Collective Molecular Activities of the Plant: Oxera Splendida
Plant ID: NPO7087
Plant Latin Name: Oxera Splendida
Taxonomy Genus: Oxera
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
54231
Plant-of-the-World-Online:
77155760-1
Unknown.
Australia; Papua New Guinea; Indonesia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
70 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
27 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97345
Ingredient ID: NPC96294
Ingredient ID: NPC95447
Ingredient ID: NPC7883
Ingredient ID: NPC78399
Ingredient ID: NPC70946
Ingredient ID: NPC67396
Ingredient ID: NPC61522
Ingredient ID: NPC58085
Ingredient ID: NPC5622
Ingredient ID: NPC50102
Ingredient ID: NPC43918
Ingredient ID: NPC41930
Ingredient ID: NPC39072
Ingredient ID: NPC313148
Ingredient ID: NPC307063
Ingredient ID: NPC302324
Ingredient ID: NPC301377
Ingredient ID: NPC299436
Ingredient ID: NPC293549
Ingredient ID: NPC293319
Ingredient ID: NPC292925
Ingredient ID: NPC292419
Ingredient ID: NPC290791
Ingredient ID: NPC290598
Ingredient ID: NPC281131
Ingredient ID: NPC274618
Ingredient ID: NPC270213
Ingredient ID: NPC266605
Ingredient ID: NPC264145
Ingredient ID: NPC25701
Ingredient ID: NPC252990
Ingredient ID: NPC252044
Ingredient ID: NPC240937
Ingredient ID: NPC23111
Ingredient ID: NPC223834
Ingredient ID: NPC223730
Ingredient ID: NPC22150
Ingredient ID: NPC219934
Ingredient ID: NPC213896
Ingredient ID: NPC212885
Ingredient ID: NPC21210
Ingredient ID: NPC210459
Ingredient ID: NPC201814
Ingredient ID: NPC201800
Ingredient ID: NPC201093
Ingredient ID: NPC2003
Ingredient ID: NPC192811
Ingredient ID: NPC186463
Ingredient ID: NPC178134
Ingredient ID: NPC176740
Ingredient ID: NPC170828
Ingredient ID: NPC169468
Ingredient ID: NPC16895
Ingredient ID: NPC159362
Ingredient ID: NPC157792
Ingredient ID: NPC150385
Ingredient ID: NPC144054
Ingredient ID: NPC142754
Ingredient ID: NPC138122
Ingredient ID: NPC136486
Ingredient ID: NPC135855
Ingredient ID: NPC13143
Ingredient ID: NPC131364
Ingredient ID: NPC122504
Ingredient ID: NPC120621
Ingredient ID: NPC11536
Ingredient ID: NPC113828
Ingredient ID: NPC112585
Ingredient ID: NPC111520
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Other cytosolic protein | HSPA1A | Heat shock 70 kDa protein 1 | P0DMV8 | CHEMBL5460 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Ellagic Acid (NPC178134) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT04011618 | Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion | metabolic syndrome | Ellagic Acid (NPC178134) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
INSR,AKR1B1,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,ACHE,GPR35
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
RECQL,NUAK1,POLB,TEK,ACHE,CES1,ALOX5,MET
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MET
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
INSR,KDR,ACHE,MET
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ALOX5
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
