Collective Molecular Activities of the Plant: Typha Angustata
Plant ID: NPO5243
Plant Latin Name: Typha Angustata
Taxonomy Genus: Typha
Taxonomy Family: Typhaceae
Plant External Links:
NCBI TaxonomyDB:
453243
Plant-of-the-World-Online:
n.a.
Country/Region:
China; IndiaTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; AyurvedaIndia; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
46 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
17 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
8 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94699
Ingredient ID: NPC90232
Ingredient ID: NPC86412
Ingredient ID: NPC78585
Ingredient ID: NPC78437
Ingredient ID: NPC7753
Ingredient ID: NPC72063
Ingredient ID: NPC62387
Ingredient ID: NPC53028
Ingredient ID: NPC326329
Ingredient ID: NPC323434
Ingredient ID: NPC311485
Ingredient ID: NPC30277
Ingredient ID: NPC296258
Ingredient ID: NPC283274
Ingredient ID: NPC264726
Ingredient ID: NPC261038
Ingredient ID: NPC257885
Ingredient ID: NPC253509
Ingredient ID: NPC249045
Ingredient ID: NPC236709
Ingredient ID: NPC218109
Ingredient ID: NPC216714
Ingredient ID: NPC214046
Ingredient ID: NPC211913
Ingredient ID: NPC209971
Ingredient ID: NPC209970
Ingredient ID: NPC187911
Ingredient ID: NPC186653
Ingredient ID: NPC18335
Ingredient ID: NPC174660
Ingredient ID: NPC173208
Ingredient ID: NPC170067
Ingredient ID: NPC164700
Ingredient ID: NPC163242
Ingredient ID: NPC158306
Ingredient ID: NPC148756
Ingredient ID: NPC148086
Ingredient ID: NPC140939
Ingredient ID: NPC140737
Ingredient ID: NPC132565
Ingredient ID: NPC131013
Ingredient ID: NPC126004
Ingredient ID: NPC125731
Ingredient ID: NPC116990
Ingredient ID: NPC111888
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 46 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00113854 | Mannitol as Adjunct Therapy for Childhood Cerebral Malaria | malaria | Mannitol (NPC86412) | NP level |
| NCT00117208 | Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00189007 | Antenatal Allopurinol During Fetal Hypoxia | fetal hypoxia | Mannitol (NPC86412) | NP level |
| NCT00251056 | Mannitol Dose Response Study in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00277537 | Safety and Efficacy of Bronchitol in Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT00303849 | Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors | anaplastic oligodendroglioma | Mannitol (NPC86412) | NP level |
| NCT00359697 | Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure | intracranial hypertension | Mannitol (NPC86412) | NP level |
| NCT00446667 | A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD | chronic obstructive pulmonary disease | Mannitol (NPC86412) | NP level |
| NCT00446680 | Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00455130 | A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
NCT02861898
|
BronchiectasisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA24 |
NCT01076491,NCT00277537,NCT00669331,NCT00730977
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT01233492
|
Cerebral oedemaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.1 |
NCT02037815,NCT03573999
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Chronic myeloid leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4XG8 |
NCT03747679
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT00446667
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT04534465
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT04870073
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
