Collective Molecular Activities of the Plant: Ophioglossum Vulgatum
Plant ID: NPO5764
Plant Latin Name: Ophioglossum Vulgatum
Taxonomy Genus: Ophioglossum
Taxonomy Family: Ophioglossaceae
Plant External Links:
NCBI TaxonomyDB:
49227
Plant-of-the-World-Online:
n.a.
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Emetic; Skin; Vulnerary
India; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
106 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
89 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95309
Ingredient ID: NPC91858
Ingredient ID: NPC87457
Ingredient ID: NPC86126
Ingredient ID: NPC80230
Ingredient ID: NPC79273
Ingredient ID: NPC74101
Ingredient ID: NPC7302
Ingredient ID: NPC71665
Ingredient ID: NPC68816
Ingredient ID: NPC66501
Ingredient ID: NPC58212
Ingredient ID: NPC56184
Ingredient ID: NPC55802
Ingredient ID: NPC55138
Ingredient ID: NPC51945
Ingredient ID: NPC50230
Ingredient ID: NPC45956
Ingredient ID: NPC39068
Ingredient ID: NPC3753
Ingredient ID: NPC34497
Ingredient ID: NPC33611
Ingredient ID: NPC32938
Ingredient ID: NPC32373
Ingredient ID: NPC32222
Ingredient ID: NPC3182
Ingredient ID: NPC310837
Ingredient ID: NPC310512
Ingredient ID: NPC309399
Ingredient ID: NPC299676
Ingredient ID: NPC297280
Ingredient ID: NPC294575
Ingredient ID: NPC292559
Ingredient ID: NPC285390
Ingredient ID: NPC283039
Ingredient ID: NPC279666
Ingredient ID: NPC277279
Ingredient ID: NPC274022
Ingredient ID: NPC269802
Ingredient ID: NPC268466
Ingredient ID: NPC264107
Ingredient ID: NPC263043
Ingredient ID: NPC261652
Ingredient ID: NPC260484
Ingredient ID: NPC260473
Ingredient ID: NPC254808
Ingredient ID: NPC252655
Ingredient ID: NPC245948
Ingredient ID: NPC24567
Ingredient ID: NPC241643
Ingredient ID: NPC240308
Ingredient ID: NPC239936
Ingredient ID: NPC237946
Ingredient ID: NPC230968
Ingredient ID: NPC227894
Ingredient ID: NPC227331
Ingredient ID: NPC226008
Ingredient ID: NPC225284
Ingredient ID: NPC224291
Ingredient ID: NPC223064
Ingredient ID: NPC219106
Ingredient ID: NPC218973
Ingredient ID: NPC218525
Ingredient ID: NPC216460
Ingredient ID: NPC215894
Ingredient ID: NPC21430
Ingredient ID: NPC213336
Ingredient ID: NPC210354
Ingredient ID: NPC199786
Ingredient ID: NPC19890
Ingredient ID: NPC197011
Ingredient ID: NPC195777
Ingredient ID: NPC193770
Ingredient ID: NPC19202
Ingredient ID: NPC191436
Ingredient ID: NPC188650
Ingredient ID: NPC184639
Ingredient ID: NPC183193
Ingredient ID: NPC181474
Ingredient ID: NPC180903
Ingredient ID: NPC179546
Ingredient ID: NPC172968
Ingredient ID: NPC172298
Ingredient ID: NPC171512
Ingredient ID: NPC169418
Ingredient ID: NPC166303
Ingredient ID: NPC165780
Ingredient ID: NPC165462
Ingredient ID: NPC165241
Ingredient ID: NPC161923
Ingredient ID: NPC160295
Ingredient ID: NPC156249
Ingredient ID: NPC155922
Ingredient ID: NPC149505
Ingredient ID: NPC146081
Ingredient ID: NPC142545
Ingredient ID: NPC137320
Ingredient ID: NPC133666
Ingredient ID: NPC132263
Ingredient ID: NPC125226
Ingredient ID: NPC119753
Ingredient ID: NPC119277
Ingredient ID: NPC117581
Ingredient ID: NPC115388
Ingredient ID: NPC101755
Ingredient ID: NPC100570
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | NR3C1 | Glucocorticoid receptor | P04150 | CHEMBL2034 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 6 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01062620 | A Dose Escalating Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer | neoplasm | Picropodophyllotoxin (NPC32373) | NP level |
| NCT01466647 | A Study of the IGF-1R Inhibitor AXL1717 in Combination With Gemcitabine HCL and Carboplatin to Treat Non-small-cell Lung Cancer (NSCLC) | non-small cell lung carcinoma | Picropodophyllotoxin (NPC32373) | NP level |
| NCT01561456 | Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung | lung adenocarcinoma;squamous cell carcinoma | Picropodophyllotoxin (NPC32373) | NP level |
| NCT01721577 | Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas | anaplastic astrocytoma;anaplastic oligodendroglioma;gliosarcoma | Picropodophyllotoxin (NPC32373) | NP level |
| NCT01725555 | A Study to Assess the Effect of Food on the Bioavailability of the IGF-1R Inhibitor AXL1717 in Patients With Advanced Malignant Tumors | lymphoid neoplasm | Picropodophyllotoxin (NPC32373) | NP level |
| NCT03532776 | Comparison Between Podofilox Topical Gel 0.5% and Allergan's Condylox® Gel 0.5% for External Anogenital Warts | anogenital venereal wart | Podofilox (NPC237946) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
NR3C1
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9,CA12,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPC1,HIF1A,PAX8,CA9,CA2,TUBB6,CA7,CA14,LMNA
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT01561456
|
Adrenogenital disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A71 |
NR3C1
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
NR3C1
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
NCT03532776
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
