NPASS Compound

Structure

CID104222 OpenBabel06191715452D 67 72 0 0 1 0 0 0 0 0999 V2000 4.3301 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4641 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 3.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 3.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4641 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4641 2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1962 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3301 0.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -5.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -5.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 -4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 3.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 4.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -1.0000 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.1962 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -6.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 -4.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.1962 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 5.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -1.5000 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.7321 -1.0000 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.7321 -0.0000 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 2.5981 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 2.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 0.5000 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 6.0622 -1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.3301 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -6.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -6.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 -2.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 -5.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.3301 4.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 5.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 5.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0622 0.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -7.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 -4.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.0622 3.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 6.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5981 -2.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 -2.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 -3.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7321 2.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8660 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7321 -1.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 -2.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 -1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.5981 0.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.8660 1.5000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 12 2 0 0 0 0 1 17 1 0 0 0 0 2 12 1 0 0 0 0 2 18 2 0 0 0 0 3 13 2 0 0 0 0 3 19 1 0 0 0 0 4 13 1 0 0 0 0 4 20 2 0 0 0 0 5 14 2 0 0 0 0 5 21 1 0 0 0 0 6 14 1 0 0 0 0 6 22 2 0 0 0 0 7 15 2 0 0 0 0 7 23 1 0 0 0 0 8 15 1 0 0 0 0 8 24 2 0 0 0 0 9 16 2 0 0 0 0 9 25 1 0 0 0 0 10 16 1 0 0 0 0 10 26 2 0 0 0 0 11 62 1 0 0 0 0 12 36 1 0 0 0 0 13 37 1 0 0 0 0 14 38 1 0 0 0 0 15 39 1 0 0 0 0 16 40 1 0 0 0 0 17 28 2 0 0 0 0 17 42 1 0 0 0 0 18 28 1 0 0 0 0 18 43 1 0 0 0 0 19 29 2 0 0 0 0 19 44 1 0 0 0 0 20 29 1 0 0 0 0 20 45 1 0 0 0 0 21 30 2 0 0 0 0 21 46 1 0 0 0 0 22 30 1 0 0 0 0 22 47 1 0 0 0 0 23 31 2 0 0 0 0 23 48 1 0 0 0 0 24 31 1 0 0 0 0 24 49 1 0 0 0 0 25 32 2 0 0 0 0 25 50 1 0 0 0 0 26 32 1 0 0 0 0 26 51 1 0 0 0 0 27 11 1 6 0 0 0 27 33 1 0 0 0 0 27 63 1 0 0 0 0 28 52 1 0 0 0 0 29 53 1 0 0 0 0 30 54 1 0 0 0 0 31 55 1 0 0 0 0 32 56 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 1 0 0 0 34 35 1 0 0 0 0 34 65 1 6 0 0 0 35 41 1 0 0 0 0 35 66 1 1 0 0 0 36 57 2 0 0 0 0 36 62 1 0 0 0 0 37 58 2 0 0 0 0 37 64 1 0 0 0 0 38 59 2 0 0 0 0 38 65 1 0 0 0 0 39 60 2 0 0 0 0 39 66 1 0 0 0 0 40 61 2 0 0 0 0 40 67 1 0 0 0 0 41 63 1 0 0 0 0 41 67 1 6 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	940.12
Volume:	842.17
LogP:	2.246
LogD:	1.17
LogS:	-2.167
# Rotatable Bonds:	16
TPSA:	444.18
# H-Bond Aceptor:	26
# H-Bond Donor:	15
# Rings:	6
# Heavy Atoms:	26

MedChem Properties

QED Drug-Likeness Score:	0.051
Synthetic Accessibility Score:	4.753
Fsp3:	0.146
Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Accepted
GSK Rule:	Rejected
BMS Rule:	1
Golden Triangle Rule:	Rejected
Chelating Alert:	1
PAINS Alert:	1

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-7.265
MDCK Permeability:	1.0437927812745329e-05
Pgp-inhibitor:	0.163
Pgp-substrate:	0.0
Human Intestinal Absorption (HIA):	0.997
20% Bioavailability (F20%):	1.0
30% Bioavailability (F30%):	1.0

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.002
Plasma Protein Binding (PPB):	83.35474395751953%
Volume Distribution (VD):	0.289
Pgp-substrate:	34.644412994384766%

ADMET: Metabolism

CYP1A2-inhibitor:	0.706
CYP1A2-substrate:	0.003
CYP2C19-inhibitor:	0.012
CYP2C19-substrate:	0.01
CYP2C9-inhibitor:	0.223
CYP2C9-substrate:	0.011
CYP2D6-inhibitor:	0.0
CYP2D6-substrate:	0.051
CYP3A4-inhibitor:	0.01
CYP3A4-substrate:	0.001

ADMET: Excretion

Clearance (CL):	15.905
Half-life (T1/2):	0.983

ADMET: Toxicity

hERG Blockers:	0.158
Human Hepatotoxicity (H-HT):	0.16
Drug-inuced Liver Injury (DILI):	0.986
AMES Toxicity:	0.046
Rat Oral Acute Toxicity:	0.0
Maximum Recommended Daily Dose:	0.003
Skin Sensitization:	0.98
Carcinogencity:	0.008
Eye Corrosion:	0.003
Eye Irritation:	0.961
Respiratory Toxicity:	0.001

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC104222

Natural Product ID:	NPC104222
*Common Name:**	Pentagalloyl Glucose
IUPAC Name:	[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
Synonyms:	Pentagalloyl Glucose; Pentagalloylglucose
Standard InCHIKey:	QJYNZEYHSMRWBK-NIKIMHBISA-N
Standard InCHI:	InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35-,41+/m1/s1
SMILES:	c1c(cc(c(c1O)O)O)C(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC(=O)c1cc(c(c(c1)O)O)O)OC(=O)c1cc(c(c(c1)O)O)O)OC(=O)c1cc(c(c(c1)O)O)O)OC(=O)c1cc(c(c(c1)O)O)O
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL382408
PubChem CID:	65238
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000261] Phenylpropanoids and polyketides [CHEMONTID:0000238] Tannins

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	fruit	n.a.	DOI[10.1007/s00217-007-0799-1]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	flower	n.a.	DOI[10.1016/j.foodchem.2011.01.077]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Anhui province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Gansu province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Henan province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shandong province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shanxi province, China		DOI[10.1016/j.foodres.2020.109416]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	whole plant	n.a.	DOI[10.1021/np50028a032]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1246/bcsj.30.618]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	DOI[10.2174/092986712800229032]
NPO18142	Elysia ornata	Species	Placobranchidae	Eukaryota	n.a.	n.a.	n.a.	PMID[10650101]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10757709]
NPO6039	Aglaia laxiflora	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10785416]
NPO2130	Ehretia dicksonii	Species	Ehretiaceae	Eukaryota	n.a.	leaf	n.a.	PMID[10830513]
NPO2130	Ehretia dicksonii	Species	Ehretiaceae	Eukaryota	n.a.	twig	n.a.	PMID[10830513]
NPO2130	Ehretia dicksonii	Species	Ehretiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10830513]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[10993241]
NPO24559	Cotinus coggygria	Species	Anacardiaceae	Eukaryota	Whole plant	n.a.	n.a.	PMID[11141121]
NPO8621	Cylindrospermopsis raciborskii	Species	Aphanizomenonaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11223086]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11339628]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11520216]
NPO9973	Euphorbia turczaninowii	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11520228]
NPO6774	Khaya senegalensis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12193039]
NPO28847	Plectranthus fruticosus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12713399]
NPO20652	Phytolacca acinosa	Species	Phytolaccaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12932140]
NPO8621	Cylindrospermopsis raciborskii	Species	Aphanizomenonaceae	Bacteria	n.a.	n.a.	n.a.	PMID[14559084]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	leaf	n.a.	PMID[14727919]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	root	n.a.	PMID[14727919]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	bark	n.a.	PMID[14727919]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	xylem	n.a.	PMID[14727919]
NPO28847	Plectranthus fruticosus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15104491]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Seeds	n.a.	n.a.	PMID[15620261]
NPO20779	Garcinia hombroniana	Species	Clusiaceae	Eukaryota	leaves	n.a.	n.a.	PMID[16124765]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16309313]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	bark	n.a.	PMID[17260795]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	n.a.	leaf	n.a.	PMID[17685627]
NPO27743	Aaptos aaptos	Species	Suberitidae	Eukaryota	n.a.	n.a.	n.a.	PMID[17716892]
NPO28785	Lumbricus terrestris	Species	Lumbricidae	Eukaryota	n.a.	n.a.	n.a.	PMID[1909513]
NPO29381	Trichilia rubescens	Species	Meliaceae	Eukaryota	leaves	Kibale National Park, Uganda	2000-2001	PMID[19299148]
NPO28864	Nauclea officinalis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19299148]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19402674]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	Daejeon, Korea	2007-Jan	PMID[19670875]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19721258]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19772486]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20121251]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[20806783]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[20822014]
NPO18584	Streptoalloteichus hindustanus	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21210656]
NPO1103	Dioscorea japonica	Species	Dioscoreaceae	Eukaryota	rhizomes	n.a.	n.a.	PMID[21353549]
NPO25909	Leonurus sibiricus	Species	Lamiaceae	Eukaryota	n.a.	leaf	n.a.	PMID[21375312]
NPO20842	Beauveria felina	Species	Cordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21438588]
NPO13504	Lotus japonicus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21510636]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[21782011]
NPO20146	Cladiella krempfi	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[21861494]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	whole plant	n.a.	PMID[21899269]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[22190295]
NPO3864	Hamamelis virginiana	Species	Hamamelidaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22216935]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[22547314]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22612410]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	Stems	n.a.	n.a.	PMID[23078294]
NPO6774	Khaya senegalensis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23210623]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[23497864]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23513740]
NPO20842	Beauveria felina	Species	Cordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23822585]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	root bark	Bozhou, Anhui Province, China	2010-AUG	PMID[24377852]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	flower	n.a.	PMID[24504864]
NPO33051	mango tree	n.a.	n.a.	n.a.	stem bark	n.a.	n.a.	PMID[24613627]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	Flowers	LuoYang, HeNan, China	n.a.	PMID[24621197]
NPO27743	Aaptos aaptos	Species	Suberitidae	Eukaryota	n.a.	South China Sea	n.a.	PMID[25211032]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	roots	n.a.	n.a.	PMID[26259802]
NPO20842	Beauveria felina	Species	Cordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26295595]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[26838074]
NPO29940	Schinus terebinthifolius	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[2723668]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27313650]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27429639]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27466882]
NPO5842	Annulohypoxylon truncatum	Species	n.a.	Eukaryota	n.a.	n.a.	n.a.	PMID[28009172]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29019685]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[29140705]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29741372]
NPO18584	Streptoalloteichus hindustanus	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[29792433]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30379546]
NPO4055	Aspergillus unguis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31117521]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31596079]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	Rhizomes	n.a.	n.a.	PMID[31873014]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	HeZe, ShanDong, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[32951423]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Xinjiang,China		PMID[33063333]
NPO22052	Aspergillus candidus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[5391291]
NPO7381	Ircinia spinosula	Species	Irciniidae	Eukaryota	n.a.	Bay of Naples, Italy	n.a.	PMID[7714539]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8759159]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[8759159]
NPO12148.2	Acer pictum subsp. okamotoanum	Subspecies	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9461665]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9834152]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Root Bark	n.a.	n.a.	Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Bark	n.a.	n.a.	Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Essential Oil	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	Flower	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Stem Bark	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Twig	n.a.	n.a.	Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO22976	Ruta microcarpa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO1103	Dioscorea japonica	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29004	Ruta pinnata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25774	Virola multinervia	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16414	Thuja plicata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5065	Cladonia fallax	Species	Cladoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28949	Croton cumingii	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24559	Cotinus coggygria	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28864	Nauclea officinalis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19095	Strophanthus preussii	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3864	Hamamelis virginiana	Species	Hamamelidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21096	Cardiospermum halicacabum	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO18827	Aspidosperma olivaceum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25909	Leonurus sibiricus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13907	Senecio renardii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17566	Magnolia biloba	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29030	Zanthoxylum americanum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29940	Schinus terebinthifolius	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO20652	Phytolacca acinosa	Species	Phytolaccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29466	Triglochin maritima	Species	Juncaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28805	Thymus piperella	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28949	Croton cumingii	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17566	Magnolia biloba	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29004	Ruta pinnata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO1103	Dioscorea japonica	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6395	Phedimus kamtschaticus	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22624	Clematis tangutica	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9734	Vincetoxicum hirundinaria	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22976	Ruta microcarpa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3199	Balanophora involucrata	Species	Balanophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO16414	Thuja plicata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9207	Styrax ferrugineus	Species	Styracaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28864	Nauclea officinalis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24559	Cotinus coggygria	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13907	Senecio renardii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25909	Leonurus sibiricus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29030	Zanthoxylum americanum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18827	Aspidosperma olivaceum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4055	Aspergillus unguis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21096	Cardiospermum halicacabum	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25774	Virola multinervia	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11222	Rubus alceifolius	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29344	Parabenzoin trilobum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[TCMID]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5065	Cladonia fallax	Species	Cladoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19095	Strophanthus preussii	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22121	Piper arboreum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3864	Hamamelis virginiana	Species	Hamamelidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25909	Leonurus sibiricus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24559	Cotinus coggygria	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28864	Nauclea officinalis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20652	Phytolacca acinosa	Species	Phytolaccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17566	Magnolia biloba	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29940	Schinus terebinthifolius	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29030	Zanthoxylum americanum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22976	Ruta microcarpa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21096	Cardiospermum halicacabum	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3864	Hamamelis virginiana	Species	Hamamelidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29030	Zanthoxylum americanum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Title]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28912	Astragalus gummifer	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO1103	Dioscorea japonica	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO20652	Phytolacca acinosa	Species	Phytolaccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO21991	Modiolus demissus	Species	Mytilidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25774	Virola multinervia	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6179	Aframomum amaniense	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29446	Stevia polycephala	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11222	Rubus alceifolius	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12234	Khaya ivorensis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28949	Croton cumingii	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19558	Meryta lanceolata	Species	Araliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14504	Alectoria divergens	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19095	Strophanthus preussii	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22250	Parastrephia lepidophylla	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4055	Aspergillus unguis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18775	Cratena peregrina	Species	Facelinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3744	Polycephalomyces nipponicus	Species	Ophiocordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18584	Streptoalloteichus hindustanus	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO28912	Astragalus gummifer	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27269	Annona impressivenia	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8773	Sonchus ortunoi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5065	Cladonia fallax	Species	Cladoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2174	Polysiphonia elongata	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23010	Crinum defixum	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6039	Aglaia laxiflora	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12585	Craspidospermum verticillatum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9157	Rubrivivax gelatinosus	Species	n.a.	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO8909	Pteris radiata	Species	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8621	Cylindrospermopsis raciborskii	Species	Aphanizomenonaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO29415	Hovenia acerba	Species	Rhamnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1661	Bartramia pomiformis	Species	Bartramiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12061	Justicia paniculata	Species	Acanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29363	Aconitum nevadense	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12588	Cornus officinalis	Species	Cornaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29154	Heliotropium floridum	Species	Heliotropiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25715	Senna siamea	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18827	Aspidosperma olivaceum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24559	Cotinus coggygria	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22381	Euphorbia segetalis	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13907	Senecio renardii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28785	Lumbricus terrestris	Species	Lumbricidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19521	Inella verrucosa	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO2130	Ehretia dicksonii	Species	Ehretiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17195	Felicia wrightii	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29292	Teucrium depressum	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13701	Melaleuca rhaphiophylla	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21096	Cardiospermum halicacabum	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28828	Rana arvalis	Species	Ranidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13818	Narcissus concolor	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2359	Cynoglossum germanicum	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22121	Piper arboreum	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14089	Hypericum ascyron	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12910	Ixeris stolonifera	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22763	Cuphea carthagenensis	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26192	Cordylanthus kingii	Species	Orobanchaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16492	Mentha gattefossei	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4073	Geranium sylvaticum	Species	Geraniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13504	Lotus japonicus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24360	Centaurea squarrosa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7169	Nama hispidum	Species	Namaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1103	Dioscorea japonica	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3924	Penicillium alutaceum	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6774	Khaya senegalensis	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18680	Larix decidua	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22550	Paeonia suffruticosa	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12754	Cerinthe minor	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18077	Liquidambar formosana	Species	Altingiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22315	Phlogacanthus thyrsiflorus	Species	Acanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1245	Eunicella cavolinii	Species	Gorgoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20332	Dioscoreophyllum cumminsii	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28824	Forsteronia refracta	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15448	Chrysothamnus parryi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27743	Aaptos aaptos	Species	Suberitidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22635	Penstemon secundiflorus	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22568	Aristolochia elegans	Species	Aristolochiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9734	Vincetoxicum hirundinaria	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10389	Larix cajanderi	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2780	Brenneria rubrifaciens	Species	Pectobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO29127	Cystophora scalaris	Species	Sargassaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29488	Sophora angustifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20972	Oscillatoria princeps	Species	Oscillatoriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO29004	Ruta pinnata	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29030	Zanthoxylum americanum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29203	Gymnocarpium robertianum	Species	Cystopteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28805	Thymus piperella	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18537	Leontopodium nanum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10865	Sextonia rubra	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29381	Trichilia rubescens	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28898	Grewia mollis	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22447	Sidastrum acuminatum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28784	Alseodaphne corneri	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12148.2	Acer pictum subsp. okamotoanum	Subspecies	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29510	Aulacocephalus temmincki	Species	Serranidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21420	Phormia regina	Species	Calliphoridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29314	Mangifera indica	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21603	Eskemukerjea megacarpum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO20652	Phytolacca acinosa	Species	Phytolaccaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22052	Aspergillus candidus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6382	Chlorocebus aethiops	Species	Cercopithecidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5541	Crotalaria aegyptiaca	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20779	Garcinia hombroniana	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8437	Encyothalia cliftonii	Species	Sporochnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29242	Salvia dorrii	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22976	Ruta microcarpa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17726	Helichrysum cymosum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12362	Coreopsis fasciculata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29450	Streptomyces parvisporogenes	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO3864	Hamamelis virginiana	Species	Hamamelidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9207	Styrax ferrugineus	Species	Styracaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28918	Ophiolepis superba	Species	Ophiolepididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29452	Plantago indica	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13076	Cephalaria grossheimii	Species	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3199	Balanophora involucrata	Species	Balanophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14289	Pieris napi	Species	Pieridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11882	Cedrus libani	Species	Pinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3458	Lupinus verbasciformis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18142	Elysia ornata	Species	Placobranchidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23953	Zanthoxylum monophyllum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13355	Selinum carvifolium	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7752	Beilschmiedia anacardioides	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2922	Botryosphaeria berengeriana	Species	Botryosphaeriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21473	Urtica triangularis	Species	Urticaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28847	Plectranthus fruticosus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20096	Cirsium japonicum	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25981	Crinipellis scabella	Species	Marasmiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29533	Argusia argentea	Species	Heliotropiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28937	Heterotheca grandiflora	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29344	Parabenzoin trilobum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO21498	Coccus ilicis	Species	Coccidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7625	Scopolia hladnikiana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14200	Aristolochia zollingeriana	Species	Aristolochiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12414	Penicillium paxilli	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17566	Magnolia biloba	Species	Magnoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20842	Beauveria felina	Species	Cordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29047	Disynaphia halimifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28924	Spongilla lacustris	Species	Spongillidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17247	Actinoplanes friuliensis	Species	Micromonosporaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO21227	Aglaia elaeagnoidea	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21282	Aplidium orthium	Species	Polyclinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22893	Apterostigma dentigerum	Species	Formicidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25909	Leonurus sibiricus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29068	Papilio phorcas	Species	Papilionidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21859	Centaurea nigrescens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1290	Trilisa odoratissima	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26170	Haliclona mucosa	Species	Chalinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3340	Fridericia chica	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25381	Litsea rotundifolia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20209	Dorstenia lindeniana	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22509	Syncolostemon parviflorus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29400	Conocephalum japonicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29189	Castanopsis sclerophylla	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29466	Triglochin maritima	Species	Juncaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21730	Pouzolzia occidentalis	Species	Urticaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29145	Carya tonkinensis	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18408	Litsea lancifolia	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22624	Clematis tangutica	Species	Ranunculaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3119	Cephalaria uralensis	Species	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9973	Euphorbia turczaninowii	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7013	Dicoma capensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29401	Bupleurum chinense	Species	Apiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29276	Juglans nigra	Species	Juglandaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5842	Annulohypoxylon truncatum	Species	n.a.	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28864	Nauclea officinalis	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10012	Triaenophora rupestris	Species	Orobanchaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28845	Eragrostis viscosa	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2723	Artemisia carvifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6395	Phedimus kamtschaticus	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14615	Streptomyces paulus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO9669	Dictyopteris acrostichoides	Species	Dictyotaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4244	Doodia picta	Species	Blechnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13823	Hypericum mysorense	Species	Hypericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28867	Holocarpha obconica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5301	Haplophyllum ferganicum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28971	Bersama yangambiensis	Species	Melianthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20146	Cladiella krempfi	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12088	Conyza canadensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23759	Litsea zeylanica	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12069	Isaria felina	Species	Cordycipitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO762	Digitalis isabelliana	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7381	Ircinia spinosula	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29225	Oncoba echinata	Species	Salicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3129	Geum japonicum	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29142	Kaunia saltensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19259	Agrostis epigeios	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16414	Thuja plicata	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25023	Lactarius camphoratus	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22829	Ozoroa insignis	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19899	Crepis foetida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO550	Callicarpa maingayi	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	5
ED50	5
GI50	57
IC50	34
Ki	4
MIC	3
Others	142

Activity Type	# Activity
Cell Line	169
Individual Protein	19
NON-MOLECULAR	4
Organism	19
Others	23
Protein Family	2
SINGLE PROTEIN	6
Tissue	8

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT459	Individual Protein	Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Inhibition	=	0.0	%	PMID[549852]
NPT459	Individual Protein	Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Inhibition	=	2.0	%	PMID[549853]
NPT5224	Individual Protein	NS3	Hepatitis C virus	IC50	=	1600.0	nM	PMID[549855]
NPT520	Cell Line	3T3-L1	Mus musculus	Activity	=	107.0	Bq	PMID[549856]
NPT326	Individual Protein	Squalene monooxygenase	Rattus norvegicus	IC50	=	470.0	nM	PMID[549858]
NPT672	Cell Line	TE-671	Homo sapiens	ED50	>	10.0	ug ml-1	PMID[549859]
NPT180	Cell Line	HCT-8	Homo sapiens	ED50	>	10.0	ug ml-1	PMID[549859]
NPT81	Cell Line	A549	Homo sapiens	ED50	>	10.0	ug ml-1	PMID[549859]
NPT91	Cell Line	KB	Homo sapiens	ED50	>	10.0	ug ml-1	PMID[549859]
NPT2533	Individual Protein	Coagulation factor X	Homo sapiens	IC50	=	170.0	nM	PMID[549860]
NPT2533	Individual Protein	Coagulation factor X	Homo sapiens	Ki	=	570.0	nM	PMID[549860]
NPT2534	Individual Protein	Thrombin	Bos taurus	IC50	=	50.0	nM	PMID[549860]
NPT2534	Individual Protein	Thrombin	Bos taurus	IC50	=	110.0	nM	PMID[549860]
NPT2534	Individual Protein	Thrombin	Bos taurus	Ki	=	3900.0	nM	PMID[549860]
NPT12	Individual Protein	Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	IC50	=	28.0	ug.mL-1	PMID[549862]
NPT1310	Individual Protein	Xanthine dehydrogenase	Bos taurus	Activity	=	2.12	10'-6M	PMID[549864]
NPT1310	Individual Protein	Xanthine dehydrogenase	Bos taurus	IC50	=	3200.0	nM	PMID[549864]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	28.0	ug.mL-1	PMID[549868]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	34.0	ug.mL-1	PMID[549868]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	8.0	%	PMID[549868]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	11.0	%	PMID[549868]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	5.0	%	PMID[549868]
NPT368	Cell Line	SN12C	Homo sapiens	GI50	n.a.	11885.02	nM	PMID[549869]
NPT369	Cell Line	ACHN	Homo sapiens	GI50	n.a.	3890.45	nM	PMID[549869]
NPT370	Cell Line	NCI-H23	Homo sapiens	GI50	n.a.	2162.72	nM	PMID[549869]
NPT371	Cell Line	UO-31	Homo sapiens	GI50	n.a.	5794.29	nM	PMID[549869]
NPT372	Cell Line	HOP-92	Homo sapiens	GI50	n.a.	5584.7	nM	PMID[549869]
NPT116	Cell Line	HL-60	Homo sapiens	GI50	n.a.	3647.54	nM	PMID[549869]
NPT374	Cell Line	SF-539	Homo sapiens	GI50	n.a.	2488.86	nM	PMID[549869]
NPT373	Cell Line	SK-MEL-5	Homo sapiens	GI50	n.a.	11271.97	nM	PMID[549869]
NPT376	Cell Line	A498	Homo sapiens	GI50	n.a.	6324.12	nM	PMID[549869]
NPT111	Cell Line	K562	Homo sapiens	GI50	n.a.	47206.3	nM	PMID[549869]
NPT377	Cell Line	OVCAR-3	Homo sapiens	GI50	n.a.	3784.43	nM	PMID[549869]
NPT112	Cell Line	MOLT-4	Homo sapiens	GI50	n.a.	2999.16	nM	PMID[549869]
NPT379	Cell Line	HOP-62	Homo sapiens	GI50	n.a.	3890.45	nM	PMID[549869]
NPT380	Cell Line	U-251	Homo sapiens	GI50	n.a.	5333.35	nM	PMID[549869]
NPT382	Cell Line	OVCAR-5	Homo sapiens	GI50	n.a.	7943.28	nM	PMID[549869]
NPT381	Cell Line	OVCAR-8	Homo sapiens	GI50	n.a.	5223.96	nM	PMID[549869]
NPT383	Cell Line	SNB-19	Homo sapiens	GI50	n.a.	4875.28	nM	PMID[549869]
NPT572	Cell Line	DMS-273	Homo sapiens	GI50	n.a.	1458.81	nM	PMID[549869]
NPT384	Cell Line	TK-10	Homo sapiens	GI50	n.a.	4875.28	nM	PMID[549869]
NPT385	Cell Line	SR	Homo sapiens	GI50	n.a.	4130.48	nM	PMID[549869]
NPT323	Cell Line	SW-620	Homo sapiens	GI50	n.a.	5997.91	nM	PMID[549869]
NPT573	Cell Line	M19-MEL	Homo sapiens	GI50	n.a.	9141.13	nM	PMID[549869]
NPT455	Cell Line	NCI-H522	Homo sapiens	GI50	n.a.	3459.39	nM	PMID[549869]
NPT386	Cell Line	KM12	Homo sapiens	GI50	n.a.	2338.84	nM	PMID[549869]
NPT387	Cell Line	M14	Homo sapiens	GI50	n.a.	7227.7	nM	PMID[549869]
NPT574	Cell Line	XF498	Homo sapiens	GI50	n.a.	4852.89	nM	PMID[549869]
NPT388	Cell Line	NCI-H322M	Homo sapiens	GI50	n.a.	5296.63	nM	PMID[549869]
NPT389	Cell Line	RPMI-8226	Homo sapiens	GI50	n.a.	2760.58	nM	PMID[549869]
NPT456	Cell Line	OVCAR-4	Homo sapiens	GI50	n.a.	8912.51	nM	PMID[549869]
NPT390	Cell Line	LOX IMVI	Homo sapiens	GI50	n.a.	1721.87	nM	PMID[549869]
NPT147	Cell Line	SK-MEL-2	Homo sapiens	GI50	n.a.	10690.55	nM	PMID[549869]
NPT81	Cell Line	A549	Homo sapiens	GI50	n.a.	3539.97	nM	PMID[549869]
NPT575	Cell Line	KM-20L2	Homo sapiens	GI50	n.a.	4265.8	nM	PMID[549869]
NPT391	Cell Line	HCC 2998	Homo sapiens	GI50	n.a.	3213.66	nM	PMID[549869]
NPT148	Cell Line	HCT-15	Homo sapiens	GI50	n.a.	5211.95	nM	PMID[549869]
NPT393	Cell Line	HCT-116	Homo sapiens	GI50	n.a.	5105.05	nM	PMID[549869]
NPT395	Cell Line	SF-268	Homo sapiens	GI50	n.a.	4570.88	nM	PMID[549869]
NPT394	Cell Line	EKVX	Homo sapiens	GI50	n.a.	6039.49	nM	PMID[549869]
NPT731	Cell Line	LXFL 529	Homo sapiens	GI50	n.a.	11350.11	nM	PMID[549869]
NPT576	Cell Line	DMS-114	Homo sapiens	GI50	n.a.	4207.27	nM	PMID[549869]
NPT146	Cell Line	SK-OV-3	Homo sapiens	GI50	n.a.	6165.95	nM	PMID[549869]
NPT397	Cell Line	NCI-H460	Homo sapiens	GI50	n.a.	3265.88	nM	PMID[549869]
NPT398	Cell Line	UACC-62	Homo sapiens	GI50	n.a.	2259.44	nM	PMID[549869]
NPT308	Cell Line	CAKI-1	Homo sapiens	GI50	n.a.	7673.61	nM	PMID[549869]
NPT458	Cell Line	IGROV-1	Homo sapiens	GI50	n.a.	5727.96	nM	PMID[549869]
NPT399	Cell Line	SF-295	Homo sapiens	GI50	n.a.	3917.42	nM	PMID[549869]
NPT403	Cell Line	UACC-257	Homo sapiens	GI50	n.a.	14893.61	nM	PMID[549869]
NPT401	Cell Line	786-0	Homo sapiens	GI50	n.a.	4988.84	nM	PMID[549869]
NPT578	Cell Line	SNB-78	Homo sapiens	GI50	n.a.	9506.05	nM	PMID[549869]
NPT404	Cell Line	CCRF-CEM	Homo sapiens	GI50	n.a.	3326.6	nM	PMID[549869]
NPT579	Cell Line	DLD-1	Homo sapiens	GI50	n.a.	6998.42	nM	PMID[549869]
NPT405	Cell Line	NCI-H226	Homo sapiens	GI50	n.a.	1492.79	nM	PMID[549869]
NPT170	Cell Line	SK-MEL-28	Homo sapiens	GI50	n.a.	15310.87	nM	PMID[549869]
NPT139	Cell Line	HT-29	Homo sapiens	GI50	n.a.	6918.31	nM	PMID[549869]
NPT406	Cell Line	RXF 393	Homo sapiens	GI50	n.a.	7726.81	nM	PMID[549869]
NPT407	Cell Line	COLO 205	Homo sapiens	GI50	n.a.	4977.37	nM	PMID[549869]
NPT732	Cell Line	HOP-18	Homo sapiens	GI50	n.a.	36559.48	nM	PMID[549869]
NPT3084	Individual Protein	Neuraminidase	Influenza A virus	Inhibition	=	84.1	%	PMID[549873]
NPT3084	Individual Protein	Neuraminidase	Influenza A virus	IC50	=	11900.0	nM	PMID[549873]
NPT65	Cell Line	HepG2	Homo sapiens	IC50	=	92400.0	nM	PMID[549873]
NPT165	Cell Line	HeLa	Homo sapiens	IC50	=	356300.0	nM	PMID[549873]
NPT1580	Individual Protein	Salivary alpha-amylase	Homo sapiens	IC50	=	2350.0	nM	PMID[549875]
NPT1580	Individual Protein	Salivary alpha-amylase	Homo sapiens	Ki	=	2600.0	nM	PMID[549875]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	37.5	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	34.0	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	17.9	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	32.2	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	9.8	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	9.0	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	17.8	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	11.8	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	18.1	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	20.5	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	20.9	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	51.3	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	47.2	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	43.9	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	37.3	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	12.7	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	13.4	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	14.3	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	13.9	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	14.8	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	20.8	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	16.3	%	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	Activity	=	11.7	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	98.25	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	97.55	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	93.35	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	90.45	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	1.0	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	1.35	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	1.85	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	3.2	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	0.65	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	4.35	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	6.1	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	0.1	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	0.45	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	Activity	=	0.25	%	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.8	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	2.5	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	4.9	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	8.1	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.3	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.4	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.7	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.6	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.6	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.5	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.9	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.8	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.4	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	0.3	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.2	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.0	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	2.0	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	1.7	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	29.6	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	109.9	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	309.9	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	FC	=	488.4	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.7	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	4.4	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	3.0	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	6.0	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	2.4	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	2.8	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	1.8	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.1	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	1.2	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.9	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.8	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.4	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	0.3	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	7.0	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	5.7	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	1.6	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	4.7	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	5.9	n.a.	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	FC	=	5.8	n.a.	PMID[549877]
NPT393	Cell Line	HCT-116	Homo sapiens	IC50	=	1610.0	nM	PMID[549877]
NPT139	Cell Line	HT-29	Homo sapiens	IC50	=	4460.0	nM	PMID[549877]
NPT4218	Individual Protein	5'-nucleotidase	Homo sapiens	IC50	=	10540.0	nM	PMID[549880]
NPT82	Cell Line	MDA-MB-231	Homo sapiens	IC50	=	9120.0	nM	PMID[549880]
NPT783	Cell Line	MIA PaCa-2	Homo sapiens	IC50	=	72590.0	nM	PMID[549880]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50	=	45000.0	nM	PMID[549852]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	=	18000.0	nM	PMID[549852]
NPT27	Others	Unspecified		Therapeutic index	=	2.5	n.a.	PMID[549852]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	Inhibition	=	65.0	%	PMID[549852]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50	=	19000.0	nM	PMID[549853]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	=	15000.0	nM	PMID[549853]
NPT27	Others	Unspecified		Therapeutic index	=	1.3	n.a.	PMID[549853]
NPT24	Organism	Human immunodeficiency virus 1	Human immunodeficiency virus 1	Inhibition	=	60.0	%	PMID[549853]
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	4000.0	nM	PMID[549854]
NPT727	Protein Family	Protein kinase C, PKC; classical/novel	Homo sapiens	Phorbol displacement	<=	50.0	uM	PMID[549854]
NPT2	Others	Unspecified		IC50	=	2.8	ug.mL-1	PMID[549857]
NPT20	Organism	Candida albicans	Candida albicans	IC50	>	50.0	ug.mL-1	PMID[549857]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	IC50	>	50.0	ug.mL-1	PMID[549857]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	ED50	=	5.01	ug ml-1	PMID[549859]
NPT2	Others	Unspecified		Ratio Ki	=	1.2	n.a.	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	APTT	>	300.0	s	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	PT	>	300.0	s	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	TT	>	300.0	s	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	APTT	=	42.6	s	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	TT	=	11.2	s	PMID[549860]
NPT2535	Tissue	Plasma	Oryctolagus cuniculus	PT	=	10.2	s	PMID[549860]
NPT2	Others	Unspecified		Activity	=	62.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	80.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	7.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	25.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	30.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	39.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	67.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	44.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	27.0	%	PMID[549861]
NPT2	Others	Unspecified		Activity	=	15.0	%	PMID[549861]
NPT35	Others	n.a.		log KOW	=	32.0	n.a.	PMID[549863]
NPT2	Others	Unspecified		Ka	=	33.7	/M	PMID[549863]
NPT2	Others	Unspecified		Ka	=	20.0	/M	PMID[549863]
NPT2	Others	Unspecified		Ka	=	20.4	/M	PMID[549863]
NPT2	Others	Unspecified		Ka	=	13.0	/M	PMID[549863]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	-7.1	mmHg	PMID[549865]
NPT1	Others	Radical scavenging activity		IC50	=	12.6	ug.mL-1	PMID[549866]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	72.3	%	PMID[549867]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	28.9	%	PMID[549867]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	4.2	%	PMID[549867]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	40.7	%	PMID[549867]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	22.8	%	PMID[549867]
NPT191	Organism	Hepatitis C virus	Hepatitis C virus	Inhibition	=	5.0	%	PMID[549867]
NPT1	Others	Radical scavenging activity		EC50	=	23.8	ug	PMID[549868]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	54.8	ug	PMID[549868]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	EC50	=	2403.9	ug	PMID[549868]
NPT27	Others	Unspecified		IC50	=	23.0	ug.mL-1	PMID[549868]
NPT2	Others	Unspecified		IC50	=	390.0	nM	PMID[549870]
NPT32	Organism	Mus musculus	Mus musculus	Cmax	<	1000.0	nM	PMID[549872]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	820.0	nM	PMID[549872]
NPT22562	SINGLE PROTEIN	Anthrax toxin receptor 2	Homo sapiens	IC50	=	300.0	nM	PMID[549872]
NPT24971	SINGLE PROTEIN	Genome polyprotein	Coxsackievirus B3 (strain Nancy)	Inhibition	=	100.0	%	PMID[549873]
NPT24971	SINGLE PROTEIN	Genome polyprotein	Coxsackievirus B3 (strain Nancy)	IC50	=	1100.0	nM	PMID[549873]
NPT740	Individual Protein	Beta-secretase 1	Homo sapiens	IC50	=	3760.0	nM	PMID[549874]
NPT740	Individual Protein	Beta-secretase 1	Homo sapiens	Ki	=	5130.0	nM	PMID[549874]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	68000.0	nM	PMID[549878]
NPT22562	SINGLE PROTEIN	Anthrax toxin receptor 2	Homo sapiens	IC50	=	607.0	nM	PMID[549879]
NPT26738	SINGLE PROTEIN	5'-nucleotidase	Mus musculus	IC50	>	100000.0	nM	PMID[549880]
NPT26739	SINGLE PROTEIN	Ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	IC50	=	1560.0	nM	PMID[549880]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC104222 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	371
0.1-0.2	1665
0.2-0.3	4050
0.3-0.4	8745
0.4-0.5	9313
0.5-0.6	5266
0.6-0.7	7475
0.7-0.8	4865
0.8-0.85	767
0.85-0.9	120
0.9-0.95	43
0.95-1	17

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC114791
1.0	High Similarity	NPC141331
1.0	High Similarity	NPC210501
1.0	High Similarity	NPC318826
0.9801	High Similarity	NPC172419
0.9801	High Similarity	NPC238419
0.9735	High Similarity	NPC239019
0.9735	High Similarity	NPC247629
0.9536	High Similarity	NPC44260
0.9536	High Similarity	NPC3746
0.9536	High Similarity	NPC205037
0.9536	High Similarity	NPC61152
0.9536	High Similarity	NPC16024
0.9494	High Similarity	NPC149300
0.943	High Similarity	NPC43918
0.943	High Similarity	NPC190204
0.943	High Similarity	NPC261411
0.9313	High Similarity	NPC47521
0.9308	High Similarity	NPC470271
0.9308	High Similarity	NPC311389
0.9272	High Similarity	NPC92117
0.925	High Similarity	NPC198125
0.925	High Similarity	NPC95421
0.9245	High Similarity	NPC175793
0.9226	High Similarity	NPC134925
0.9205	High Similarity	NPC142528
0.9205	High Similarity	NPC120621
0.9205	High Similarity	NPC248257
0.9193	High Similarity	NPC470272
0.915	High Similarity	NPC140151
0.913	High Similarity	NPC658
0.913	High Similarity	NPC197708
0.9068	High Similarity	NPC31034
0.9057	High Similarity	NPC14030
0.9057	High Similarity	NPC291957
0.9051	High Similarity	NPC289346
0.9026	High Similarity	NPC252979
0.9018	High Similarity	NPC102851
0.9018	High Similarity	NPC5786
0.9007	High Similarity	NPC108455
0.9	High Similarity	NPC470898
0.897	High Similarity	NPC472723
0.894	High Similarity	NPC229036
0.894	High Similarity	NPC22176
0.894	High Similarity	NPC190587
0.894	High Similarity	NPC226738
0.894	High Similarity	NPC121573
0.8938	High Similarity	NPC90905
0.8938	High Similarity	NPC285108
0.8938	High Similarity	NPC4013
0.8938	High Similarity	NPC33298
0.8922	High Similarity	NPC8940
0.8896	High Similarity	NPC75945
0.8862	High Similarity	NPC80956
0.8834	High Similarity	NPC217781
0.8834	High Similarity	NPC473818
0.8824	High Similarity	NPC260521
0.8824	High Similarity	NPC65489
0.8824	High Similarity	NPC469649
0.8805	High Similarity	NPC1913
0.8805	High Similarity	NPC472860
0.8797	High Similarity	NPC172920
0.8797	High Similarity	NPC156624
0.8788	High Similarity	NPC100251
0.8782	High Similarity	NPC477334
0.8773	High Similarity	NPC26536
0.8773	High Similarity	NPC49983
0.8773	High Similarity	NPC142707
0.8773	High Similarity	NPC317671
0.8772	High Similarity	NPC158214
0.8772	High Similarity	NPC240200
0.8772	High Similarity	NPC290289
0.8772	High Similarity	NPC223534
0.8757	High Similarity	NPC135831
0.8757	High Similarity	NPC297503
0.8757	High Similarity	NPC97119
0.875	High Similarity	NPC471030
0.875	High Similarity	NPC287872
0.875	High Similarity	NPC74319
0.875	High Similarity	NPC160780
0.875	High Similarity	NPC289811
0.8735	High Similarity	NPC98583
0.8721	High Similarity	NPC31208
0.8721	High Similarity	NPC93065
0.8721	High Similarity	NPC472724
0.8721	High Similarity	NPC472720
0.8721	High Similarity	NPC469652
0.8721	High Similarity	NPC160543
0.8721	High Similarity	NPC187632
0.8721	High Similarity	NPC472721
0.8713	High Similarity	NPC475179
0.8712	High Similarity	NPC166851
0.8712	High Similarity	NPC162169
0.871	High Similarity	NPC43123
0.8706	High Similarity	NPC231254
0.8696	High Similarity	NPC119125
0.8696	High Similarity	NPC203020
0.8696	High Similarity	NPC476373
0.8696	High Similarity	NPC166277
0.8696	High Similarity	NPC239966
0.8688	High Similarity	NPC4747
0.8688	High Similarity	NPC104275
0.8688	High Similarity	NPC133984
0.8679	High Similarity	NPC203757
0.8675	High Similarity	NPC75763
0.8675	High Similarity	NPC225036
0.8675	High Similarity	NPC65333
0.8675	High Similarity	NPC12218
0.8675	High Similarity	NPC105525
0.8671	High Similarity	NPC97924
0.8671	High Similarity	NPC40078
0.8671	High Similarity	NPC471091
0.8663	High Similarity	NPC142291
0.8663	High Similarity	NPC7839
0.8655	High Similarity	NPC104910
0.8655	High Similarity	NPC111490
0.8655	High Similarity	NPC474093
0.8655	High Similarity	NPC261623
0.8655	High Similarity	NPC469650
0.8654	High Similarity	NPC42464
0.865	High Similarity	NPC227297
0.865	High Similarity	NPC121290
0.865	High Similarity	NPC469651
0.8642	High Similarity	NPC311803
0.8642	High Similarity	NPC472859
0.8642	High Similarity	NPC25389
0.8639	High Similarity	NPC198902
0.8631	High Similarity	NPC67629
0.8631	High Similarity	NPC297574
0.8631	High Similarity	NPC79736
0.8625	High Similarity	NPC291948
0.8625	High Similarity	NPC250436
0.8625	High Similarity	NPC104983
0.8625	High Similarity	NPC300845
0.8625	High Similarity	NPC88803
0.8623	High Similarity	NPC163165
0.8623	High Similarity	NPC172033
0.8623	High Similarity	NPC88560
0.8623	High Similarity	NPC175230
0.8614	High Similarity	NPC149011
0.8614	High Similarity	NPC204937
0.8605	High Similarity	NPC97817
0.8605	High Similarity	NPC30011
0.8605	High Similarity	NPC72554
0.8599	High Similarity	NPC306343
0.8589	High Similarity	NPC476372
0.8589	High Similarity	NPC476371
0.8589	High Similarity	NPC246024
0.8588	High Similarity	NPC469371
0.8581	High Similarity	NPC473867
0.858	High Similarity	NPC253521
0.858	High Similarity	NPC267549
0.858	High Similarity	NPC113836
0.858	High Similarity	NPC258044
0.858	High Similarity	NPC293626
0.858	High Similarity	NPC267680
0.858	High Similarity	NPC217387
0.858	High Similarity	NPC37668
0.858	High Similarity	NPC196127
0.8571	High Similarity	NPC289322
0.8571	High Similarity	NPC68324
0.8571	High Similarity	NPC38779
0.8571	High Similarity	NPC135222
0.8571	High Similarity	NPC474010
0.8571	High Similarity	NPC476358
0.8571	High Similarity	NPC114179
0.8571	High Similarity	NPC187205
0.8571	High Similarity	NPC156818
0.8571	High Similarity	NPC160512
0.8571	High Similarity	NPC49173
0.8563	High Similarity	NPC264302
0.8563	High Similarity	NPC47140
0.8563	High Similarity	NPC67134
0.8555	High Similarity	NPC173872
0.8555	High Similarity	NPC269046
0.8555	High Similarity	NPC119094
0.8553	High Similarity	NPC87403
0.8553	High Similarity	NPC105827
0.8553	High Similarity	NPC310661
0.8538	High Similarity	NPC162394
0.8538	High Similarity	NPC35924
0.8538	High Similarity	NPC123259
0.8538	High Similarity	NPC156785
0.8538	High Similarity	NPC199172
0.8538	High Similarity	NPC129533
0.8538	High Similarity	NPC241781
0.8538	High Similarity	NPC470718
0.8528	High Similarity	NPC266365
0.8521	High Similarity	NPC144097
0.8521	High Similarity	NPC472991
0.8521	High Similarity	NPC472992
0.8521	High Similarity	NPC61904
0.8519	High Similarity	NPC87317
0.8516	High Similarity	NPC477333
0.8512	High Similarity	NPC472993
0.8509	High Similarity	NPC318432
0.8506	High Similarity	NPC201814
0.8503	High Similarity	NPC476365
0.85	High Similarity	NPC327032
0.85	High Similarity	NPC191046

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC104222 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	322
0.1-0.2	909
0.2-0.3	1899
0.3-0.4	2862
0.4-0.5	1898
0.5-0.6	930
0.6-0.7	236
0.7-0.8	83
0.8-0.85	10
0.85-0.9	1
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.8625	High Similarity	NPD4868	Clinical (unspecified phase)
0.8563	High Similarity	NPD7993	Clinical (unspecified phase)
0.8284	Intermediate Similarity	NPD7472	Approved
0.8278	Intermediate Similarity	NPD230	Phase 1
0.8225	Intermediate Similarity	NPD7054	Approved
0.8187	Intermediate Similarity	NPD7251	Discontinued
0.8176	Intermediate Similarity	NPD7074	Phase 3
0.8153	Intermediate Similarity	NPD6190	Approved
0.814	Intermediate Similarity	NPD7808	Phase 3
0.814	Intermediate Similarity	NPD4338	Clinical (unspecified phase)
0.8129	Intermediate Similarity	NPD6797	Phase 2
0.8129	Intermediate Similarity	NPD7266	Discontinued
0.8081	Intermediate Similarity	NPD7685	Pre-registration
0.8059	Intermediate Similarity	NPD3818	Discontinued
0.7953	Intermediate Similarity	NPD7228	Approved
0.7904	Intermediate Similarity	NPD4381	Clinical (unspecified phase)
0.7901	Intermediate Similarity	NPD6980	Clinical (unspecified phase)
0.7886	Intermediate Similarity	NPD8312	Approved
0.7886	Intermediate Similarity	NPD8313	Approved
0.7865	Intermediate Similarity	NPD8397	Clinical (unspecified phase)
0.7836	Intermediate Similarity	NPD6166	Phase 2
0.7836	Intermediate Similarity	NPD6168	Clinical (unspecified phase)
0.7836	Intermediate Similarity	NPD6167	Clinical (unspecified phase)
0.7751	Intermediate Similarity	NPD6234	Discontinued
0.7725	Intermediate Similarity	NPD1465	Phase 2
0.7725	Intermediate Similarity	NPD8455	Phase 2
0.7725	Intermediate Similarity	NPD8151	Discontinued
0.7701	Intermediate Similarity	NPD7804	Clinical (unspecified phase)
0.7697	Intermediate Similarity	NPD8055	Clinical (unspecified phase)
0.768	Intermediate Similarity	NPD7879	Clinical (unspecified phase)
0.7667	Intermediate Similarity	NPD9269	Phase 2
0.7665	Intermediate Similarity	NPD1934	Approved
0.7636	Intermediate Similarity	NPD1653	Approved
0.7619	Intermediate Similarity	NPD2393	Clinical (unspecified phase)
0.7607	Intermediate Similarity	NPD6143	Clinical (unspecified phase)
0.76	Intermediate Similarity	NPD5844	Phase 1
0.7571	Intermediate Similarity	NPD7240	Approved
0.756	Intermediate Similarity	NPD37	Approved
0.7545	Intermediate Similarity	NPD4380	Phase 2
0.7529	Intermediate Similarity	NPD4967	Phase 2
0.7529	Intermediate Similarity	NPD4966	Approved
0.7529	Intermediate Similarity	NPD4965	Approved
0.7515	Intermediate Similarity	NPD2801	Approved
0.7514	Intermediate Similarity	NPD6232	Discontinued
0.7486	Intermediate Similarity	NPD7473	Discontinued
0.7485	Intermediate Similarity	NPD7075	Discontinued
0.7472	Intermediate Similarity	NPD6559	Discontinued
0.7471	Intermediate Similarity	NPD3817	Phase 2
0.7429	Intermediate Similarity	NPD7852	Clinical (unspecified phase)
0.7427	Intermediate Similarity	NPD3882	Suspended
0.7423	Intermediate Similarity	NPD8166	Discontinued
0.74	Intermediate Similarity	NPD9268	Approved
0.7394	Intermediate Similarity	NPD1511	Approved
0.7356	Intermediate Similarity	NPD7199	Phase 2
0.7356	Intermediate Similarity	NPD6959	Discontinued
0.7326	Intermediate Similarity	NPD7768	Phase 2
0.731	Intermediate Similarity	NPD7096	Clinical (unspecified phase)
0.731	Intermediate Similarity	NPD7819	Suspended
0.7305	Intermediate Similarity	NPD1512	Approved
0.7296	Intermediate Similarity	NPD943	Approved
0.7294	Intermediate Similarity	NPD7411	Suspended
0.7278	Intermediate Similarity	NPD7458	Discontinued
0.7273	Intermediate Similarity	NPD7184	Clinical (unspecified phase)
0.7267	Intermediate Similarity	NPD8443	Clinical (unspecified phase)
0.7267	Intermediate Similarity	NPD5402	Approved
0.7267	Intermediate Similarity	NPD5353	Approved
0.724	Intermediate Similarity	NPD8320	Phase 1
0.724	Intermediate Similarity	NPD8319	Approved
0.7196	Intermediate Similarity	NPD7700	Phase 2
0.7196	Intermediate Similarity	NPD7699	Phase 2
0.7188	Intermediate Similarity	NPD7680	Approved
0.7188	Intermediate Similarity	NPD7435	Discontinued
0.7186	Intermediate Similarity	NPD7390	Discontinued
0.7174	Intermediate Similarity	NPD8150	Discontinued
0.717	Intermediate Similarity	NPD3764	Approved
0.7158	Intermediate Similarity	NPD7237	Clinical (unspecified phase)
0.7151	Intermediate Similarity	NPD3751	Discontinued
0.715	Intermediate Similarity	NPD7871	Phase 2
0.715	Intermediate Similarity	NPD7870	Phase 2
0.7128	Intermediate Similarity	NPD6535	Approved
0.7128	Intermediate Similarity	NPD6534	Approved
0.7119	Intermediate Similarity	NPD3787	Discontinued
0.7108	Intermediate Similarity	NPD4628	Phase 3
0.7105	Intermediate Similarity	NPD9545	Approved
0.7102	Intermediate Similarity	NPD5494	Approved
0.7091	Intermediate Similarity	NPD1549	Phase 2
0.7086	Intermediate Similarity	NPD3749	Approved
0.7083	Intermediate Similarity	NPD6799	Approved
0.7059	Intermediate Similarity	NPD5403	Approved
0.7056	Intermediate Similarity	NPD7875	Clinical (unspecified phase)
0.7056	Intermediate Similarity	NPD7874	Approved
0.7052	Intermediate Similarity	NPD6801	Discontinued
0.7041	Intermediate Similarity	NPD7422	Clinical (unspecified phase)
0.7031	Intermediate Similarity	NPD6781	Approved
0.7031	Intermediate Similarity	NPD6780	Approved
0.7031	Intermediate Similarity	NPD6776	Approved
0.7031	Intermediate Similarity	NPD6777	Approved
0.7031	Intermediate Similarity	NPD6779	Approved
0.7031	Intermediate Similarity	NPD6778	Approved
0.7031	Intermediate Similarity	NPD6782	Approved
0.703	Intermediate Similarity	NPD1550	Clinical (unspecified phase)
0.703	Intermediate Similarity	NPD1552	Clinical (unspecified phase)
0.702	Intermediate Similarity	NPD7783	Phase 2
0.702	Intermediate Similarity	NPD7782	Clinical (unspecified phase)
0.7012	Intermediate Similarity	NPD1510	Phase 2
0.701	Intermediate Similarity	NPD7698	Approved
0.701	Intermediate Similarity	NPD7696	Phase 3
0.701	Intermediate Similarity	NPD7697	Approved
0.7006	Intermediate Similarity	NPD3750	Approved
0.7	Intermediate Similarity	NPD3027	Phase 3
0.6988	Remote Similarity	NPD970	Clinical (unspecified phase)
0.6981	Remote Similarity	NPD9494	Approved
0.6977	Remote Similarity	NPD3455	Phase 2
0.6975	Remote Similarity	NPD1612	Clinical (unspecified phase)
0.6975	Remote Similarity	NPD1613	Approved
0.6973	Remote Similarity	NPD7090	Clinical (unspecified phase)
0.6957	Remote Similarity	NPD6859	Clinical (unspecified phase)
0.6954	Remote Similarity	NPD7701	Phase 2
0.6946	Remote Similarity	NPD7421	Clinical (unspecified phase)
0.6941	Remote Similarity	NPD5401	Approved
0.6941	Remote Similarity	NPD7410	Clinical (unspecified phase)
0.6909	Remote Similarity	NPD651	Clinical (unspecified phase)
0.6905	Remote Similarity	NPD1878	Clinical (unspecified phase)
0.6897	Remote Similarity	NPD6385	Approved
0.6897	Remote Similarity	NPD6386	Approved
0.6895	Remote Similarity	NPD6212	Phase 3
0.6895	Remote Similarity	NPD6214	Clinical (unspecified phase)
0.6895	Remote Similarity	NPD6213	Phase 3
0.6889	Remote Similarity	NPD5242	Approved
0.6878	Remote Similarity	NPD8155	Clinical (unspecified phase)
0.6875	Remote Similarity	NPD1530	Clinical (unspecified phase)
0.6872	Remote Similarity	NPD6823	Phase 2
0.6867	Remote Similarity	NPD5404	Approved
0.6867	Remote Similarity	NPD5406	Approved
0.6867	Remote Similarity	NPD5408	Approved
0.6867	Remote Similarity	NPD5405	Approved
0.6867	Remote Similarity	NPD1551	Phase 2
0.685	Remote Similarity	NPD7801	Approved
0.6842	Remote Similarity	NPD2532	Approved
0.6842	Remote Similarity	NPD2534	Approved
0.6842	Remote Similarity	NPD4378	Clinical (unspecified phase)
0.6842	Remote Similarity	NPD2533	Approved
0.6842	Remote Similarity	NPD7004	Clinical (unspecified phase)
0.6839	Remote Similarity	NPD6599	Discontinued
0.6832	Remote Similarity	NPD1529	Clinical (unspecified phase)
0.6829	Remote Similarity	NPD1933	Approved
0.6784	Remote Similarity	NPD7585	Approved
0.6778	Remote Similarity	NPD8127	Discontinued
0.6768	Remote Similarity	NPD1240	Approved
0.6766	Remote Similarity	NPD2796	Approved
0.6766	Remote Similarity	NPD2935	Discontinued
0.6747	Remote Similarity	NPD7097	Phase 1
0.6734	Remote Similarity	NPD7583	Approved
0.673	Remote Similarity	NPD4379	Clinical (unspecified phase)
0.6727	Remote Similarity	NPD447	Suspended
0.672	Remote Similarity	NPD8434	Phase 2
0.6707	Remote Similarity	NPD1509	Clinical (unspecified phase)
0.6707	Remote Similarity	NPD6233	Phase 2
0.6707	Remote Similarity	NPD3748	Approved
0.6706	Remote Similarity	NPD6398	Clinical (unspecified phase)
0.6701	Remote Similarity	NPD8090	Clinical (unspecified phase)
0.6687	Remote Similarity	NPD1607	Approved
0.6686	Remote Similarity	NPD5808	Clinical (unspecified phase)
0.6683	Remote Similarity	NPD7211	Clinical (unspecified phase)
0.665	Remote Similarity	NPD7584	Approved
0.6647	Remote Similarity	NPD4978	Clinical (unspecified phase)
0.6631	Remote Similarity	NPD7038	Approved
0.6631	Remote Similarity	NPD7039	Approved
0.6612	Remote Similarity	NPD3926	Phase 2
0.6608	Remote Similarity	NPD7003	Approved
0.6575	Remote Similarity	NPD919	Approved
0.6559	Remote Similarity	NPD8470	Clinical (unspecified phase)
0.6557	Remote Similarity	NPD7229	Phase 3
0.655	Remote Similarity	NPD6674	Discontinued
0.6545	Remote Similarity	NPD6798	Discontinued
0.6532	Remote Similarity	NPD7440	Discontinued
0.6524	Remote Similarity	NPD4908	Phase 1
0.6519	Remote Similarity	NPD6971	Discontinued
0.6517	Remote Similarity	NPD7615	Clinical (unspecified phase)
0.6514	Remote Similarity	NPD6273	Approved
0.6508	Remote Similarity	NPD7549	Discontinued
0.6505	Remote Similarity	NPD7799	Discontinued
0.65	Remote Similarity	NPD1091	Approved
0.6497	Remote Similarity	NPD3226	Approved
0.6494	Remote Similarity	NPD4357	Discontinued
0.649	Remote Similarity	NPD9265	Clinical (unspecified phase)
0.6489	Remote Similarity	NPD5953	Discontinued
0.6485	Remote Similarity	NPD5952	Clinical (unspecified phase)
0.6471	Remote Similarity	NPD6099	Approved
0.6471	Remote Similarity	NPD6100	Approved
0.6471	Remote Similarity	NPD7286	Phase 2
0.6467	Remote Similarity	NPD5711	Approved
0.6467	Remote Similarity	NPD5710	Approved
0.6467	Remote Similarity	NPD7966	Clinical (unspecified phase)
0.6455	Remote Similarity	NPD8368	Discontinued
0.6446	Remote Similarity	NPD4907	Clinical (unspecified phase)
0.6442	Remote Similarity	NPD1203	Approved
0.6436	Remote Similarity	NPD7999	Approved
0.6433	Remote Similarity	NPD9493	Approved
0.6432	Remote Similarity	NPD8486	Clinical (unspecified phase)

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data