Collective Molecular Activities of the Plant: Ligularia Songarica
Plant ID: NPO5813
Plant Latin Name: Ligularia Songarica
Taxonomy Genus: Ligularia
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
27 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
12 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC92898
Ingredient ID: NPC83938
Ingredient ID: NPC71074
Ingredient ID: NPC65905
Ingredient ID: NPC50898
Ingredient ID: NPC470980
Ingredient ID: NPC470979
Ingredient ID: NPC470978
Ingredient ID: NPC470975
Ingredient ID: NPC470974
Ingredient ID: NPC470973
Ingredient ID: NPC470972
Ingredient ID: NPC307176
Ingredient ID: NPC304309
Ingredient ID: NPC301589
Ingredient ID: NPC300351
Ingredient ID: NPC284172
Ingredient ID: NPC282188
Ingredient ID: NPC270383
Ingredient ID: NPC263049
Ingredient ID: NPC231772
Ingredient ID: NPC228834
Ingredient ID: NPC222898
Ingredient ID: NPC22140
Ingredient ID: NPC189142
Ingredient ID: NPC166190
Ingredient ID: NPC140255
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C2 | Mineralocorticoid receptor | P08235 | CHEMBL1994 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C1 | Glucocorticoid receptor | P04150 | CHEMBL2034 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | PGR | Progesterone receptor | P06401 | CHEMBL208 |
| Therapeutic Target | Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 105 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000176 | Alzheimer's Disease Prevention Trial | Alzheimer disease;memory impairment | Progesterone (NPC307176) | NP level |
| NCT00000295 | Progesterone Treatment in Female Smokers - 12 | nicotine dependence | Progesterone (NPC307176) | NP level |
| NCT00000430 | Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis | Osteopenia;osteoporosis | Progesterone (NPC307176) | NP level |
| NCT00000466 | Postmenopausal Estrogen/Progestin Interventions (PEPI) | diabetes mellitus;Hypercholesterolemia;hypertension;menopause;Myocardial Ischemia;osteoporosis;thrombotic disease | Progesterone (NPC307176) | NP level |
| NCT00000555 | Women's Angiographic Vitamin and Estrogen Trial (WAVE) | menopause;Myocardial Ischemia | Progesterone (NPC307176) | NP level |
| NCT00000601 | Postmenopausal Hormone Therapy in Unstable Angina | intermediate coronary syndrome;menopause | Progesterone (NPC307176) | NP level |
| NCT00001481 | The Role of Hormones in Postpartum Mood Disorders | postpartum depression | Progesterone (NPC307176) | NP level |
| NCT00006399 | Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease | Alzheimer disease | Progesterone (NPC307176) | NP level |
| NCT00029536 | Progesterone vs Placebo Therapy for Women With Epilepsy | epilepsy | Progesterone (NPC307176) | NP level |
| NCT00048646 | Progesterone Treatment of Blunt Traumatic Brain Injury | brain injury | Progesterone (NPC307176) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
AR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA,MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HSD11B1,DPP4,NR3C1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK8,AR
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,THPO,XDH,TTR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,PGR,DPP4,XDH,CYP1B1,CYP2C19,MAOB,HSD11B1,HIF1A,TTR
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SERPINA6,TTR
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SERPINA6,CYP19A1
|
Adrenocortical insufficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A74 |
NR3C2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
