CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Crinum Asiaticum Var. Sinicum

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO9927.2
Plant Latin Name: Crinum Asiaticum Var. Sinicum
Taxonomy Genus: Crinum
Taxonomy Family: Amaryllidaceae

Plant External Links:

NCBI TaxonomyDB: 205937
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

55 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

40 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

13 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC329039

Ingredient ID: NPC328202

Ingredient ID: NPC327879

Ingredient ID: NPC327746

Ingredient ID: NPC327558

Ingredient ID: NPC325696

Ingredient ID: NPC324838

Ingredient ID: NPC324191

Ingredient ID: NPC323542

Ingredient ID: NPC322490

Ingredient ID: NPC322079

Ingredient ID: NPC321966

Ingredient ID: NPC321689

Ingredient ID: NPC321487

Ingredient ID: NPC321124

Ingredient ID: NPC318976

Ingredient ID: NPC318007

Ingredient ID: NPC317951

Ingredient ID: NPC316661

Ingredient ID: NPC316515

Ingredient ID: NPC309728

Ingredient ID: NPC305985

Ingredient ID: NPC300240

Ingredient ID: NPC299459

Ingredient ID: NPC298862

Ingredient ID: NPC292602

Ingredient ID: NPC290282

Ingredient ID: NPC281856

Ingredient ID: NPC278683

Ingredient ID: NPC277333

Ingredient ID: NPC250

Ingredient ID: NPC2499

Ingredient ID: NPC236579

Ingredient ID: NPC235251

Ingredient ID: NPC234888

Ingredient ID: NPC229347

Ingredient ID: NPC223695

Ingredient ID: NPC223125

Ingredient ID: NPC223124

Ingredient ID: NPC218614

Ingredient ID: NPC196776

Ingredient ID: NPC190332

Ingredient ID: NPC188341

Ingredient ID: NPC182257

Ingredient ID: NPC181653

Ingredient ID: NPC179662

Ingredient ID: NPC167072

Ingredient ID: NPC164067

Ingredient ID: NPC153231

Ingredient ID: NPC148409

Ingredient ID: NPC142753

Ingredient ID: NPC137167

Ingredient ID: NPC128061

Ingredient ID: NPC127454

Ingredient ID: NPC122561

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CYP3A4
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	CYP3A4
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CYP3A4
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP3A4
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CYP3A4
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP3A4
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CYP3A4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Crinum Asiaticum Var. Sinicum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

55 All known Ingredients in Total

40 Ingredients with Acceptable Bioavailablity

13 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Atopic eczema

Anxiety

Solid tumour/cancer

Urothelial carcinoma of bladder

Malignant neoplasms of thymus

Renal cell carcinoma, chromophobe type

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities