Natural Product: NPC3658
Natural Product ID:   | NPC3658 |
Common Name*:   | CSKUUHDAPAWYTK-NNEDUNNPSA-N |
IUPAC Name:   | n.a. |
Synonyms:   | |
Standard InCHIKey:   | CSKUUHDAPAWYTK-NNEDUNNPSA-N |
Standard InCHI:   | InChI=1S/C20H28O5/c1-12-6-5-7-13(2)16(25-22)8-9-20(4)18(24-20)11-15-14(3)19(21)23-17(15)10-12/h6,15-18,22H,2-3,5,7-11H2,1,4H3/b12-6+/t15-,16+,17+,18+,20+/m1/s1 |
SMILES:   | C/C/1=CCCC(=C)[C@H](CC[C@@]2(C)[C@H](C[C@@H]3C(=C)C(=O)O[C@H]3C1)O2)OO
|
Synthetic Gene Cluster:   |
n.a. |
ChEMBL Identifier:   |
n.a. |
PubChem CID:   |
n.a. |
Chemical Classification**:   |
-
CHEMONTID:0000000 [Organic compounds]
-
[CHEMONTID:0000261] Phenylpropanoids and polyketides
-
[CHEMONTID:0000147] Macrolides and analogues
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
  Species Source
Organism ID |
Organism Name |
Taxonomy Level |
Family |
SuperKingdom |
Isolation Part |
Collection Location |
Collection Time |
Reference |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[10556916] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[10757709] |
NPO9909 |
Sarcophyton crassocaule |
Species |
Alcyoniidae |
Eukaryota |
n.a. |
formosan soft coral |
n.a. |
PMID[11141104] |
NPO15773 |
Ecteinascidia thurstoni |
Species |
Perophoridae |
Eukaryota |
n.a. |
Thai |
n.a. |
PMID[12088444] |
NPO10443 |
Sloanea zuliaensis |
Species |
Elaeocarpaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[14640532] |
NPO16560 |
Palhinhaea cernua |
Species |
Lycopodiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[16872152] |
NPO9909 |
Sarcophyton crassocaule |
Species |
Alcyoniidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[17067165] |
NPO9909 |
Sarcophyton crassocaule |
Species |
Alcyoniidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[17125220] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
n.a. |
leaf |
n.a. |
PMID[17685627] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[19406895] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[19917748] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[20932054] |
NPO9909 |
Sarcophyton crassocaule |
Species |
Alcyoniidae |
Eukaryota |
n.a. |
Formosan soft coral |
n.a. |
PMID[22014827] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
Stems |
n.a. |
n.a. |
PMID[23078294] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[23513740] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[25043228] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[25960261] |
NPO16560 |
Palhinhaea cernua |
Species |
Lycopodiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
PMID[31994397] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
PMID[32603106] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
Antarctic |
n.a. |
PMID[8882433] |
NPO16101 |
Gleditsia triacanthos |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[HerDing] |
NPO13417 |
Campanula medium |
Species |
Campanulaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[HerDing] |
NPO13931 |
Selaginella uncinata |
Species |
Selaginellaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[HerDing] |
NPO15294 |
Magnolia salicifolia |
Species |
Magnoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[HerDing] |
NPO20404.1 |
Eruca vesicaria subsp. sativa |
Subspecies |
Brassicaceae |
Eukaryota |
n.a. |
n.a. |
|
Database[Phenol-Explorer] |
NPO13417 |
Campanula medium |
Species |
Campanulaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO13931 |
Selaginella uncinata |
Species |
Selaginellaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO15294 |
Magnolia salicifolia |
Species |
Magnoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO16101 |
Gleditsia triacanthos |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO13577 |
Pieris formosa |
Species |
Ericaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO16560 |
Palhinhaea cernua |
Species |
Lycopodiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO20404.1 |
Eruca vesicaria subsp. sativa |
Subspecies |
Brassicaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCMID] |
NPO15294 |
Magnolia salicifolia |
Species |
Magnoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TCM_Taiwan] |
NPO15294 |
Magnolia salicifolia |
Species |
Magnoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[TM-MC] |
NPO14909 |
Artemisia caerulescens |
Species |
Asteraceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16453 |
Lycium cestroides |
Species |
Solanaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15037 |
Echinops spinosissimus |
Species |
Asteraceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15294 |
Magnolia salicifolia |
Species |
Magnoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO6809 |
Cailliea cinerea |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO26988 |
Acinos thymoides |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO21926 |
Pseudomonas aeruginosa |
Species |
Pseudomonadaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO10443 |
Sloanea zuliaensis |
Species |
Elaeocarpaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO11762 |
Agrimonia eupatoria |
Species |
Rosaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13733 |
Saccharopolyspora erythraea |
Species |
Pseudonocardiaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO9909 |
Sarcophyton crassocaule |
Species |
Alcyoniidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16534 |
Pterocaulon alopecuroides |
Species |
Asteraceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO26508 |
Uvariopsis tripetala |
Species |
Annonaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO5719 |
Hedyotis lawsoniae |
Species |
Rubiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13417 |
Campanula medium |
Species |
Campanulaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13931 |
Selaginella uncinata |
Species |
Selaginellaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15428 |
Cheilanthes tenuifolia |
Species |
Pteridaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15983 |
Udotea cyathiformis |
Species |
Udoteaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO11365 |
Lecidea lithophila |
Species |
Lecideaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16617 |
Paepalanthus hilairei |
Species |
Eriocaulaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO12764 |
Tillandsia fragrans |
Species |
Bromeliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15879 |
Euphorbia nivulia |
Species |
Euphorbiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16101 |
Gleditsia triacanthos |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO73 |
Pseudanabaena persicina |
Species |
Pseudanabaenaceae |
Bacteria |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO12451 |
Dermocybe cinnabarina |
Species |
Cortinariaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO12217 |
Buccinum undatum |
Species |
Buccinidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16774 |
Hermidium alipes |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO14434 |
Alluaudia humbertii |
Species |
Didiereaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13577 |
Pieris formosa |
Species |
Ericaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16560 |
Palhinhaea cernua |
Species |
Lycopodiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO14591 |
Rhabdodendron amazonicum |
Species |
Rhabdodendraceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16301 |
Ilex macropoda |
Species |
Aquifoliaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO2584 |
Monostroma fuscum |
Species |
Monostromataceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16740 |
Helipterum venustum |
Species |
Asteraceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO25715 |
Senna siamea |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO25278 |
Cystofilobasidium infirmominiatum |
Species |
Cystofilobasidiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO10877 |
Humboldtia laurifolia |
Species |
Fabaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO1655 |
Corydendrium parasiticum |
Species |
Oceaniidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15674 |
Acanthosyris spinescens |
Species |
Cervantesiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO5127 |
Cladocroce incurvata |
Species |
Chalinidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13264 |
Alstonia lanceolifera |
Species |
Apocynaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO9314 |
Gouania ulmifolia |
Species |
Gobiesocidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO7023 |
Tetracera rosiflora |
Species |
Dilleniaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO15773 |
Ecteinascidia thurstoni |
Species |
Perophoridae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO16206 |
Umbilicaria indica |
Species |
Umbilicariaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO13036 |
Culicinomyces clavisporus |
Species |
Clavicipitaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO20404.1 |
Eruca vesicaria subsp. sativa |
Subspecies |
Brassicaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO639 |
Formica polyctena |
Species |
Formicidae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
NPO14107 |
Teucrium montanum |
Species |
Lamiaceae |
Eukaryota |
n.a. |
n.a. |
n.a. |
Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
  NP Quantity Composition/Concentration
Organism ID |
NP ID |
Organism Material Preparation |
Organism Part |
NP Quantity (Standard) |
NP Quantity (Minimum) |
NP Quantity (Maximum) |
Quantity Unit |
Reference |
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
  Biological Activity
Target ID |
Target Type |
Target Name |
Target Organism |
Activity Type |
Activity Relation |
Value |
Unit |
Reference |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
  Chemically structural similarity: I. Similar Active Natural Products in NPASS
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC3658 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 209 |
0.1-0.2 | 1452 |
0.2-0.3 | 5609 |
0.3-0.4 | 12772 |
0.4-0.5 | 11691 |
0.5-0.6 | 6701 |
0.6-0.7 | 3204 |
0.7-0.8 | 900 |
0.8-0.85 | 90 |
0.85-0.9 | 54 |
0.9-0.95 | 12 |
0.95-1 | 3 |
Similarity Score |
Similarity Level |
Natural Product ID |
  Chemically structural similarity: II. Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC3658 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 191 |
0.1-0.2 | 2018 |
0.2-0.3 | 3891 |
0.3-0.4 | 2120 |
0.4-0.5 | 569 |
0.5-0.6 | 301 |
0.6-0.7 | 53 |
0.7-0.8 | 5 |
0.8-0.85 | 1 |
0.85-0.9 | 1 |
0.9-0.95 | 0 |
0.95-1 | 0 |
Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |