Targeted Human Proteins by the Ingredients of Prescription
References are linked to referred publications via PubMed ID or DOI.There may be multiple activity records for a specific ingredient-target pair.
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| Ingredient ID & Structure | Target ID | Target Name | Target Organism | Activity Records & Reference |
|---|---|---|---|---|
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TCMT138 | Carbonic anhydrase VII | Homo sapiens |
Ki: 8710 (nM), Ref: 22892213 |
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TCMT136 | Carbonic anhydrase XII | Homo sapiens |
Ki: 4050 (nM), Ref: 22892213 |
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TCMT137 | Carbonic anhydrase IX | Homo sapiens |
Ki: 960 (nM), Ref: 22892213 |
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TCMT290 | Muscarinic acetylcholine receptor M5 | Homo sapiens |
Ki: 0.14 (nM), Ref: 23707254 Ki: 0.3388 (nM), Ref: 24365159 Ki: 0.34 (nM), Ref: 24365159 Ki: 3.02 (nM), Ref: 25051097 |
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TCMT291 | Muscarinic acetylcholine receptor M3 | Homo sapiens |
Ki: 0.2692 (nM), Ref: 24365159 Ki: 0.27 (nM), Ref: 24365159 |
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TCMT292 | Muscarinic acetylcholine receptor M1 | Homo sapiens |
Ki: 0.2692 (nM), Ref: 24365159 Ki: 0.27 (nM), Ref: 24365159 |
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TCMT293 | Muscarinic acetylcholine receptor M2 | Homo sapiens |
Ki: 5.012 (nM), Ref: 25051097 Ki: 12.88 (nM), Ref: 25051097 Ki: 3.631 (nM), Ref: 25051097 Ki: 2.818 (nM), Ref: 25051097 |
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TCMT203 | Glucose-6-phosphate 1-dehydrogenase | Homo sapiens |
Ki: 3400 (nM), Ref: 19231202 Ki: 3000 (nM), Ref: 19231202 IC50: 9400 (nM), Ref: 22506561 |
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TCMT44 | Glyoxalase I | Homo sapiens |
IC50: 560 (nM), Ref: 18258440 IC50: 560 (nM), Ref: 21669529 |
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TCMT156 | Cytochrome P450 19A1 | Homo sapiens |
IC50: 10000 (nM), Ref: 18778944 |
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TCMT737 | DNA dC->dU-editing enzyme APOBEC-3G | Homo sapiens | IC50: 2390 (nM), Ref: |
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TCMT739 | G-protein coupled receptor 35 | Homo sapiens |
IC50: 2120 (nM), Ref: 24900447 |
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TCMT558 | DNA topoisomerase II alpha | Homo sapiens |
IC50: 390 (nM), Ref: 10.1007/s00044-009-9233-5 |
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TCMT207 | Beta-secretase 1 | Homo sapiens |
IC50: 2800 (nM), Ref: 10.1007/s00044-012-0353-y |
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TCMT131 | Acetylcholinesterase | Homo sapiens |
IC50: 12 (nM), Ref: 10.1007/s00044-012-0353-y |
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TCMT260 | Tyrosine-protein kinase receptor FLT3 | Homo sapiens |
IC50: 1690 (nM), Ref: 23411073 |
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TCMT2 | Microtubule-associated protein tau | Homo sapiens |
IC50: 1200 (nM), Ref: 23484434 IC50: 3000 (nM), Ref: 25086914 |
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TCMT8 | Lysine-specific demethylase 4D-like | Homo sapiens |
IC50: 3000 (nM), Ref: 10.1039/C1MD00199J |
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TCMT45 | Beta amyloid A4 protein | Homo sapiens |
IC50: 3000 (nM), Ref: 25086914 |
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TCMT740 | PI3-kinase p110-gamma subunit | Homo sapiens |
IC50: 4720 (nM), Ref: 25050878 |
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TCMT13 | DNA-(apurinic or apyrimidinic site) lyase | Homo sapiens |
IC50: 320 (nM), Ref: 25280182 |
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TCMT230 | Estradiol 17-beta-dehydrogenase 3 | Homo sapiens |
IC50: 330 (nM), Ref: 11086723 IC50: 330 (nM), Ref: 16078844 |
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TCMT807 | Solute carrier family 22 member 12 | Homo sapiens |
IC50: 2000 (nM), Ref: 17325024 Ki: 5740 (nM), Ref: 17325024 |
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TCMT236 | Estrogen receptor beta | Homo sapiens | IC50: 2927.18 (nM), Ref: |
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TCMT61 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens | IC50: 2988.26 (nM), Ref: |
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TCMT739 | G-protein coupled receptor 35 | Homo sapiens |
IC50: 1600 (nM), Ref: 24900447 |
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TCMT261 | Death-associated protein kinase 1 | Homo sapiens |
IC50: 1600 (nM), Ref: 26322379 |
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TCMT283 | Receptor-type tyrosine-protein phosphatase S | Homo sapiens |
IC50: 4300 (nM), Ref: 26602279 |
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TCMT215 | Cytochrome P450 1A1 | Homo sapiens |
IC50: 7906 (nM), Ref: 20696580 |
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TCMT257 | Cytochrome P450 1B1 | Homo sapiens |
IC50: 1679 (nM), Ref: 20696580 |
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TCMT219 | Cytochrome P450 1A2 | Homo sapiens |
IC50: 1491 (nM), Ref: 20696580 |
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TCMT156 | Cytochrome P450 19A1 | Homo sapiens |
IC50: 900 (nM), Ref: 10.1039/C3MD00166K |
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TCMT137 | Carbonic anhydrase IX | Homo sapiens |
Ki: 482 (nM), Ref: 21067924 Ki: 478 (nM), Ref: 22077347 Ki: 480 (nM), Ref: 26688270 |
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TCMT136 | Carbonic anhydrase XII | Homo sapiens |
Ki: 754 (nM), Ref: 22077347 Ki: 750 (nM), Ref: 26688270 |
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TCMT280 | Aldo-keto reductase family 1 member B10 | Homo sapiens |
IC50: 5900 (nM), Ref: 21561086 |
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TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3500 (nM), Ref: 18798681 IC50: 5320 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 5320 (nM), Ref: 10.1007/s00044-010-9529-5 |
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TCMT135 | Carbonic anhydrase XIV | Homo sapiens |
Ki: 8710 (nM), Ref: 20185318 Ki: 8710 (nM), Ref: 26498394 |
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TCMT136 | Carbonic anhydrase XII | Homo sapiens |
Ki: 9060 (nM), Ref: 20185318 Ki: 9060 (nM), Ref: 26498394 |
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TCMT137 | Carbonic anhydrase IX | Homo sapiens |
Ki: 7870 (nM), Ref: 20185318 |
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TCMT138 | Carbonic anhydrase VII | Homo sapiens |
Ki: 6420 (nM), Ref: 20185318 |
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TCMT139 | Carbonic anhydrase VI | Homo sapiens |
Ki: 7330 (nM), Ref: 20185318 |
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TCMT140 | Carbonic anhydrase VB | Homo sapiens |
Ki: 9080 (nM), Ref: 20185318 |
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TCMT141 | Carbonic anhydrase VA | Homo sapiens |
Ki: 6490 (nM), Ref: 20185318 |
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TCMT143 | Carbonic anhydrase III | Homo sapiens |
Ki: 10000 (nM), Ref: 20185318 |
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TCMT134 | Carbonic anhydrase II | Homo sapiens |
Ki: 1610 (nM), Ref: 20185318 |
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TCMT133 | Carbonic anhydrase I | Homo sapiens |
Ki: 2380 (nM), Ref: 20185318 |
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TCMT101 | Protein-tyrosine phosphatase 1B | Homo sapiens |
IC50: 3060 (nM), Ref: 19476336 |
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TCMT321 | Matrix metalloproteinase 9 | Homo sapiens |
IC50: 21.22 (nM), Ref: 23375794 IC50: 10 (nM), Ref: 23375794 |
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TCMT306 | Matrix metalloproteinase-2 | Homo sapiens |
IC50: 24.26 (nM), Ref: 23375794 |
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TCMT295 | Matrix metalloproteinase-1 | Homo sapiens |
IC50: 238.91 (nM), Ref: 23375794 |
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TCMT130 | Arachidonate 5-lipoxygenase | Homo sapiens |
IC50: 8500 (nM), Ref: 26197161 |
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TCMT34 | Cytochrome P450 2D6 | Homo sapiens |
Ki: 3.3 (nM), Ref: 8487254 Ki: 4.6 (nM), Ref: 8487254 Ki: 14 (nM), Ref: 8487254 Ki: 5.7 (nM), Ref: 8487254 Ki: 3.5 (nM), Ref: 8487254 Ki: 13 (nM), Ref: 8487254 Ki: 4.6 (nM), Ref: 8487254 |
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TCMT82 | Estrogen receptor alpha | Homo sapiens |
IC50: 1.3 (nM), Ref: 15203155 IC50: 3 (nM), Ref: 10673099 IC50: 1.3 (nM), Ref: 15203156 Ki: 100 (nM), Ref: 12954056 IC50: 2 (nM), Ref: 12749898 IC50: 5.9 (nM), Ref: 10447957 IC50: 1.3 (nM), Ref: 15745820 IC50: 1.3 (nM), Ref: 15664843 IC50: 1.3 (nM), Ref: 15582421 IC50: 1.3 (nM), Ref: 15225685 IC50: 1.3 (nM), Ref: 15225686 IC50: 3.2 (nM), Ref: 15341953 IC50: 3.2 (nM), Ref: 15456246 IC50: 3.2 (nM), Ref: 15876535 IC50: 3.2 (nM), Ref: 15943471 IC50: 28 (nM), Ref: 15658851 Ki: 1.995 (nM), Ref: 15771467 IC50: 3.2 (nM), Ref: 16098741 IC50: 0.75 (nM), Ref: 16219463 IC50: 1.4 (nM), Ref: 16309907 IC50: 1.35 (nM), Ref: 16412638 IC50: 10 (nM), Ref: 16610787 IC50: 1.3 (nM), Ref: 16632357 IC50: 1.3 (nM), Ref: 16730987 IC50: 46 (nM), Ref: 16942012 IC50: 1.6 (nM), Ref: 16942012 IC50: 1.3 (nM), Ref: 16777408 IC50: 1.2 (nM), Ref: 17149865 IC50: 4.7 (nM), Ref: 17696335 IC50: 3.6 (nM), Ref: 17049855 IC50: 3.2 (nM), Ref: 17188490 IC50: 1 (nM), Ref: 17289385 IC50: 1.4 (nM), Ref: 17448656 IC50: 1.4 (nM), Ref: 17890084 IC50: 4 (nM), Ref: 18760603 Ki: 2 (nM), Ref: 18722117 IC50: 12.5 (nM), Ref: 19836949 IC50: 3.2 (nM), Ref: 19705860 Ki: 0.16 (nM), Ref: 20621492 IC50: 21.04 (nM), Ref: 20812681 IC50: 46 (nM), Ref: 20875743 IC50: 1.3 (nM), Ref: 24315190 IC50: 5.7 (nM), Ref: 25369367 IC50: 0.9 (nM), Ref: 26183544 Ki: 0.21 (nM), Ref: Ki: 0.21 (nM), Ref: IC50: 1.7 (nM), Ref: 27407030 |
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TCMT236 | Estrogen receptor beta | Homo sapiens |
IC50: 1.1 (nM), Ref: 15203155 IC50: 4 (nM), Ref: 10673099 IC50: 1.1 (nM), Ref: 15203156 Ki: 100 (nM), Ref: 12954056 IC50: 2 (nM), Ref: 12749898 IC50: 1.1 (nM), Ref: 15745820 IC50: 1.1 (nM), Ref: 15664843 IC50: 1.1 (nM), Ref: 15993065 IC50: 1.1 (nM), Ref: 15582421 IC50: 1.1 (nM), Ref: 15225685 IC50: 1.1 (nM), Ref: 15225686 IC50: 3.6 (nM), Ref: 15341953 IC50: 3.6 (nM), Ref: 15456246 IC50: 3.6 (nM), Ref: 15876535 IC50: 3.6 (nM), Ref: 15943471 IC50: 24 (nM), Ref: 15658851 Ki: 3.162 (nM), Ref: 15771467 IC50: 3.6 (nM), Ref: 16098741 IC50: 1.18 (nM), Ref: 16219463 IC50: 1.2 (nM), Ref: 16309907 IC50: 1.2 (nM), Ref: 16412638 IC50: 11 (nM), Ref: 16610787 IC50: 1.2 (nM), Ref: 16632357 IC50: 1.2 (nM), Ref: 16730987 IC50: 1.4 (nM), Ref: 16942012 IC50: 1.1 (nM), Ref: 16777408 IC50: 1.4 (nM), Ref: 17149865 IC50: 16.7 (nM), Ref: 17696335 IC50: 3.2 (nM), Ref: 17049855 IC50: 3.6 (nM), Ref: 17188490 IC50: 1 (nM), Ref: 17289385 IC50: 1.2 (nM), Ref: 17448656 IC50: 1.2 (nM), Ref: 17890084 IC50: 4 (nM), Ref: 18760603 Ki: 2 (nM), Ref: 18722117 IC50: 2.9 (nM), Ref: 19705860 IC50: 10.74 (nM), Ref: 20812681 IC50: 0.046 (nM), Ref: 24315190 IC50: 5.6 (nM), Ref: 25369367 Ki: 0.015 (nM), Ref: Ki: 0.015 (nM), Ref: IC50: 3 (nM), Ref: 27407030 |
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TCMT187 | Androgen Receptor | Homo sapiens |
IC50: 19.1 (nM), Ref: 16309907 |
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TCMT99 | Testis-specific androgen-binding protein | Homo sapiens |
IC50: 50 (nM), Ref: 17149875 |
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TCMT591 | Estrogen-related receptor alpha | Homo sapiens |
IC50: 3.6 (nM), Ref: 17482813 IC50: 6 (nM), Ref: 23448346 |
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TCMT910 | Estrogen-related receptor beta | Homo sapiens |
IC50: 3.2 (nM), Ref: 17482813 IC50: 8.7 (nM), Ref: 23448346 |
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TCMT344 | Aldehyde oxidase | Homo sapiens |
IC50: 80 (nM), Ref: 20853847 Ki: 4400 (nM), Ref: 22996261 Ki: 870 (nM), Ref: 22996261 |
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TCMT974 | G-protein coupled estrogen receptor 1 | Homo sapiens |
Ki: 5.7 (nM), Ref: 23672690 Ki: 2.7 (nM), Ref: 10.1039/C5MD00455A |
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TCMT154 | Protein kinase C delta | Homo sapiens |
Ki: 9.7 (nM), Ref: 23582444 |
