Organism Name: A new engineered strain of Yarrowia Lipolytica ATCC 201249 [CYPs, CPRs, ERG1, ERG9, and HMG1]| Organism ID: | NPO41918 |
| Organism Name: | A new engineered strain of Yarrowia Lipolytica ATCC 201249 [CYPs, CPRs, ERG1, ERG9, and HMG1] |
| Native / Engineered Organism: | Engineered Organism |
| Matched Taxonomy Level: | Strain |
| Organism External ID: | NCBI_Taxonomy_ID[ n.a.] |
| Organism Synonyms: | |
| Genus: | Yarrowia |
| Family: | Dipodascaceae |
| Kingdom: | Fungi |
| SuperKingdom: | Eukaryota |
Individual Natural Products| Natural Product ID | Prefer Name (or InChiKey) | IUPAC Name | Number of Targets | Number of Activity Records |
|---|---|---|---|---|
| NPC123965 | Squalene | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene | 9 | 17 |
NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)| Organism Name | Producer Organism | Inducer Organism | NP ID | NP Name | Effect of Co-culture | Reference |
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NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)| Organism Name | Parent Organism Name | Engineered Gene in Organism | Purpose of Engineering | Engineering Category | Engineering Description | NP ID | NP Name | NP Yeild of Parent Organism | NP Yeild of Engineered Organism | Yeild Change | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A new engineered strain of Yarrowia Lipolytica ATCC 201249 | Yarrowia Lipolytica ATCC 201249 | CYPs, CPRs, ERG1, ERG9, and HMG1 | Increase NP yield | n.a. | First, by screening 25 combinations of cytochrome P450 monooxygenases (CYPs) and NADPH-cytochrome P450 reductases (CPRs), each of which originated from 5 different sources, we selected two optimal betulinic acid-producing strains. Then, ERG1, ERG9, and HMG1 in the MVA module were overexpressed in the two strains | NPC123965 | Squalene | n.a. | 51.87 ± 2.77 mg/L | n.a. |
PMID[31053076] |
The Quantitative Compositions of NPs in Organism| Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
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