Plant ID: NPO30855
Plant Latin Name: Aleurites Moluccana
Taxonomy Genus: Aleurites
Taxonomy Family: Euphorbiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC157340
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 15 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03901144 | A NOVel Moisturiser for Atopic Dermatitis: Effect on the Skin Barrier | atopic eczema | Glycerin (NPC157340) | NP level |
NCT01575418 | An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations | HIV infection | Glycerin (NPC157340) | NP level |
NCT01687218 | Safety and Acceptability Study of Oral Emtricitabine/Tenofovir Disoproxil Fumarate Tablet and Rectally-Applied Tenofovir Reduced-Glycerin 1% Gel | HIV infection | Glycerin (NPC157340) | NP level |
NCT00243711 | A Multi-Center Randomized Study to Evaluate the Efficacy and Safety of an Investigational Lubricant Eye Drop | dry eye syndrome | Glycerin (NPC157340) | NP level |
NCT02110810 | Indomethacin Decreases Post-ERCP Pancreatitis | acute pancreatitis | Glycerin (NPC157340) | NP level |
NCT00619203 | Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis | bacterial meningitis | Glycerin (NPC157340) | NP level |
NCT00841256 | Multicenter Trial of Sublingual Immunotherapy With a Solution of Grass Pollen Allergen Extract in Children | allergic conjunctivitis | Glycerin (NPC157340) | NP level |
NCT00580606 | A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy Trial | peanut allergic reaction | Glycerin (NPC157340) | NP level |
NCT00691197 | Safety and Acceptability of Using a Rewetting Drop With Contact Lens Wear | Abnormality of refraction | Glycerin (NPC157340) | NP level |
NCT01575405 | A Study to Compare Three Different Formulations of Tenofovir 1% Gel When Administered Rectally | HIV infection | Glycerin (NPC157340) | NP level |
NCT01335386 | Investigation of KLYX in Patients With Constipation | Constipation | Glycerin (NPC157340) | NP level |
NCT01474499 | A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation | Constipation | Glycerin (NPC157340) | NP level |
NCT02936830 | Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity | allergic disease | Glycerin (NPC157340) | NP level |
NCT02044341 | Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media | Otitis media | Glycerin (NPC157340) | NP level |
NCT00003667 | Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma | sarcoma | Glycerin (NPC157340) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT01575418,NCT01575405,NCT01687218
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT01335386,NCT01474499
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
NCT00003667
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02110810
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT03901144
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
NCT02936830
|
Allergic conjunctivitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A60.02 |
NCT00841256
|
Bacterial meningitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D01.0 |
NCT00619203
|
Diseases of the visual system, unspecifiedDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9E1Z |
NCT00243711
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
NCT02044341
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|