Collective Molecular Activities of the Plant: Cinnamomum Zeylanicum
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PLANiTS DNA barcode
Taxonomic Information
Plant ID: NPO31015
Plant Latin Name: Cinnamomum Zeylanicum
Taxonomy Genus: Cinnamomum
Taxonomy Family: Lauraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
3 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
2 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
2 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC4809
Ingredient ID: NPC28318
Ingredient ID: NPC235059
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 18 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT03219411 | Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes | Dysglycemia|Obesity | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT04476160 | Effectiveness of Cinnamon on Insulin Resistance ( ECIRCCOS ) December 1;2019 | Obesity;Childhood|Insulin Resistance|Insulin Sensitivity | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00331279 | The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study | Polycystic Ovary Syndrome | Cinnamomum Zeylanicum | Plant level As plant Extract |
| NCT00846898 | Is There a Metabolic Effect of Cinnamon on HbA1c;Blood Pressure and Serum Lipids in Type 2 Diabetes Mellitus? | Type 2 Diabetes Mellitus | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00237640 | Effect of Cinnamon on Glucose and Lipid Levels in Non-Insulin Dependent Type 2 Diabetes Mellitus | Diabetes Mellitus;Adult Onset | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00371800 | The Effect of Cinnamon on HbA1c Among Adolescents With Type I Diabetes | Type 1 Diabetes Mellitus | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00445354 | Randomized Controlled Clinical Trial of Cinnamon to Lower Hemoglobin A1c | Diabetes | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT03711682 | Reducing Plasma Glucose Effect of Cinnamon in Type 2 Diabetic Patients in the Municipality of Comasagua | Type 2 Diabetes Mellitus | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT03946163 | The Effect of Cinnamon on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome; a Pilot Study | Chronic Prostatitis|Chronic Pelvic Pain Syndrome | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00479973 | The Anti-Diabetic and Cholesterol-Lowering Effects of Cinnamon and Cassia Bark | Type 2 Diabetes|Hypercholesterolemia | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT05570357 | Berberine and Cinnamon in Management of Diabetes | Diabetes | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT01085019 | Impact of Spices and Herbs on Endothelial Function | Endothelial Function | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT03778099 | The Effect of Cinnamon on Ovulation Induction in Women With Polycystic Ovary Syndrome | Polycystic Ovary Syndrome|Ovulation | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT01302743 | Cinnamon Bark;Water-Soluble Cinnamon Extract;and Metformin for Treatment of Type 2 DM. | Diabetes | Cinnamomum Zeylanicum | Plant level As plant Extract |
| NCT01301521 | Cinnamon Trial-lIfestyle iNtervention Plus Water-soluble Cinnamon Extract On loweriNg Blood Glucose in Pre-diabetics | Diabetes|Pre-Diabetes | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT02455778 | Effect of Oral Cinnamon Intervention in Metabolic Syndrome | Metabolic Syndrome | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT02942056 | The Effect of Cinnamon Cassia on Diabetes Control and Cardiometabolic Risk Factors in Adults With Type 2 Diabetes Mellitus | Diabetes Mellitus | Cinnamomum Zeylanicum | Plant level As single plant |
| NCT00970541 | Effect of Cinnamon Extract on Insulin Resistance in Polycystic Ovary Syndrome | Polycystic Ovary Syndrome|Insulin Resistance | Cinnamomum Zeylanicum | Plant level As plant Extract |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NCT01302743,NCT00445354,NCT01301521,NCT05570357,NCT00237640,NCT02942056
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT03711682,NCT00479973,NCT00846898
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
NCT03778099,NCT00970541,NCT00331279
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B81 |
NCT03219411,NCT04476160
|
Insulin-resistance syndromesDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A44 |
NCT00970541,NCT04476160
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
NCT02455778
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT03219411
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT00479973
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT01301521
|
Type 1 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT00371800
|
Chronic primary visceral painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.00 |
NCT03946163
|
Chronic prostatitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA91.0 |
NCT03946163
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
