Collective Molecular Activities of the Plant: Daphne Giraldii
Plant ID: NPO8912
Plant Latin Name: Daphne Giraldii
Taxonomy Genus: Daphne
Taxonomy Family: Thymelaeaceae
Plant External Links:
NCBI TaxonomyDB:
1799574
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
87 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
63 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
48 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99068
Ingredient ID: NPC85561
Ingredient ID: NPC7973
Ingredient ID: NPC78302
Ingredient ID: NPC75844
Ingredient ID: NPC7466
Ingredient ID: NPC74580
Ingredient ID: NPC70036
Ingredient ID: NPC67195
Ingredient ID: NPC65435
Ingredient ID: NPC55900
Ingredient ID: NPC49448
Ingredient ID: NPC481772
Ingredient ID: NPC481771
Ingredient ID: NPC481770
Ingredient ID: NPC481769
Ingredient ID: NPC481768
Ingredient ID: NPC481767
Ingredient ID: NPC481766
Ingredient ID: NPC481765
Ingredient ID: NPC481764
Ingredient ID: NPC481763
Ingredient ID: NPC481762
Ingredient ID: NPC481761
Ingredient ID: NPC481760
Ingredient ID: NPC481759
Ingredient ID: NPC481758
Ingredient ID: NPC481757
Ingredient ID: NPC481756
Ingredient ID: NPC4481
Ingredient ID: NPC43412
Ingredient ID: NPC312617
Ingredient ID: NPC310934
Ingredient ID: NPC299565
Ingredient ID: NPC29841
Ingredient ID: NPC293539
Ingredient ID: NPC292902
Ingredient ID: NPC288669
Ingredient ID: NPC287979
Ingredient ID: NPC287865
Ingredient ID: NPC286342
Ingredient ID: NPC286170
Ingredient ID: NPC281131
Ingredient ID: NPC266960
Ingredient ID: NPC26596
Ingredient ID: NPC26496
Ingredient ID: NPC262756
Ingredient ID: NPC25495
Ingredient ID: NPC253634
Ingredient ID: NPC238192
Ingredient ID: NPC235215
Ingredient ID: NPC234952
Ingredient ID: NPC233980
Ingredient ID: NPC22472
Ingredient ID: NPC22449
Ingredient ID: NPC222750
Ingredient ID: NPC221388
Ingredient ID: NPC219737
Ingredient ID: NPC214138
Ingredient ID: NPC209846
Ingredient ID: NPC208683
Ingredient ID: NPC208553
Ingredient ID: NPC20791
Ingredient ID: NPC207691
Ingredient ID: NPC204854
Ingredient ID: NPC203050
Ingredient ID: NPC197679
Ingredient ID: NPC197499
Ingredient ID: NPC19687
Ingredient ID: NPC195046
Ingredient ID: NPC191459
Ingredient ID: NPC190322
Ingredient ID: NPC189958
Ingredient ID: NPC185170
Ingredient ID: NPC176665
Ingredient ID: NPC166778
Ingredient ID: NPC163524
Ingredient ID: NPC142771
Ingredient ID: NPC137915
Ingredient ID: NPC130894
Ingredient ID: NPC123557
Ingredient ID: NPC117418
Ingredient ID: NPC1157
Ingredient ID: NPC115245
Ingredient ID: NPC114132
Ingredient ID: NPC10980
Ingredient ID: NPC105242
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3226 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000122 | Fluorouracil Filtering Surgery Study (FFSS) | glaucoma | Fluorouracil (NPC75844) | NP level |
| NCT00000758 | A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women | dysplasia of cervix | Fluorouracil (NPC75844) | NP level |
| NCT00001272 | A Phase I Study of Taxol, Cisplatin, Cyclophosphamide and Granulocyte Colony-Stimulating Factor (G-CSF) in Previously Nontreated Ovarian Cancer Patients | ovarian neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001383 | A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC 833 | renal cell carcinoma;lymphoma;ovarian cancer;breast cancer | Paclitaxel (NPC208553) | NP level |
| NCT00001384 | A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients | breast cancer | Paclitaxel (NPC208553) | NP level |
| NCT00001387 | Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusion in Pediatric Patients With Refractory Malignancy | neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001426 | A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer | ovarian neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001428 | A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer | colorectal neoplasm | Fluorouracil (NPC75844) | NP level |
| NCT00001442 | A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer | squamous cell carcinoma;upper aerodigestive tract neoplasm | Paclitaxel (NPC208553) | NP level |
| NCT00001450 | Phase II Trial of a 96-Hour Continuous Infusion of Paclitaxel Followed by Cisplatin for Patients With Stage III/IV and Relapsed NSCLC | non-small cell lung carcinoma | Paclitaxel (NPC208553) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02281682,NCT05078827,NCT03083470,NCT00377273,NCT00696488,NCT02616601,NCT01354717,NCT03037541,NCT01525329,NCT02019355,NCT04875026,NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,AURKB,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,FLT3,AXL,AURKB,SRC,TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CDK1,THPO,GMNN,AURKB,XDH,TSHR,SLCO1B3,NPSR1,CA7,CYP2C9,SLCO1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
RECQL,POLB,XDH,SLCO1B3,ITGAV,MET,LMNA,AURKB,PIM1,CYP1B1,CA7,HSD17B2,DPP4,CISD1,PMP22,NPSR1,ALOX15,ALOX5,CYP2C9,AXL,NPC1,TUBB6,ABCG2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,SLCO1B3,NOX4,SLCO1B1
NCT01912820,NCT04221828,NCT00521781 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,NOX4,AURKB,SLCO1B3,NPSR1,ALOX15,CYP19A1,MET,SLCO1B1
NCT02494583,NCT04908566,NCT04675983,NCT02625610,NCT01336062,NCT00183911,NCT04510064,NCT03959293,NCT02449655,NCT03193918,NCT03281369,NCT04190745,NCT02615730,NCT01641783,NCT04572542,NCT05268510,NCT04604132,NCT02545504,NCT03990103,NCT02448329,NCT04077255,NCT01567618,NCT04523818,NCT02625623,NCT04209686 |
Adenocarcinoma, endocervical typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH0GS9 |
NCT00295789,NCT01755897,NCT04516616,NCT04723875,NCT02020707,NCT00064077
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
