Collective Molecular Activities of the Plant: Asimina Triloba
Plant ID: NPO7697
Plant Latin Name: Asimina Triloba
Taxonomy Genus: Asimina
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
12953
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
31 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
15 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97028
Ingredient ID: NPC93794
Ingredient ID: NPC90859
Ingredient ID: NPC81778
Ingredient ID: NPC66288
Ingredient ID: NPC480253
Ingredient ID: NPC480252
Ingredient ID: NPC480220
Ingredient ID: NPC475232
Ingredient ID: NPC474100
Ingredient ID: NPC473504
Ingredient ID: NPC37669
Ingredient ID: NPC331654
Ingredient ID: NPC331613
Ingredient ID: NPC320569
Ingredient ID: NPC318591
Ingredient ID: NPC294965
Ingredient ID: NPC279450
Ingredient ID: NPC274446
Ingredient ID: NPC270837
Ingredient ID: NPC25703
Ingredient ID: NPC256849
Ingredient ID: NPC24101
Ingredient ID: NPC239517
Ingredient ID: NPC234077
Ingredient ID: NPC22005
Ingredient ID: NPC198418
Ingredient ID: NPC161423
Ingredient ID: NPC142117
Ingredient ID: NPC12609
Ingredient ID: NPC110710
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Drug Transporter | SLC superfamily of solute carriers | SLC19A1 | Folate transporter 1 | P41440 | CHEMBL4833 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Drug Transporter | Voltage-gated calcium channel | CACNA1C | Voltage-gated L-type calcium channel alpha-1C subunit | Q13936 | CHEMBL1940 |
| Therapeutic Target | Enzyme | ATIC | AICAR transformylase | P31939 | CHEMBL2518 |
| Therapeutic Target | Metallo protease | METAP2 | Methionine aminopeptidase 2 | P50579 | CHEMBL3922 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C2 | Mineralocorticoid receptor | P08235 | CHEMBL1994 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | PGR | Progesterone receptor | P06401 | CHEMBL208 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C1 | Glucocorticoid receptor | P04150 | CHEMBL2034 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 317 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000197 | Propranolol for Treatment of Cocaine Addiction - 2 | cocaine dependence | Propranolol (NPC318591) | NP level |
| NCT00000492 | Beta-Blocker Heart Attack Trial (BHAT) | myocardial infarction;Myocardial Ischemia;sudden cardiac arrest;ventricular fibrillation | Propranolol (NPC318591) | NP level |
| NCT00000493 | Multicenter Investigation of Limitation of Infarct Size (MILIS) | myocardial infarction;Myocardial Ischemia | Propranolol (NPC318591) | NP level |
| NCT00006044 | Testosterone in Treating Patients With Progressive Prostate Cancer That No Longer Responds to Hormone Therapy | prostate cancer | Testosterone (NPC161423) | NP level |
| NCT00006158 | AIDS Wasting in Women: Anabolic Effects of Testosterone | AIDS | Testosterone (NPC161423) | NP level |
| NCT00069355 | Propranolol for the Treatment of Acute Stress Disorder | injury | Propranolol (NPC318591) | NP level |
| NCT00075855 | Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors | sexual dysfunction | Testosterone (NPC161423) | NP level |
| NCT00080756 | Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease | Hereditary breast and ovarian cancer syndrome | Testosterone (NPC161423) | NP level |
| NCT00089843 | Bone Loss in Women With Anorexia Nervosa | anorexia nervosa | Testosterone (NPC161423) | NP level |
| NCT00093860 | Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance | Syncope | Propranolol (NPC318591) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
ADRB3
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
AR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,HTR2C,NR3C1,FGFR1,ADRB3,HTR2A,PDGFRB,ADRB1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC,PDGFRA,AR,CDK19,FLT3,ABL1,FGFR1,CDK8,KIT
|
Acute stress reactionDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QE84 |
NCT04982211
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TYMS,RET,TSHR,HTR2B,HTR2C
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LCK,CSNK1A1,HCK,ADRB3,TYMS,CACNA1C,CSF1R,PGR,PDGFRB,FOLR2,DDR2,FOLR1,HTR2B,CDK19,TEK,HTR2A,KIT
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SERPINA6
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TYMS,CYP19A1,CDK6,SERPINA6,HTR2C
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
