Plant ID: NPO4947
Plant Latin Name: Tagetes Minuta
Taxonomy Genus: Tagetes
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
169607
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC98086
Ingredient ID: NPC8981
Ingredient ID: NPC76924
Ingredient ID: NPC66577
Ingredient ID: NPC55247
Ingredient ID: NPC46565
Ingredient ID: NPC33906
Ingredient ID: NPC292559
Ingredient ID: NPC239938
Ingredient ID: NPC231852
Ingredient ID: NPC223277
Ingredient ID: NPC222713
Ingredient ID: NPC218525
Ingredient ID: NPC218359
Ingredient ID: NPC19123
Ingredient ID: NPC166303
Ingredient ID: NPC133115
Ingredient ID: NPC108779
Ingredient ID: NPC108218
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Histone deacetylase | HDAC2 | Histone deacetylase 2 | Q92769 | CHEMBL1937 |
Therapeutic Target | Histone deacetylase | HDAC8 | Histone deacetylase 8 | Q9BY41 | CHEMBL3192 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
HDAC2,HDAC8,CYP3A4
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HDAC8,HDAC2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP3A4,HDAC2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
HDAC8,HDAC2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
HDAC2
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HDAC2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP3A4
|