Collective Molecular Activities of the Plant: Ajuga Ciliata
Plant ID: NPO9680
Plant Latin Name: Ajuga Ciliata
Taxonomy Genus: Ajuga
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
199542
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
62 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
32 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
20 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98241
Ingredient ID: NPC97202
Ingredient ID: NPC87446
Ingredient ID: NPC84249
Ingredient ID: NPC81288
Ingredient ID: NPC80964
Ingredient ID: NPC72647
Ingredient ID: NPC70381
Ingredient ID: NPC67867
Ingredient ID: NPC67826
Ingredient ID: NPC64799
Ingredient ID: NPC51555
Ingredient ID: NPC49552
Ingredient ID: NPC41434
Ingredient ID: NPC40356
Ingredient ID: NPC3908
Ingredient ID: NPC37565
Ingredient ID: NPC37435
Ingredient ID: NPC33026
Ingredient ID: NPC328726
Ingredient ID: NPC32692
Ingredient ID: NPC322912
Ingredient ID: NPC319438
Ingredient ID: NPC311241
Ingredient ID: NPC300053
Ingredient ID: NPC297639
Ingredient ID: NPC280214
Ingredient ID: NPC279203
Ingredient ID: NPC266728
Ingredient ID: NPC265997
Ingredient ID: NPC263016
Ingredient ID: NPC259048
Ingredient ID: NPC249011
Ingredient ID: NPC238741
Ingredient ID: NPC235020
Ingredient ID: NPC216636
Ingredient ID: NPC214211
Ingredient ID: NPC209297
Ingredient ID: NPC201020
Ingredient ID: NPC196277
Ingredient ID: NPC194132
Ingredient ID: NPC172405
Ingredient ID: NPC170777
Ingredient ID: NPC162287
Ingredient ID: NPC155235
Ingredient ID: NPC147734
Ingredient ID: NPC140277
Ingredient ID: NPC133789
Ingredient ID: NPC125853
Ingredient ID: NPC124447
Ingredient ID: NPC124038
Ingredient ID: NPC11974
Ingredient ID: NPC119589
Ingredient ID: NPC11375
Ingredient ID: NPC113172
Ingredient ID: NPC112294
Ingredient ID: NPC109195
Ingredient ID: NPC108433
Ingredient ID: NPC107806
Ingredient ID: NPC106455
Ingredient ID: NPC100953
Ingredient ID: NPC100912
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
