
IC50: 7150 (nM), Ref: 24099220
Ki: 4810 (nM), Ref: 24099220
TCMC1329
TCMT239 Serine/threonine-protein kinase PIM1 Homo sapiens IC50: 2710 (nM), Ref: 26275107
TCMC2204
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 482 (nM), Ref: 21067924
Ki: 478 (nM), Ref: 22077347
Ki: 480 (nM), Ref: 26688270
TCMC2204
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 754 (nM), Ref: 22077347
Ki: 750 (nM), Ref: 26688270
TCMC1377
TCMT186 Monoamine oxidase B Homo sapiens Ki: 3000 (nM), Ref: 16137882
Ki: 3000 (nM), Ref: 19342233
IC50: 7943.28 (nM), Ref: 20934874
Ki: 5340 (nM), Ref: 21134756
Ki: 3000 (nM), Ref: 21778064
Ki: 2000 (nM), Ref: 24140951
TCMC1377
TCMT208 Monoamine oxidase A Homo sapiens Ki: 8380 (nM), Ref: 21134756
TCMC732
TCMT280 Aldo-keto reductase family 1 member B10 Homo sapiens IC50: 5900 (nM), Ref: 21561086
TCMC825
TCMT605 Endothelin receptor ET-A Homo sapiens Ki: 18 (nM), Ref: 10.1016/0960-894X(95)00019-P
TCMC1090
TCMT118 Maltase-glucoamylase Homo sapiens IC50: 40 (nM), Ref: 15771446
TCMC1090
TCMT18 Lysosomal alpha-glucosidase Homo sapiens IC50: 1000 (nM), Ref: 18595718
IC50: 60 (nM), Ref: 18595718
IC50: 1500 (nM), Ref: 19853441
TCMC2018
TCMT907 Farnesyl diphosphate synthase Homo sapiens IC50: 452.9 (nM), Ref: 18327899
Ki: 82.2 (nM), Ref: 18327899
IC50: 5.7 (nM), Ref: 18327899
Ki: 0.36 (nM), Ref: 18327899
IC50: 5.7 (nM), Ref: 18434151
IC50: 300 (nM), Ref: 20801032
IC50: 11 (nM), Ref: 22390415
IC50: 860 (nM), Ref: 22390415
IC50: 11 (nM), Ref: 22884353
IC50: 10 (nM), Ref: 21780776
IC50: 5.2 (nM), Ref: 23998921
IC50: 11 (nM), Ref: 23998921
IC50: 6 (nM), Ref: 24911527
IC50: 11 (nM), Ref: 25630225
IC50: 6 (nM), Ref: 25935643
IC50: 0.36 (nM), Ref: 25815158
IC50: 82 (nM), Ref: 25815158
TCMC770
TCMT588 D-amino-acid oxidase Homo sapiens Ki: 7000 (nM), Ref: 23391306
IC50: 2089.3 (nM), Ref: 23631755
Ki: 2000 (nM), Ref: 23631755

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC1329
TCMT1099 Neuraminidase Influenza A virus (A/Puerto Rico/8/1934(H1N1)) IC50: 13.9 (ug/ml), Ref: 20116898
TCMC2051
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 42 (ug/ml), Ref: 22280816
MIC: 42.1 (ug/ml), Ref: 26112067
TCMC1515
TCMT1463 Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 20542692
TCMC2196
TCMT1463 Mycobacterium tuberculosis Mycobacterium tuberculosis MIC: 10 (ug/ml), Ref: 22819942
MIC: 0.5 (ug/ml), Ref: 26253635
TCMC2196
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 1 (ug/ml), Ref: 23360475
MIC: 1 (ug/ml), Ref: 26253635
TCMC2196
TCMT1439 Mycobacterium smegmatis Mycobacterium smegmatis MIC: 6 (ug/ml), Ref: 26253635
TCMC801
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 32 (ug/ml), Ref: 15844943
TCMC801
TCMT1465 Entamoeba histolytica Entamoeba histolytica IC50: 52.3 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1329
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC348
TCMT1232 Pseudomonas aeruginosa Pseudomonas aeruginosa MIC: 62 (ug/ml), Ref: 25813159
TCMC732
TCMT1255 Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50: 9 (ug/ml), Ref: 9748372
TCMC2018
TCMT1155 Farnesyl pyrophosphate synthase Leishmania major Ki: 17 (nM), Ref: 15828834
TCMC791
TCMT1221 Human herpesvirus 4 Human herpesvirus 4 IC50: 12.7 (nM), Ref: 17503850