Target Reference

Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1041	TCMT636	DNA polymerase alpha subunit	Homo sapiens	Ki: 830 (nM), Ref: 1705574
TCMC1041	TCMT17	DNA polymerase beta	Homo sapiens	Ki: 390 (nM), Ref: 1705574
TCMC1086	TCMT114	Cannabinoid CB2 receptor	Homo sapiens	Ki: 36 (nM), Ref: 16005223 Ki: 3.3 (nM), Ref: 17531479 Ki: 36 (nM), Ref: 17919913 Ki: 41 (nM), Ref: 18522867 Ki: 36 (nM), Ref: 20621488 Ki: 36 (nM), Ref: 20943404 IC50: 9.5 (nM), Ref: 21999614 Ki: 24 (nM), Ref: 22284817 Ki: 36 (nM), Ref: 22341572 Ki: 71.6 (nM), Ref: 23679955 Ki: 71.6 (nM), Ref: 10.1039/C3MD00394A Ki: 36.4 (nM), Ref: 23865723 Ki: 46 (nM), Ref: 25072877 Ki: 42 (nM), Ref: 26000707
TCMC1086	TCMT115	Cannabinoid CB1 receptor	Homo sapiens	Ki: 17 (nM), Ref: 17531479 Ki: 2.9 (nM), Ref: 18522867 IC50: 2.8 (nM), Ref: 21999614 Ki: 10 (nM), Ref: 22284817 Ki: 3.88 (nM), Ref: 23679955 Ki: 3.88 (nM), Ref: 10.1039/C3MD00394A Ki: 40.7 (nM), Ref: 23865723 Ki: 22 (nM), Ref: 25072877 Ki: 18 (nM), Ref: 26000707
TCMC1105	TCMT752	Casein kinase II alpha	Homo sapiens	IC50: 2000 (nM), Ref: 19414254
TCMC1105	TCMT239	Serine/threonine-protein kinase PIM1	Homo sapiens	IC50: 2500 (nM), Ref: 27173800
TCMC1111	TCMT174	11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	IC50: 11.78 (nM), Ref: 18242087 IC50: 13 (nM), Ref: 18653260 IC50: 778 (nM), Ref: 20851614 IC50: 778 (nM), Ref: 21376605 IC50: 8.6 (nM), Ref: 21873057 IC50: 29.1 (nM), Ref: 23747808 IC50: 29.1 (nM), Ref: 25590374
TCMC1111	TCMT209	11-beta-hydroxysteroid dehydrogenase 2	Homo sapiens	IC50: 257 (nM), Ref: 20851614 IC50: 257 (nM), Ref: 21376605 IC50: 1.22 (nM), Ref: 23747808 IC50: 1.2 (nM), Ref: 25590374
TCMC1111	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 4900 (nM), Ref: 21561086
TCMC1113	TCMT47	Apoptosis regulator Bcl-2	Homo sapiens	Ki: 400 (nM), Ref: 10.1007/s00044-009-9233-5

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Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1033	TCMT1439	Mycobacterium smegmatis	Mycobacterium smegmatis	MIC: 100 (ug/ml), Ref: 10924184
TCMC1033	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 100 (ug/ml), Ref: 10924184
TCMC1033	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC: 30 (ug/ml), Ref: 18564877
TCMC1047	TCMT1464	Hepatitis B virus	Hepatitis B virus	IC50: 50 (nM), Ref: 24549242
TCMC1086	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 2 (ug/ml), Ref: 18681481 MIC: 1 (ug/ml), Ref: 18681481 MIC: 0.5 (ug/ml), Ref: 18681481
TCMC1095	TCMT1136	Neuraminidase	H1N1 swine influenza virus	IC50: 2.19 (ug/ml), Ref: 21123068 IC50: 2.49 (ug/ml), Ref: 21123068 IC50: 5.7 (ug/ml), Ref: 21123068 IC50: 5.8 (ug/ml), Ref: 21123068 IC50: 8.23 (ug/ml), Ref: 21123068
TCMC1095	TCMT1136	Neuraminidase	Influenza A virus	IC50: 2.19 (ug/ml), Ref: 21123068 IC50: 2.49 (ug/ml), Ref: 21123068 IC50: 5.7 (ug/ml), Ref: 21123068 IC50: 5.8 (ug/ml), Ref: 21123068 IC50: 8.23 (ug/ml), Ref: 21123068
TCMC1095	TCMT1121	Sialidase	Clostridium perfringens	IC50: 8.13 (ug/ml), Ref: 21123068
TCMC1105	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 51.7 (ug/ml), Ref: 10.1007/s00044-013-0485-8 MIC: 50.3 (ug/ml), Ref: 10.1007/s00044-013-0485-8
TCMC1105	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 23534483

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TCM Putative Target References: TCMF7388

Targeted Human Proteins by the Ingredients of Prescription

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription