Collective Molecular Activities of the Plant: Aglaia Lawii
Plant ID: NPO9964
Plant Latin Name: Aglaia Lawii
Taxonomy Genus: Aglaia
Taxonomy Family: Meliaceae
Plant External Links:
NCBI TaxonomyDB:
306522
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
61 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
59 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
17 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9611
Ingredient ID: NPC94399
Ingredient ID: NPC93500
Ingredient ID: NPC87397
Ingredient ID: NPC86054
Ingredient ID: NPC85346
Ingredient ID: NPC75425
Ingredient ID: NPC74304
Ingredient ID: NPC7365
Ingredient ID: NPC71786
Ingredient ID: NPC71536
Ingredient ID: NPC71347
Ingredient ID: NPC67308
Ingredient ID: NPC65786
Ingredient ID: NPC3936
Ingredient ID: NPC39
Ingredient ID: NPC31428
Ingredient ID: NPC308718
Ingredient ID: NPC302293
Ingredient ID: NPC299804
Ingredient ID: NPC298049
Ingredient ID: NPC29183
Ingredient ID: NPC291704
Ingredient ID: NPC288298
Ingredient ID: NPC282086
Ingredient ID: NPC279980
Ingredient ID: NPC279696
Ingredient ID: NPC273699
Ingredient ID: NPC269171
Ingredient ID: NPC264779
Ingredient ID: NPC26417
Ingredient ID: NPC253729
Ingredient ID: NPC250543
Ingredient ID: NPC249714
Ingredient ID: NPC238010
Ingredient ID: NPC237460
Ingredient ID: NPC230301
Ingredient ID: NPC224731
Ingredient ID: NPC216489
Ingredient ID: NPC212625
Ingredient ID: NPC200528
Ingredient ID: NPC198251
Ingredient ID: NPC197606
Ingredient ID: NPC189062
Ingredient ID: NPC188330
Ingredient ID: NPC184049
Ingredient ID: NPC180968
Ingredient ID: NPC179169
Ingredient ID: NPC173265
Ingredient ID: NPC172653
Ingredient ID: NPC163294
Ingredient ID: NPC155025
Ingredient ID: NPC151923
Ingredient ID: NPC145015
Ingredient ID: NPC139548
Ingredient ID: NPC129841
Ingredient ID: NPC120926
Ingredient ID: NPC114979
Ingredient ID: NPC109813
Ingredient ID: NPC108960
Ingredient ID: NPC104387
Classification of Human Proteins Collectively Targeted by the Plant
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,CNR2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
