Structure

Physi-Chem Properties

Molecular Weight:  260.09
Volume:  250.898
LogP:  0.739
LogD:  1.328
LogS:  -1.445
# Rotatable Bonds:  6
TPSA:  90.06
# H-Bond Aceptor:  7
# H-Bond Donor:  1
# Rings:  2
# Heavy Atoms:  7

MedChem Properties

QED Drug-Likeness Score:  0.644
Synthetic Accessibility Score:  2.091
Fsp3:  0.167
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -4.29
MDCK Permeability:  0.00019039747712668031
Pgp-inhibitor:  0.0
Pgp-substrate:  0.003
Human Intestinal Absorption (HIA):  0.031
20% Bioavailability (F20%):  0.002
30% Bioavailability (F30%):  0.0

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.578
Plasma Protein Binding (PPB):  66.09228515625%
Volume Distribution (VD):  0.664
Pgp-substrate:  36.10029983520508%

ADMET: Metabolism

CYP1A2-inhibitor:  0.194
CYP1A2-substrate:  0.067
CYP2C19-inhibitor:  0.405
CYP2C19-substrate:  0.081
CYP2C9-inhibitor:  0.226
CYP2C9-substrate:  0.556
CYP2D6-inhibitor:  0.013
CYP2D6-substrate:  0.318
CYP3A4-inhibitor:  0.059
CYP3A4-substrate:  0.193

ADMET: Excretion

Clearance (CL):  8.615
Half-life (T1/2):  0.816

ADMET: Toxicity

hERG Blockers:  0.044
Human Hepatotoxicity (H-HT):  0.722
Drug-inuced Liver Injury (DILI):  0.765
AMES Toxicity:  0.973
Rat Oral Acute Toxicity:  0.021
Maximum Recommended Daily Dose:  0.396
Skin Sensitization:  0.336
Carcinogencity:  0.836
Eye Corrosion:  0.003
Eye Irritation:  0.014
Respiratory Toxicity:  0.052

Download Data

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  Natural Product: NPC478930

Natural Product ID:  NPC478930
Common Name*:   CULUWZNBISUWAS-UHFFFAOYSA-N
IUPAC Name:   n.a.
Synonyms:  
Standard InCHIKey:  CULUWZNBISUWAS-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
SMILES:  c1ccc(cc1)CN=C(Cn1ccnc1N(=O)=O)O
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   n.a.
PubChem CID:   31593
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0003630] Organic 1,3-dipolar compounds
      • [CHEMONTID:0003631] Allyl-type 1,3-dipolar organic compounds
        • [CHEMONTID:0001152] Organic nitro compounds
          • [CHEMONTID:0004117] C-nitro compounds
            • [CHEMONTID:0004612] Nitroaromatic compounds

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. DOI[10.1016/0006-291X(79)91731-5]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. DOI[10.1093/emboj/18.8.2021]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[1091286]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[10977898]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[1100617]
NPO40017 Ancistrocladus ealaensis Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[11087584]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[11745165]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[11750815]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[12369847]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[12467448]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[12805358]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. ChEBI[131529]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[13610867]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[13831814]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[14973046]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[15031653]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[15292242]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[15610037]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[1644759]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[16630633]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[170247]
NPO28537 Ancistrocladus abbreviatus Species Ancistrocladaceae Eukaryota n.a. aerial part n.a. PMID[1766007]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[17765195]
NPO40426 Agelas oroides enoyl Strain Agelasidae Eukaryota Tubers n.a. n.a. PMID[17765547]
NPO1848 Cussonia zimmermannii Species Araliaceae Eukaryota n.a. n.a. n.a. PMID[17922552]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[179975]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[19026742]
NPO40258 Oxandra espintana Species Annonaceae Eukaryota n.a. n.a. n.a. PMID[1919589]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[19514719]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[19561621]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[21437340]
NPO24632 Salvia hydrangea Species Lamiaceae Eukaryota n.a. aerial part n.a. PMID[21967089]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[21988831]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[22289691]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[22855027]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[23501116]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[23537328]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[23676670]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[241475]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24206068]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[24471493]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24783849]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24831709]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24939187]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24966042]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[24967680]
NPO8987 Xenorhabdus nematophila Species Morganellaceae Bacteria n.a. n.a. n.a. PMID[25080196]
NPO22669 Waltheria indica Species Malvaceae Eukaryota roots n.a. n.a. PMID[25314007]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[2543976]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[25867074]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[26195826]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[26337258]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[26670289]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[26826371]
NPO22669 Waltheria indica Species Malvaceae Eukaryota n.a. n.a. n.a. PMID[26848627]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota Flowers n.a. n.a. PMID[28116906]
NPO40018 Ancistrocladus ileboensis Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[28121440]
NPO21618 Ircinia oros Species Irciniidae Eukaryota n.a. n.a. n.a. PMID[28840725]
NPO40018 Ancistrocladus ileboensis Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[29043798]
NPO40017 Ancistrocladus ealaensis Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[29560715]
NPO40335 Salvia leriifolia Species Lamiaceae Eukaryota Roots n.a. n.a. PMID[29896963]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[29897754]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[30302998]
NPO24632 Salvia hydrangea Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[30565934]
NPO21299 Porcelia macrocarpa Species n.a. n.a. Seeds n.a. n.a. PMID[31046273]
NPO40017 Ancistrocladus ealaensis Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[31630523]
NPO28537 Ancistrocladus abbreviatus Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. PMID[31642313]
NPO41008 Photorhabdus temperata Meg1 Strain Morganellaceae Bacteria n.a. n.a. n.a. PMID[31799840]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[318639]
NPO28537 Ancistrocladus abbreviatus Species Ancistrocladaceae Eukaryota Roots n.a. n.a. PMID[32125158]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[3283102]
NPO40516 Arrabidaea brachypoda Species Bignoniaceae Eukaryota n.a. n.a. n.a. PMID[32902988]
NPO22669 Waltheria indica Species Malvaceae Eukaryota n.a. n.a. n.a. PMID[33095014]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[398096]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[4877125]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[4879561]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[4908789]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[5332408]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[6102982]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[6284709]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[6338507]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[7042909]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[7601837]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[8852895]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. PMID[9470222]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota Flower n.a. n.a. Database[FooDB]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24632 Salvia hydrangea Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21618 Ircinia oros Species Irciniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1848 Cussonia zimmermannii Species Araliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8987 Xenorhabdus nematophila Species Morganellaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO22669 Waltheria indica Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28537 Ancistrocladus abbreviatus Species Ancistrocladaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21299 Porcelia macrocarpa Species n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO15440 Chamaemelum nobile Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO730 Escherichia coli Species Enterobacteriaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO24632 Salvia hydrangea Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT886 Cell Line NIH3T3 Mus musculus ED50 > 50.0 uM PMID[11206479]
NPT1224 Individual Protein Glyceraldehyde-3-phosphate dehydrogenase liver Homo sapiens IC50 > 50000.0 nM PMID[11405646]
NPT886 Cell Line NIH3T3 Mus musculus ED50 > 50.0 uM PMID[11405646]
NPT171 Cell Line MRC5 Homo sapiens CC50 > 50000.0 nM PMID[12443785]
NPT171 Cell Line MRC5 Homo sapiens CC50 > 50000.0 nM PMID[10893302]
NPT1886 Cell Line J774 Mus musculus Activity = 1.4 % PMID[16455249]
NPT1886 Cell Line J774 Mus musculus Activity = 1.6 % PMID[16455249]
NPT1886 Cell Line J774 Mus musculus Activity = 1.9 % PMID[16455249]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 3.53 ug.mL-1 PMID[17222558]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 > 1000000.0 nM PMID[17889546]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[18293910]
NPT1970 Cell Line THP-1 Homo sapiens ID50 > 300.0 uM PMID[17709156]
NPT3171 Cell Line V79 Cricetulus griseus IC50 = 2000000.0 nM PMID[18570370]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 90000.0 nM PMID[19781948]
NPT2679 Cell Line LLC-MK2 Macaca mulatta IC50 > 1366000.0 nM PMID[20934347]
NPT2561 Individual Protein Triosephosphate isomerase, glycosomal Trypanosoma cruzi Inhibition = 18.0 % PMID[20889239]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13560.0 nM PMID[21229977]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[21466157]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 14000.0 nM PMID[21397502]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 2100.0 nM PMID[22414614]
NPT1886 Cell Line J774 Mus musculus IC50 = 3840700.0 nM PMID[22727447]
NPT2679 Cell Line LLC-MK2 Macaca mulatta CC50 = 614700.0 nM PMID[22440015]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 48000.0 nM PMID[22795899]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 82790.0 nM PMID[22840495]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[22443115]
NPT1886 Cell Line J774 Mus musculus GI = 12.98 % PMID[23124218]
NPT1886 Cell Line J774 Mus musculus GI = 13.02 % PMID[23124218]
NPT1886 Cell Line J774 Mus musculus GI = 14.81 % PMID[23124218]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 384000.0 nM PMID[23153330]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[23043291]
NPT886 Cell Line NIH3T3 Mus musculus EC50 > 50000.0 nM PMID[23448316]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 100000.0 nM PMID[23462713]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 150000.0 nM PMID[23795673]
NPT1886 Cell Line J774 Mus musculus IC50 > 400000.0 nM PMID[23816040]
NPT1886 Cell Line J774 Mus musculus CC50 >= 300000.0 nM PMID[24151871]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[24158012]
NPT1460 Cell Line L929 Mus musculus CC50 > 1000000.0 nM PMID[24321832]
NPT2679 Cell Line LLC-MK2 Macaca mulatta CC50 = 614700.0 nM PMID[24398381]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 14000.0 nM PMID[24529307]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[24448422]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[24410674]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 309100.0 nM DOI[10.1039/C2MD00283C]
NPT65 Cell Line HepG2 Homo sapiens IC50 = 2126160.0 nM PMID[24630563]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 150000.0 nM PMID[24956553]
NPT65 Cell Line HepG2 Homo sapiens IC50 = 28100.0 nM PMID[24929292]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[25462275]
NPT1045 Cell Line U2OS Homo sapiens CC50 > 50000.0 nM PMID[25036797]
NPT2679 Cell Line LLC-MK2 Macaca mulatta IC50 = 477000.0 nM PMID[25924111]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 384000.0 nM PMID[26237241]
NPT466 Cell Line U-937 Homo sapiens LC50 = 687700.0 nM PMID[26218652]
NPT1460 Cell Line L929 Mus musculus CC50 = 2381000.0 nM PMID[26231082]
NPT1886 Cell Line J774 Mus musculus CC50 > 100000.0 nM PMID[26549870]
NPT839 Cell Line L6 Rattus norvegicus IC50 = 510000.0 nM PMID[26479031]
NPT1460 Cell Line L929 Mus musculus LC50 > 256000.0 nM PMID[27017556]
NPT1970 Cell Line THP-1 Homo sapiens CC50 > 500000.0 nM PMID[28152426]
NPT1460 Cell Line L929 Mus musculus CC50 = 2381000.0 nM PMID[28215783]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 385000.0 nM PMID[28284860]
NPT612 Individual Protein Canalicular multispecific organic anion transporter 1 Homo sapiens IC50 > 133000.0 nM PMID[23956101]
NPT1249 Individual Protein Canalicular multispecific organic anion transporter 2 Homo sapiens IC50 > 133000.0 nM PMID[23956101]
NPT1028 Individual Protein Multidrug resistance-associated protein 4 Homo sapiens IC50 > 133000.0 nM PMID[23956101]
NPT466 Cell Line U-937 Homo sapiens LC50 = 180.0 ug.mL-1 PMID[28329730]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 14000.0 nM PMID[28645659]
NPT1460 Cell Line L929 Mus musculus LC50 > 400000.0 nM PMID[29748049]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 23200.0 nM PMID[29883536]
NPT1460 Cell Line L929 Mus musculus IC50 > 200000.0 nM PMID[28881289]
NPT466 Cell Line U-937 Homo sapiens LC50 = 687800.0 nM PMID[29028533]
NPT1460 Cell Line L929 Mus musculus IC50 > 256000.0 nM PMID[28499168]
NPT1886 Cell Line J774 Mus musculus CC50 > 50000.0 nM PMID[29031078]
NPT1635 Cell Line H9c2 Rattus norvegicus CC50 > 50000.0 nM PMID[29031078]
NPT466 Cell Line U-937 Homo sapiens LC50 = 180.0 ug.mL-1 PMID[29102177]
NPT1045 Cell Line U2OS Homo sapiens CC50 > 200000.0 nM PMID[29247858]
NPT81 Cell Line A549 Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT208 Individual Protein Cytochrome P450 1A2 Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT212 Individual Protein Cytochrome P450 2C9 Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT213 Individual Protein Cytochrome P450 2C19 Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT110 Individual Protein Cytochrome P450 2D6 Homo sapiens IC50 = 77800.0 nM PMID[29407968]
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens IC50 = 98200.0 nM PMID[29407968]
NPT1433 Individual Protein Serine/threonine-protein kinase Aurora-B Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT401 Cell Line 786-0 Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT1460 Cell Line L929 Mus musculus LC50 > 200000.0 nM PMID[29501946]
NPT1635 Cell Line H9c2 Rattus norvegicus IC50 > 50000.0 nM PMID[30100019]
NPT1970 Cell Line THP-1 Homo sapiens CC50 > 500000.0 nM PMID[30173929]
NPT993 Cell Line Hepatocyte Mus musculus CC50 > 500000.0 nM PMID[29289882]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 365710.0 nM PMID[29289882]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 30170.0 nM PMID[30344907]
NPT1460 Cell Line L929 Mus musculus CC50 > 200000.0 nM PMID[31000155]
NPT1460 Cell Line L929 Mus musculus CC50 = 190600.0 nM PMID[31103897]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 > 500000.0 nM PMID[31434040]
NPT1182 Cell Line J774.A1 Mus musculus CC50 = 352200.0 nM PMID[30784876]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 > 200000.0 nM PMID[31345745]
NPT1045 Cell Line U2OS Homo sapiens CC50 > 200000.0 nM PMID[30562700]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 23200.0 nM PMID[30583247]
NPT839 Cell Line L6 Rattus norvegicus CC50 > 385000.0 nM PMID[30615444]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 23200.0 nM PMID[30728107]
NPT1460 Cell Line L929 Mus musculus EC50 > 200000.0 nM PMID[31495177]
NPT171 Cell Line MRC5 Homo sapiens EC50 > 64000.0 nM PMID[30677668]
NPT113 Cell Line RAW264.7 Mus musculus CC50 = 137540.0 nM PMID[30996772]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 > 500000.0 nM PMID[30996772]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[30641409]
NPT189 Cell Line Vero Chlorocebus aethiops ED50 > 10.0 uM PMID[30808607]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 380000.0 nM PMID[31784198]
NPT1635 Cell Line H9c2 Rattus norvegicus EC50 > 40000.0 nM PMID[32551008]
NPT2679 Cell Line LLC-MK2 Macaca mulatta CC50 > 200000.0 nM PMID[33199200]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 80400.0 nM PMID[33253573]
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 13600.0 nM PMID[28002965]
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 706000.0 nM PMID[31771829]
NPT65 Cell Line HepG2 Homo sapiens GI50 > 500000.0 nM PMID[31787363]
NPT113 Cell Line RAW264.7 Mus musculus GI50 > 500000.0 nM PMID[31787363]
NPT1635 Cell Line H9c2 Rattus norvegicus CC50 = 31600.0 nM PMID[33479668]
NPT839 Cell Line L6 Rattus norvegicus IC50 > 345000.0 nM PMID[33095014]
NPT1970 Cell Line THP-1 Homo sapiens CC50 > 200000.0 nM PMID[32652409]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 0.6 uM PMID[11206479]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 0.5 uM PMID[11405646]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1270.0 nM PMID[12781196]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3.5 nM PMID[11300872]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7.4 ug.mL-1 PMID[11591517]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 30000.0 nM PMID[11591517]
NPT2 Others Unspecified Ratio = 1.0 n.a. PMID[11591517]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 7.1 uM PMID[11459645]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 7.45 ug ml-1 PMID[10866389]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 3.31 uM PMID[12443785]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 8.5 ug ml-1 PMID[10866368]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2200.0 nM PMID[15177472]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2580.0 nM PMID[15177472]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % DOI[10.1016/0960-894X(95)00248-R]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8950.0 nM DOI[10.1016/0960-894X(95)00248-R]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8050.0 nM DOI[10.1016/0960-894X(95)00248-R]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8970.0 nM DOI[10.1016/0960-894X(95)00248-R]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3130.0 nM PMID[10893302]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 800.0 nM PMID[15603944]
NPT2 Others Unspecified Survival > 30.0 day PMID[16107157]
NPT2 Others Unspecified Inhibition = 100.0 % PMID[16107157]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei IC50 = 116300.0 nM PMID[16107157]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei IC50 = 114200.0 nM PMID[16107157]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 96.6 % PMID[16455249]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 9.2 % PMID[16455249]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 83.2 % PMID[16455249]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8500.0 nM PMID[16722639]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 92.0 % PMID[16722639]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3400.0 nM PMID[16722639]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[16722639]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1040.0 nM PMID[16677813]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 1.0 uM PMID[17004723]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.74 ug.mL-1 PMID[17253841]
NPT633 Organism Leishmania donovani Leishmania donovani ED50 = 28.9 uM PMID[16279799]
NPT844 Organism Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense ED50 = 0.1 nM PMID[16279799]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 4.2 uM PMID[16279799]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 91.7 % PMID[17055730]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 92.6 % PMID[17055730]
NPT32 Organism Mus musculus Mus musculus Activity = 0.0 % PMID[17220408]
NPT32 Organism Mus musculus Mus musculus Activity = 100.0 % PMID[17220408]
NPT32 Organism Mus musculus Mus musculus Activity = 17.0 % PMID[17220408]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 86.0 % PMID[17220408]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[17220408]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 39.0 % PMID[17220408]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4.12 ug.mL-1 PMID[17222558]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7400.0 nM PMID[17287123]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4500.0 nM PMID[17287123]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[17287123]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8700.0 nM PMID[17532634]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 14580.0 nM PMID[17889546]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 92.0 % PMID[17889546]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2130.0 nM PMID[17949068]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7400.0 nM PMID[17960923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4500.0 nM PMID[17960923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[17960923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.17 ug.mL-1 PMID[17765547]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2400.0 nM PMID[17922552]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 74000.0 nM PMID[18024033]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[18353643]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15800.0 nM PMID[18293910]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 20600.0 nM PMID[18029184]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 57.8 % PMID[18029184]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 82.0 % PMID[18029184]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2210.0 nM PMID[18226906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2510.0 nM PMID[18226906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6610.0 nM PMID[18226906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36.3 ug.mL-1 PMID[18177008]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 25.0 ug PMID[1919589]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 50.0 ug PMID[1919589]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 100.0 ug PMID[1919589]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 > 100.0 ug PMID[1919589]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.3 ug.mL-1 PMID[11087584]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[18378461]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 0.25 ug.mL-1 PMID[17475370]
NPT27 Others Unspecified Ratio IC50 > 360.0 n.a. PMID[17475370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.317 ug.mL-1 PMID[18683985]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7.4 ug.mL-1 PMID[18712933]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % PMID[17709156]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ID50 = 7.4 uM PMID[17709156]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 30.0 % PMID[19303308]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 3.0 % PMID[19303308]
NPT32 Organism Mus musculus Mus musculus Survival = 60.0 % PMID[18706738]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.29 ug.mL-1 PMID[15165131]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 86.0 nM PMID[18476684]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ID50 = 4.5 uM PMID[18706821]
NPT18219 ORGANISM Leishmania pifanoi Leishmania pifanoi ID50 = 3.8 uM PMID[18706821]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.42 ug.mL-1 PMID[14510589]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 50.0 ug.mL-1 DOI[10.1021/np50099a013]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.55 ug.mL-1 PMID[15620251]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % PMID[18547811]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7400.0 nM PMID[18547811]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4500.0 nM PMID[18547811]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 0.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 7.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 11.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 15.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 24.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 26.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 31.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 > 1000000.0 nM PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 20.0 % PMID[18570370]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 35.4 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 54.4 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 70.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 59.1 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 17.4 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 24.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity < 33.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 22.7 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 25.9 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 14.3 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 83.3 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 19.8 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 79.3 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 93.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 96.4 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 99.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 50.0 % PMID[17638698]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.83 ug.mL-1 PMID[19095449]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[18045742]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.382 ug.mL-1 PMID[12193010]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1.5 ug.mL-1 PMID[15921407]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.55 ug.mL-1 PMID[15921410]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.14 ug.mL-1 PMID[17562801]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7400.0 nM PMID[18068272]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4500.0 nM PMID[18068272]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[18068272]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 54700.0 nM PMID[18192088]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 192100.0 nM PMID[18192088]
NPT32 Organism Mus musculus Mus musculus Activity = 100.0 % PMID[18255195]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1480.0 nM PMID[19414258]
NPT1019 Organism Trichomonas vaginalis Trichomonas vaginalis IC50 = 18620.0 nM PMID[19208443]
NPT2645 Organism Giardia intestinalis Giardia intestinalis IC50 = 22580.0 nM PMID[19208443]
NPT992 Organism Entamoeba histolytica Entamoeba histolytica IC50 = 4270.0 nM PMID[19208443]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[19606868]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 521.0 nM PMID[19817445]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7400.0 nM PMID[19837489]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4500.0 nM PMID[19837489]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5000.0 nM PMID[19539479]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[19539479]
NPT27 Others Unspecified Activity = 25.0 ug ml-1 PMID[19539479]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ID50 = 7.4 uM PMID[19616875]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1250.0 nM PMID[19781948]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5000.0 nM PMID[19683450]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5011.87 nM PMID[19683450]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[19683450]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1540.0 nM PMID[19942439]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1800.0 nM PMID[20185305]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3000.0 nM PMID[20185316]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2640.0 nM PMID[20614907]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34380.0 nM PMID[20674375]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 89.6 % PMID[20573426]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.489 ug.mL-1 PMID[20855214]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1979.0 nM PMID[20850207]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 97.0 % PMID[20961766]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[20961766]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5000.0 nM PMID[20961766]
NPT27 Others Unspecified Activity = 25.0 ug ml-1 PMID[20961766]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 43.0 % PMID[20961766]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 85.0 % PMID[20961766]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 172370.0 nM PMID[20934347]
NPT2 Others Unspecified Ratio > 4.0 n.a. PMID[20889239]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ID50 = 7.4 uM PMID[20889239]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[20404124]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[20404124]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei EC50 = 30000.0 nM PMID[20439607]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei EC50 = 154000.0 nM PMID[20439607]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei Ratio EC50 = 5.0 n.a. PMID[20439607]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei EC50 = 155000.0 nM PMID[20439607]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1.8 nM PMID[19364854]
NPT32 Organism Mus musculus Mus musculus Activity = 100.0 % PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 79.4 % PMID[20457822]
NPT32 Organism Mus musculus Mus musculus Activity = 7.0 % PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5060.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6440.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5300.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 13700.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3960.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7900.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12570.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7650.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[20457822]
NPT32 Organism Mus musculus Mus musculus Activity = 68.0 % PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 99.0 % PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 86560.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 225580.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 195740.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 20420.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 58330.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 38170.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 30590.0 nM PMID[20457822]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 35680.0 nM PMID[20457822]
NPT605 Organism Homo sapiens Homo sapiens Activity = 56.2 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 50.5 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 43.4 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 35.8 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 13.2 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 36.2 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 27.6 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 15.0 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 1.0 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 40.0 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 30.0 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 11.0 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 12.4 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 57.1 % PMID[20823286]
NPT605 Organism Homo sapiens Homo sapiens Activity = 42.9 % PMID[20823286]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 33.3 % PMID[20566772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[20566772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 50.0 % PMID[20566772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3700.0 nM PMID[20625148]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15830.0 nM PMID[21229977]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 39.0 % PMID[21229977]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 15.0 % PMID[21229977]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 43.0 % PMID[21229977]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 80.0 % PMID[21229977]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 22.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 66.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 86.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 6.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 67.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 86.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[19001113]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1970.0 nM PMID[19564359]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2768.0 nM PMID[21419634]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[21506600]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 87.5 % PMID[21506600]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 75.0 % PMID[21506600]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1350.0 nM PMID[21348447]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1950.0 nM PMID[21456549]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15800.0 nM PMID[21466157]
NPT2 Others Unspecified Ratio IC50 = 0.9 n.a. PMID[21466157]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 39.0 % PMID[21466157]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 37.0 % PMID[21466157]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 80.0 % PMID[21466157]
NPT2645 Organism Giardia intestinalis Giardia intestinalis IC50 = 22580.0 nM PMID[21397502]
NPT1019 Organism Trichomonas vaginalis Trichomonas vaginalis IC50 = 18620.0 nM PMID[21397502]
NPT992 Organism Entamoeba histolytica Entamoeba histolytica IC50 = 4270.0 nM PMID[21397502]
NPT842 Organism Leishmania mexicana Leishmania mexicana IC50 > 50000.0 nM PMID[21397502]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34380.0 nM PMID[21397502]
NPT474 Organism Plasmodium berghei Plasmodium berghei IC50 = 4070.0 nM PMID[21397502]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 37300.0 nM PMID[21506530]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[21450374]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5800.0 nM PMID[21664012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34100.0 nM PMID[21664012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3600.0 nM PMID[21664012]
NPT21850 CELL-LINE COS-7 Chlorocebus aethiops CC50 = 706000.0 nM PMID[21664012]
NPT2 Others Unspecified Ratio CC50/IC50 = 20.7 n.a. PMID[21664012]
NPT2 Others Unspecified Ratio CC50/IC50 = 196.1 n.a. PMID[21664012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1800.0 nM PMID[21846091]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 886.0 nM PMID[21868222]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[21940071]
NPT2 Others Unspecified Ratio IC50 > 135.0 n.a. PMID[21937228]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2550.0 nM PMID[21937228]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 20840.0 nM PMID[21962987]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1320.0 nM PMID[22023653]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 = 1.0 n.a. PMID[22023653]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1134.0 nM PMID[22061825]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 125000.0 nM PMID[22154559]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.464 ug.mL-1 PMID[22217867]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1400.0 nM PMID[22285027]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2100.0 nM PMID[22414614]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[22483633]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.48 ug.mL-1 PMID[22352841]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10800.0 nM PMID[22727447]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 122.0 nM PMID[22727447]
NPT2 Others Unspecified Ratio IC50 = 356.0 n.a. PMID[22727447]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 42700.0 nM PMID[22559947]
NPT27 Others Unspecified IC50 = 1141000.0 nM PMID[22559947]
NPT2 Others Unspecified Ratio IC50 = 26.7 n.a. PMID[22559947]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6500.0 nM PMID[22440015]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 34500.0 nM PMID[22440015]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19200.0 nM PMID[22440015]
NPT27 Others Unspecified Ratio CC50/IC50 = 32.0 n.a. PMID[22440015]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 26.8 % PMID[22795899]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 11500.0 nM PMID[22795899]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity > 99.0 % PMID[22536986]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5390.0 nM PMID[22840495]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 30260.0 nM PMID[22840495]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18900.0 nM PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[22443115]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[22443115]
NPT2 Others Unspecified Ratio IC50 = 0.7 n.a. PMID[22443115]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 23.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 13.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 46.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 26.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 6.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 80.0 % PMID[22443115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1562.0 nM PMID[22550999]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 = 21800.0 nM PMID[22550999]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 = 2200.0 nM PMID[22550999]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 = 10.0 n.a. PMID[22550999]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1470.0 nM PMID[22932312]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27320.0 nM PMID[23124218]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 70.95 % PMID[23124218]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 79.75 % PMID[23124218]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 82.01 % PMID[23124218]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7500.0 nM PMID[23006639]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 11300.0 nM PMID[23006639]
NPT2 Others Unspecified Ratio IC50 > 225.0 n.a. PMID[23153330]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[23153330]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 13900.0 nM PMID[23167554]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[23167554]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6200.0 nM PMID[23167554]
NPT27 Others Unspecified Activity = 25.0 ug ml-1 PMID[23167554]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity > 99.0 % PMID[23167554]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 36.0 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 16.7 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 20.0 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 15.3 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 41.6 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 12.5 % PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 39.4 % PMID[23043291]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[23043291]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[23043291]
NPT2 Others Unspecified Ratio IC50 = 0.7 n.a. PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16400.0 nM PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18900.0 nM PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[23043291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 42700.0 nM DOI[10.1007/s00044-008-9161-9]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM DOI[10.1007/s00044-012-0010-5]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5000.0 nM DOI[10.1007/s00044-012-0010-5]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 204.64 ug.mL-1 DOI[10.1007/s00044-012-0264-y]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 116.61 ug.mL-1 DOI[10.1007/s00044-012-0264-y]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1800.0 nM PMID[23265884]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1606.0 nM PMID[23360309]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 51.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 66.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 60.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 75.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 80.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 91.0 % PMID[23391336]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 1.7 uM PMID[23318904]
NPT2 Others Unspecified Ratio EC50 < 26.0 n.a. PMID[23448316]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1900.0 nM PMID[23448316]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1150.0 nM PMID[23462713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI50 = 440700.0 nM PMID[23266185]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 30000.0 nM PMID[23415086]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3660.0 nM PMID[23518280]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1671.0 nM PMID[24900706]
NPT27 Others Unspecified IC50 > 200000.0 nM PMID[23644203]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI50 = 22690.0 nM PMID[23644203]
NPT2 Others Unspecified Ratio CC50/IC50 = 1.0 n.a. PMID[23659860]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 25600.0 nM PMID[23659860]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 >= 500000.0 nM PMID[23659860]
NPT2 Others Unspecified Ratio IC50 = 115.0 n.a. PMID[23795673]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1300.0 nM PMID[23795673]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1460.0 nM PMID[23831695]
NPT27 Others Unspecified Activity > 500.0 umol/L PMID[23850203]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 19.0 umol/L PMID[23850203]
NPT2 Others Unspecified Ratio IC50 > 9.0 n.a. PMID[23816040]
NPT27 Others Unspecified IC50 > 200000.0 nM PMID[23816040]
NPT2 Others Unspecified Ratio IC50 > 18.0 n.a. PMID[23816040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 22690.0 nM PMID[23816040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34600.0 nM PMID[23851115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2.5 ug.mL-1 PMID[23910983]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 800.0 nM PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 41.64 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 55.64 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 64.37 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 74.71 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 96.63 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[23899616]
NPT27 Others Unspecified LC50 > 256000.0 nM PMID[23899616]
NPT27 Others Unspecified Activity = 17.38 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27120.0 nM PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 66.24 % PMID[23899616]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1573.0 nM PMID[23968432]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 1.75 uM PMID[24090919]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1850.0 nM PMID[24012457]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 192100.0 nM PMID[24151871]
NPT27 Others Unspecified CC50 > 194000.0 nM PMID[24151871]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 54700.0 nM PMID[24151871]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 27.0 % PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 12.0 % PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 39.0 % PMID[24158012]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[24158012]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 22600.0 nM PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23000.0 nM PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16000.0 nM PMID[24158012]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 2.77 uM PMID[24300918]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 1.44 uM PMID[24300918]
NPT2 Others Unspecified Ratio CC50/IC50 > 262.0 n.a. PMID[24321832]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[24321832]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 34500.0 nM PMID[24398381]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6500.0 nM PMID[24398381]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 25.0 day PMID[24299463]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[24299463]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34380.0 nM PMID[24529307]
NPT634 Organism Leishmania amazonensis Leishmania amazonensis IC50 > 50000.0 nM PMID[24529307]
NPT1019 Organism Trichomonas vaginalis Trichomonas vaginalis IC50 = 18620.0 nM PMID[24529307]
NPT2645 Organism Giardia intestinalis Giardia intestinalis IC50 = 22580.0 nM PMID[24529307]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 800.0 nM PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 41.64 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 55.64 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 64.37 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 74.71 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 96.63 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % PMID[24461296]
NPT27 Others Unspecified LC50 > 256000.0 nM PMID[24461296]
NPT27 Others Unspecified Inhibition = 17.38 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27120.0 nM PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 82.01 % PMID[24461296]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 48800.0 nM PMID[24561675]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi CC50 = 6200.0 nM PMID[24561675]
NPT32 Organism Mus musculus Mus musculus Survival = 80.0 % PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 23.0 % PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 41.0 % PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 37.0 % PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 19.0 % PMID[24448422]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[24448422]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16400.0 nM PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[24448422]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 26.0 % PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 21.0 % PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 15.0 % PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 20.0 % PMID[24410674]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[24410674]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[24410674]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM DOI[10.1039/C3MD00065F]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM DOI[10.1039/C1MD00237F]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12500.0 nM DOI[10.1039/C2MD00283C]
NPT2 Others Unspecified Ratio CC50/IC50 = 25.0 n.a. DOI[10.1039/C2MD00283C]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 27.0 % DOI[10.1039/C2MD00283C]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 77.0 % DOI[10.1039/C2MD00283C]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 85.0 % DOI[10.1039/C2MD00283C]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 886.0 nM DOI[10.1039/C2MD20136D]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 44.0 % DOI[10.1039/C2MD20019H]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 66.0 % DOI[10.1039/C2MD20019H]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 77.0 % DOI[10.1039/C2MD20019H]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ID50 = 7.4 uM DOI[10.1039/C1MD00223F]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei IC50 = 207570.0 nM PMID[24630563]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Ratio IC50 = 10.24 n.a. PMID[24630563]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei IC50 = 149580.0 nM PMID[24630563]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Ratio IC50 = 14.21 n.a. PMID[24630563]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34000.0 nM PMID[24630563]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Ratio IC50 = 62.53 n.a. PMID[24630563]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1730.0 nM PMID[24673206]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4800.0 nM PMID[24533839]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3300.0 nM PMID[24749923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7000.0 nM PMID[24749923]
NPT2 Others Unspecified Ratio IC50 = 300.0 n.a. PMID[24749923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[24749923]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 11300.0 nM PMID[24871307]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 14000.0 nM PMID[24871307]
NPT27 Others Unspecified LC50 > 20000.0 nM PMID[24871307]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 99.0 % PMID[24871307]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1870.0 nM PMID[24956553]
NPT2 Others Unspecified Ratio IC50 > 80.0 n.a. PMID[24956553]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1500.0 nM PMID[24929292]
NPT2 Others Unspecified Ratio IC50 = 18.7 n.a. PMID[24929292]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 409.0 nM PMID[25547934]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2130.0 nM PMID[25563890]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[25462275]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 36.0 % PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 16.7 % PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16400.0 nM PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15900.0 nM PMID[25462275]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 0.38 ug.mL-1 PMID[24978605]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1730.0 nM PMID[25080196]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 20700.0 nM PMID[25036797]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2560.0 nM PMID[25199582]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 6.5 ug.mL-1 PMID[25238291]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 4.0 ug.mL-1 PMID[25238291]
NPT27 Others Unspecified Activity = 42.51 % PMID[25238291]
NPT27 Others Unspecified Activity = 0.12 % PMID[25238291]
NPT27 Others Unspecified Activity = 0.02 % PMID[25238291]
NPT27 Others Unspecified Activity = 22.95 % PMID[25238291]
NPT27 Others Unspecified Activity = 76.91 % PMID[25238291]
NPT27 Others Unspecified Activity = 0.51 % PMID[25238291]
NPT27 Others Unspecified Activity = 4.78 % PMID[25238291]
NPT27 Others Unspecified Activity = 18.79 % PMID[25238291]
NPT27 Others Unspecified Activity = 75.92 % PMID[25238291]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 = 21800.0 nM PMID[25240098]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 = 2200.0 nM PMID[25240098]
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 = 9.9 n.a. PMID[25240098]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2130.0 nM PMID[25240098]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6200.0 nM PMID[25147146]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[25147146]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2900.0 nM PMID[25314007]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8100.0 nM PMID[25461316]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 3400.0 nM PMID[25461316]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 26100.0 nM PMID[25461316]
NPT27 Others Unspecified LC50 = 180.0 ug.mL-1 PMID[25725376]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % PMID[25725376]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 10.7 ug.mL-1 PMID[25725376]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2180.0 nM PMID[25580906]
NPT2 Others Unspecified Activity = 1540.0 nmol/min PMID[25580906]
NPT2 Others Unspecified Activity = 680.0 nmol/min PMID[25580906]
NPT25484 SINGLE PROTEIN Sterol 14-alpha demethylase Trypanosoma cruzi (strain CL Brener) Ratio = 43.2 n.a. PMID[25580906]
NPT25484 SINGLE PROTEIN Sterol 14-alpha demethylase Trypanosoma cruzi (strain CL Brener) Ratio = 45.0 n.a. PMID[25580906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity < 4.0 % PMID[25580906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 13.38 n.a. PMID[25580906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[25642604]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 54700.0 nM PMID[25884114]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 690000.0 nM PMID[25899334]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 780000.0 nM PMID[25899334]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 40400.0 nM PMID[25899337]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 29160.0 nM PMID[25899337]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 30630.0 nM PMID[25899337]
NPT27 Others Unspecified IC50 > 200000.0 nM PMID[25899337]
NPT2 Others Unspecified Ratio IC50 > 5.0 n.a. PMID[25899337]
NPT2 Others Unspecified Ratio IC50 > 7.0 n.a. PMID[25899337]
NPT2 Others Unspecified Ratio IC50 > 6.0 n.a. PMID[25899337]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 441000.0 nM PMID[25924111]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1200.0 nM PMID[26087257]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 18800.0 nM PMID[26072173]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6800.0 nM PMID[26037321]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 4070.0 nM PMID[26055530]
NPT2 Others Unspecified Ratio IC50 > 225.0 n.a. PMID[26237241]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[26237241]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 87.6 % PMID[26218652]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 10.5 ug.mL-1 PMID[26218652]
NPT2 Others Unspecified Ratio = 17.0 n.a. PMID[26218652]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 48800.0 nM PMID[26231082]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi CC50 = 6200.0 nM PMID[26231082]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2153.0 nM PMID[26344593]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[26231082]
NPT2 Others Unspecified Ratio CC50/IC50 = 625.0 n.a. PMID[26231082]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 4.2 % PMID[26231082]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 56.4 % PMID[26231082]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34000.0 nM PMID[26476667]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16000.0 nM PMID[26476667]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10600.0 nM PMID[26549870]
NPT2 Others Unspecified Ratio CC50/IC50 > 9.4 n.a. PMID[26549870]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 13900.0 nM PMID[26549870]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity > 99.0 % PMID[26549870]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2325.0 nM DOI[10.1039/C4MD00406J]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2153.0 nM PMID[26363868]
NPT2 Others Unspecified Activity = 1540.0 nmol/min/mg PMID[26363868]
NPT2 Others Unspecified Activity = 680.0 nmol/min/mg PMID[26363868]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 99.0 % PMID[26363868]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36200.0 nM PMID[26479031]
NPT2 Others Unspecified Ratio IC50 = 14.1 n.a. PMID[26479031]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8000.0 nM PMID[26750255]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 100.0 % PMID[26750255]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 12500.0 nM PMID[26774036]
NPT2 Others Unspecified Ratio CC50/IC50 = 25.0 n.a. PMID[26774036]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3000.0 nM PMID[26810263]
NPT27 Others Unspecified IC50 > 100000.0 nM PMID[26810263]
NPT2 Others Unspecified Ratio IC50 > 100.0 n.a. PMID[26810263]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 440700.0 nM PMID[26821820]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 230300.0 nM PMID[26821820]
NPT27 Others Unspecified CC50 = 269900.0 nM PMID[26821820]
NPT2 Others Unspecified Ratio CC50/IC50 = 0.6 n.a. PMID[26821820]
NPT2 Others Unspecified Ratio CC50/IC50 = 1.2 n.a. PMID[26821820]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[26774924]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 48800.0 nM PMID[26854377]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6300.0 nM PMID[26854377]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 56.0 % PMID[26854377]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1950.0 nM PMID[26922226]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10180.0 nM PMID[26906638]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. CC50 > 125400.0 nM PMID[26906638]
NPT2 Others Unspecified Ratio CC50/IC50 > 12.0 n.a. PMID[26906638]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 22730.0 nM PMID[27017556]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 680.0 nM PMID[27017556]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1660.0 nM PMID[27017556]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 28110.0 nM PMID[27017556]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1770.0 nM PMID[27017556]
NPT27 Others Unspecified LC50 > 100000.0 nM PMID[27017556]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2100.0 nM DOI[10.1039/C5MD00498E]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2100.0 nM PMID[26849852]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2206.0 nM PMID[27092415]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6500.0 nM DOI[10.1039/C5MD00599J]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 34500.0 nM DOI[10.1039/C5MD00599J]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 94.5 % PMID[27475533]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1170.0 nM PMID[27475533]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 100.0 % PMID[27475533]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 11400.0 nM PMID[27475533]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. EC50 = 3960.0 nM PMID[27318979]
NPT2 Others Unspecified Ratio CC50/EC50 > 101.0 n.a. PMID[27318979]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 16000.0 nM PMID[27586460]
NPT32 Organism Mus musculus Mus musculus CC50 > 150000.0 nM PMID[27586460]
NPT2 Others Unspecified Ratio CC50/IC50 > 9.0 n.a. PMID[27586460]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 4.4 uM PMID[28131508]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 85.94 % PMID[28152426]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10180.0 nM PMID[28152426]
NPT2 Others Unspecified Ratio CC50/IC50 > 49.1 n.a. PMID[28152426]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3800.0 nM PMID[28215783]
NPT2 Others Unspecified Ratio CC50/IC50 = 626.0 n.a. PMID[28215783]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1640.0 nM PMID[28284860]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 3600.0 nM PMID[28189084]
NPT2 Others Unspecified Ratio CC50/EC50 > 235.0 n.a. PMID[28189084]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 56.0 % PMID[28364659]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 40.6 ug.mL-1 PMID[28364659]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 69.0 % PMID[28364659]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 46.6 ug.mL-1 PMID[28364659]
NPT713 Individual Protein Bile salt export pump Homo sapiens IC50 > 133000.0 nM PMID[23956101]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC90 = 1.36 uM PMID[28740614]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 690.0 nM PMID[28740614]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2000.0 nM PMID[28116906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 10.7 ug.mL-1 PMID[28329730]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 8.0 % PMID[28463485]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 76.0 % PMID[28463485]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 25.0 10'6/ml PMID[27688187]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[27688187]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 63.3 % PMID[28789893]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 98.5 % PMID[28789893]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2130.0 nM PMID[28789893]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi CC50 = 6200.0 nM PMID[28242550]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi CC50 = 48800.0 nM PMID[28242550]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 4.2 % PMID[28242550]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 56.4 % PMID[28242550]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2317.0 nM PMID[28121440]
NPT2645 Organism Giardia intestinalis Giardia intestinalis IC50 = 22580.0 nM PMID[28645659]
NPT1019 Organism Trichomonas vaginalis Trichomonas vaginalis IC50 = 18620.0 nM PMID[28645659]
NPT634 Organism Leishmania amazonensis Leishmania amazonensis IC50 > 50000.0 nM PMID[28645659]
NPT842 Organism Leishmania mexicana Leishmania mexicana IC50 > 50000.0 nM PMID[28645659]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34380.0 nM PMID[28645659]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 7500.0 nM PMID[28648464]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 89.3 % PMID[29748049]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 3510.0 nM PMID[29748049]
NPT2 Others Unspecified LC50 > 1000000.0 nM PMID[29748049]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 11200.0 nM PMID[29748049]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16900.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36200.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19700.0 nM PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 1.4 n.a. PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 1.2 n.a. PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8300.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12400.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16600.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36100.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15100.0 nM PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 2.8 n.a. PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 1.9 n.a. PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 2.3 n.a. PMID[29883536]
NPT2 Others Unspecified Ratio IC50 = 1.5 n.a. PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 20.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity > 10.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 70.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 75.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 51.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 55.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 33.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity <= 30.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity > 40.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity < 10.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity <= 20.0 % PMID[29883536]
NPT32 Organism Mus musculus Mus musculus Activity <= 10.0 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 35.4 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 22.4 % PMID[29883536]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2240.0 nM PMID[28763645]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3070.0 nM PMID[28840725]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16200.0 nM PMID[28881289]
NPT2 Others Unspecified Ratio IC50 > 36.0 n.a. PMID[28881289]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[28881289]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 40300.0 nM PMID[29028533]
NPT2 Others Unspecified Ratio = 17.0 n.a. PMID[29028533]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2317.0 nM PMID[29043798]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 49.0 % PMID[28499168]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27100.0 nM PMID[28499168]
NPT2 Others Unspecified Ratio IC50 > 9.4 n.a. PMID[28499168]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 100.0 % PMID[28499168]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 800.0 nM PMID[28499168]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 9680.0 nM PMID[28521262]
NPT21752 CELL-LINE Peritoneal macrophage cells n.a. LC50 > 4000000.0 nM PMID[28521262]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10610.0 nM PMID[29031078]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity > 99.0 % PMID[29031078]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 10.7 ug.mL-1 PMID[29102177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2560.0 nM PMID[29197735]
NPT2 Others Unspecified IC50 > 64000.0 nM PMID[29197735]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 47910.0 nM PMID[29247858]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27150.0 nM PMID[29247858]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 40230.0 nM PMID[29247858]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 29230.0 nM PMID[29247858]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 64340.0 nM PMID[29247858]
NPT2 Others Unspecified Ratio CC50/IC50 > 3.0 n.a. PMID[29247858]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2200.0 nM PMID[29896963]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 34500.0 nM PMID[29920454]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6500.0 nM PMID[29920454]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 46.3 % PMID[30006170]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 129650.0 nM PMID[30006170]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 56.0 % PMID[30006170]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LC50 = 123680.0 nM PMID[30006170]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 1.5 uM PMID[29107437]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1650.0 nM PMID[28926763]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 0.04 nM PMID[28926763]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2400.0 nM PMID[29407968]
NPT98 Individual Protein HERG Homo sapiens IC50 > 100000.0 nM PMID[29407968]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2630.0 nM PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 89.3 % PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 > 10000.0 nM PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 6020.0 nM PMID[29501946]
NPT2 Others Unspecified LC50 > 200000.0 nM PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Survival = 100.0 % PMID[29501946]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.5 ug.mL-1 PMID[30037754]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1260.0 nM PMID[30100019]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5300.0 nM PMID[30100019]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 22990.0 nM PMID[30100019]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei IC50 = 3240.0 nM PMID[30100019]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI50 = 10200.0 nM PMID[30173929]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 93.0 % PMID[30173929]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 29800.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18090.0 nM PMID[29289882]
NPT27 Others Unspecified Ratio CC50/IC50 = 12.25 n.a. PMID[29289882]
NPT27 Others Unspecified Ratio CC50/IC50 = 20.21 n.a. PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 93300.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 69300.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 24680.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4390.0 nM PMID[29289882]
NPT27 Others Unspecified Ratio CC50/IC50 = 83.21 n.a. PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1100.0 nM PMID[29289882]
NPT2 Others Unspecified CC50 > 500000.0 nM PMID[29289882]
NPT27 Others Unspecified Ratio CC50/IC50 > 455.0 n.a. PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 68500.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 > 100000.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 92280.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 24870.0 nM PMID[29289882]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3560.0 nM PMID[29560715]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM PMID[28993794]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI50 = 10200.0 nM PMID[30194008]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi GI = 96.6 % PMID[30194008]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 790.0 nM PMID[30344906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18160.0 nM PMID[30344907]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 27070.0 nM PMID[30344907]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3920.0 nM PMID[30344907]
NPT2 Others Unspecified Ratio IC50 = 2.0 n.a. PMID[30344907]
NPT2 Others Unspecified Ratio IC50 = 1.0 n.a. PMID[30344907]
NPT2 Others Unspecified Ratio IC50 = 8.0 n.a. PMID[30344907]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1650.0 nM PMID[30006174]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 99.9 % PMID[30006174]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = 0.65 % DOI[10.21203/rs.3.rs-23951/v1]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2200.0 nM PMID[31542713]
NPT1018 Organism Trypanosoma brucei Trypanosoma brucei EC50 = 16.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2400.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 3900.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 5100.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 600.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1000.0 nM PMID[31542713]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 4.0 n.a. PMID[31630056]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 80.0 % PMID[31630056]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.0 % PMID[31630056]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5500.0 nM PMID[31046273]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18700.0 nM PMID[31046273]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi LD50 = 1.5 uM PMID[31539239]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2690.0 nM PMID[30638761]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2600.0 nM PMID[31642313]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2100.0 nM PMID[31799840]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 16500.0 nM PMID[31000155]
NPT2 Others Unspecified Ratio CC50/EC50 = 12.0 n.a. PMID[31000155]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2000.0 nM PMID[31706667]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 500.0 nM PMID[32292551]
NPT2 Others Unspecified Ratio CC50/IC50 = 38.1 n.a. PMID[31103897]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5000.0 nM PMID[31103897]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 17700.0 nM PMID[31103897]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19100.0 nM PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1900.0 nM PMID[31434040]
NPT2 Others Unspecified Ratio CC50/IC50 > 21.4 n.a. PMID[31434040]
NPT2 Others Unspecified Ratio CC50/IC50 > 26.3 n.a. PMID[31434040]
NPT2 Others Unspecified Ratio CC50/IC50 > 263.1 n.a. PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 900.0 nM PMID[31434040]
NPT2 Others Unspecified CC50 > 500000.0 nM PMID[31434040]
NPT2 Others Unspecified Ratio CC50/IC50 > 555.0 n.a. PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 > 100000.0 nM PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 94100.0 nM PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 6900.0 nM PMID[31434040]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6600.0 nM PMID[31306906]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6200.0 nM PMID[31306906]
NPT844 Organism Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 = 0.04 ug.mL-1 PMID[31515186]
NPT633 Organism Leishmania donovani Leishmania donovani IC50 = 0.2 ug.mL-1 PMID[31515186]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 0.36 ug.mL-1 PMID[31515186]
NPT633 Organism Leishmania donovani Leishmania donovani IC50 = 33.26 ug.mL-1 PMID[31515186]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5.42 ug.mL-1 PMID[31515186]
NPT844 Organism Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 = 0.001 ug.mL-1 PMID[31515186]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2280.0 nM PMID[30234983]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 11500.0 nM PMID[30234983]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 354.0 nM PMID[30234983]
NPT2 Others Unspecified EC50 > 400000.0 nM PMID[30234983]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5100.0 nM PMID[30565934]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1200.0 nM PMID[30655943]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 685070.0 nM PMID[30655955]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 2.58 uM PMID[31296439]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2400.0 nM PMID[30908048]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 77.4 % PMID[30784876]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 42300.0 nM PMID[30784876]
NPT2 Others Unspecified Ratio CC50/IC50 = 8.31 n.a. PMID[30784876]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 26200.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15300.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 25300.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3000.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6200.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4400.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 33300.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3900.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6700.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Ratio = 18.0 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 4100.0 nM PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 65.0 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 40.0 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 25.0 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 38.0 % PMID[31345745]
NPT27 Others Unspecified Activity <= 30.0 % PMID[31345745]
NPT27 Others Unspecified Activity <= 10.0 % PMID[31345745]
NPT27 Others Unspecified Activity <= 20.0 % PMID[31345745]
NPT27 Others Unspecified Activity > 40.0 % PMID[31345745]
NPT27 Others Unspecified Activity > 10.0 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 15.2 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = -4.7 % PMID[31345745]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 1940.0 nM PMID[32134269]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 9680.0 nM PMID[31306817]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[31306817]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3300.0 nM PMID[31306817]
NPT2 Others Unspecified Ratio IC50 = 16.8 n.a. PMID[31306817]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19930.0 nM PMID[31306817]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2800.0 nM PMID[30302998]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 3100.0 nM PMID[30562700]
NPT2 Others Unspecified Ratio CC50/EC50 > 127.6 n.a. PMID[30562700]
NPT27 Others Unspecified Activity = 4.0 mg/dl PMID[30583247]
NPT27 Others Unspecified Activity <= 10.0 % PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 22.4 % PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = -35.4 % PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 75.0 % PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 51.2 % PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15100.0 nM PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 1.5 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 2.3 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 1.2 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 1.4 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 1.9 n.a. PMID[30583247]
NPT2 Others Unspecified Ratio IC50 = 2.8 n.a. PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19700.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36100.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16600.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36200.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12400.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8300.0 nM PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16900.0 nM PMID[30583247]
NPT27 Others Unspecified Activity = 535.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity = 496.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity = 538.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity = 3275.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity = 2761.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity > 40.0 % PMID[30583247]
NPT27 Others Unspecified Activity <= 20.0 % PMID[30583247]
NPT27 Others Unspecified Activity = 49.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity = 64.0 U/L PMID[30583247]
NPT27 Others Unspecified Activity <= 30.0 % PMID[30583247]
NPT27 Others Unspecified Activity = 161.0 U/L PMID[30583247]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1650.0 nM PMID[30615444]
NPT2 Others Unspecified Ratio IC50 > 233.3 n.a. PMID[30615444]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 99.9 % PMID[30615444]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16900.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8300.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12400.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36200.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16600.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36100.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19700.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15100.0 nM PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 1.4 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 2.8 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 1.9 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 1.2 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 2.3 n.a. PMID[30728107]
NPT2 Others Unspecified Ratio IC50 = 1.5 n.a. PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 70.0 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 75.0 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 51.0 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 33.0 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 55.0 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = -35.38 % PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 22.38 % PMID[30728107]
NPT27 Others Unspecified Activity > 10.0 % PMID[30728107]
NPT27 Others Unspecified Activity = 20.0 mg/dl PMID[30728107]
NPT27 Others Unspecified Activity > 40.0 mg/dl PMID[30728107]
NPT27 Others Unspecified Activity = 4.0 mg/dl PMID[30728107]
NPT27 Others Unspecified Activity = 10.0 mg/dl PMID[30728107]
NPT27 Others Unspecified Activity = 535.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 496.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 10.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 538.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 3275.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 2761.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 20.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity > 40.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 49.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 64.0 U/L PMID[30728107]
NPT27 Others Unspecified Activity = 30.0 mg/dl PMID[30728107]
NPT27 Others Unspecified Activity = 161.0 U/L PMID[30728107]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2360.0 nM PMID[31495177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 100.0 % PMID[31495177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 5700.0 nM PMID[31495177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 350.0 nM PMID[31495177]
NPT2 Others Unspecified EC50 > 400000.0 nM PMID[31495177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2700.0 nM PMID[31495177]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3600.0 nM PMID[31630523]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2730.0 nM PMID[30677668]
NPT2 Others Unspecified Ratio EC50 > 23.0 n.a. PMID[30677668]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi MIC = 32000.0 nM PMID[30996772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 29120.0 nM PMID[30996772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 17000.0 nM PMID[30996772]
NPT2 Others Unspecified Ratio CC50/IC50 = 4.77 n.a. PMID[30996772]
NPT2 Others Unspecified Ratio CC50/IC50 = 8.09 n.a. PMID[30996772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15600.0 nM PMID[30996772]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1700.0 nM PMID[30996772]
NPT2 Others Unspecified Ratio CC50/IC50 > 32.0 n.a. PMID[30996772]
NPT2 Others Unspecified Ratio CC50/IC50 > 294.1 n.a. PMID[30996772]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[30641409]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[30641409]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[30641409]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15800.0 nM PMID[30641409]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi ED50 = 2.48 uM PMID[30808607]
NPT20556 SINGLE PROTEIN Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 Inhibition = 2.226 % DOI[10.6019/CHEMBL4495564]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = 0.15 % DOI[10.6019/CHEMBL4495565]
NPT22194 ORGANISM Naegleria gruberi Naegleria gruberi Inhibition n.a. 37.4 % DOI[10.6019/CHEMBL4513101]
NPT20 Organism Candida albicans Candida albicans Inhibition = 2.82 % DOI[10.6019/CHEMBL4296181]
NPT85 Organism Filobasidiella neoformans Cryptococcus neoformans Inhibition = -2.09 % DOI[10.6019/CHEMBL4296181]
NPT19 Organism Escherichia coli Escherichia coli Inhibition = 9.92 % DOI[10.6019/CHEMBL4296181]
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae Inhibition = 18.48 % DOI[10.6019/CHEMBL4296181]
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition = 15.47 % DOI[10.6019/CHEMBL4296181]
NPT747 Organism Acinetobacter baumannii Acinetobacter baumannii Inhibition = 13.69 % DOI[10.6019/CHEMBL4296181]
NPT2922 Organism Staphylococcus aureus subsp. aureus Staphylococcus aureus subsp. aureus Inhibition = 21.81 % DOI[10.6019/CHEMBL4296181]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2410.0 nM PMID[31784198]
NPT2 Others Unspecified Ratio IC50 > 158.0 n.a. PMID[31784198]
NPT2 Others Unspecified Ratio IC50 = 196.0 n.a. PMID[31784198]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2000.0 nM PMID[32113841]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 2200.0 nM PMID[32551008]
NPT2 Others Unspecified Ratio EC50 > 18.0 n.a. PMID[32551008]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[33479619]
NPT2 Others Unspecified LC50 > 4000000.0 nM PMID[33479619]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 9700.0 nM PMID[33479619]
NPT2 Others Unspecified Inhibition = 76.0 % PMID[33199200]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 100.0 % PMID[33199200]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 99.0 % PMID[33199200]
NPT2 Others Unspecified Ratio CC50/IC50 > 50.25 n.a. PMID[33199200]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3980.0 nM PMID[33199200]
NPT2 Others Unspecified Inhibition = 22.4 % PMID[33253573]
NPT2 Others Unspecified Inhibition = 35.4 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 42.9 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 28.5 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 68.3 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 81.5 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 100.0 % PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15100.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 19700.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 10000.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36100.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 36200.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16600.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12400.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8300.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 16900.0 nM PMID[33253573]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 20.0 % PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 30.0 % PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 22.0 % PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 15800.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23700.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12600.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 18700.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 21700.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12800.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 23300.0 nM PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6200.0 nM PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 0.9 n.a. PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 0.6 n.a. PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 0.8 n.a. PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 1.1 n.a. PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 1.2 n.a. PMID[28002965]
NPT2 Others Unspecified Ratio IC50 = 0.5 n.a. PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 0.837 % PMID[28002965]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5800.0 nM PMID[31771829]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 34100.0 nM PMID[31771829]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 3600.0 nM PMID[31771829]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Activity = 58.9 % PMID[31771829]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8800.0 nM PMID[31787363]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8700.0 nM PMID[31787363]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2310.0 nM PMID[32088496]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1580.0 nM PMID[33479668]
NPT2 Others Unspecified CC50 > 100000.0 nM PMID[32902988]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 1400.0 nM PMID[32902988]
NPT2 Others Unspecified Ratio CC50/IC50 > 35.0 n.a. PMID[32902988]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2900.0 nM PMID[33095014]
NPT2 Others Unspecified Ratio IC50 > 119.0 n.a. PMID[33095014]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 37000.0 nM PMID[33007723]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 12000.0 nM PMID[33007723]
NPT2 Others Unspecified IC50 > 127000.0 nM PMID[33007723]
NPT2 Others Unspecified IC50 > 10000.0 nM PMID[33007723]
NPT2 Others Unspecified Ratio IC50 > 11.0 n.a. PMID[33007723]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2020.0 nM PMID[33385837]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 6260.0 nM PMID[27295485]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 2206.0 nM PMID[27543881]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 103600.0 nM PMID[32631558]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 8800.0 nM PMID[32631558]
NPT21752 CELL-LINE Peritoneal macrophage cells n.a. LD50 > 1000.0 uM PMID[32631558]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 32500.0 nM PMID[32795626]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 14900.0 nM PMID[32795626]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC50 = 5600.0 nM PMID[32590115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 100.0 % PMID[32590115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 92.77 % PMID[32590115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi Inhibition = 85.47 % PMID[32590115]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi EC50 = 500.0 nM PMID[32652409]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC478930 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC478930 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data