Collective Molecular Activities of the Plant: Senna Tora
Plant ID: NPO7672
Plant Latin Name: Senna Tora
Taxonomy Genus: Senna
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
362788
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Nigeria; Indonesia; India; Burkina FasoTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Ayurveda; SiddhaMedicinal Functions:
Anthelmintic; Anticholesterolemic; Antispasmodic; Carminative; Febrifuge; Hepatic; Ophthalmic; Parasiticide; Purgative
Thailand; Nigeria; Indonesia; India; Burkina Faso
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
53 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
42 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
35 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97444
Ingredient ID: NPC94076
Ingredient ID: NPC88466
Ingredient ID: NPC70622
Ingredient ID: NPC676
Ingredient ID: NPC5379
Ingredient ID: NPC46958
Ingredient ID: NPC37543
Ingredient ID: NPC3224
Ingredient ID: NPC315417
Ingredient ID: NPC312929
Ingredient ID: NPC305846
Ingredient ID: NPC302783
Ingredient ID: NPC297532
Ingredient ID: NPC291895
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289042
Ingredient ID: NPC288089
Ingredient ID: NPC282923
Ingredient ID: NPC278329
Ingredient ID: NPC278175
Ingredient ID: NPC274769
Ingredient ID: NPC273995
Ingredient ID: NPC267205
Ingredient ID: NPC256263
Ingredient ID: NPC254848
Ingredient ID: NPC254847
Ingredient ID: NPC245585
Ingredient ID: NPC245584
Ingredient ID: NPC245531
Ingredient ID: NPC243062
Ingredient ID: NPC236609
Ingredient ID: NPC2316
Ingredient ID: NPC22523
Ingredient ID: NPC221786
Ingredient ID: NPC213052
Ingredient ID: NPC199463
Ingredient ID: NPC199357
Ingredient ID: NPC19256
Ingredient ID: NPC182472
Ingredient ID: NPC178851
Ingredient ID: NPC176893
Ingredient ID: NPC165122
Ingredient ID: NPC153500
Ingredient ID: NPC146837
Ingredient ID: NPC146803
Ingredient ID: NPC14561
Ingredient ID: NPC108855
Ingredient ID: NPC107638
Ingredient ID: NPC105591
Ingredient ID: NPC103540
Ingredient ID: NPC101401
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Threonine protease | PSMB1 | Proteasome component C5 | P20618 | CHEMBL4208 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 4 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01985321 | Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores | Herpes Labialis | Glycolic Acid (NPC165122) | NP level |
| NCT02126657 | The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars | acne | Glycolic Acid (NPC165122) | NP level |
| NCT02812719 | Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel | freckles | Glycolic Acid (NPC165122) | NP level |
| NCT05362500 | Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma | freckles | Glycolic Acid (NPC165122) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT02126657 |
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2C9,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,F2,CYP2C9
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
