Collective Molecular Activities of the Plant: Mosla Scabra
Plant ID: NPO4176
Plant Latin Name: Mosla Scabra
Taxonomy Genus: Mosla
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
1898873
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
55 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
30 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97131
Ingredient ID: NPC95796
Ingredient ID: NPC88131
Ingredient ID: NPC87389
Ingredient ID: NPC82183
Ingredient ID: NPC78182
Ingredient ID: NPC70122
Ingredient ID: NPC59642
Ingredient ID: NPC54603
Ingredient ID: NPC54408
Ingredient ID: NPC52593
Ingredient ID: NPC44945
Ingredient ID: NPC41170
Ingredient ID: NPC35961
Ingredient ID: NPC34402
Ingredient ID: NPC33611
Ingredient ID: NPC33271
Ingredient ID: NPC32741
Ingredient ID: NPC311702
Ingredient ID: NPC305529
Ingredient ID: NPC305483
Ingredient ID: NPC302733
Ingredient ID: NPC28943
Ingredient ID: NPC286283
Ingredient ID: NPC265140
Ingredient ID: NPC264885
Ingredient ID: NPC258563
Ingredient ID: NPC258483
Ingredient ID: NPC241307
Ingredient ID: NPC214491
Ingredient ID: NPC212823
Ingredient ID: NPC205980
Ingredient ID: NPC204838
Ingredient ID: NPC204578
Ingredient ID: NPC203634
Ingredient ID: NPC198658
Ingredient ID: NPC189248
Ingredient ID: NPC184184
Ingredient ID: NPC18316
Ingredient ID: NPC181904
Ingredient ID: NPC18136
Ingredient ID: NPC175174
Ingredient ID: NPC173875
Ingredient ID: NPC172373
Ingredient ID: NPC172136
Ingredient ID: NPC168188
Ingredient ID: NPC162470
Ingredient ID: NPC138030
Ingredient ID: NPC135167
Ingredient ID: NPC12710
Ingredient ID: NPC12116
Ingredient ID: NPC107791
Ingredient ID: NPC10602
Ingredient ID: NPC10522
Ingredient ID: NPC105205
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
