Targeted Human Proteins by the Ingredients of Prescription
References are linked to referred publications via PubMed ID or DOI.There may be multiple activity records for a specific ingredient-target pair.
.
| Ingredient ID & Structure | Target ID | Target Name | Target Organism | Activity Records & Reference |
|---|---|---|---|---|
 |
TCMT298 | Fatty acid binding protein muscle | Homo sapiens |
IC50: 1000 (nM), Ref: 20471252 IC50: 1000 (nM), Ref: 25461324 IC50: 1000 (nM), Ref: 25461324 Ki: 9300 (nM), Ref: 27460668 |
|
|
TCMT297 | Fatty acid binding protein adipocyte | Homo sapiens |
IC50: 1000 (nM), Ref: 20471252 Ki: 6800 (nM), Ref: 27460668 |
|
|
TCMT63 | Peroxisome proliferator-activated receptor alpha | Homo sapiens |
IC50: 1100 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT64 | Peroxisome proliferator-activated receptor delta | Homo sapiens |
IC50: 10000 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT67 | Peroxisome proliferator-activated receptor gamma | Homo sapiens |
IC50: 6200 (nM), Ref: 10.1007/s00044-012-0285-6 |
 |
TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3900 (nM), Ref: 16580200 IC50: 7600 (nM), Ref: 18798681 IC50: 4200 (nM), Ref: 19702283 IC50: 3840 (nM), Ref: 22044245 IC50: 5600 (nM), Ref: 22690646 IC50: 9500 (nM), Ref: 21453996 Ki: 6000 (nM), Ref: 21453996 IC50: 5050.1 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3370 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2600 (nM), Ref: 23357636 IC50: 1100 (nM), Ref: 23434422 IC50: 3020 (nM), Ref: 23942421 IC50: 2010 (nM), Ref: 24090912 IC50: 1900 (nM), Ref: 24684845 IC50: 3020 (nM), Ref: 25497963 IC50: 9500 (nM), Ref: 25264584 Ki: 6000 (nM), Ref: 25264584 IC50: 1030 (nM), Ref: 25595683 IC50: 1170 (nM), Ref: 25600405 IC50: 3020 (nM), Ref: 25872983 IC50: 1000 (nM), Ref: 26083682 IC50: 1536 (nM), Ref: 26100442 IC50: 700 (nM), Ref: 26115570 IC50: 700 (nM), Ref: 26253631 IC50: 1536 (nM), Ref: 26481657 IC50: 730 (nM), Ref: 26711144 IC50: 3020 (nM), Ref: 26774579 IC50: 1536 (nM), Ref: 27123900 |
|
|
TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
IC50: 4000 (nM), Ref: 21561086 Ki: 3560 (nM), Ref: 21561086 Ki: 660 (nM), Ref: 21561086 Ki: 940 (nM), Ref: 21561086 Ki: 160 (nM), Ref: 21561086 Ki: 72 (nM), Ref: 21561086 IC50: 90 (nM), Ref: 21561086 |
|
|
TCMT190 | T-cell protein-tyrosine phosphatase | Homo sapiens |
IC50: 4230 (nM), Ref: 24684845 IC50: 4440 (nM), Ref: 25497963 IC50: 5460 (nM), Ref: 26100442 IC50: 5460 (nM), Ref: 26481657 IC50: 5460 (nM), Ref: 27123900 |
|
|
TCMT563 | Dual specificity phosphatase Cdc25B | Homo sapiens |
IC50: 980 (nM), Ref: 25497963 |
 |
TCMT142 | Carbonic anhydrase IV | Homo sapiens |
Ki: 101.2 (nM), Ref: 26498393 |
|
|
TCMT138 | Carbonic anhydrase VII | Homo sapiens |
Ki: 268.3 (nM), Ref: 26498393 |
|
|
TCMT136 | Carbonic anhydrase XII | Homo sapiens |
Ki: 4.8 (nM), Ref: 26498393 |
 |
TCMT297 | Fatty acid binding protein adipocyte | Homo sapiens |
IC50: 930 (nM), Ref: 15357969 |
|
|
TCMT298 | Fatty acid binding protein muscle | Homo sapiens |
IC50: 2600 (nM), Ref: 15357969 |
|
|
TCMT808 | Fatty acid binding protein epidermal | Homo sapiens |
IC50: 1200 (nM), Ref: 15357969 |
|
|
TCMT809 | Fatty acid binding protein intestinal | Homo sapiens |
IC50: 1700 (nM), Ref: 15357969 |
|
|
TCMT810 | Toll-like receptor 2 | Homo sapiens |
IC50: 5000 (nM), Ref: 16509590 |
|
|
TCMT64 | Peroxisome proliferator-activated receptor delta | Homo sapiens |
IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT63 | Peroxisome proliferator-activated receptor alpha | Homo sapiens |
IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6 |
 |
TCMT63 | Peroxisome proliferator-activated receptor alpha | Homo sapiens |
IC50: 600 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 600 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT64 | Peroxisome proliferator-activated receptor delta | Homo sapiens |
IC50: 5300 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT67 | Peroxisome proliferator-activated receptor gamma | Homo sapiens |
IC50: 4100 (nM), Ref: 10.1007/s00044-012-0285-6 |
|
|
TCMT126 | Telomerase reverse transcriptase | Homo sapiens |
IC50: 8600 (nM), Ref: 10.1039/C0MD00241K |
|
|
TCMT297 | Fatty acid binding protein adipocyte | Homo sapiens |
Ki: 1500 (nM), Ref: 27460668 |
 |
TCMT176 | Acyl coenzyme A:cholesterol acyltransferase 1 | Homo sapiens |
IC50: 600 (nM), Ref: 17157006 |
|
|
TCMT263 | Acyl coenzyme A:cholesterol acyltransferase 2 | Homo sapiens |
IC50: 800 (nM), Ref: 17157006 |
 |
TCMT135 | Carbonic anhydrase XIV | Homo sapiens |
Ki: 8710 (nM), Ref: 20185318 Ki: 8710 (nM), Ref: 26498394 |
|
|
TCMT136 | Carbonic anhydrase XII | Homo sapiens |
Ki: 9060 (nM), Ref: 20185318 Ki: 9060 (nM), Ref: 26498394 |
|
|
TCMT137 | Carbonic anhydrase IX | Homo sapiens |
Ki: 7870 (nM), Ref: 20185318 |
|
|
TCMT138 | Carbonic anhydrase VII | Homo sapiens |
Ki: 6420 (nM), Ref: 20185318 |
|
|
TCMT139 | Carbonic anhydrase VI | Homo sapiens |
Ki: 7330 (nM), Ref: 20185318 |
|
|
TCMT140 | Carbonic anhydrase VB | Homo sapiens |
Ki: 9080 (nM), Ref: 20185318 |
|
|
TCMT141 | Carbonic anhydrase VA | Homo sapiens |
Ki: 6490 (nM), Ref: 20185318 |
|
|
TCMT143 | Carbonic anhydrase III | Homo sapiens |
Ki: 10000 (nM), Ref: 20185318 |
|
|
TCMT134 | Carbonic anhydrase II | Homo sapiens |
Ki: 1610 (nM), Ref: 20185318 |
|
|
TCMT133 | Carbonic anhydrase I | Homo sapiens |
Ki: 2380 (nM), Ref: 20185318 |
|
|
TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3060 (nM), Ref: 19476336 |
|
|
TCMT321 | Matrix metalloproteinase 9 | Homo sapiens |
IC50: 21.22 (nM), Ref: 23375794 IC50: 10 (nM), Ref: 23375794 |
|
|
TCMT306 | Matrix metalloproteinase-2 | Homo sapiens |
IC50: 24.26 (nM), Ref: 23375794 |
|
|
TCMT295 | Matrix metalloproteinase-1 | Homo sapiens |
IC50: 238.91 (nM), Ref: 23375794 |
|
|
TCMT130 | Arachidonate 5-lipoxygenase | Homo sapiens |
IC50: 8500 (nM), Ref: 26197161 |
 |
TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3600 (nM), Ref: 17489632 IC50: 3100 (nM), Ref: 18798681 IC50: 3600 (nM), Ref: 19008110 IC50: 3600 (nM), Ref: 17125223 IC50: 3800 (nM), Ref: 19846295 IC50: 3900 (nM), Ref: 19632832 IC50: 3600 (nM), Ref: 19836230 IC50: 3100 (nM), Ref: 21555221 IC50: 3600 (nM), Ref: 21571537 IC50: 3100 (nM), Ref: 22940448 IC50: 2300 (nM), Ref: 21453996 Ki: 3400 (nM), Ref: 21453996 IC50: 3600 (nM), Ref: 23022281 IC50: 3080 (nM), Ref: 23141910 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2750 (nM), Ref: 23387824 IC50: 4120 (nM), Ref: 24224843 IC50: 4000 (nM), Ref: 24953600 IC50: 3500 (nM), Ref: 25559759 IC50: 3400 (nM), Ref: 25907369 Ki: 6400 (nM), Ref: 25907369 IC50: 5200 (nM), Ref: 26841168 |
|
|
TCMT174 | 11-beta-hydroxysteroid dehydrogenase 1 | Homo sapiens |
IC50: 1900 (nM), Ref: 20100662 |
|
|
TCMT102 | Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens |
IC50: 7200 (nM), Ref: 21453996 |
|
|
TCMT103 | Receptor-type tyrosine-protein phosphatase F (LAR) | Homo sapiens |
IC50: 3800 (nM), Ref: 21453996 |
|
|
TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
Ki: 6000 (nM), Ref: 21561086 Ki: 3700 (nM), Ref: 21561086 Ki: 2100 (nM), Ref: 21561086 Ki: 2800 (nM), Ref: 21561086 Ki: 2000 (nM), Ref: 21561086 IC50: 4000 (nM), Ref: 21561086 |
|
|
TCMT190 | T-cell protein-tyrosine phosphatase | Homo sapiens |
IC50: 2400 (nM), Ref: 23387824 |
|
|
TCMT150 | Nuclear receptor ROR-gamma | Homo sapiens |
IC50: 680 (nM), Ref: 10.1039/C3MD00005B IC50: 130 (nM), Ref: 24704616 IC50: 1060 (nM), Ref: 24704616 IC50: 9410 (nM), Ref: 24704616 |
