Organism Name: A new engineered strain of Saccharomyces cerevisiae W303-1a [ERG1, ERG7, ERG9, ERG20]| Organism ID: | NPO41901 |
| Organism Name: | A new engineered strain of Saccharomyces cerevisiae W303-1a [ERG1, ERG7, ERG9, ERG20] |
| Native / Engineered Organism: | Engineered Organism |
| Matched Taxonomy Level: | Strain |
| Organism External ID: | NCBI_Taxonomy_ID[ n.a.] |
| Organism Synonyms: | |
| Genus: | Saccharomyces |
| Family: | Saccharomycetaceae |
| Kingdom: | Fungi |
| SuperKingdom: | Eukaryota |
Individual Natural Products| Natural Product ID | Prefer Name (or InChiKey) | IUPAC Name | Number of Targets | Number of Activity Records |
|---|---|---|---|---|
| NPC490496 | taxa-4(5),11(12)-diene | n.a. | 0 | 0 |
NPs produced by Co-culture Organisms (for Co-culture organisms, the full organism list can be found HERE)| Organism Name | Producer Organism | Inducer Organism | NP ID | NP Name | Effect of Co-culture | Reference |
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NPs produced by Engineered Organisms (for Engineered organisms, the full organism list can be found HERE)| Organism Name | Parent Organism Name | Engineered Gene in Organism | Purpose of Engineering | Engineering Category | Engineering Description | NP ID | NP Name | NP Yeild of Parent Organism | NP Yeild of Engineered Organism | Yeild Change | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A new engineered strain of Saccharomyces cerevisiae W303-1a | Saccharomyces cerevisiae W303-1a | ERG1, ERG7, ERG9, ERG20 | Increase NP yield | n.a. | 1) Combinatorially overexpressing every gene in MVA pathway and optimizing metabolic balance in triterpene biosynthesis module; 2) In sterol biosynthesis module, fine-tuning lanosterol synthase gene (ERG7) expression using TetR–TetO gene regulation system; 3) increasing cytoplasmic acetyl-CoA supply by overexpressing a Salmonella ACS (acetyl-CoA synthetase gene) mutant ACSseL641P | NPC490496 | taxadiene | n.a. | 8.09 g/L | n.a. | DOI[10.1002/aic.16502] |
The Quantitative Compositions of NPs in Organism| Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
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