Organism Name: A new engineered strain of Escherichia coli XL1-Blue [hSQS, tHMGR, EGR13, EGR12, EGR8, MVD1, atoB, ispA]| Organism ID: | NPO41943 |
| Organism Name: | A new engineered strain of Escherichia coli XL1-Blue [hSQS, tHMGR, EGR13, EGR12, EGR8, MVD1, atoB, ispA] |
| Native / Engineered Organism: | Engineered Organism |
| Matched Taxonomy Level: | Strain |
| Organism External ID: | NCBI_Taxonomy_ID[ n.a.] |
| Organism Synonyms: | |
| Genus: | Escherichia |
| Family: | Enterobacteriaceae |
| Kingdom: | n.a. |
| SuperKingdom: | Bacteria |
Individual Natural Products| Natural Product ID | Prefer Name (or InChiKey) | IUPAC Name | Number of Targets | Number of Activity Records |
|---|---|---|---|---|
| NPC123965 | Squalene | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene | 9 | 17 |
NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)| Organism Name | Producer Organism | Inducer Organism | NP ID | NP Name | Effect of Co-culture | Reference |
|---|
NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)| Organism Name | Parent Organism Name | Engineered Gene in Organism | Purpose of Engineering | Engineering Category | Engineering Description | NP ID | NP Name | NP Yeild of Parent Organism | NP Yeild of Engineered Organism | Yeild Change | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A new engineered strain of Escherichia coli XL1-Blue | Escherichia coli XL1-Blue | hSQS, tHMGR, EGR13, EGR12, EGR8, MVD1, atoB, ispA | Increase NP yield | n.a. | Co-expression of hSQS, chimeric mevalonate pathway containing tHMGR, ERG13 (hydroxymethylglutaryl-CoA synthase), ERG12 (mevalonate kinase), ERG8 (phosphomevalonate kinase) and MVD1 (mevalonate diphosphate decarboxylase) from S. cerevisiae, overexpression of atoB (acetyl-CoA acetyltransferase), idi (isoprenyl diphosphate isomerise) and ispA (farnesyl diphosphate synthase) | NPC123965 | Squalene | n.a. | 54mg/g DCW; 230mg/L | n.a. |
PMID[25282635] |
The Quantitative Compositions of NPs in Organism| Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
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