CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Berberis Japonica

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO5144
Plant Latin Name: Berberis Japonica
Taxonomy Genus: Berberis
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 116719
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

89 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

54 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

17 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98900

Ingredient ID: NPC96553

Ingredient ID: NPC96294

Ingredient ID: NPC91382

Ingredient ID: NPC88864

Ingredient ID: NPC88132

Ingredient ID: NPC86239

Ingredient ID: NPC83423

Ingredient ID: NPC79549

Ingredient ID: NPC78673

Ingredient ID: NPC70488

Ingredient ID: NPC61527

Ingredient ID: NPC57486

Ingredient ID: NPC53844

Ingredient ID: NPC51952

Ingredient ID: NPC47746

Ingredient ID: NPC43791

Ingredient ID: NPC39372

Ingredient ID: NPC33186

Ingredient ID: NPC311509

Ingredient ID: NPC305796

Ingredient ID: NPC301903

Ingredient ID: NPC301377

Ingredient ID: NPC29799

Ingredient ID: NPC294189

Ingredient ID: NPC28728

Ingredient ID: NPC286124

Ingredient ID: NPC284021

Ingredient ID: NPC281733

Ingredient ID: NPC27951

Ingredient ID: NPC279251

Ingredient ID: NPC276178

Ingredient ID: NPC275821

Ingredient ID: NPC275593

Ingredient ID: NPC274791

Ingredient ID: NPC269989

Ingredient ID: NPC26324

Ingredient ID: NPC261414

Ingredient ID: NPC256298

Ingredient ID: NPC248109

Ingredient ID: NPC242991

Ingredient ID: NPC24093

Ingredient ID: NPC239546

Ingredient ID: NPC22704

Ingredient ID: NPC221622

Ingredient ID: NPC217635

Ingredient ID: NPC217266

Ingredient ID: NPC214009

Ingredient ID: NPC210930

Ingredient ID: NPC208542

Ingredient ID: NPC205234

Ingredient ID: NPC205186

Ingredient ID: NPC204991

Ingredient ID: NPC202605

Ingredient ID: NPC195427

Ingredient ID: NPC193907

Ingredient ID: NPC190584

Ingredient ID: NPC188336

Ingredient ID: NPC186918

Ingredient ID: NPC183485

Ingredient ID: NPC181790

Ingredient ID: NPC17976

Ingredient ID: NPC178453

Ingredient ID: NPC176058

Ingredient ID: NPC171409

Ingredient ID: NPC166604

Ingredient ID: NPC16452

Ingredient ID: NPC161103

Ingredient ID: NPC160517

Ingredient ID: NPC157579

Ingredient ID: NPC153170

Ingredient ID: NPC147278

Ingredient ID: NPC144876

Ingredient ID: NPC141378

Ingredient ID: NPC13826

Ingredient ID: NPC134621

Ingredient ID: NPC132198

Ingredient ID: NPC121877

Ingredient ID: NPC12053

Ingredient ID: NPC119871

Ingredient ID: NPC11823

Ingredient ID: NPC115096

Ingredient ID: NPC113472

Ingredient ID: NPC11203

Ingredient ID: NPC112016

Ingredient ID: NPC10908

Ingredient ID: NPC108287

Ingredient ID: NPC10587

Ingredient ID: NPC101638

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Show entries

Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 2 of 2 entries

Previous1Next

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

Show entries

Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CA12
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	LMNA
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA12
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA12
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CA12,LMNA
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA12
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA12,LMNA
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	CA12
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	CA12,CA12

Showing 1 to 10 of 23 entries

Previous1 2 3Next

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Berberis Japonica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

89 All known Ingredients in Total

54 Ingredients with Acceptable Bioavailablity

17 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Bacterial infection

Breast cancer

Chikungunya virus disease

Diffuse large B-cell lymphomas

Germ cell tumour of testis

Glioblastoma of brain

Hepatoblastoma

Hepatocellular carcinoma of liver

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities