Similar Natural Products in NPASS
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient ![](images/questionmark.png)
●  The left chart: Distribution of similarity level between NPC320704 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 6427 |
0.1-0.2 | 19870 |
0.2-0.3 | 3786 |
0.3-0.4 | 540 |
0.4-0.5 | 188 |
0.5-0.6 | 63 |
0.6-0.7 | 11 |
0.7-0.8 | 3 |
0.8-0.85 | 1 |
0.85-0.9 | 0 |
0.9-0.95 | 0 |
0.95-1 | 0 |
  Similar Clinical/Approved Drugs
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC320704 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
range |
Tanimoto Coefficient |
0-0.1 | 4497 |
0.1-0.2 | 3724 |
0.2-0.3 | 598 |
0.3-0.4 | 219 |
0.4-0.5 | 68 |
0.5-0.6 | 45 |
0.6-0.7 | 7 |
0.7-0.8 | 3 |
0.8-0.85 | 0 |
0.85-0.9 | 0 |
0.9-0.95 | 0 |
0.95-1 | 0 |
Similarity Score |
Similarity Level |
Drug ID |
Developmental Stage |
0.7812 |
Intermediate Similarity |
NPD8596 |
Approved |
0.7576 |
Intermediate Similarity |
NPD8597 |
Approved |
0.7308 |
Intermediate Similarity |
NPD8201 |
Phase 2 |
0.6875 |
Remote Similarity |
NPD8595 |
Approved |
0.6579 |
Remote Similarity |
NPD8215 |
Approved |
0.6579 |
Remote Similarity |
NPD8214 |
Approved |
0.6333 |
Remote Similarity |
NPD8189 |
Approved |
0.6154 |
Remote Similarity |
NPD7364 |
Approved |
0.6154 |
Remote Similarity |
NPD8200 |
Phase 2 |
0.6 |
Remote Similarity |
NPD8231 |
Approved |
0.5952 |
Remote Similarity |
NPD8870 |
Approved |
0.5938 |
Remote Similarity |
NPD8593 |
Approved |
0.5938 |
Remote Similarity |
NPD8594 |
Approved |
0.5854 |
Remote Similarity |
NPD8869 |
Approved |
0.5758 |
Remote Similarity |
NPD8619 |
Approved |
0.5758 |
Remote Similarity |
NPD8617 |
Approved |
0.5682 |
Remote Similarity |
NPD9214 |
Phase 3 |
0.5682
|
Remote Similarity |
NPD9213 |
Approved |