Collective Molecular Activities of the Plant: Valeriana Jatamansi
Plant ID: NPO29016
Plant Latin Name: Valeriana Jatamansi
Taxonomy Genus: Valeriana
Taxonomy Family: Caprifoliaceae
Plant External Links:
NCBI TaxonomyDB:
59170
Plant-of-the-World-Online:
60458931-2
Country/Region:
IndiaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Ayurveda; SiddhaIndia; Nepal; China; Vietnam; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
154 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
105 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
65 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9880
Ingredient ID: NPC96630
Ingredient ID: NPC96399
Ingredient ID: NPC96102
Ingredient ID: NPC95675
Ingredient ID: NPC93869
Ingredient ID: NPC91574
Ingredient ID: NPC90819
Ingredient ID: NPC89069
Ingredient ID: NPC88566
Ingredient ID: NPC87828
Ingredient ID: NPC8706
Ingredient ID: NPC86843
Ingredient ID: NPC86683
Ingredient ID: NPC85683
Ingredient ID: NPC85037
Ingredient ID: NPC79241
Ingredient ID: NPC78551
Ingredient ID: NPC75584
Ingredient ID: NPC75158
Ingredient ID: NPC7491
Ingredient ID: NPC73414
Ingredient ID: NPC71703
Ingredient ID: NPC7057
Ingredient ID: NPC67986
Ingredient ID: NPC67968
Ingredient ID: NPC6765
Ingredient ID: NPC66504
Ingredient ID: NPC52394
Ingredient ID: NPC49769
Ingredient ID: NPC476320
Ingredient ID: NPC476230
Ingredient ID: NPC476228
Ingredient ID: NPC476211
Ingredient ID: NPC469919
Ingredient ID: NPC469918
Ingredient ID: NPC469695
Ingredient ID: NPC46330
Ingredient ID: NPC37871
Ingredient ID: NPC36408
Ingredient ID: NPC34440
Ingredient ID: NPC329997
Ingredient ID: NPC329834
Ingredient ID: NPC329704
Ingredient ID: NPC32021
Ingredient ID: NPC3155
Ingredient ID: NPC309317
Ingredient ID: NPC308218
Ingredient ID: NPC30430
Ingredient ID: NPC300969
Ingredient ID: NPC30025
Ingredient ID: NPC298327
Ingredient ID: NPC296014
Ingredient ID: NPC294136
Ingredient ID: NPC294049
Ingredient ID: NPC292340
Ingredient ID: NPC291709
Ingredient ID: NPC290078
Ingredient ID: NPC284731
Ingredient ID: NPC284063
Ingredient ID: NPC28402
Ingredient ID: NPC283655
Ingredient ID: NPC282861
Ingredient ID: NPC281780
Ingredient ID: NPC27491
Ingredient ID: NPC27474
Ingredient ID: NPC274588
Ingredient ID: NPC274584
Ingredient ID: NPC26906
Ingredient ID: NPC268987
Ingredient ID: NPC264470
Ingredient ID: NPC262020
Ingredient ID: NPC260756
Ingredient ID: NPC257819
Ingredient ID: NPC254156
Ingredient ID: NPC252978
Ingredient ID: NPC252635
Ingredient ID: NPC248355
Ingredient ID: NPC24822
Ingredient ID: NPC246173
Ingredient ID: NPC244878
Ingredient ID: NPC24327
Ingredient ID: NPC241407
Ingredient ID: NPC239039
Ingredient ID: NPC239037
Ingredient ID: NPC233376
Ingredient ID: NPC231738
Ingredient ID: NPC230291
Ingredient ID: NPC227378
Ingredient ID: NPC225463
Ingredient ID: NPC22484
Ingredient ID: NPC224111
Ingredient ID: NPC223700
Ingredient ID: NPC220860
Ingredient ID: NPC217191
Ingredient ID: NPC216911
Ingredient ID: NPC216900
Ingredient ID: NPC214584
Ingredient ID: NPC213749
Ingredient ID: NPC210658
Ingredient ID: NPC209275
Ingredient ID: NPC208361
Ingredient ID: NPC208307
Ingredient ID: NPC20673
Ingredient ID: NPC206050
Ingredient ID: NPC205464
Ingredient ID: NPC204145
Ingredient ID: NPC20306
Ingredient ID: NPC202933
Ingredient ID: NPC199474
Ingredient ID: NPC196490
Ingredient ID: NPC193454
Ingredient ID: NPC193081
Ingredient ID: NPC192962
Ingredient ID: NPC189631
Ingredient ID: NPC189036
Ingredient ID: NPC186826
Ingredient ID: NPC184831
Ingredient ID: NPC180684
Ingredient ID: NPC180418
Ingredient ID: NPC178223
Ingredient ID: NPC170527
Ingredient ID: NPC170392
Ingredient ID: NPC169702
Ingredient ID: NPC169393
Ingredient ID: NPC168714
Ingredient ID: NPC166894
Ingredient ID: NPC161928
Ingredient ID: NPC16157
Ingredient ID: NPC157250
Ingredient ID: NPC156320
Ingredient ID: NPC151093
Ingredient ID: NPC15061
Ingredient ID: NPC14682
Ingredient ID: NPC146667
Ingredient ID: NPC13991
Ingredient ID: NPC138530
Ingredient ID: NPC138113
Ingredient ID: NPC13789
Ingredient ID: NPC129085
Ingredient ID: NPC127997
Ingredient ID: NPC126240
Ingredient ID: NPC124885
Ingredient ID: NPC123229
Ingredient ID: NPC117787
Ingredient ID: NPC117066
Ingredient ID: NPC114239
Ingredient ID: NPC109813
Ingredient ID: NPC107473
Ingredient ID: NPC106250
Ingredient ID: NPC104569
Ingredient ID: NPC10455
Ingredient ID: NPC102091
Ingredient ID: NPC101285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | CHEMBL2052028 |
| Therapeutic Target | Oxidoreductase | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR1B | Serotonin 1b (5-HT1b) receptor | P28222 | CHEMBL1898 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2A | Serotonin 2a (5-HT2a) receptor | P28223 | CHEMBL224 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR7 | Serotonin 7 (5-HT7) receptor | P34969 | CHEMBL3155 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR1D | Serotonin 1d (5-HT1d) receptor | P28221 | CHEMBL1983 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
| NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
| NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C,HTR2A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
HTR2C,HTR1D
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HTR1B,HTR2A,CNR2,HTR1D,LMNA,HTR7
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
HTR2C
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HTR7,HTR2C,HTR1B,HTR2A,HTR6,HTR1D
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT02029118,NCT01659580
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HTR2C,HTR2A,HTR6
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
HTR2C,CNR2,HTR7,HTR1B,HTR2A
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
HTR2A,HTR7
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
