Natural Product: NPC314282

Natural Product ID:  NPC314282
Common Name:   Miocamycin
IUPAC Name:   [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-10-acetyloxy-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4-acetyloxy-4,6-dimethyl-5-propanoyloxyoxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] propanoate
Synonyms:   Miocamycin; Miokamycin
Molecular Formula:   C45H71NO17
Standard InCHIKey:  GQNZGCARKRHPOH-RQIKCTSVSA-N
Standard InCHI:  InChI=1S/C45H71NO17/c1-13-34(50)59-33-23-36(52)55-26(4)18-16-15-17-19-32(58-29(7)48)25(3)22-31(20-21-47)41(42(33)54-12)62-44-39(53)38(46(10)11)40(27(5)57-44)61-37-24-45(9,63-30(8)49)43(28(6)56-37)60-35(51)14-2/h15-17,19,21,25-28,31-33,37-44,53H,13-14,18,20,22-24H2,1-12H3/b16-15+,19-17+/t25-,26-,27-,28+,31+,32+,33-,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1
Canonical SMILES:  O=CC[C@H]1C[C@@H](C)[C@H](/C=C/C=C/C[C@H](OC(=O)C[C@H]([C@@H]([C@H]1O[C@@H]1O[C@H](C)[C@H]([C@@H]([C@H]1O)N(C)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)OC(=O)C)OC(=O)CC)OC)OC(=O)CC)C)OC(=O)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO11143 Streptomyces mycarofaciens Species Streptomycetaceae Bacteria StreptomeDB*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 0.2 ug/ml 18258437
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 0.78 ug/ml 18258437
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 100 ug/ml 18258437
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1.56 ug/ml 18258437
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.1 ug/ml 18258437
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC > 100 ug/ml 18258437
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 6.25 ug/ml 18258437
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.2 ug/ml 18258437
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.1 ug/ml 18258437
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC > 100 ug/ml 18258437
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.2 ug/ml 18258437
NPT1121 Organism Moraxella catarrhalis Moraxella catarrhalis MIC = 0.78 ug/ml 18258437
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 3.13 ug/ml 18258437
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 25 ug/ml 18258437
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 0.5 ug/ml 18986810
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 18986810
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 128 ug/ml 18986810
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.25 ug/ml 18986810
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.5 ug/ml 18986810
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC > 128 ug/ml 18986810
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 64 ug/ml 18986810
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 128 ug/ml 18986810
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.25 ug/ml 18986810
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC > 128 ug/ml 18986810
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.5 ug/ml 18986810
NPT1121 Organism Moraxella catarrhalis Moraxella catarrhalis MIC = 1 ug/ml 18986810
NPT1121 Organism Moraxella catarrhalis Moraxella catarrhalis MIC = 2 ug/ml 18986810
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 64 ug/ml 18986810
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 2 ug/ml 18986810
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 32 ug/ml 18986810
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 16 ug/ml 18986810
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 0.5 ug/ml 20236827
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.13 ug/ml 20236827
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC > 128 ug/ml 20236827
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 4 ug/ml 20236827
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 8 ug/ml 20236827
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 0.25 ug/ml 20236827
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.13 ug/ml 20236827
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC > 128 ug/ml 20236827
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC = 0.5 ug/ml 20236827
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 4 ug/ml 20236827
NPT1122 Organism Haemophilus influenzae Haemophilus influenzae MIC = 16 ug/ml 20236827

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC314282 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9658 High Similarity NPC314451
0.9658 High Similarity NPC313333
0.9658 High Similarity NPC313342
0.9658 High Similarity NPC314512
0.9344 High Similarity NPC316401
0.9024 High Similarity NPC315387
0.9024 High Similarity NPC316205
0.8926 High Similarity NPC314629
0.877 High Similarity NPC316133
0.877 High Similarity NPC318445
0.875 High Similarity NPC313802
0.875 High Similarity NPC67917
0.875 High Similarity NPC477515
0.875 High Similarity NPC314268
0.843 Intermediate Similarity NPC6531
0.8347 Intermediate Similarity NPC30196
0.832 Intermediate Similarity NPC315783
0.825 Intermediate Similarity NPC1111
0.825 Intermediate Similarity NPC261750
0.8099 Intermediate Similarity NPC60432
0.7949 Intermediate Similarity NPC227622
0.7704 Intermediate Similarity NPC99864
0.7667 Intermediate Similarity NPC469869
0.763 Intermediate Similarity NPC120420
0.7541 Intermediate Similarity NPC137453
0.7462 Intermediate Similarity NPC156379
0.7462 Intermediate Similarity NPC475383
0.7442 Intermediate Similarity NPC241050
0.7422 Intermediate Similarity NPC475642
0.7419 Intermediate Similarity NPC313668
0.7419 Intermediate Similarity NPC315836
0.7339 Intermediate Similarity NPC193765
0.7333 Intermediate Similarity NPC469870
0.7333 Intermediate Similarity NPC469871
0.7328 Intermediate Similarity NPC170880
0.7328 Intermediate Similarity NPC473228
0.7328 Intermediate Similarity NPC469812
0.7328 Intermediate Similarity NPC470829
0.7328 Intermediate Similarity NPC183353
0.7317 Intermediate Similarity NPC476740
0.7317 Intermediate Similarity NPC476738
0.7265 Intermediate Similarity NPC320089
0.7259 Intermediate Similarity NPC477793
0.7259 Intermediate Similarity NPC329919
0.725 Intermediate Similarity NPC187761
0.725 Intermediate Similarity NPC255592
0.725 Intermediate Similarity NPC261377
0.725 Intermediate Similarity NPC83895
0.725 Intermediate Similarity NPC308567
0.7231 Intermediate Similarity NPC13710
0.7203 Intermediate Similarity NPC472198
0.72 Intermediate Similarity NPC473807
0.7197 Intermediate Similarity NPC23963
0.7167 Intermediate Similarity NPC40812
0.7165 Intermediate Similarity NPC29501
0.7165 Intermediate Similarity NPC475608
0.7165 Intermediate Similarity NPC21713
0.7154 Intermediate Similarity NPC473816
0.7154 Intermediate Similarity NPC475367
0.7154 Intermediate Similarity NPC309398
0.7154 Intermediate Similarity NPC474581
0.7059 Intermediate Similarity NPC71589
0.705 Intermediate Similarity NPC314361
0.704 Intermediate Similarity NPC478038
0.7034 Intermediate Similarity NPC472197
0.7034 Intermediate Similarity NPC472199
0.7 Intermediate Similarity NPC265699
0.6992 Remote Similarity NPC314482
0.6992 Remote Similarity NPC154132
0.6992 Remote Similarity NPC2313
0.6992 Remote Similarity NPC475655
0.6992 Remote Similarity NPC57586
0.6992 Remote Similarity NPC475157
0.6992 Remote Similarity NPC471637
0.6975 Remote Similarity NPC478037
0.6975 Remote Similarity NPC478036
0.697 Remote Similarity NPC475309
0.697 Remote Similarity NPC106791
0.697 Remote Similarity NPC201889
0.6954 Remote Similarity NPC187497
0.6954 Remote Similarity NPC113620
0.6954 Remote Similarity NPC475599
0.6954 Remote Similarity NPC100612
0.6954 Remote Similarity NPC174336
0.6953 Remote Similarity NPC83005
0.6949 Remote Similarity NPC313670
0.6942 Remote Similarity NPC165332
0.6942 Remote Similarity NPC180722
0.6942 Remote Similarity NPC195645
0.6939 Remote Similarity NPC316249
0.6935 Remote Similarity NPC313569
0.6929 Remote Similarity NPC475960
0.6923 Remote Similarity NPC243680
0.6923 Remote Similarity NPC200788
0.6923 Remote Similarity NPC75167
0.6923 Remote Similarity NPC311592
0.6905 Remote Similarity NPC315070
0.6901 Remote Similarity NPC145899
0.6899 Remote Similarity NPC126897
0.6899 Remote Similarity NPC297945
0.6891 Remote Similarity NPC470379
0.6891 Remote Similarity NPC470373
0.6887 Remote Similarity NPC475527
0.6885 Remote Similarity NPC472290
0.688 Remote Similarity NPC197736
0.6879 Remote Similarity NPC78189
0.6875 Remote Similarity NPC133625
0.687 Remote Similarity NPC181145
0.6866 Remote Similarity NPC48692
0.6853 Remote Similarity NPC230889
0.6831 Remote Similarity NPC75318
0.6828 Remote Similarity NPC82931
0.6828 Remote Similarity NPC172365
0.6828 Remote Similarity NPC210729
0.6825 Remote Similarity NPC231271
0.6825 Remote Similarity NPC470519
0.6822 Remote Similarity NPC46407
0.6803 Remote Similarity NPC475892
0.6803 Remote Similarity NPC54731
0.68 Remote Similarity NPC473596
0.68 Remote Similarity NPC477198
0.6788 Remote Similarity NPC469494
0.6783 Remote Similarity NPC472430
0.6777 Remote Similarity NPC5418
0.6777 Remote Similarity NPC159698
0.6772 Remote Similarity NPC475918
0.6772 Remote Similarity NPC201128
0.6769 Remote Similarity NPC30911
0.6769 Remote Similarity NPC316984
0.6763 Remote Similarity NPC470476
0.6763 Remote Similarity NPC470475
0.6761 Remote Similarity NPC76999
0.6748 Remote Similarity NPC266842
0.6741 Remote Similarity NPC477143
0.6741 Remote Similarity NPC477140
0.6738 Remote Similarity NPC477195
0.6735 Remote Similarity NPC475394
0.6735 Remote Similarity NPC475152
0.6735 Remote Similarity NPC475584
0.6721 Remote Similarity NPC36954
0.672 Remote Similarity NPC476611
0.672 Remote Similarity NPC154127
0.6718 Remote Similarity NPC174836
0.6716 Remote Similarity NPC156336
0.6716 Remote Similarity NPC93688
0.6716 Remote Similarity NPC235625
0.6716 Remote Similarity NPC200412
0.6716 Remote Similarity NPC45475
0.6716 Remote Similarity NPC120599
0.6716 Remote Similarity NPC109603
0.6713 Remote Similarity NPC472428
0.6713 Remote Similarity NPC280941
0.6713 Remote Similarity NPC235772
0.6713 Remote Similarity NPC110700
0.6713 Remote Similarity NPC279915
0.6695 Remote Similarity NPC477959
0.6695 Remote Similarity NPC86005
0.6694 Remote Similarity NPC472195
0.6694 Remote Similarity NPC238090
0.6694 Remote Similarity NPC472196
0.6694 Remote Similarity NPC203627
0.6694 Remote Similarity NPC476300
0.6693 Remote Similarity NPC472748
0.6693 Remote Similarity NPC474917
0.6692 Remote Similarity NPC277583
0.6691 Remote Similarity NPC470780
0.6691 Remote Similarity NPC204556
0.669 Remote Similarity NPC119794
0.669 Remote Similarity NPC73829
0.669 Remote Similarity NPC476779
0.6667 Remote Similarity NPC306041
0.6667 Remote Similarity NPC475150
0.6667 Remote Similarity NPC477197
0.6667 Remote Similarity NPC130124
0.6667 Remote Similarity NPC127656
0.6667 Remote Similarity NPC193471
0.6667 Remote Similarity NPC13171
0.6667 Remote Similarity NPC195510
0.6667 Remote Similarity NPC473311
0.6667 Remote Similarity NPC59288
0.6643 Remote Similarity NPC476777
0.6643 Remote Similarity NPC475281
0.6643 Remote Similarity NPC476778
0.6643 Remote Similarity NPC477078
0.6643 Remote Similarity NPC329923
0.6643 Remote Similarity NPC477075
0.6642 Remote Similarity NPC473231
0.6642 Remote Similarity NPC23046
0.6642 Remote Similarity NPC275343
0.6641 Remote Similarity NPC472749
0.6641 Remote Similarity NPC472751
0.6638 Remote Similarity NPC470313
0.6638 Remote Similarity NPC156089
0.6638 Remote Similarity NPC473500
0.6638 Remote Similarity NPC38295
0.662 Remote Similarity NPC475472
0.6618 Remote Similarity NPC473130
0.6614 Remote Similarity NPC4620
0.6614 Remote Similarity NPC472750
0.6614 Remote Similarity NPC472747

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC314282 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD8448 Approved
0.9914 High Similarity NPD8451 Approved
0.9658 High Similarity NPD8340 Approved
0.9658 High Similarity NPD8342 Approved
0.9658 High Similarity NPD8341 Approved
0.9658 High Similarity NPD8299 Approved
0.9583 High Similarity NPD8392 Approved
0.9583 High Similarity NPD8391 Approved
0.9583 High Similarity NPD8390 Approved
0.877 High Similarity NPD7642 Approved
0.8512 High Similarity NPD7641 Discontinued
0.832 Intermediate Similarity NPD7830 Approved
0.832 Intermediate Similarity NPD7829 Approved
0.8306 Intermediate Similarity NPD8444 Approved
0.8279 Intermediate Similarity NPD8137 Clinical (unspecified phase)
0.8051 Intermediate Similarity NPD8393 Approved
0.8034 Intermediate Similarity NPD8276 Approved
0.8034 Intermediate Similarity NPD8275 Approved
0.8016 Intermediate Similarity NPD8274 Clinical (unspecified phase)
0.7953 Intermediate Similarity NPD8080 Discontinued
0.7949 Intermediate Similarity NPD8085 Approved
0.7949 Intermediate Similarity NPD8139 Approved
0.7949 Intermediate Similarity NPD8083 Approved
0.7949 Intermediate Similarity NPD8082 Approved
0.7949 Intermediate Similarity NPD8084 Approved
0.7949 Intermediate Similarity NPD8138 Approved
0.7949 Intermediate Similarity NPD8086 Approved
0.7815 Intermediate Similarity NPD8081 Approved
0.7762 Intermediate Similarity NPD8389 Clinical (unspecified phase)
0.7704 Intermediate Similarity NPD8415 Approved
0.7647 Intermediate Similarity NPD8387 Clinical (unspecified phase)
0.7541 Intermediate Similarity NPD8140 Approved
0.7541 Intermediate Similarity NPD8307 Discontinued
0.75 Intermediate Similarity NPD8273 Phase 1
0.7419 Intermediate Similarity NPD8305 Approved
0.7419 Intermediate Similarity NPD8306 Approved
0.736 Intermediate Similarity NPD8087 Discontinued
0.7328 Intermediate Similarity NPD8516 Approved
0.7328 Intermediate Similarity NPD8517 Approved
0.7328 Intermediate Similarity NPD8513 Phase 3
0.7328 Intermediate Similarity NPD8515 Approved
0.7313 Intermediate Similarity NPD8074 Phase 3
0.7213 Intermediate Similarity NPD8300 Approved
0.7213 Intermediate Similarity NPD8301 Approved
0.7133 Intermediate Similarity NPD8384 Approved
0.7034 Intermediate Similarity NPD7983 Approved
0.7007 Intermediate Similarity NPD8336 Approved
0.7007 Intermediate Similarity NPD8337 Approved
0.6992 Remote Similarity NPD8347 Approved
0.6992 Remote Similarity NPD8346 Approved
0.6992 Remote Similarity NPD8345 Approved
0.6967 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6942 Remote Similarity NPD7839 Suspended
0.6899 Remote Similarity NPD8413 Clinical (unspecified phase)
0.6815 Remote Similarity NPD6921 Approved
0.6809 Remote Similarity NPD8338 Approved
0.6769 Remote Similarity NPD2204 Approved
0.6569 Remote Similarity NPD8266 Approved
0.6569 Remote Similarity NPD8267 Approved
0.6569 Remote Similarity NPD8268 Approved
0.6569 Remote Similarity NPD8269 Approved
0.6565 Remote Similarity NPD6421 Discontinued
0.6538 Remote Similarity NPD8414 Discontinued
0.6538 Remote Similarity NPD6686 Approved
0.6529 Remote Similarity NPD46 Approved
0.6529 Remote Similarity NPD6698 Approved
0.6479 Remote Similarity NPD7319 Approved
0.6423 Remote Similarity NPD5779 Approved
0.6423 Remote Similarity NPD5778 Approved
0.6393 Remote Similarity NPD7838 Discovery
0.6393 Remote Similarity NPD8522 Clinical (unspecified phase)
0.6389 Remote Similarity NPD7260 Phase 2
0.6383 Remote Similarity NPD7507 Approved
0.6357 Remote Similarity NPD8328 Phase 3
0.6357 Remote Similarity NPD7122 Discontinued
0.6343 Remote Similarity NPD6430 Approved
0.6343 Remote Similarity NPD6429 Approved
0.634 Remote Similarity NPD2575 Approved
0.6284 Remote Similarity NPD7966 Clinical (unspecified phase)
0.6277 Remote Similarity NPD8295 Clinical (unspecified phase)
0.6233 Remote Similarity NPD2613 Approved
0.6233 Remote Similarity NPD6845 Suspended
0.6216 Remote Similarity NPD3088 Approved
0.6216 Remote Similarity NPD3615 Approved
0.6216 Remote Similarity NPD2572 Clinical (unspecified phase)
0.6216 Remote Similarity NPD2566 Approved
0.6216 Remote Similarity NPD3089 Approved
0.6216 Remote Similarity NPD2574 Discontinued
0.6216 Remote Similarity NPD3614 Approved
0.6216 Remote Similarity NPD4746 Phase 3
0.6216 Remote Similarity NPD2570 Approved
0.6216 Remote Similarity NPD4745 Approved
0.6216 Remote Similarity NPD3087 Approved
0.6216 Remote Similarity NPD3090 Approved
0.6216 Remote Similarity NPD3616 Approved
0.6216 Remote Similarity NPD2571 Approved
0.6216 Remote Similarity NPD2573 Approved
0.6212 Remote Similarity NPD7899 Clinical (unspecified phase)
0.6179 Remote Similarity NPD6101 Approved
0.6179 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6176 Remote Similarity NPD8133 Approved
0.6159 Remote Similarity NPD7500 Approved
0.6141 Remote Similarity NPD8319 Approved
0.6141 Remote Similarity NPD8320 Phase 1
0.6133 Remote Similarity NPD4684 Phase 3
0.6133 Remote Similarity NPD4686 Approved
0.6133 Remote Similarity NPD4685 Phase 3
0.6096 Remote Similarity NPD6914 Discontinued
0.608 Remote Similarity NPD6411 Approved
0.6045 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6012 Remote Similarity NPD8368 Discontinued
0.6 Remote Similarity NPD7747 Phase 1
0.6 Remote Similarity NPD8407 Phase 2
0.6 Remote Similarity NPD7746 Phase 1
0.5956 Remote Similarity NPD6371 Approved
0.5944 Remote Similarity NPD7623 Phase 3
0.5944 Remote Similarity NPD7624 Clinical (unspecified phase)
0.593 Remote Similarity NPD8470 Clinical (unspecified phase)
0.5912 Remote Similarity NPD7116 Clinical (unspecified phase)
0.5909 Remote Similarity NPD7141 Clinical (unspecified phase)
0.5909 Remote Similarity NPD7140 Approved
0.5909 Remote Similarity NPD7139 Approved
0.5906 Remote Similarity NPD1446 Phase 3
0.5906 Remote Similarity NPD1447 Phase 3
0.5891 Remote Similarity NPD5349 Clinical (unspecified phase)
0.5882 Remote Similarity NPD8132 Clinical (unspecified phase)
0.5882 Remote Similarity NPD6941 Approved
0.5874 Remote Similarity NPD7503 Approved
0.5874 Remote Similarity NPD8033 Approved
0.5804 Remote Similarity NPD8294 Approved
0.5804 Remote Similarity NPD8377 Approved
0.5802 Remote Similarity NPD2255 Approved
0.5793 Remote Similarity NPD8417 Discontinued
0.5789 Remote Similarity NPD7701 Phase 2
0.5778 Remote Similarity NPD4211 Phase 1
0.5769 Remote Similarity NPD4228 Discovery
0.5766 Remote Similarity NPD6413 Approved
0.5764 Remote Similarity NPD8335 Approved
0.5764 Remote Similarity NPD8380 Approved
0.5764 Remote Similarity NPD8296 Approved
0.5764 Remote Similarity NPD8379 Approved
0.5764 Remote Similarity NPD8378 Approved
0.5764 Remote Similarity NPD7739 Clinical (unspecified phase)
0.5753 Remote Similarity NPD2612 Approved
0.5753 Remote Similarity NPD3132 Approved
0.5753 Remote Similarity NPD2611 Approved
0.5753 Remote Similarity NPD4215 Approved
0.5753 Remote Similarity NPD2610 Approved
0.5753 Remote Similarity NPD3131 Approved
0.5753 Remote Similarity NPD4218 Approved
0.5753 Remote Similarity NPD2609 Approved
0.5753 Remote Similarity NPD4216 Approved
0.5753 Remote Similarity NPD4217 Approved
0.5753 Remote Similarity NPD2608 Approved
0.5746 Remote Similarity NPD1407 Approved
0.5743 Remote Similarity NPD7736 Approved
0.5738 Remote Similarity NPD7345 Approved
0.5735 Remote Similarity NPD6412 Phase 2
0.5714 Remote Similarity NPD1376 Discontinued
0.5714 Remote Similarity NPD3731 Phase 3
0.5704 Remote Similarity NPD7505 Discontinued
0.5695 Remote Similarity NPD5202 Clinical (unspecified phase)
0.5694 Remote Similarity NPD7299 Clinical (unspecified phase)
0.5692 Remote Similarity NPD1698 Clinical (unspecified phase)
0.5691 Remote Similarity NPD8360 Approved
0.5691 Remote Similarity NPD8361 Approved
0.5691 Remote Similarity NPD8435 Approved
0.5683 Remote Similarity NPD1719 Phase 1
0.568 Remote Similarity NPD5786 Approved
0.5676 Remote Similarity NPD8293 Discontinued
0.5664 Remote Similarity NPD7328 Approved
0.5664 Remote Similarity NPD7327 Approved
0.5658 Remote Similarity NPD8450 Suspended
0.5655 Remote Similarity NPD6908 Approved
0.5655 Remote Similarity NPD6909 Approved
0.5649 Remote Similarity NPD5120 Approved
0.5649 Remote Similarity NPD5121 Approved
0.5649 Remote Similarity NPD5119 Approved
0.5646 Remote Similarity NPD4806 Approved
0.5646 Remote Similarity NPD4807 Approved
0.5643 Remote Similarity NPD6053 Discontinued
0.5635 Remote Similarity NPD8327 Clinical (unspecified phase)
0.5635 Remote Similarity NPD8325 Phase 3
0.5635 Remote Similarity NPD8326 Phase 3
0.5634 Remote Similarity NPD4830 Approved
0.5634 Remote Similarity NPD4831 Approved
0.5634 Remote Similarity NPD4832 Approved
0.5629 Remote Similarity NPD5204 Approved
0.5629 Remote Similarity NPD3663 Approved
0.5629 Remote Similarity NPD3664 Approved
0.5629 Remote Similarity NPD3661 Approved
0.5629 Remote Similarity NPD3662 Phase 3
0.5625 Remote Similarity NPD7625 Phase 1
0.5625 Remote Similarity NPD7517 Approved
0.5625 Remote Similarity NPD7519 Approved
0.5625 Remote Similarity NPD7518 Approved
0.5625 Remote Similarity NPD7516 Approved
0.5616 Remote Similarity NPD6370 Approved
0.5612 Remote Similarity NPD7930 Approved
0.5612 Remote Similarity NPD6420 Discontinued

Structure

External Identifiers

PubChem CID   5282188
ChEMBL   CHEMBL1091024
ZINC  

Physicochemical Properties

Molecular Weight:  897.47
ALogP:  -0.4856
MLogP:  4.43
XLogP:  3.607
# Rotatable Bonds:  31
Polar Surface Area:  218.19
# H-Bond Aceptor:  18
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  63

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