Collective Molecular Activities of the Plant: Echinacea Angustifolia
Country/Region:
United States; Italy; IndiaTraditional Medicine System:
HomeopathyMedicinal Functions:
Adaptogen; Alterative; Antiseptic; Depurative; Diaphoretic; Digestive; Sialagogue; Stings
Canada; Italy; United States; India
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
66 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
44 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
18 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96218
Ingredient ID: NPC90566
Ingredient ID: NPC90232
Ingredient ID: NPC77249
Ingredient ID: NPC63067
Ingredient ID: NPC62805
Ingredient ID: NPC61693
Ingredient ID: NPC57801
Ingredient ID: NPC56028
Ingredient ID: NPC54542
Ingredient ID: NPC49177
Ingredient ID: NPC37214
Ingredient ID: NPC31929
Ingredient ID: NPC308749
Ingredient ID: NPC305288
Ingredient ID: NPC304223
Ingredient ID: NPC29858
Ingredient ID: NPC296288
Ingredient ID: NPC295014
Ingredient ID: NPC291376
Ingredient ID: NPC278683
Ingredient ID: NPC273023
Ingredient ID: NPC272700
Ingredient ID: NPC272103
Ingredient ID: NPC270019
Ingredient ID: NPC26974
Ingredient ID: NPC26229
Ingredient ID: NPC252762
Ingredient ID: NPC24631
Ingredient ID: NPC246108
Ingredient ID: NPC244534
Ingredient ID: NPC243539
Ingredient ID: NPC241653
Ingredient ID: NPC241390
Ingredient ID: NPC238041
Ingredient ID: NPC237196
Ingredient ID: NPC236536
Ingredient ID: NPC236141
Ingredient ID: NPC235251
Ingredient ID: NPC223455
Ingredient ID: NPC223452
Ingredient ID: NPC220324
Ingredient ID: NPC21806
Ingredient ID: NPC217052
Ingredient ID: NPC216127
Ingredient ID: NPC208699
Ingredient ID: NPC193109
Ingredient ID: NPC187659
Ingredient ID: NPC176740
Ingredient ID: NPC168609
Ingredient ID: NPC167759
Ingredient ID: NPC163912
Ingredient ID: NPC157950
Ingredient ID: NPC153958
Ingredient ID: NPC145032
Ingredient ID: NPC140455
Ingredient ID: NPC134016
Ingredient ID: NPC13011
Ingredient ID: NPC12775
Ingredient ID: NPC127122
Ingredient ID: NPC124382
Ingredient ID: NPC123669
Ingredient ID: NPC11911
Ingredient ID: NPC112427
Ingredient ID: NPC105852
Ingredient ID: NPC104428
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 1 | |
 NP level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT03463018 | Echinacea Angustifolia (AnxioCalm) in Anxiety | Generalized Anxiety Disorder | Echinacea Angustifolia | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CNR2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TP53
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,TP53,HSD17B10
|
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
