Collective Molecular Activities of the Plant: Adiantum Capillus-Veneris
Plant ID: NPO9241
Plant Latin Name: Adiantum Capillus-Veneris
Taxonomy Genus: Adiantum
Taxonomy Family: Pteridaceae
Plant External Links:
NCBI TaxonomyDB:
13818
Plant-of-the-World-Online:
n.a.
Country/Region:
India; TurkmenistanTraditional Medicine System:
Indian Folk; UnaniMedicinal Functions:
Antidandruff; Antitussive; Depurative; Emmenagogue; Expectorant; Galactogogue; Refrigerant; Stings; Tonic; Vermifuge
India; Turkmenistan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
54 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
45 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94520
Ingredient ID: NPC76527
Ingredient ID: NPC74731
Ingredient ID: NPC71941
Ingredient ID: NPC68269
Ingredient ID: NPC6713
Ingredient ID: NPC66677
Ingredient ID: NPC63690
Ingredient ID: NPC60334
Ingredient ID: NPC52419
Ingredient ID: NPC52169
Ingredient ID: NPC45347
Ingredient ID: NPC32351
Ingredient ID: NPC317092
Ingredient ID: NPC310443
Ingredient ID: NPC303876
Ingredient ID: NPC303395
Ingredient ID: NPC301972
Ingredient ID: NPC301696
Ingredient ID: NPC300940
Ingredient ID: NPC284039
Ingredient ID: NPC275472
Ingredient ID: NPC266439
Ingredient ID: NPC25908
Ingredient ID: NPC258028
Ingredient ID: NPC251901
Ingredient ID: NPC2518
Ingredient ID: NPC250069
Ingredient ID: NPC247808
Ingredient ID: NPC237638
Ingredient ID: NPC234075
Ingredient ID: NPC230301
Ingredient ID: NPC208025
Ingredient ID: NPC203402
Ingredient ID: NPC202850
Ingredient ID: NPC198685
Ingredient ID: NPC198023
Ingredient ID: NPC18984
Ingredient ID: NPC180814
Ingredient ID: NPC160900
Ingredient ID: NPC155762
Ingredient ID: NPC154172
Ingredient ID: NPC151330
Ingredient ID: NPC142759
Ingredient ID: NPC141777
Ingredient ID: NPC133048
Ingredient ID: NPC131981
Ingredient ID: NPC124289
Ingredient ID: NPC121742
Ingredient ID: NPC120471
Ingredient ID: NPC115719
Ingredient ID: NPC110942
Ingredient ID: NPC109083
Ingredient ID: NPC10576
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Oxidoreductase | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 86 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02645656 | Topical Application of Curcumin Orabase in Oral Submucous Fibrosis (OSMF) | oral submucous fibrosis | Curcumin (NPC109083) | NP level |
| NCT01902381 | CPI-613 in Treating Patients With Myelodysplastic Syndromes Who Failed Previous Therapy | myelodysplastic syndrome | Octanoic Acid (NPC301696) | NP level |
| NCT00889161 | Curcumin in Pediatric Inflammatory Bowel Disease | Crohn's disease;ulcerative colitis | Curcumin (NPC109083) | NP level |
| NCT02782949 | Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia | atrophic gastritis | Curcumin (NPC109083) | NP level |
| NCT03953261 | Effect of Curcumin on Systemic Lupus Erythematosus | systemic lupus erythematosus | Curcumin (NPC109083) | NP level |
| NCT03192059 | Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer | cervical cancer;endometrial cancer | Curcumin (NPC109083) | NP level |
| NCT00248053 | Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
| NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Curcumin (NPC109083) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT00641147 | Curcumin in Treating Patients With Familial Adenomatous Polyposis | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
| NCT00192842 | Gemcitabine With Curcumin for Pancreatic Cancer | pancreatic carcinoma | Curcumin (NPC109083) | NP level |
| NCT02848417 | Glutathione vs. Curcumin Clinical Trial | persian gulf syndrome | Curcumin (NPC109083) | NP level |
| NCT00973869 | Curcumin in Preventing Colorectal Cancer in Patients Undergoing Colorectal Endoscopy or Colorectal Surgery | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT05147376 | Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances | Oral ulcer | Curcumin (NPC109083) | NP level |
| NCT02064673 | Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy | prostate cancer | Curcumin (NPC109083) | NP level |
| NCT04266275 | Topical Curcumin for HPV Related Cervical Disease | cervical adenocarcinoma | Curcumin (NPC109083) | NP level |
| NCT01333917 | Curcumin Biomarkers | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT01928043 | Adjunctive Curcumin for Symptomatic Adolescents With Bipolar Disorder: Brain and Body Considerations | bipolar disorder | Curcumin (NPC109083) | NP level |
| NCT03769766 | Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance | prostate cancer | Curcumin (NPC109083) | NP level |
| NCT03790605 | A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis | periodontitis | Curcumin (NPC109083) | NP level |
| NCT01931787 | CPI-613 in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer | small cell lung carcinoma | Octanoic Acid (NPC301696) | NP level |
| NCT02978339 | A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis (PSC) | sclerosing cholangitis | Curcumin (NPC109083) | NP level |
| NCT00848172 | Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor | essential tremor | Octanoic Acid (NPC301696) | NP level |
| NCT00365209 | Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) | nicotine dependence | Curcumin (NPC109083) | NP level |
| NCT02529982 | Curcumin Supplementation and Patients With Type 2 Diabetes | type 1 diabetes mellitus | Curcumin (NPC109083) | NP level |
| NCT03511261 | Efficacy of Curcumin in Oral Submucous Fibrosis | oral submucous fibrosis | Curcumin (NPC109083) | NP level |
| NCT02944578 | Topical Curcumin for Precancer Cervical Lesions | neoplasm | Curcumin (NPC109083) | NP level |
| NCT01811381 | Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease | Cognitive impairment | Curcumin (NPC109083) | NP level |
| NCT05430087 | Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients | systemic lupus erythematosus | Curcumin (NPC109083) | NP level |
| NCT03072992 | "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer | breast cancer | Curcumin (NPC109083) | NP level |
| NCT04355416 | Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket | periodontitis | Curcumin (NPC109083) | NP level |
| NCT01320436 | Curcumin + Aminosalicylic Acid (5ASA) Versus 5ASA Alone in the Treatment of Mild to Moderate Ulcerative Colitis | ulcerative colitis | Curcumin (NPC109083) | NP level |
| NCT00164749 | A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease | Alzheimer disease | Curcumin (NPC109083) | NP level |
| NCT00295035 | Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer | colonic neoplasm | Curcumin (NPC109083) | NP level |
| NCT03845322 | Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence | intracranial subdural hematoma | Curcumin (NPC109083) | NP level |
| NCT01608139 | Study of Curcumin, Vorinostat, and Sorafenib | cancer | Curcumin (NPC109083) | NP level |
| NCT02472626 | 6,8-Bis(Benzylthio)Octanoic Acid, Cytarabine, and Daunorubicin Hydrochloride in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia | acute myeloid leukemia | Octanoic Acid (NPC301696) | NP level |
| NCT01383161 | 18-Month Study of Memory Effects of Curcumin | Cognitive impairment | Curcumin (NPC109083) | NP level |
| NCT05062486 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | age-related macular degeneration | Curcumin (NPC109083) | NP level |
| NCT01766219 | CPI-613 in Treating Patients With Advanced or Metastatic Bile Duct Cancer That Cannot Be Removed By Surgery | cholangiocarcinoma;gallbladder neoplasm | Octanoic Acid (NPC301696) | NP level |
| NCT01740323 | Phase II Study of Curcumin vs Placebo for Chemotherapy-Treated Breast Cancer Patients Undergoing Radiotherapy | breast cancer | Curcumin (NPC109083) | NP level |
| NCT00247026 | The Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes | myelodysplastic syndrome | Curcumin (NPC109083) | NP level |
| NCT04896164 | Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting | oral mucositis | Curcumin (NPC109083) | NP level |
| NCT01859858 | Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumors | colorectal cancer | Curcumin (NPC109083) | NP level |
| NCT01269203 | Efficacy of NF-kB Inhibition for Reducing Symptoms During Maintenance Therapy in Multiple Myeloma Patients | multiple myeloma | Curcumin (NPC109083) | NP level |
| NCT01042938 | Curcumin for the Prevention of Radiation-induced Dermatitis in Breast Cancer Patients | breast cancer | Curcumin (NPC109083) | NP level |
| NCT00027495 | Curcumin for the Prevention of Colon Cancer | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT02724618 | Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) | prostate cancer | Curcumin (NPC109083) | NP level |
| NCT01831193 | Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease | Proteinuria | Curcumin (NPC109083) | NP level |
| NCT00099710 | Curcumin in Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Curcumin (NPC109083) | NP level |
| NCT03980509 | A "Window Trial" on Curcumin for Invasive Breast Cancer Primary Tumors | breast cancer | Curcumin (NPC109083) | NP level |
| NCT02095717 | Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL) | prostate cancer | Curcumin (NPC109083) | NP level |
| NCT00745134 | Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer | rectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT02300727 | Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy | mucositis | Curcumin (NPC109083) | NP level |
| NCT02277223 | Curcumin in Pediatric Ulcerative Colitis | ulcerative colitis | Curcumin (NPC109083) | NP level |
| NCT01201694 | Phase I Study of Surface-Controlled Water Soluble Curcumin (THERACURMIN CR-011L) | cancer | Curcumin (NPC109083) | NP level |
| NCT00528151 | A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) | Leber hereditary optic neuropathy | Curcumin (NPC109083) | NP level |
| NCT04837664 | Curcumin | nicotine dependence | Curcumin (NPC109083) | NP level |
| NCT01294072 | Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue | malignant colon neoplasm | Curcumin (NPC109083) | NP level |
| NCT00486460 | Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Advance or Inoperable Pancreatic Cancer | pancreatic carcinoma | Curcumin (NPC109083) | NP level |
| NCT02100423 | Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | chronic lymphocytic leukemia | Curcumin (NPC109083) | NP level |
| NCT01035580 | Trial on Safety and Pharmacokinetics of Intravaginal Curcumin | dysplasia of cervix | Curcumin (NPC109083) | NP level |
| NCT04353310 | Evaluating Effects of Curcumin in Moderate to Severe Asthmatics | asthma | Curcumin (NPC109083) | NP level |
| NCT02439385 | Avastin/FOLFIRI in Combination With Curcumin in Colorectal Cancer Patients With Unresectable Metastasis | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT02554344 | Effect of Curcumin in Treatment of Squamous Cervical Intraepithelial Neoplasias (CINs) | cervical intraepithelial neoplasia | Curcumin (NPC109083) | NP level |
| NCT00226174 | A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus | oral lichen planus | Curcumin (NPC109083) | NP level |
| NCT02484391 | CPI-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma | Granulocytic Sarcoma | Octanoic Acid (NPC301696) | NP level |
| NCT00852332 | Docetaxel With or Without a Phytochemical in Treating Patients With Breast Cancer | breast cancer | Curcumin (NPC109083) | NP level |
| NCT02369549 | Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease | chronic kidney disease | Curcumin (NPC109083) | NP level |
| NCT04713631 | Safety and Efficacy of Artesunate & Curcumin in Crohn's Disease | Crohn's disease | Curcumin (NPC109083) | NP level |
| NCT02529969 | Effects of Curcumin Supplementation on Lipid Profile and Inflammatory Markers of Patients With Type 2 Diabetes | type 1 diabetes mellitus | Curcumin (NPC109083) | NP level |
| NCT01468948 | Octanoic Acid for Essential Tremor | essential tremor | Octanoic Acid (NPC301696) | NP level |
| NCT00118989 | Curcumin for the Chemoprevention of Colorectal Cancer | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
| NCT01048983 | Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) | non-small cell lung carcinoma | Curcumin (NPC109083) | NP level |
| NCT00525421 | A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus | oral lichen planus | Curcumin (NPC109083) | NP level |
| NCT03019848 | Effect of Oral Supplementation With Curcumin in Patients With Proteinuric Diabetic Kidney Disease | Proteinuria | Curcumin (NPC109083) | NP level |
| NCT01514370 | Dietary Supplement of Curcumin in Subjects With Active Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta 1a | multiple sclerosis | Curcumin (NPC109083) | NP level |
| NCT03370159 | CPI-613 and Docetaxel in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer | non-small cell lung carcinoma | Octanoic Acid (NPC301696) | NP level |
| NCT00969085 | Trial of Curcumin in Cutaneous T-cell Lymphoma Patients | Cutaneous T-cell lymphoma | Curcumin (NPC109083) | NP level |
| NCT04870060 | Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant | oral mucositis | Curcumin (NPC109083) | NP level |
| NCT01246973 | Oral Curcumin for Radiation Dermatitis | radiodermatitis | Curcumin (NPC109083) | NP level |
| NCT02255370 | Curcumin Associated With Thiopurin in the Prevention of Post-op Recurrence in Crohn Disease | Crohn's disease | Curcumin (NPC109083) | NP level |
| NCT04294836 | Curcumin in Advanced Cervical Cancer | cervical cancer | Curcumin (NPC109083) | NP level |
| NCT04590196 | Effect of Oral Curcumin Supplementation in Dry Age-related Macular Degeneration (AMD) Patients | age-related macular degeneration | Curcumin (NPC109083) | NP level |
| NCT05045443 | Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia | acute lymphoblastic leukemia | Curcumin (NPC109083) | NP level |
| NCT02138955 | A Phase IB Dose Escalation Study of Lipocurc in Patients With Cancer | cancer | Curcumin (NPC109083) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOA
NCT02064673,NCT04403568,NCT02724618,NCT03769766,NCT02095717 |
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA,PTGES,APP,MAOA
NCT00099710,NCT00164749 |
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA2
NCT00852332,NCT01740323,NCT01042938,NCT03072992,NCT03980509 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
NPSR1,CA2,CISD1,GLO1,AKR1B10,PTGES
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ALOX5,CA2,CISD1,GLO1,AKR1B10,PTGES
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX5,SNCA,NPSR1,F2,GLO1,APP
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01333917,NCT01859858,NCT00027495,NCT02439385,NCT00973869
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SNCA,FOS,CA2,PTGES,APP
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CISD1,GLO1,PTGES,F3,LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ALOX5,SNCA,AKR1B10,PTGES,LMNA
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA2,F3,ALOX5,APP
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX5,PTGES,F3,LMNA
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ALOX5,AKR1B10,F2,ALOX5
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
NPSR1,F2,AKR1B10,PTGES
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CA2,SNCA,PTGES,LMNA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,F2,AKR1B10,PTGES
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
NPSR1,F2,CA2,AKR1B10
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2,ALOX5
NCT04353310 |
Other specified malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NCT00248053,NCT00641147,NCT00118989
|
Oral mucositisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA01 |
NCT02300727,NCT04896164,NCT04870060
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00889161,NCT02255370,NCT04713631
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT01201694,NCT01608139,NCT02138955
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
NCT00889161,NCT01320436,NCT02277223
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
NCT03953261,NCT05430087 |
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
PTGES,AKR1B10,AKR1B10
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
PTGES,F3,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
PTGES,CISD1,AKR1B10
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA2,AKR1B10,LMNA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
PTGES,SNCA,GLO1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
ALOX5,GLO1
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA,MAOA
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2,ALOX5
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2,ALOX5
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
NCT01514370 |
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2,F3
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ALOX5
AKR1B10 |
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT00192842,NCT00486460
|
Periodontal diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0C |
NCT04355416,NCT03790605
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT03370159,NCT01048983
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT05062486,NCT04590196
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
NCT03192059,NCT04294836
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT02529969,NCT02529982
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
NCT01902381,NCT00247026
|
Essential tremor or related tremorsDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04.1 |
NCT01468948,NCT00848172
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT04837664,NCT00365209
|
Symptoms and signs involving cognition, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.Z |
NCT01811381,NCT01383161
|
ProteinuriaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF96 |
NCT03019848,NCT01831193
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT00226174,NCT00525421
|
Oral submucous fibrosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.2 |
NCT03511261,NCT02645656
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HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
PTGES,AKR1B10
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,NPSR1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2,NPSR1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2,F3
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NPSR1,F2
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
PTGES,NPSR1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA2,FOS
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,SNCA,NPSR1,F2,CA2,CISD1,PTGES,AKR1B10,APP,LMNA
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Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2
|
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
APP
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
ALOX5
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
ALOX5
|
Diagnostic imagingDisease Category: NADisease ICD-11 Code: N.A. |
APP
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Desmoid tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7C |
APP
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ALOX5
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOA
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOA
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ALOX5
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ALOX5
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOA
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
MAOA
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
F2
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APP
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
MAOA
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
SarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2C35 |
NCT02484391
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT02978339
|
Neoplasms of unknown behaviour of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F90.0 |
NCT00295035
|
Dermatoses due to ionizing radiation, unspecifiedDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EJ7Z |
NCT01246973
|
Noninfectious erosive or ulcerative disorders of oral mucosaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA01.1 |
NCT05147376
|
CholangiocarcinomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH7M15 |
NCT01766219
|
Cervical intraepithelial neoplasiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT02554344
|
Chronic atrophic gastritis of unknown aetiologyDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA42.73 |
NCT02782949
|
Adenocarcinoma, endocervical typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH0GS9 |
NCT04266275
|
Diseases of the nervous systemDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 08 |
NCT02848417
|
Precursor cell lymphoblastic leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH5J37 |
NCT05045443
|
Other specified mitochondrial myopathiesDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C73.Y |
NCT00528151
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT01269203
|
Small cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.1 |
NCT01931787
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT02944578
|
Cutaneous T-cell lymphoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH1951 |
NCT00969085
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT01928043
|
Low grade squamous intraepithelial lesion of cervix uteriDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA15.7 |
NCT01035580
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT02369549
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
NCT03192059
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT02472626
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT01294072
|
Malignant neoplasms of rectum, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92.Z |
NCT00745134
|
Malignant neoplasms of gallbladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C13 |
NCT01766219
|
Traumatic subdural haemorrhageDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.6 |
NCT03845322
|
Chronic lymphocytic leukaemia or small lymphocytic lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82.0 |
NCT02100423
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
NCT01119534
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
PTGES
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
MAOA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
AKR1B10
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
APP
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1B10
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALOX5
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
PTGES
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FOS
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1B10
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
