Collective Molecular Activities of the Plant: Geranium Collinum
Plant ID: NPO3521
Plant Latin Name: Geranium Collinum
Taxonomy Genus: Geranium
Taxonomy Family: Geraniaceae
Plant External Links:
NCBI TaxonomyDB:
1368250
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
54 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
51 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC88255
Ingredient ID: NPC84585
Ingredient ID: NPC72184
Ingredient ID: NPC68224
Ingredient ID: NPC65196
Ingredient ID: NPC63599
Ingredient ID: NPC61473
Ingredient ID: NPC60825
Ingredient ID: NPC56386
Ingredient ID: NPC53069
Ingredient ID: NPC51174
Ingredient ID: NPC51129
Ingredient ID: NPC308771
Ingredient ID: NPC293933
Ingredient ID: NPC291419
Ingredient ID: NPC289795
Ingredient ID: NPC281517
Ingredient ID: NPC279292
Ingredient ID: NPC273103
Ingredient ID: NPC260491
Ingredient ID: NPC254262
Ingredient ID: NPC239128
Ingredient ID: NPC22675
Ingredient ID: NPC224526
Ingredient ID: NPC223263
Ingredient ID: NPC212794
Ingredient ID: NPC212452
Ingredient ID: NPC211203
Ingredient ID: NPC210148
Ingredient ID: NPC208104
Ingredient ID: NPC206155
Ingredient ID: NPC202009
Ingredient ID: NPC197459
Ingredient ID: NPC192768
Ingredient ID: NPC190298
Ingredient ID: NPC189960
Ingredient ID: NPC185467
Ingredient ID: NPC179400
Ingredient ID: NPC179007
Ingredient ID: NPC176482
Ingredient ID: NPC165693
Ingredient ID: NPC165395
Ingredient ID: NPC159823
Ingredient ID: NPC159082
Ingredient ID: NPC15848
Ingredient ID: NPC150648
Ingredient ID: NPC142165
Ingredient ID: NPC137074
Ingredient ID: NPC136994
Ingredient ID: NPC123965
Ingredient ID: NPC122172
Ingredient ID: NPC119158
Ingredient ID: NPC111485
Ingredient ID: NPC103904
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 10 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
| NCT02082756 | Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment | prediabetes syndrome | Berberine (NPC53069) | NP level |
| NCT02084004 | Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT02226185 | Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT02548832 | Bezafibrate Plus Berberine in Mixed Dyslipidemia | Combined hyperlipidemia | Berberine (NPC53069) | NP level |
| NCT02861261 | A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT03281096 | A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT03333265 | Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT03486496 | Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation | lung adenocarcinoma | Berberine (NPC53069) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,ACHE
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT03333265,NCT02226185,NCT03281096
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ACHE
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ACHE
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
