Collective Molecular Activities of the Plant: Adiantum Capillus-Veneris
Plant ID: NPO9241
Plant Latin Name: Adiantum Capillus-Veneris
Taxonomy Genus: Adiantum
Taxonomy Family: Pteridaceae
Plant External Links:
NCBI TaxonomyDB:
13818
Plant-of-the-World-Online:
n.a.
Country/Region:
India; TurkmenistanTraditional Medicine System:
Indian Folk; UnaniMedicinal Functions:
Antidandruff; Antitussive; Depurative; Emmenagogue; Expectorant; Galactogogue; Refrigerant; Stings; Tonic; Vermifuge
India; Turkmenistan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
54 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
45 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94520
Ingredient ID: NPC76527
Ingredient ID: NPC74731
Ingredient ID: NPC71941
Ingredient ID: NPC68269
Ingredient ID: NPC6713
Ingredient ID: NPC66677
Ingredient ID: NPC63690
Ingredient ID: NPC60334
Ingredient ID: NPC52419
Ingredient ID: NPC52169
Ingredient ID: NPC45347
Ingredient ID: NPC32351
Ingredient ID: NPC317092
Ingredient ID: NPC310443
Ingredient ID: NPC303876
Ingredient ID: NPC303395
Ingredient ID: NPC301972
Ingredient ID: NPC301696
Ingredient ID: NPC300940
Ingredient ID: NPC284039
Ingredient ID: NPC275472
Ingredient ID: NPC266439
Ingredient ID: NPC25908
Ingredient ID: NPC258028
Ingredient ID: NPC251901
Ingredient ID: NPC2518
Ingredient ID: NPC250069
Ingredient ID: NPC247808
Ingredient ID: NPC237638
Ingredient ID: NPC234075
Ingredient ID: NPC230301
Ingredient ID: NPC208025
Ingredient ID: NPC203402
Ingredient ID: NPC202850
Ingredient ID: NPC198685
Ingredient ID: NPC198023
Ingredient ID: NPC18984
Ingredient ID: NPC180814
Ingredient ID: NPC160900
Ingredient ID: NPC155762
Ingredient ID: NPC154172
Ingredient ID: NPC151330
Ingredient ID: NPC142759
Ingredient ID: NPC141777
Ingredient ID: NPC133048
Ingredient ID: NPC131981
Ingredient ID: NPC124289
Ingredient ID: NPC121742
Ingredient ID: NPC120471
Ingredient ID: NPC115719
Ingredient ID: NPC110942
Ingredient ID: NPC109083
Ingredient ID: NPC10576
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Therapeutic Target | Oxidoreductase | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 86 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00027495 | Curcumin for the Prevention of Colon Cancer | colorectal carcinoma | Curcumin (NPC109083) | NP level |
| NCT00099710 | Curcumin in Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Curcumin (NPC109083) | NP level |
| NCT00118989 | Curcumin for the Chemoprevention of Colorectal Cancer | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
| NCT00164749 | A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease | Alzheimer disease | Curcumin (NPC109083) | NP level |
| NCT00192842 | Gemcitabine With Curcumin for Pancreatic Cancer | pancreatic carcinoma | Curcumin (NPC109083) | NP level |
| NCT00226174 | A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus | oral lichen planus | Curcumin (NPC109083) | NP level |
| NCT00247026 | The Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes | myelodysplastic syndrome | Curcumin (NPC109083) | NP level |
| NCT00248053 | Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients | Familial adenomatous polyposis | Curcumin (NPC109083) | NP level |
| NCT00295035 | Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer | colonic neoplasm | Curcumin (NPC109083) | NP level |
| NCT00365209 | Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) | nicotine dependence | Curcumin (NPC109083) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT02472626
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,F2,AKR1B10,PTGES
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,SNCA,NPSR1,F2,CA2,CISD1,PTGES,AKR1B10,APP,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,NPSR1
|
Adenocarcinoma, endocervical typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH0GS9 |
NCT04266275
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA,PTGES,APP,MAOA
NCT00099710,NCT00164749 |
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
