Collective Molecular Activities of the Plant: Eleutherococcus Giraldii
Plant ID: NPO3608
Plant Latin Name: Eleutherococcus Giraldii
Taxonomy Genus: Eleutherococcus
Taxonomy Family: Araliaceae
Plant External Links:
NCBI TaxonomyDB:
265763
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
137 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
123 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
18 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98340
Ingredient ID: NPC97965
Ingredient ID: NPC97632
Ingredient ID: NPC97455
Ingredient ID: NPC92573
Ingredient ID: NPC8981
Ingredient ID: NPC89102
Ingredient ID: NPC88150
Ingredient ID: NPC86541
Ingredient ID: NPC85813
Ingredient ID: NPC83798
Ingredient ID: NPC7934
Ingredient ID: NPC77338
Ingredient ID: NPC76145
Ingredient ID: NPC74923
Ingredient ID: NPC66577
Ingredient ID: NPC63632
Ingredient ID: NPC61769
Ingredient ID: NPC61076
Ingredient ID: NPC59804
Ingredient ID: NPC57877
Ingredient ID: NPC51758
Ingredient ID: NPC51743
Ingredient ID: NPC46072
Ingredient ID: NPC46056
Ingredient ID: NPC42471
Ingredient ID: NPC37818
Ingredient ID: NPC36408
Ingredient ID: NPC314267
Ingredient ID: NPC312592
Ingredient ID: NPC311749
Ingredient ID: NPC310491
Ingredient ID: NPC309778
Ingredient ID: NPC306418
Ingredient ID: NPC303693
Ingredient ID: NPC302416
Ingredient ID: NPC301632
Ingredient ID: NPC300561
Ingredient ID: NPC299401
Ingredient ID: NPC299367
Ingredient ID: NPC298215
Ingredient ID: NPC290864
Ingredient ID: NPC290078
Ingredient ID: NPC28913
Ingredient ID: NPC289032
Ingredient ID: NPC288656
Ingredient ID: NPC285391
Ingredient ID: NPC282635
Ingredient ID: NPC281220
Ingredient ID: NPC280381
Ingredient ID: NPC279870
Ingredient ID: NPC279508
Ingredient ID: NPC276673
Ingredient ID: NPC276516
Ingredient ID: NPC276262
Ingredient ID: NPC27460
Ingredient ID: NPC271450
Ingredient ID: NPC270348
Ingredient ID: NPC270028
Ingredient ID: NPC26960
Ingredient ID: NPC263662
Ingredient ID: NPC261962
Ingredient ID: NPC259459
Ingredient ID: NPC255488
Ingredient ID: NPC254713
Ingredient ID: NPC2514
Ingredient ID: NPC249910
Ingredient ID: NPC249012
Ingredient ID: NPC249009
Ingredient ID: NPC246172
Ingredient ID: NPC239406
Ingredient ID: NPC238520
Ingredient ID: NPC236224
Ingredient ID: NPC233533
Ingredient ID: NPC231738
Ingredient ID: NPC23145
Ingredient ID: NPC230747
Ingredient ID: NPC228401
Ingredient ID: NPC227750
Ingredient ID: NPC225463
Ingredient ID: NPC223455
Ingredient ID: NPC221778
Ingredient ID: NPC220053
Ingredient ID: NPC219306
Ingredient ID: NPC216692
Ingredient ID: NPC216630
Ingredient ID: NPC215835
Ingredient ID: NPC214907
Ingredient ID: NPC212442
Ingredient ID: NPC210831
Ingredient ID: NPC20550
Ingredient ID: NPC200294
Ingredient ID: NPC198706
Ingredient ID: NPC196795
Ingredient ID: NPC196636
Ingredient ID: NPC195713
Ingredient ID: NPC191474
Ingredient ID: NPC190027
Ingredient ID: NPC189853
Ingredient ID: NPC180855
Ingredient ID: NPC179831
Ingredient ID: NPC177112
Ingredient ID: NPC174812
Ingredient ID: NPC171538
Ingredient ID: NPC165973
Ingredient ID: NPC164935
Ingredient ID: NPC16157
Ingredient ID: NPC160525
Ingredient ID: NPC156655
Ingredient ID: NPC156433
Ingredient ID: NPC155182
Ingredient ID: NPC15447
Ingredient ID: NPC153046
Ingredient ID: NPC152005
Ingredient ID: NPC149115
Ingredient ID: NPC145294
Ingredient ID: NPC143591
Ingredient ID: NPC142752
Ingredient ID: NPC13991
Ingredient ID: NPC137797
Ingredient ID: NPC131489
Ingredient ID: NPC128425
Ingredient ID: NPC128174
Ingredient ID: NPC126368
Ingredient ID: NPC125359
Ingredient ID: NPC12421
Ingredient ID: NPC123034
Ingredient ID: NPC122121
Ingredient ID: NPC114011
Ingredient ID: NPC108348
Ingredient ID: NPC107325
Ingredient ID: NPC105539
Ingredient ID: NPC105509
Ingredient ID: NPC102889
Ingredient ID: NPC101733
Ingredient ID: NPC100395
Ingredient ID: NPC100037
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 8 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1C3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,AKR1C3,FFAR4,FABP3,ALOX15,OR51E2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00029679
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT00908791
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FABP5,ALOX15,FFAR4,FFAR1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FFAR4,OR51E2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
FFAR1,LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
