Organism Name: A new engineered strain of Bacillus subtilis [PbdhA]| Organism ID: | NPO41928 |
| Organism Name: | A new engineered strain of Bacillus subtilis [PbdhA] |
| Native / Engineered Organism: | Engineered Organism |
| Matched Taxonomy Level: | Strain |
| Organism External ID: | NCBI_Taxonomy_ID[ n.a.] |
| Organism Synonyms: | |
| Genus: | Bacillus |
| Family: | Bacillaceae |
| Kingdom: | n.a. |
| SuperKingdom: | Bacteria |
Individual Natural Products| Natural Product ID | Prefer Name (or InChiKey) | IUPAC Name | Number of Targets | Number of Activity Records |
|---|---|---|---|---|
| NPC74086 | Astaxanthin | (6S)-6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxocyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethylcyclohex-2-en-1-one | 7 | 14 |
NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)| Organism Name | Producer Organism | Inducer Organism | NP ID | NP Name | Effect of Co-culture | Reference |
|---|
NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)| Organism Name | Parent Organism Name | Engineered Gene in Organism | Purpose of Engineering | Engineering Category | Engineering Description | NP ID | NP Name | NP Yeild of Parent Organism | NP Yeild of Engineered Organism | Yeild Change | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A new engineered strain of Bacillus subtilis | Bacillus subtilis | PbdhA | Incerase NP yield; Shorten fermentation time | Metabolic engineering > Cofactor engineering-guided metabolic optimization | PbdhA is the promoter gene of YodC. Moderating expression of YodC via the promoter PbdhA weakened the synthesis of NADH-dependent byproduct 2,3-butanediol, lactate, and ethanol. | NPC74086 | astaxanthin | n.a. | 56.7 g/L | 35.3%; reduced fermentation duration of 1.7-fold; improved acetoin productivity to 0.639 gL/h.improved acetoin productivity to 0.639 gL/h. |
PMID[24525333] |
The Quantitative Compositions of NPs in Organism| Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
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