Natural Product: NPC137649

Natural Product ID:  NPC137649
Common Name:   (+)-Parviflorol
IUPAC Name:   (5S,6S)-1,3,5,7,9-pentahydroxy-6-(4-hydroxyphenyl)-5,6-dihydrodibenzo[2,1-[7]annulen-11-one
Synonyms:   (+)-Parviflorol
Molecular Formula:   C21H16O7
Standard InCHIKey:  QLUPKRIWOVDUPU-FXAWDEMLSA-N
Standard InCHI:  InChI=1S/C21H16O7/c22-10-3-1-9(2-4-10)17-18-13(5-11(23)7-15(18)25)21(28)19-14(20(17)27)6-12(24)8-16(19)26/h1-8,17,20,22-27H/t17-,20+/m0/s1
Canonical SMILES:  Oc1ccc(cc1)[C@@H]1[C@H](O)c2cc(O)cc(c2C(=O)c2c1c(O)cc(c2)O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO26194 Shorea roxburghii Species Dipterocarpaceae Eukaryota Barks PMID[22209731]
NPO27265 Hopea parviflora Species Dipterocarpaceae Eukaryota TCMID*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT671 Individual Protein Acidic alpha-glucosidase Rattus norvegicus IC50 > 400000 nM 22209731
NPT671 Individual Protein Acidic alpha-glucosidase Rattus norvegicus Inhibition = 6.8 % 22209731
NPT462 Individual Protein Sucrase-isomaltase Rattus norvegicus IC50 > 400000 nM 22209731
NPT462 Individual Protein Sucrase-isomaltase Rattus norvegicus Inhibition = -0.8 % 22209731
NPT68 Individual Protein Aldose reductase Rattus norvegicus IC50 > 100000 nM 22209731
NPT68 Individual Protein Aldose reductase Rattus norvegicus Inhibition = 43.7 % 22209731

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC137649 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9149 High Similarity NPC135524
0.9149 High Similarity NPC474961
0.9111 High Similarity NPC147757
0.9078 High Similarity NPC305845
0.9078 High Similarity NPC204045
0.9071 High Similarity NPC190457
0.9021 High Similarity NPC244691
0.9021 High Similarity NPC471906
0.9007 High Similarity NPC181560
0.9007 High Similarity NPC169452
0.8986 High Similarity NPC44437
0.8986 High Similarity NPC282780
0.8986 High Similarity NPC166480
0.8978 High Similarity NPC478190
0.8936 High Similarity NPC242994
0.8936 High Similarity NPC138099
0.8913 High Similarity NPC213485
0.8913 High Similarity NPC139074
0.8913 High Similarity NPC40524
0.8897 High Similarity NPC92624
0.8881 High Similarity NPC193555
0.8844 High Similarity NPC477221
0.8832 High Similarity NPC259942
0.8828 High Similarity NPC34482
0.8815 High Similarity NPC8745
0.8794 High Similarity NPC53206
0.8794 High Similarity NPC53414
0.8794 High Similarity NPC471905
0.8786 High Similarity NPC70859
0.8786 High Similarity NPC61153
0.8786 High Similarity NPC130899
0.8786 High Similarity NPC283590
0.8768 High Similarity NPC475042
0.8767 High Similarity NPC470570
0.8759 High Similarity NPC193703
0.8759 High Similarity NPC48762
0.8759 High Similarity NPC102829
0.8759 High Similarity NPC120488
0.8759 High Similarity NPC21599
0.875 High Similarity NPC469520
0.875 High Similarity NPC85310
0.875 High Similarity NPC73061
0.8741 High Similarity NPC10926
0.8732 High Similarity NPC20210
0.8723 High Similarity NPC191976
0.8723 High Similarity NPC254847
0.871 High Similarity NPC474591
0.8707 High Similarity NPC290194
0.8705 High Similarity NPC175738
0.869 High Similarity NPC295712
0.869 High Similarity NPC474203
0.869 High Similarity NPC313047
0.869 High Similarity NPC451542
0.8681 High Similarity NPC246638
0.8681 High Similarity NPC91019
0.8681 High Similarity NPC106519
0.8671 High Similarity NPC143438
0.8667 High Similarity NPC13238
0.8662 High Similarity NPC44960
0.8662 High Similarity NPC474110
0.8662 High Similarity NPC290030
0.8643 High Similarity NPC52407
0.8643 High Similarity NPC267205
0.8623 High Similarity NPC109123
0.8621 High Similarity NPC49108
0.8611 High Similarity NPC203063
0.8603 High Similarity NPC477454
0.8601 High Similarity NPC175552
0.86 High Similarity NPC470569
0.8581 High Similarity NPC37709
0.8581 High Similarity NPC81835
0.8571 High Similarity NPC17843
0.8571 High Similarity NPC70622
0.8562 High Similarity NPC174905
0.8562 High Similarity NPC293545
0.8562 High Similarity NPC238629
0.8552 High Similarity NPC290550
0.8552 High Similarity NPC472904
0.8552 High Similarity NPC187843
0.8551 High Similarity NPC247250
0.8551 High Similarity NPC767
0.8551 High Similarity NPC473017
0.8543 High Similarity NPC113608
0.8543 High Similarity NPC470338
0.8543 High Similarity NPC470340
0.8543 High Similarity NPC474843
0.8543 High Similarity NPC268992
0.8543 High Similarity NPC180944
0.8543 High Similarity NPC470337
0.8543 High Similarity NPC51824
0.8542 High Similarity NPC162939
0.8542 High Similarity NPC472903
0.854 High Similarity NPC473691
0.8533 High Similarity NPC255641
0.8533 High Similarity NPC147735
0.8533 High Similarity NPC290954
0.8533 High Similarity NPC470568
0.8523 High Similarity NPC106328
0.8523 High Similarity NPC221352
0.8523 High Similarity NPC35150
0.8519 High Similarity NPC133909
0.8519 High Similarity NPC32032
0.8514 High Similarity NPC110882
0.8514 High Similarity NPC51513
0.8514 High Similarity NPC271944
0.8514 High Similarity NPC314437
0.8514 High Similarity NPC85393
0.8514 High Similarity NPC202112
0.8511 High Similarity NPC314048
0.8506 High Similarity NPC324736
0.8503 High Similarity NPC10764
0.8503 High Similarity NPC227841
0.85 High Similarity NPC93015
0.8489 Intermediate Similarity NPC474998
0.8487 Intermediate Similarity NPC218870
0.8487 Intermediate Similarity NPC182921
0.8487 Intermediate Similarity NPC470408
0.8487 Intermediate Similarity NPC474824
0.8483 Intermediate Similarity NPC155205
0.8478 Intermediate Similarity NPC23126
0.8478 Intermediate Similarity NPC72158
0.8478 Intermediate Similarity NPC105157
0.8478 Intermediate Similarity NPC103356
0.8478 Intermediate Similarity NPC100067
0.8478 Intermediate Similarity NPC162612
0.8478 Intermediate Similarity NPC190043
0.8478 Intermediate Similarity NPC30501
0.8478 Intermediate Similarity NPC266689
0.8478 Intermediate Similarity NPC169250
0.8478 Intermediate Similarity NPC98254
0.8472 Intermediate Similarity NPC177307
0.8472 Intermediate Similarity NPC475974
0.8472 Intermediate Similarity NPC9121
0.8472 Intermediate Similarity NPC472403
0.8462 Intermediate Similarity NPC118919
0.8456 Intermediate Similarity NPC77903
0.8456 Intermediate Similarity NPC17101
0.8444 Intermediate Similarity NPC156139
0.8444 Intermediate Similarity NPC242895
0.8444 Intermediate Similarity NPC45438
0.8444 Intermediate Similarity NPC115159
0.8444 Intermediate Similarity NPC224273
0.8444 Intermediate Similarity NPC19174
0.8444 Intermediate Similarity NPC73532
0.8444 Intermediate Similarity NPC267552
0.8444 Intermediate Similarity NPC143427
0.8444 Intermediate Similarity NPC196976
0.844 Intermediate Similarity NPC135801
0.8431 Intermediate Similarity NPC68727
0.8429 Intermediate Similarity NPC136588
0.8429 Intermediate Similarity NPC31799
0.8429 Intermediate Similarity NPC17840
0.8429 Intermediate Similarity NPC199253
0.8429 Intermediate Similarity NPC247477
0.8417 Intermediate Similarity NPC21305
0.8417 Intermediate Similarity NPC221777
0.8417 Intermediate Similarity NPC179898
0.8414 Intermediate Similarity NPC112789
0.8414 Intermediate Similarity NPC19622
0.8414 Intermediate Similarity NPC472368
0.8411 Intermediate Similarity NPC225854
0.8406 Intermediate Similarity NPC267846
0.8406 Intermediate Similarity NPC62952
0.8403 Intermediate Similarity NPC474849
0.8403 Intermediate Similarity NPC71256
0.8403 Intermediate Similarity NPC170742
0.8403 Intermediate Similarity NPC178467
0.8403 Intermediate Similarity NPC213603
0.8403 Intermediate Similarity NPC474771
0.8403 Intermediate Similarity NPC149372
0.8403 Intermediate Similarity NPC65837
0.8389 Intermediate Similarity NPC143685
0.8389 Intermediate Similarity NPC299011
0.8378 Intermediate Similarity NPC117836
0.8378 Intermediate Similarity NPC218866
0.8378 Intermediate Similarity NPC476178
0.8378 Intermediate Similarity NPC84568
0.8378 Intermediate Similarity NPC300684
0.8378 Intermediate Similarity NPC48130
0.8378 Intermediate Similarity NPC475705
0.8378 Intermediate Similarity NPC51887
0.8378 Intermediate Similarity NPC19896
0.8377 Intermediate Similarity NPC474861
0.837 Intermediate Similarity NPC297186
0.837 Intermediate Similarity NPC248363
0.8369 Intermediate Similarity NPC469526
0.8369 Intermediate Similarity NPC34070
0.8367 Intermediate Similarity NPC321980
0.8367 Intermediate Similarity NPC257644
0.8367 Intermediate Similarity NPC470087
0.8366 Intermediate Similarity NPC472211
0.8357 Intermediate Similarity NPC99731
0.8357 Intermediate Similarity NPC476119
0.8356 Intermediate Similarity NPC183345
0.8356 Intermediate Similarity NPC109232
0.8356 Intermediate Similarity NPC275903
0.8355 Intermediate Similarity NPC476552
0.8355 Intermediate Similarity NPC476553
0.8355 Intermediate Similarity NPC227485
0.8355 Intermediate Similarity NPC476551

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC137649 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8723 High Similarity NPD1509 Clinical (unspecified phase)
0.8503 High Similarity NPD7390 Discontinued
0.844 Intermediate Similarity NPD943 Approved
0.8333 Intermediate Similarity NPD1470 Approved
0.8333 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.8207 Intermediate Similarity NPD1510 Phase 2
0.8175 Intermediate Similarity NPD1201 Approved
0.8151 Intermediate Similarity NPD5404 Approved
0.8151 Intermediate Similarity NPD5405 Approved
0.8151 Intermediate Similarity NPD5408 Approved
0.8151 Intermediate Similarity NPD5406 Approved
0.8052 Intermediate Similarity NPD4380 Phase 2
0.8041 Intermediate Similarity NPD1549 Phase 2
0.7973 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.7973 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.7963 Intermediate Similarity NPD7473 Discontinued
0.7962 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7937 Intermediate Similarity NPD6959 Discontinued
0.7931 Intermediate Similarity NPD1240 Approved
0.7898 Intermediate Similarity NPD7819 Suspended
0.7898 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.7888 Intermediate Similarity NPD6232 Discontinued
0.7843 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7843 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7834 Intermediate Similarity NPD1934 Approved
0.7823 Intermediate Similarity NPD1607 Approved
0.78 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.7791 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.7791 Intermediate Similarity NPD6166 Phase 2
0.7791 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7785 Intermediate Similarity NPD2796 Approved
0.775 Intermediate Similarity NPD3749 Approved
0.775 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.7737 Intermediate Similarity NPD405 Clinical (unspecified phase)
0.7727 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.7697 Intermediate Similarity NPD3818 Discontinued
0.7688 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7673 Intermediate Similarity NPD2801 Approved
0.7662 Intermediate Similarity NPD1511 Approved
0.7658 Intermediate Similarity NPD7411 Suspended
0.7613 Intermediate Similarity NPD2534 Approved
0.7613 Intermediate Similarity NPD2532 Approved
0.7613 Intermediate Similarity NPD2533 Approved
0.7582 Intermediate Similarity NPD3750 Approved
0.7578 Intermediate Similarity NPD3882 Suspended
0.7564 Intermediate Similarity NPD1512 Approved
0.7551 Intermediate Similarity NPD3764 Approved
0.755 Intermediate Similarity NPD2935 Discontinued
0.7546 Intermediate Similarity NPD5494 Approved
0.7545 Intermediate Similarity NPD5844 Phase 1
0.7531 Intermediate Similarity NPD7075 Discontinued
0.747 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7469 Intermediate Similarity NPD7768 Phase 2
0.7468 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7456 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7453 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.7448 Intermediate Similarity NPD1164 Approved
0.7407 Intermediate Similarity NPD5402 Approved
0.7396 Intermediate Similarity NPD7074 Phase 3
0.7391 Intermediate Similarity NPD6801 Discontinued
0.7372 Intermediate Similarity NPD3300 Phase 2
0.7361 Intermediate Similarity NPD9269 Phase 2
0.7337 Intermediate Similarity NPD7054 Approved
0.7325 Intermediate Similarity NPD6799 Approved
0.7324 Intermediate Similarity NPD9268 Approved
0.7312 Intermediate Similarity NPD3226 Approved
0.7312 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.731 Intermediate Similarity NPD6559 Discontinued
0.7308 Intermediate Similarity NPD6190 Approved
0.7301 Intermediate Similarity NPD3817 Phase 2
0.7299 Intermediate Similarity NPD8150 Discontinued
0.7294 Intermediate Similarity NPD7472 Approved
0.729 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7285 Intermediate Similarity NPD230 Phase 1
0.7273 Intermediate Similarity NPD2344 Approved
0.7273 Intermediate Similarity NPD3019 Approved
0.7267 Intermediate Similarity NPD6599 Discontinued
0.7267 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7255 Intermediate Similarity NPD3299 Clinical (unspecified phase)
0.7255 Intermediate Similarity NPD2799 Discontinued
0.7255 Intermediate Similarity NPD3748 Approved
0.7251 Intermediate Similarity NPD6797 Phase 2
0.7235 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7232 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7225 Intermediate Similarity NPD8313 Approved
0.7225 Intermediate Similarity NPD8312 Approved
0.7209 Intermediate Similarity NPD7251 Discontinued
0.7208 Intermediate Similarity NPD1551 Phase 2
0.7188 Intermediate Similarity NPD5403 Approved
0.7179 Intermediate Similarity NPD2800 Approved
0.7178 Intermediate Similarity NPD37 Approved
0.7176 Intermediate Similarity NPD3751 Discontinued
0.717 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7168 Intermediate Similarity NPD7808 Phase 3
0.7162 Intermediate Similarity NPD2798 Approved
0.7161 Intermediate Similarity NPD2346 Discontinued
0.7153 Intermediate Similarity NPD2932 Approved
0.7134 Intermediate Similarity NPD1465 Phase 2
0.7124 Intermediate Similarity NPD6651 Approved
0.7097 Intermediate Similarity NPD6973 Clinical (unspecified phase)
0.7097 Intermediate Similarity NPD6100 Approved
0.7097 Intermediate Similarity NPD6099 Approved
0.7089 Intermediate Similarity NPD2309 Approved
0.7083 Intermediate Similarity NPD4196 Clinical (unspecified phase)
0.7081 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7069 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7067 Intermediate Similarity NPD4908 Phase 1
0.7063 Intermediate Similarity NPD5401 Approved
0.7056 Intermediate Similarity NPD6535 Approved
0.7056 Intermediate Similarity NPD6534 Approved
0.7048 Intermediate Similarity NPD4967 Phase 2
0.7048 Intermediate Similarity NPD4965 Approved
0.7048 Intermediate Similarity NPD4966 Approved
0.7041 Intermediate Similarity NPD3787 Discontinued
0.7041 Intermediate Similarity NPD5710 Approved
0.7041 Intermediate Similarity NPD5711 Approved
0.7041 Intermediate Similarity NPD7229 Phase 3
0.7035 Intermediate Similarity NPD6020 Phase 2
0.7029 Intermediate Similarity NPD9266 Approved
0.7029 Intermediate Similarity NPD74 Approved
0.7025 Intermediate Similarity NPD7003 Approved
0.7025 Intermediate Similarity NPD4628 Phase 3
0.7022 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7 Intermediate Similarity NPD3926 Phase 2
0.6993 Remote Similarity NPD9493 Approved
0.6982 Remote Similarity NPD7199 Phase 2
0.698 Remote Similarity NPD3094 Phase 2
0.6978 Remote Similarity NPD4750 Phase 3
0.6975 Remote Similarity NPD920 Approved
0.6974 Remote Similarity NPD6859 Clinical (unspecified phase)
0.6974 Remote Similarity NPD4907 Clinical (unspecified phase)
0.6974 Remote Similarity NPD2313 Discontinued
0.6964 Remote Similarity NPD6234 Discontinued
0.6957 Remote Similarity NPD6782 Approved
0.6957 Remote Similarity NPD6780 Approved
0.6957 Remote Similarity NPD6777 Approved
0.6957 Remote Similarity NPD6781 Approved
0.6957 Remote Similarity NPD9264 Approved
0.6957 Remote Similarity NPD9263 Approved
0.6957 Remote Similarity NPD9265 Clinical (unspecified phase)
0.6957 Remote Similarity NPD6778 Approved
0.6957 Remote Similarity NPD6779 Approved
0.6957 Remote Similarity NPD642 Clinical (unspecified phase)
0.6957 Remote Similarity NPD9267 Approved
0.6957 Remote Similarity NPD6776 Approved
0.6954 Remote Similarity NPD5953 Discontinued
0.694 Remote Similarity NPD7699 Phase 2
0.694 Remote Similarity NPD7700 Phase 2
0.6939 Remote Similarity NPD1547 Clinical (unspecified phase)
0.6936 Remote Similarity NPD7286 Phase 2
0.6931 Remote Similarity NPD8151 Discontinued
0.6928 Remote Similarity NPD6663 Approved
0.6918 Remote Similarity NPD3400 Discontinued
0.6914 Remote Similarity NPD6273 Approved
0.6898 Remote Similarity NPD8320 Phase 1
0.6898 Remote Similarity NPD7870 Phase 2
0.6898 Remote Similarity NPD8319 Approved
0.6898 Remote Similarity NPD7871 Phase 2
0.6897 Remote Similarity NPD9545 Approved
0.6897 Remote Similarity NPD3091 Approved
0.689 Remote Similarity NPD7458 Discontinued
0.6889 Remote Similarity NPD1242 Phase 1
0.6887 Remote Similarity NPD5736 Approved
0.6875 Remote Similarity NPD5034 Approved
0.6875 Remote Similarity NPD4954 Approved
0.6875 Remote Similarity NPD4955 Approved
0.6875 Remote Similarity NPD36 Approved
0.6875 Remote Similarity NPD5026 Approved
0.6875 Remote Similarity NPD5028 Approved
0.6871 Remote Similarity NPD3026 Approved
0.6871 Remote Similarity NPD3023 Approved
0.6868 Remote Similarity NPD4360 Phase 2
0.6868 Remote Similarity NPD4363 Phase 3
0.6867 Remote Similarity NPD1203 Approved
0.6865 Remote Similarity NPD7501 Clinical (unspecified phase)
0.6861 Remote Similarity NPD1237 Approved
0.6854 Remote Similarity NPD8055 Clinical (unspecified phase)
0.6849 Remote Similarity NPD3025 Approved
0.6849 Remote Similarity NPD3024 Approved
0.6845 Remote Similarity NPD7697 Approved
0.6845 Remote Similarity NPD7696 Phase 3
0.6845 Remote Similarity NPD7435 Discontinued
0.6845 Remote Similarity NPD7698 Approved
0.6838 Remote Similarity NPD846 Approved
0.6838 Remote Similarity NPD940 Approved
0.6836 Remote Similarity NPD5035 Approved
0.6833 Remote Similarity NPD4287 Approved
0.6832 Remote Similarity NPD643 Clinical (unspecified phase)
0.6826 Remote Similarity NPD5760 Phase 2
0.6826 Remote Similarity NPD5761 Phase 2
0.6824 Remote Similarity NPD3092 Approved
0.6824 Remote Similarity NPD1610 Phase 2
0.6818 Remote Similarity NPD5030 Phase 2
0.6816 Remote Similarity NPD5038 Approved
0.6816 Remote Similarity NPD5037 Approved
0.6813 Remote Similarity NPD6398 Clinical (unspecified phase)
0.6813 Remote Similarity NPD6213 Phase 3
0.6813 Remote Similarity NPD6212 Phase 3
0.6813 Remote Similarity NPD6214 Clinical (unspecified phase)
0.6813 Remote Similarity NPD8166 Discontinued

Structure

External Identifiers

PubChem CID   57402416
ChEMBL   CHEMBL1939430
ZINC  

Physicochemical Properties

Molecular Weight:  380.09
ALogP:  -3.2069
MLogP:  3
XLogP:  0.599
# Rotatable Bonds:  7
Polar Surface Area:  138.45
# H-Bond Aceptor:  2
# H-Bond Donor:  6
# Rings:  4
# Heavy Atoms:  28

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs