Collective Molecular Activities of the Plant: Anaphalis Margaritacea
Plant ID: NPO6722
Plant Latin Name: Anaphalis Margaritacea
Taxonomy Genus: Anaphalis
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
49045
Plant-of-the-World-Online:
30173179-2
Unknown.
Canada; Pakistan; Mexico; Nepal; India; United States; Sri Lanka
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
69 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
34 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
20 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95920
Ingredient ID: NPC95381
Ingredient ID: NPC91604
Ingredient ID: NPC88186
Ingredient ID: NPC83733
Ingredient ID: NPC79835
Ingredient ID: NPC77184
Ingredient ID: NPC76902
Ingredient ID: NPC75742
Ingredient ID: NPC7479
Ingredient ID: NPC71915
Ingredient ID: NPC692
Ingredient ID: NPC64381
Ingredient ID: NPC56223
Ingredient ID: NPC50528
Ingredient ID: NPC4309
Ingredient ID: NPC37250
Ingredient ID: NPC33378
Ingredient ID: NPC32833
Ingredient ID: NPC30856
Ingredient ID: NPC307270
Ingredient ID: NPC307113
Ingredient ID: NPC304552
Ingredient ID: NPC284104
Ingredient ID: NPC274516
Ingredient ID: NPC273965
Ingredient ID: NPC270674
Ingredient ID: NPC268755
Ingredient ID: NPC267838
Ingredient ID: NPC267179
Ingredient ID: NPC26306
Ingredient ID: NPC262922
Ingredient ID: NPC25455
Ingredient ID: NPC243014
Ingredient ID: NPC242419
Ingredient ID: NPC241997
Ingredient ID: NPC232572
Ingredient ID: NPC230301
Ingredient ID: NPC22861
Ingredient ID: NPC227952
Ingredient ID: NPC2232
Ingredient ID: NPC217245
Ingredient ID: NPC216515
Ingredient ID: NPC212911
Ingredient ID: NPC212874
Ingredient ID: NPC206687
Ingredient ID: NPC205152
Ingredient ID: NPC204025
Ingredient ID: NPC195749
Ingredient ID: NPC184608
Ingredient ID: NPC180256
Ingredient ID: NPC1786
Ingredient ID: NPC175795
Ingredient ID: NPC16983
Ingredient ID: NPC169493
Ingredient ID: NPC161543
Ingredient ID: NPC160633
Ingredient ID: NPC153375
Ingredient ID: NPC151448
Ingredient ID: NPC147753
Ingredient ID: NPC145901
Ingredient ID: NPC139665
Ingredient ID: NPC136633
Ingredient ID: NPC129683
Ingredient ID: NPC129253
Ingredient ID: NPC126681
Ingredient ID: NPC122819
Ingredient ID: NPC119405
Ingredient ID: NPC119343
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Transcription factor | GLI1 | Zinc finger protein GLI1 | P08151 | CHEMBL5461 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 19 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00005658 | Glycine to Treat Psychotic Disorders in Children | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00133406 | Long-term Impact and Intervention for Diarrhea in Brazil | diarrheal disease | Glycine (NPC126681) | NP level |
| NCT00133562 | HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition | malnutrition | Glycine (NPC126681) | NP level |
| NCT00222235 | Adjunctive Treatment for Decreasing Symptoms of Schizophrenia | schizoaffective disorder;schizophrenia | Glycine (NPC126681) | NP level |
| NCT00268749 | Glycine Treatment of Prodromal Symptoms | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00276263 | Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00291226 | Glycine vs Placebo for the Schizophrenia Prodrome | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00338221 | Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition | malnutrition | Glycine (NPC126681) | NP level |
| NCT00575848 | Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia | schizoaffective disorder;schizophrenia | Glycine (NPC126681) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
GLI1,OR51E2,F2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
NCT04740580
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
NCT01501942 |
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT01720316
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
