Structure

Physi-Chem Properties

Molecular Weight:  255.05
Volume:  221.7
LogP:  0.66
LogD:  0.499
LogS:  -1.56
# Rotatable Bonds:  4
TPSA:  83.66
# H-Bond Aceptor:  7
# H-Bond Donor:  1
# Rings:  2
# Heavy Atoms:  8

MedChem Properties

QED Drug-Likeness Score:  0.488
Synthetic Accessibility Score:  2.916
Fsp3:  0.333
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -4.613
MDCK Permeability:  5.56920058443211e-05
Pgp-inhibitor:  0.0
Pgp-substrate:  0.015
Human Intestinal Absorption (HIA):  0.004
20% Bioavailability (F20%):  0.001
30% Bioavailability (F30%):  0.001

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.535
Plasma Protein Binding (PPB):  43.72837829589844%
Volume Distribution (VD):  1.344
Pgp-substrate:  69.68376159667969%

ADMET: Metabolism

CYP1A2-inhibitor:  0.308
CYP1A2-substrate:  0.386
CYP2C19-inhibitor:  0.314
CYP2C19-substrate:  0.159
CYP2C9-inhibitor:  0.068
CYP2C9-substrate:  0.586
CYP2D6-inhibitor:  0.074
CYP2D6-substrate:  0.771
CYP3A4-inhibitor:  0.021
CYP3A4-substrate:  0.264

ADMET: Excretion

Clearance (CL):  9.989
Half-life (T1/2):  0.765

ADMET: Toxicity

hERG Blockers:  0.056
Human Hepatotoxicity (H-HT):  0.41
Drug-inuced Liver Injury (DILI):  0.224
AMES Toxicity:  0.024
Rat Oral Acute Toxicity:  0.941
Maximum Recommended Daily Dose:  0.573
Skin Sensitization:  0.76
Carcinogencity:  0.708
Eye Corrosion:  0.004
Eye Irritation:  0.037
Respiratory Toxicity:  0.984

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Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs  

  Natural Product: NPC482940

Natural Product ID:  NPC482940
Common Name*:   YWTYJOPNNQFBPC-UHFFFAOYSA-N
IUPAC Name:   n.a.
Synonyms:  
Standard InCHIKey:  YWTYJOPNNQFBPC-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C9H10ClN5O2/c10-8-2-1-7(5-12-8)6-14-4-3-11-9(14)13-15(16)17/h1-2,5H,3-4,6H2,(H,11,13)
SMILES:  c1cc(Cl)ncc1CN1CCN=C1NN(=O)=O
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   n.a.
PubChem CID:   86418
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0004707] Organic nitrogen compounds
      • [CHEMONTID:0000278] Organonitrogen compounds
        • [CHEMONTID:0000375] Guanidines
          • [CHEMONTID:0004667] Nitroguanidines

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[19388660]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[21524573]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[28362501]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 50.0 nM PMID[11150171]
NPT427 Individual Protein Neuronal acetylcholine receptor subunit alpha-4 Gallus gallus IC50 = 2600.0 nM PMID[18570364]
NPT2933 Individual Protein Aldehyde oxidase Oryctolagus cuniculus Inhibition = 6.0 % PMID[21476569]
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = 29.0 % PMID[21476569]
NPT2933 Individual Protein Aldehyde oxidase Oryctolagus cuniculus IC50 > 1000000.0 nM PMID[21476569]
NPT43 Individual Protein Tyrosinase Agaricus bisporus IC50 > 1000000.0 nM PMID[21476569]
NPT6202 Individual Protein Muscarinic acetylcholine receptor DM1 Drosophila melanogaster Inhibition = 1.0 % PMID[17319687]
NPT6202 Individual Protein Muscarinic acetylcholine receptor DM1 Drosophila melanogaster Inhibition = 3.0 % PMID[17319687]
NPT6202 Individual Protein Muscarinic acetylcholine receptor DM1 Drosophila melanogaster Ki > 100000.0 nM PMID[17319687]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Ki = 4.6 nM PMID[20973548]
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 970.0 nM PMID[21341671]
NPT1862 Individual Protein Soluble acetylcholine receptor Aplysia californica Ki = 19.0 nM PMID[21341671]
NPT427 Individual Protein Neuronal acetylcholine receptor subunit alpha-4 Gallus gallus Ki = 970.0 nM PMID[21341671]
NPT4533 Individual Protein Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster Ki = 3.0 nM PMID[21341671]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica IC50 = 2.6 nM PMID[10936213]
NPT4533 Individual Protein Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster IC50 = 2.3 nM PMID[10936213]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica IC50 = 20.0 nM PMID[12834274]
NPT5039 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Mus musculus IC50 = 2600.0 nM PMID[11312774]
NPT424 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens IC50 = 14000.0 nM PMID[11312774]
NPT5033 Individual Protein Acetylcholine receptor protein alpha chain Homo sapiens Inhibition = 39.0 % PMID[11312774]
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens IC50 = 270000.0 nM PMID[11312774]
NPT5033 Individual Protein Acetylcholine receptor protein alpha chain Homo sapiens IC50 > 300000.0 nM PMID[11312774]
NPT4533 Individual Protein Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster IC50 = 4.6 nM PMID[11312774]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Ratio = 160.0 n.a. DOI[10.1584/jpestics.27.249]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica IC50 = 20.0 nM DOI[10.1584/jpestics.27.249]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Activity = 0.02 uM DOI[10.1584/jpestics.29.43]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica IC50 = 19.95 nM DOI[10.1584/jpestics.31.110]
NPT436 Individual Protein Nicotinic acetylcholine receptor alpha8 subunit Periplaneta americana EC50 = 1318.26 nM DOI[10.1584/jpestics.31.35]
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Ki = 7470.0 nM DOI[10.1584/jpestics.17.4_231]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica Activity = 300.0 % DOI[10.1584/jpestics.20.33]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica IC50 = 1060000.0 nM DOI[10.1584/jpestics.20.33]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica Activity = 108.0 % DOI[10.1584/jpestics.20.49]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica Activity = 92.4 % DOI[10.1584/jpestics.20.49]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica Activity = 287.0 % DOI[10.1584/jpestics.20.49]
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica IC50 = 1060000.0 nM DOI[10.1584/jpestics.20.49]
NPT2 Others Unspecified Ki = 290.0 nM PMID[11150171]
NPT14526 PROTEIN COMPLEX GROUP Nicotinic acetylcholine receptor Myzus persicae Ki = 1.9 nM PMID[11150171]
NPT14527 PROTEIN COMPLEX GROUP Nicotinic acetylcholine receptor Drosophila melanogaster Ki = 2.1 nM PMID[11150171]
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 720.0 nM PMID[12061885]
NPT2 Others Unspecified Ki = 2.2 nM PMID[12061885]
NPT3063 Organism Aphis gossypii Aphis gossypii EC50 = 0.4 ppm PMID[18207749]
NPT348 Organism Myzus persicae Myzus persicae EC50 = 0.3 ppm PMID[18207749]
NPT3063 Organism Aphis gossypii Aphis gossypii EC50 = 0.3 ppm PMID[18207749]
NPT3063 Organism Aphis gossypii Aphis gossypii EC50 = 0.6 ppm PMID[18207749]
NPT348 Organism Myzus persicae Myzus persicae EC50 = 0.2 ppm PMID[18207749]
NPT2 Others Unspecified Ki = 267.0 nM PMID[17485662]
NPT2 Others Unspecified Ki = 180.0 nM PMID[17485662]
NPT2 Others Unspecified Activity = 50.0 % PMID[17485662]
NPT2 Others Unspecified Ratio IC50 = 605.0 n.a. PMID[18570364]
NPT32 Organism Mus musculus Mus musculus LD50 = 45.0 mg.kg-1 PMID[18570364]
NPT2 Others Unspecified IC50 = 3.6 nM PMID[18570364]
NPT734 Organism Musca domestica Musca domestica Activity = 0.0 % PMID[18570364]
NPT2 Others Unspecified IC50 = 4.3 nM PMID[18570364]
NPT734 Organism Musca domestica Musca domestica LD50 > 10.0 mg.kg-1 PMID[18570364]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora Activity = 100.0 % PMID[18951786]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 7.9 ug.mL-1 PMID[18951786]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 0.14 ug.mL-1 PMID[18951786]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 19.73 ug.mL-1 PMID[18951786]
NPT734 Organism Musca domestica Musca domestica LD50 = 84.0 ng PMID[19409782]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 0.108 ug.mL-1 PMID[21469732]
NPT2 Others Unspecified Inhibition = 0.0 % PMID[21476569]
NPT348 Organism Myzus persicae Myzus persicae LD50 = 24.2 ug ml-1 PMID[22546079]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[20000775]
NPT2 Others Unspecified IC50 > 1000000.0 nM PMID[21476569]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps Activity = 70.0 % PMID[20919736]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella Activity = 70.0 % PMID[20919736]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 > 3000.0 ppm PMID[21728333]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 7.0 ppm PMID[21728333]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 31000.0 nM PMID[21043520]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 22.16 ng PMID[21043520]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 38820.0 nM PMID[21043520]
NPT6355 Organism Aphis fabae Aphis fabae Activity = 100.0 % PMID[20041716]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 > 1000.0 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 1.23 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 4500.0 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 4.4 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 174.0 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.2 ppm PMID[21105655]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.37 ppm PMID[21105655]
NPT14556 ORGANISM Latrodectus Hesperus Latrodectus Hesperus LC50 = 1.32 ppm PMID[21105655]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 7.8 ppm PMID[21105655]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 15.3 ppm PMID[21105655]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 0.896 ppm PMID[21105655]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 0.09 ppm PMID[21105655]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[21894959]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 30900.0 nM PMID[22122797]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LC50 = 49800.0 nM PMID[19138119]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps LC50 = 20860.0 nM PMID[19138119]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[19138119]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens Ratio = 1.0 n.a. PMID[20000414]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 38820.0 nM PMID[20000414]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 1730.0 nM PMID[20000414]
NPT1769 Organism Mythimna separata Mythimna separata LC50 = 125490.0 nM PMID[20000414]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[20000414]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 22.16 ng PMID[20000569]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 0.1316 ng PMID[20000569]
NPT1769 Organism Mythimna separata Mythimna separata LC50 = 125490.0 nM PMID[20000569]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[20000569]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35020.0 nM PMID[20423095]
NPT2 Others Unspecified Ki = 3.0 nM PMID[19253973]
NPT1367 Organism Bemisia tabaci Bemisia tabaci Ratio = 0.56 n.a. DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci Activity = 87.42 % DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 11.81 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 71.62 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 2854.0 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 334.85 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 85.42 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 19.3 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 151.02 ppm DOI[10.1016/j.cropro.2011.05.004]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps LC90 < 0.32 ppm PMID[20718435]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 35000.0 nM PMID[17311404]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Ratio = 0.52 n.a. DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Ratio = 0.59 n.a. DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Ratio = 0.54 n.a. DOI[10.1016/j.cropro.2011.10.005]
NPT734 Organism Musca domestica Musca domestica LD50 = 0.03 mg.kg-1 PMID[20973548]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Activity = 4.75 /day DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Activity = 2.77 /day DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Activity = 5.44 /day DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron LC50 = 208.9 ppm DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron LC90 = 13407.0 ppm DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Activity = 15.0 % DOI[10.1016/j.cropro.2011.10.005]
NPT14559 ORGANISM Encarsia inaron Encarsia inaron Activity = 7.0 % DOI[10.1016/j.cropro.2011.10.005]
NPT6340 Organism Trichogramma nubilale Trichogramma nubilale Ratio = 0.096 n.a. DOI[10.1016/j.cropro.2011.12.007]
NPT6340 Organism Trichogramma nubilale Trichogramma nubilale LC95 = 2675.0 mgAi/L DOI[10.1016/j.cropro.2011.12.007]
NPT6340 Organism Trichogramma nubilale Trichogramma nubilale LC50 = 311.9 mgAi/L DOI[10.1016/j.cropro.2011.12.007]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.17 ugAi/ml DOI[10.1016/j.cropro.2012.03.024]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 2.18 ugAi/ml DOI[10.1016/j.cropro.2012.03.024]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.2 ugAi/ml DOI[10.1016/j.cropro.2012.03.024]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 1.29 ugAi/ml DOI[10.1016/j.cropro.2012.03.024]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.09 ugAi/ml DOI[10.1016/j.cropro.2012.03.024]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 1.84 /hr DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 1.53 /hr DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 2.12 /hr DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 6.4 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 11.1 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 87.0 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 82.0 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 73.0 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14566 ORGANISM Frankliniella fusca Frankliniella fusca Activity = 74.0 % DOI[10.1016/S0261-2194(00)00171-X]
NPT14563 ORGANISM Aphis medicaginis Aphis medicaginis LC50 = 9.1 ug.mL-1 PMID[18959421]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 1.7 ppm PMID[17696361]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 0.05 ppm PMID[17696361]
NPT27 Others Unspecified LC50 = 0.021 mgAi/L DOI[10.1016/j.cropro.2007.08.004]
NPT14568 ORGANISM Agrilus planipennis Agrilus planipennis Activity = 70.0 % DOI[10.1016/j.cropro.2009.03.012]
NPT14568 ORGANISM Agrilus planipennis Agrilus planipennis Activity = 11.0 % DOI[10.1016/j.cropro.2009.03.012]
NPT14568 ORGANISM Agrilus planipennis Agrilus planipennis Activity = 44.0 % DOI[10.1016/j.cropro.2009.03.012]
NPT14568 ORGANISM Agrilus planipennis Agrilus planipennis Activity = 17.0 % DOI[10.1016/j.cropro.2009.03.012]
NPT118 Organism Oryza sativa Oryza sativa Activity = 3.21 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 3.73 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 4.27 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 15.11 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 17.78 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 18.89 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 21.11 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 17.67 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 18.0 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 8.08 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 8.0 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 9.67 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 8.8 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 12.72 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 11.85 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 40.45 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 37.0 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 40.98 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 39.91 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 2.02 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 2.48 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 2.4 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 2.68 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 5.56 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 6.06 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 6.67 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 14.75 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 14.08 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 6.17 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 7.28 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 6.63 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 8.81 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 34.55 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 30.27 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 31.34 mg DOI[10.1016/j.cropro.2010.11.008]
NPT118 Organism Oryza sativa Oryza sativa Activity = 32.41 mg DOI[10.1016/j.cropro.2010.11.008]
NPT5551 Organism Sogatella furcifera Sogatella furcifera GI = 2.48 % DOI[10.1016/j.cropro.2010.11.008]
NPT5551 Organism Sogatella furcifera Sogatella furcifera GI = 5.91 % DOI[10.1016/j.cropro.2010.11.008]
NPT5551 Organism Sogatella furcifera Sogatella furcifera Survival = 35.56 % DOI[10.1016/j.cropro.2010.11.008]
NPT5551 Organism Sogatella furcifera Sogatella furcifera Survival = 69.72 % DOI[10.1016/j.cropro.2010.11.008]
NPT5551 Organism Sogatella furcifera Sogatella furcifera Ratio < 1.0 n.a. DOI[10.1016/j.cropro.2010.11.008]
NPT2528 Organism Rhopalosiphum padi Rhopalosiphum padi Activity = 7.1 % PMID[20533381]
NPT2528 Organism Rhopalosiphum padi Rhopalosiphum padi Activity = 3.5 % PMID[20533381]
NPT2528 Organism Rhopalosiphum padi Rhopalosiphum padi Activity = 6.7 % PMID[20533381]
NPT2528 Organism Rhopalosiphum padi Rhopalosiphum padi Activity = 3.1 % PMID[20533381]
NPT2528 Organism Rhopalosiphum padi Rhopalosiphum padi LC50 = 0.9 ug.mL-1 PMID[20533381]
NPT14572 ORGANISM Apolygus lucorum Apolygus lucorum LC50 = 148.05 ug.mL-1 DOI[10.1584/jpestics.D11-013]
NPT14572 ORGANISM Apolygus lucorum Apolygus lucorum LC50 = 238.47 ug.mL-1 DOI[10.1584/jpestics.D11-013]
NPT14572 ORGANISM Apolygus lucorum Apolygus lucorum LC50 = 1025.9 ug.mL-1 DOI[10.1584/jpestics.D11-013]
NPT14572 ORGANISM Apolygus lucorum Apolygus lucorum LC50 = 1507.97 ug.mL-1 DOI[10.1584/jpestics.D11-013]
NPT14572 ORGANISM Apolygus lucorum Apolygus lucorum LC50 = 3324.02 ug.mL-1 DOI[10.1584/jpestics.D11-013]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 23.0 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 1100.0 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 17.0 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 5.8 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 4100.0 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 2000.0 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 8.5 ug.mL-1 PMID[20632380]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 4.8 ug.mL-1 PMID[20632380]
NPT2 Others Unspecified IC50 = 3.1 nM PMID[10936213]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC50 = 0.47 mgAi/L PMID[20960471]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC50 = 0.15 mgAi/L PMID[20960471]
NPT1175 Organism Spodoptera litura Spodoptera litura LD90 > 50.0 ppm DOI[10.1584/jpestics.G07-04]
NPT348 Organism Myzus persicae Myzus persicae LD90 = 0.2 ppm DOI[10.1584/jpestics.G07-04]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LD90 = 0.2 ppm DOI[10.1584/jpestics.G07-04]
NPT2 Others Unspecified Ratio EC50 = 4.31 n.a. DOI[10.1584/jpestics.G08-26]
NPT5733 Organism Cheumatopsyche Cheumatopsyche EC50 = 0.00422 ug.mL-1 DOI[10.1584/jpestics.G08-26]
NPT5734 Organism Daphnia magna Daphnia magna EC50 = 85.2 ug.mL-1 DOI[10.1584/jpestics.G08-26]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 100.0 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 42.6 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 61.9 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 94.4 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 86.1 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 38.9 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 44.4 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 72.2 % DOI[10.1016/j.cropro.2005.07.006]
NPT846 Organism Cnaphalocrocis medinalis Cnaphalocrocis medinalis LC90 = 200.0 ppm DOI[10.1271/bbb.56.1364]
NPT849 Organism Plutella xylostella Plutella xylostella LC90 = 200.0 ppm DOI[10.1271/bbb.56.1364]
NPT1175 Organism Spodoptera litura Spodoptera litura LC90 = 40.0 ppm DOI[10.1271/bbb.56.1364]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps LC90 = 0.32 ppm DOI[10.1271/bbb.56.1364]
NPT5733 Organism Cheumatopsyche Cheumatopsyche EC50 = 0.00654 ug.mL-1 DOI[10.1584/jpestics.G08-32]
NPT5733 Organism Cheumatopsyche Cheumatopsyche EC50 = 0.0379 ug.mL-1 DOI[10.1584/jpestics.G08-32]
NPT5733 Organism Cheumatopsyche Cheumatopsyche EC50 = 0.00664 ug.mL-1 DOI[10.1584/jpestics.G08-32]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 0.0 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 33.3 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 66.7 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 76.7 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 73.2 % DOI[10.1016/j.cropro.2005.07.006]
NPT14579 ORGANISM Rhynchophorus ferrugineus Rhynchophorus ferrugineus Activity = 10.0 % DOI[10.1016/j.cropro.2005.07.006]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 9429746.11 nM PMID[19206094]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 62459715.25 nM PMID[19206094]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 30.19 ug.mL-1 PMID[19206094]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 25.68 ug.mL-1 PMID[19206094]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 106.05 ug.mL-1 PMID[19206094]
NPT2720 Organism Nilaparvata lugens Nilaparvata lugens LC50 = 0.11 ug.mL-1 PMID[19206094]
NPT14589 ORGANISM Metaseiulus occidentalis Metaseiulus occidentalis Activity = 1.3 /day PMID[19206104]
NPT14589 ORGANISM Metaseiulus occidentalis Metaseiulus occidentalis Activity = 1.54 /day PMID[19206104]
NPT14589 ORGANISM Metaseiulus occidentalis Metaseiulus occidentalis Activity = 2.05 /day PMID[19206104]
NPT14589 ORGANISM Metaseiulus occidentalis Metaseiulus occidentalis LC50 = 0.0156 gAi/L PMID[19206104]
NPT14591 ORGANISM Leuciscus idus Leuciscus idus LC50 = 237.0 ug.mL-1 DOI[10.1271/bbb.56.364]
NPT29 Organism Rattus norvegicus Rattus norvegicus LD50 > 5000.0 mg.kg-1 DOI[10.1271/bbb.56.364]
NPT29 Organism Rattus norvegicus Rattus norvegicus LD50 = 450.0 mg.kg-1 DOI[10.1271/bbb.56.364]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps LC90 = 0.32 ppm DOI[10.1271/bbb.56.364]
NPT26473 ORGANISM Nephotettix cincticeps Nephotettix cincticeps LC90 = 0.32 ppm PMID[27316887]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Activity = 2.3 uM PMID[12834274]
NPT734 Organism Musca domestica Musca domestica ED50 = 0.26 fmol PMID[12834274]
NPT734 Organism Musca domestica Musca domestica ED50 = 2.2 fmol PMID[12834274]
NPT32 Organism Mus musculus Mus musculus LD50 = 40.0 mg.kg-1 PMID[11312774]
NPT734 Organism Musca domestica Musca domestica LD50 = 0.02 mg.kg-1 PMID[11312774]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Activity = 2.3 uM DOI[10.1584/jpestics.29.376]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 371.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 357.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 231.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 94.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 273.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 102.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.4 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 1.22 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.91 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 28.6 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 30.9 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 411.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 485.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 254.0 ug.mL-1 PMID[19562662]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.99 ug.mL-1 PMID[19562662]
NPT14599 ORGANISM Contarinia nasturtii Contarinia nasturtii Activity = 100.0 % PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus FC = 2.2 n.a. PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition = 100.0 % PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus FC = 2.4 n.a. PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus FC = 2.0 n.a. PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus FC = 2.1 n.a. PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus FC = 1.9 n.a. PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition = 98.0 % PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition = 96.0 % PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition = 88.0 % PMID[19642076]
NPT5808 Organism Ceutorhynchus obstrictus Ceutorhynchus obstrictus Inhibition = 39.4 % PMID[19642076]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Ratio = 36.0 n.a. DOI[10.1584/jpestics.27.249]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Ratio = 13.0 n.a. DOI[10.1584/jpestics.27.249]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Ratio = 3.0 n.a. DOI[10.1584/jpestics.27.249]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 412.0 ug.mL-1 PMID[19937914]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 8.72 ug.mL-1 PMID[19937914]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Activity = 2.3 uM DOI[10.1584/jpestics.27.267]
NPT2 Others Unspecified EC50 = 2818.38 nM DOI[10.1584/jpestics.27.374]
NPT734 Organism Musca domestica Musca domestica EC50 = 1174.9 nM DOI[10.1584/jpestics.28.8]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Activity = 2.3 uM DOI[10.1584/jpestics.29.43]
NPT2 Others Unspecified Ratio = 270.0 n.a. PMID[23112103]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 108.0 ppm PMID[23112103]
NPT26271 ORGANISM Periplaneta americana Periplaneta americana Activity = 2.5 nmol DOI[10.1584/jpestics.R07-05]
NPT348 Organism Myzus persicae Myzus persicae LC50 = 0.1 ppm PMID[23112103]
NPT2 Others Unspecified Ki = 0.035 nM PMID[23112103]
NPT2 Others Unspecified Ki = 32.0 nM PMID[23112103]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC50 = 0.4 ug.mL-1 PMID[23193012]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC50 = 0.41 ug.mL-1 PMID[23193012]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC50 = 0.18 ug.mL-1 PMID[23193012]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC95 = 1.84 ug ml-1 PMID[23193012]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC95 = 1.59 ug ml-1 PMID[23193012]
NPT14573 ORGANISM Diaphorina citri Diaphorina citri LC95 = 1.09 ug ml-1 PMID[23193012]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora LC50 = 8.9 ug.mL-1 PMID[23256728]
NPT14535 ORGANISM Aphis craccivora Aphis craccivora Activity = 100.0 % PMID[23256728]
NPT2 Others Unspecified Ki = 2530.0 nM DOI[10.1584/jpestics.17.4_231]
NPT14602 ORGANISM Aulacophora femoralis Aulacophora femoralis Activity = 100.0 % DOI[10.1584/jpestics.R07-05]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 40.0 % DOI[10.1584/jpestics.R07-05]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 80.0 % DOI[10.1584/jpestics.R07-05]
NPT348 Organism Myzus persicae Myzus persicae Activity = 100.0 % DOI[10.1584/jpestics.R07-05]
NPT1175 Organism Spodoptera litura Spodoptera litura Activity = 100.0 % DOI[10.1584/jpestics.R07-05]
NPT3063 Organism Aphis gossypii Aphis gossypii Survival = 13.6 day PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii Inhibition = 23.4 % PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii Activity = 0.22 mg PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii Activity = 0.27 mg PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii Activity = 0.28 mg PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 13.5 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 0.32 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 13.2 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 12.6 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 12.2 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 10.7 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 9.12 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 7.1 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 6.35 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 5.17 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 4.2 microg/mL2 PMID[21714058]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 0.12 mg.kg-1 DOI[10.1584/jpestics.22.236]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 1.19 mg.kg-1 DOI[10.1584/jpestics.22.236]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 1.06 mg.kg-1 DOI[10.1584/jpestics.22.236]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 1.11 mg.kg-1 DOI[10.1584/jpestics.22.236]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 2.17 mg.kg-1 DOI[10.1584/jpestics.22.236]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 847.0 ug.mL-1 PMID[18951417]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.94 ug.mL-1 PMID[18951417]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 32.1 ug.mL-1 PMID[18951417]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 0.49 ug.mL-1 PMID[18951417]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 > 1000.0 ug.mL-1 PMID[18951417]
NPT1367 Organism Bemisia tabaci Bemisia tabaci LC50 = 1.49 ug.mL-1 PMID[18951417]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 3.34 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 2.41 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 1.54 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 1.23 microg/mL2 PMID[21714058]
NPT3063 Organism Aphis gossypii Aphis gossypii LC50 = 0.55 microg/mL2 PMID[21714058]
NPT2 Others Unspecified IC50 = 984.0 nM DOI[10.1584/jpestics.20.33]
NPT2 Others Unspecified IC50 = 1950.0 nM DOI[10.1584/jpestics.20.33]
NPT734 Organism Musca domestica Musca domestica LD50 = 0.553 ug DOI[10.1584/jpestics.20.57]
NPT2 Others Unspecified IC50 = 1950.0 nM DOI[10.1584/jpestics.20.57]
NPT2 Others Unspecified IC50 = 386000.0 nM DOI[10.1584/jpestics.20.57]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella Ratio = 1.0 n.a. DOI[10.1584/jpestics.25.395]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella Ratio = 2.3 n.a. DOI[10.1584/jpestics.25.395]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 0.26 mg.kg-1 DOI[10.1584/jpestics.25.395]
NPT21200 ORGANISM Laodelphax striatella Laodelphax striatella LD50 = 0.61 mg.kg-1 DOI[10.1584/jpestics.25.395]
NPT6307 Organism Amphimallon majalis Amphimallon majalis Activity = 13.0 % PMID[19742452]
NPT6307 Organism Amphimallon majalis Amphimallon majalis Activity = 18.3 % PMID[19742452]
NPT6307 Organism Amphimallon majalis Amphimallon majalis Activity = 34.2 % PMID[19742452]
NPT6276 Organism Popillia japonica Popillia japonica Activity = 9.1 % PMID[19742452]
NPT6276 Organism Popillia japonica Popillia japonica Activity = 22.6 % PMID[19742452]
NPT6276 Organism Popillia japonica Popillia japonica Activity = 41.7 % PMID[19742452]
NPT14612 ORGANISM Paralobesia Paralobesia Activity = 1.0 % PMID[22290809]
NPT14612 ORGANISM Paralobesia Paralobesia Activity = 11.8 % PMID[22290809]
NPT6276 Organism Popillia japonica Popillia japonica Activity = 4.43 % PMID[22290809]
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 90.03 % PMID[23571415]
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 73.94 % PMID[23571415]
NPT2 Others Unspecified LC50 = 49000.0 nM PMID[28362501]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = 3.94 % DOI[10.21203/rs.3.rs-23951/v1]
NPT20556 SINGLE PROTEIN Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 Inhibition = 9.01 % DOI[10.6019/CHEMBL4495564]
NPT20556 SINGLE PROTEIN Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 Inhibition = 8.12 % DOI[10.6019/CHEMBL4495564]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = -0.14 % DOI[10.6019/CHEMBL4495565]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = 0.09 % DOI[10.6019/CHEMBL4495565]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 IC50 > 20000.0 nM DOI[10.6019/CHEMBL4651402]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 IC50 > 19952.62 nM DOI[10.6019/CHEMBL4651402]
NPT26965 ORGANISM Anomala orientalis Anomala orientalis Activity = 9.7 % PMID[19742452]
NPT26965 ORGANISM Anomala orientalis Anomala orientalis Activity = 30.1 % PMID[19742452]
NPT26965 ORGANISM Anomala orientalis Anomala orientalis Activity = 68.3 % PMID[19742452]
NPT26962 ORGANISM Maladera castanea Maladera castanea Activity = 9.2 % PMID[19742452]
NPT26962 ORGANISM Maladera castanea Maladera castanea Activity = 12.2 % PMID[19742452]
NPT26962 ORGANISM Maladera castanea Maladera castanea Activity = 38.8 % PMID[19742452]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC482940 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC482940 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data