Collective Molecular Activities of the Plant: Artemisia Lactiflora
Plant ID: NPO8681
Plant Latin Name: Artemisia Lactiflora
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
669127
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Indonesia; ChinaTraditional Medicine System:
TCMMedicinal Functions:
Emmenagogue; Tonic
Thailand; Indonesia; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
124 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
76 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
31 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98213
Ingredient ID: NPC94017
Ingredient ID: NPC92970
Ingredient ID: NPC91433
Ingredient ID: NPC88550
Ingredient ID: NPC83744
Ingredient ID: NPC83409
Ingredient ID: NPC80578
Ingredient ID: NPC79294
Ingredient ID: NPC78263
Ingredient ID: NPC77672
Ingredient ID: NPC75989
Ingredient ID: NPC74210
Ingredient ID: NPC73144
Ingredient ID: NPC69731
Ingredient ID: NPC62765
Ingredient ID: NPC60643
Ingredient ID: NPC55778
Ingredient ID: NPC55678
Ingredient ID: NPC54815
Ingredient ID: NPC53887
Ingredient ID: NPC53802
Ingredient ID: NPC51966
Ingredient ID: NPC5115
Ingredient ID: NPC50898
Ingredient ID: NPC46631
Ingredient ID: NPC45188
Ingredient ID: NPC44062
Ingredient ID: NPC37556
Ingredient ID: NPC36875
Ingredient ID: NPC35103
Ingredient ID: NPC31499
Ingredient ID: NPC310291
Ingredient ID: NPC30912
Ingredient ID: NPC306048
Ingredient ID: NPC304871
Ingredient ID: NPC299822
Ingredient ID: NPC297344
Ingredient ID: NPC294726
Ingredient ID: NPC279809
Ingredient ID: NPC279098
Ingredient ID: NPC278744
Ingredient ID: NPC276223
Ingredient ID: NPC275826
Ingredient ID: NPC2738
Ingredient ID: NPC270239
Ingredient ID: NPC269079
Ingredient ID: NPC26884
Ingredient ID: NPC26867
Ingredient ID: NPC265547
Ingredient ID: NPC260268
Ingredient ID: NPC258737
Ingredient ID: NPC257767
Ingredient ID: NPC254171
Ingredient ID: NPC254057
Ingredient ID: NPC253377
Ingredient ID: NPC24971
Ingredient ID: NPC249244
Ingredient ID: NPC249048
Ingredient ID: NPC248293
Ingredient ID: NPC238437
Ingredient ID: NPC236709
Ingredient ID: NPC236626
Ingredient ID: NPC233266
Ingredient ID: NPC231707
Ingredient ID: NPC228781
Ingredient ID: NPC22531
Ingredient ID: NPC224651
Ingredient ID: NPC21777
Ingredient ID: NPC213066
Ingredient ID: NPC20791
Ingredient ID: NPC207254
Ingredient ID: NPC205868
Ingredient ID: NPC203882
Ingredient ID: NPC200639
Ingredient ID: NPC199132
Ingredient ID: NPC194633
Ingredient ID: NPC19240
Ingredient ID: NPC19211
Ingredient ID: NPC190729
Ingredient ID: NPC187006
Ingredient ID: NPC179950
Ingredient ID: NPC174089
Ingredient ID: NPC171363
Ingredient ID: NPC171137
Ingredient ID: NPC170197
Ingredient ID: NPC163757
Ingredient ID: NPC162501
Ingredient ID: NPC161083
Ingredient ID: NPC159323
Ingredient ID: NPC159259
Ingredient ID: NPC156393
Ingredient ID: NPC153696
Ingredient ID: NPC152695
Ingredient ID: NPC151364
Ingredient ID: NPC150531
Ingredient ID: NPC149433
Ingredient ID: NPC149203
Ingredient ID: NPC148739
Ingredient ID: NPC143379
Ingredient ID: NPC142146
Ingredient ID: NPC136717
Ingredient ID: NPC133671
Ingredient ID: NPC133638
Ingredient ID: NPC131076
Ingredient ID: NPC127635
Ingredient ID: NPC127446
Ingredient ID: NPC126200
Ingredient ID: NPC125675
Ingredient ID: NPC125641
Ingredient ID: NPC124834
Ingredient ID: NPC124752
Ingredient ID: NPC124437
Ingredient ID: NPC123210
Ingredient ID: NPC120217
Ingredient ID: NPC11927
Ingredient ID: NPC118369
Ingredient ID: NPC116775
Ingredient ID: NPC11523
Ingredient ID: NPC112903
Ingredient ID: NPC110530
Ingredient ID: NPC107845
Ingredient ID: NPC104287
Ingredient ID: NPC10134
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 37 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01321164 | Fumaric Acid Versus Fumaric Acid Plus Narrow Band Type B Ultraviolet (UVB) for Psoriasis | psoriasis | Fumaric Acid (NPC224651) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01352988 | Efficacy and Safety of Fumaric Acid Esters (Fumaderm®) in the Treatment of Patients With Cutaneous Lupus Erythematosus | cutaneous lupus erythematosus | Fumaric Acid (NPC224651) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,KDR,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,KDM1A,AURKB,TP53,AXL,FLT3,SRC
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,AURKB,TTR,CA12,NPSR1,THPO,CDK1,CYP2C9,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,CISD1,POLB,DPP4,CA2,XDH,HSD17B2,RECQL,NAPRT,AURKB,CYP1B1,CYP2C9,TTR,MET,ALOX15,PIM1,ABCG2,AXL,NPSR1,ALOX5,LMNA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,TTR,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKB,NOX4,ALOX15,MET,NPSR1,CDK1,CYP19A1
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,FLT3,KDR,MET,ESR2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
