Collective Molecular Activities of the Plant: Arisaema Erubescens
Country/Region:
South KoreaTraditional Medicine System:
South Korea; Nepal
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
60 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
7 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
14 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9566
Ingredient ID: NPC87372
Ingredient ID: NPC79498
Ingredient ID: NPC78736
Ingredient ID: NPC65609
Ingredient ID: NPC61198
Ingredient ID: NPC60548
Ingredient ID: NPC43246
Ingredient ID: NPC34086
Ingredient ID: NPC33103
Ingredient ID: NPC33050
Ingredient ID: NPC309192
Ingredient ID: NPC305683
Ingredient ID: NPC304984
Ingredient ID: NPC30439
Ingredient ID: NPC295501
Ingredient ID: NPC289
Ingredient ID: NPC287876
Ingredient ID: NPC28198
Ingredient ID: NPC281657
Ingredient ID: NPC280251
Ingredient ID: NPC27794
Ingredient ID: NPC276121
Ingredient ID: NPC275755
Ingredient ID: NPC27230
Ingredient ID: NPC270768
Ingredient ID: NPC264088
Ingredient ID: NPC260463
Ingredient ID: NPC25352
Ingredient ID: NPC250089
Ingredient ID: NPC245450
Ingredient ID: NPC219342
Ingredient ID: NPC190243
Ingredient ID: NPC186817
Ingredient ID: NPC18335
Ingredient ID: NPC174679
Ingredient ID: NPC173899
Ingredient ID: NPC173750
Ingredient ID: NPC171139
Ingredient ID: NPC165962
Ingredient ID: NPC157530
Ingredient ID: NPC156639
Ingredient ID: NPC156461
Ingredient ID: NPC154705
Ingredient ID: NPC150596
Ingredient ID: NPC14630
Ingredient ID: NPC14330
Ingredient ID: NPC141787
Ingredient ID: NPC138474
Ingredient ID: NPC134560
Ingredient ID: NPC124244
Ingredient ID: NPC116766
Ingredient ID: NPC116545
Ingredient ID: NPC113877
Ingredient ID: NPC112400
Ingredient ID: NPC11170
Ingredient ID: NPC109594
Ingredient ID: NPC108112
Ingredient ID: NPC102027
Ingredient ID: NPC100005
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 29 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
| NCT01747174 | REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT02681913 | Adenosine as an Adjunct to Blood Cardioplegia | cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00590070 | THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction | myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT01932112 | Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial) | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT05014061 | Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction | Myocardial Ischemia | Adenosine (NPC156461) | NP level |
| NCT00845689 | Prevention of Liver Damage During Liver Surgery | neoplasm | Adenosine (NPC156461) | NP level |
| NCT00322764 | Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression | bipolar disorder | Uridine (NPC43246) | NP level |
| NCT03032965 | Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation | atrial fibrillation | Adenosine (NPC156461) | NP level |
| NCT04392362 | A Trial to Compare American Heart Association (AHA) and Simple (SIM)Method to Give Adenosine to Treat Supra-ventricular Tachycardia (SVT) | ventricular tachycardia | Adenosine (NPC156461) | NP level |
| NCT01485315 | Transfusion-requirements in Septic Shock Trial | septic shock | Adenine (NPC18335) | NP level |
| NCT00751491 | Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI) | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT04666454 | BROKEN-SWEDEHEART-Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT02867878 | Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome | Takotsubo cardiomyopathy | Adenosine (NPC156461) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT01593644 | Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT00580905 | Role of Adenosine in the Release of VEGF and Cytokines | inflammation | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00210080 | A Study to Diagnose Lung Cancer by Sputum Cytology (01-312) | lung cancer | Uridine (NPC43246) | NP level |
| NCT01690884 | Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT01123525 | Adenosine Cardioplegia | angina pectoris | Adenosine (NPC156461) | NP level |
| NCT00714103 | 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Adenosine (NPC156461) | NP level |
| NCT00781404 | Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI | acute myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00612521 | Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis | coronary stenosis | Adenosine (NPC156461) | NP level |
| NCT00841269 | Oral Uridine for Treatment of Bipolar Depression in Adolescents | bipolar disorder | Uridine (NPC43246) | NP level |
| NCT03236311 | A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI | coronary artery disease | Adenosine (NPC156461) | NP level |
| NCT04588441 | The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19 | acute respiratory distress syndrome | Adenosine (NPC156461) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
F3,CDA,ADORA2A,ADORA3
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ADORA3,CDA,ADORA1,SLCO1B3
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
ADORA2A,ADORA3,ADORA1
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT01690884,NCT03236311,NCT01593644
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ADORA1,CDA,ADORA2A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA3,SLCO1B3,ADORA2A
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ADORA1,ADORA2A
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ADORA2A,ADORA1
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
ADORA2A,ADORA1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
NCT04588441 |
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ADORA2A
NCT00210080 |
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADORA2A,ADORA1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT00349921,NCT00298636
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01123525,NCT00751491
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01932112,NCT03032965
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT00841269,NCT00322764
|
Stress-induced cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.5 |
NCT04666454,NCT02867878
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
F3,ADORA1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ADORA3,ADORA2A
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ADORA1,F3
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ADORA3,ADORA3
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ADORA3,ADORA2A
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADORA1,ADORA1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLCO1B3,CDA
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ADORA1,CDA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B3,CDA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ADORA2A,F3
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ADORA3,ADORA2A
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CDA,ADORA2A
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
ADORA3
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADORA2A
|
Supraventricular tachyarrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81 |
ADORA1
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
ADORA2A
|
Unspecific substance use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4Z |
ADORA2A
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ADORA3
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
ADORA2A
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ADORA2A
|
Cardiac arrhythmiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC9Z |
ADORA1
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
ADORA3
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
ADORA2A
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ADORA2A
|
Radionuclide imagingDisease Category: NADisease ICD-11 Code: N.A. |
ADORA2A
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADORA2A
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADORA2A
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
ADORA3
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
ADORA2A
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ADORA3
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ADORA1
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
ADORA2A
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NCT00590070
|
Diseases of coronary artery, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Z |
NCT00612521
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT01485315
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
NCT00179010
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00845689
|
Ventricular tachycardiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71.0 |
NCT04392362
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT05014061
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT00580905
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
NCT02681913
|
Chronic lymphocytic leukaemia or small lymphocytic lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82.0 |
NCT00714103
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00565188
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ADORA1
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
SLCO1B3
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
SLCO1B3
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ADORA2A
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
SLCO1B3
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B3
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SLCO1B3
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
ADORA2A
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SLCO1B3
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ADORA2A
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ADORA3
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
ADORA2A
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
SLCO1B3
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
SLCO1B3
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SLCO1B3
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ADORA2A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B3
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
ADORA3
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
SLCO1B3
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
ADORA2A
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
ADORA3
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
ADORA3
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CDA
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ADORA3
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ADORA1
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
ADORA3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
