Plant ID: NPO29016
Plant Latin Name: Valeriana Jatamansi
Taxonomy Genus: Valeriana
Taxonomy Family: Caprifoliaceae
NCBI TaxonomyDB:
59170
Plant-of-the-World-Online:
60458931-2
India; Nepal; China; Vietnam; Thailand
Ingredient ID: NPC9880
Ingredient ID: NPC96630
Ingredient ID: NPC96399
Ingredient ID: NPC96102
Ingredient ID: NPC95675
Ingredient ID: NPC93869
Ingredient ID: NPC91574
Ingredient ID: NPC90819
Ingredient ID: NPC89069
Ingredient ID: NPC88566
Ingredient ID: NPC87828
Ingredient ID: NPC8706
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Ingredient ID: NPC86683
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Ingredient ID: NPC7491
Ingredient ID: NPC73414
Ingredient ID: NPC71703
Ingredient ID: NPC7057
Ingredient ID: NPC67986
Ingredient ID: NPC67968
Ingredient ID: NPC6765
Ingredient ID: NPC66504
Ingredient ID: NPC52394
Ingredient ID: NPC49769
Ingredient ID: NPC476320
Ingredient ID: NPC476230
Ingredient ID: NPC476228
Ingredient ID: NPC476211
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Ingredient ID: NPC469695
Ingredient ID: NPC46330
Ingredient ID: NPC37871
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Ingredient ID: NPC34440
Ingredient ID: NPC329997
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Ingredient ID: NPC329704
Ingredient ID: NPC32021
Ingredient ID: NPC3155
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Ingredient ID: NPC30430
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Ingredient ID: NPC298327
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Ingredient ID: NPC294049
Ingredient ID: NPC292340
Ingredient ID: NPC291709
Ingredient ID: NPC290078
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Ingredient ID: NPC28402
Ingredient ID: NPC283655
Ingredient ID: NPC282861
Ingredient ID: NPC281780
Ingredient ID: NPC27491
Ingredient ID: NPC27474
Ingredient ID: NPC274588
Ingredient ID: NPC274584
Ingredient ID: NPC26906
Ingredient ID: NPC268987
Ingredient ID: NPC264470
Ingredient ID: NPC262020
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Ingredient ID: NPC257819
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Ingredient ID: NPC252635
Ingredient ID: NPC248355
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Ingredient ID: NPC24327
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Ingredient ID: NPC225463
Ingredient ID: NPC22484
Ingredient ID: NPC224111
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Ingredient ID: NPC220860
Ingredient ID: NPC217191
Ingredient ID: NPC216911
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Ingredient ID: NPC214584
Ingredient ID: NPC213749
Ingredient ID: NPC210658
Ingredient ID: NPC209275
Ingredient ID: NPC208361
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Ingredient ID: NPC20673
Ingredient ID: NPC206050
Ingredient ID: NPC205464
Ingredient ID: NPC204145
Ingredient ID: NPC20306
Ingredient ID: NPC202933
Ingredient ID: NPC199474
Ingredient ID: NPC196490
Ingredient ID: NPC193454
Ingredient ID: NPC193081
Ingredient ID: NPC192962
Ingredient ID: NPC189631
Ingredient ID: NPC189036
Ingredient ID: NPC186826
Ingredient ID: NPC184831
Ingredient ID: NPC180684
Ingredient ID: NPC180418
Ingredient ID: NPC178223
Ingredient ID: NPC170527
Ingredient ID: NPC170392
Ingredient ID: NPC169702
Ingredient ID: NPC169393
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Ingredient ID: NPC166894
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Ingredient ID: NPC16157
Ingredient ID: NPC157250
Ingredient ID: NPC156320
Ingredient ID: NPC151093
Ingredient ID: NPC15061
Ingredient ID: NPC14682
Ingredient ID: NPC146667
Ingredient ID: NPC13991
Ingredient ID: NPC138530
Ingredient ID: NPC138113
Ingredient ID: NPC13789
Ingredient ID: NPC129085
Ingredient ID: NPC127997
Ingredient ID: NPC126240
Ingredient ID: NPC124885
Ingredient ID: NPC123229
Ingredient ID: NPC117787
Ingredient ID: NPC117066
Ingredient ID: NPC114239
Ingredient ID: NPC109813
Ingredient ID: NPC107473
Ingredient ID: NPC106250
Ingredient ID: NPC104569
Ingredient ID: NPC10455
Ingredient ID: NPC102091
Ingredient ID: NPC101285
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Hydrolase | EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | CHEMBL2052028 |
Therapeutic Target | Oxidoreductase | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR7 | Serotonin 7 (5-HT7) receptor | P34969 | CHEMBL3155 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR1D | Serotonin 1d (5-HT1d) receptor | P28221 | CHEMBL1983 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR1B | Serotonin 1b (5-HT1b) receptor | P28222 | CHEMBL1898 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2A | Serotonin 2a (5-HT2a) receptor | P28223 | CHEMBL224 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
HTR1B,HTR2A,EIF4A1,CNR2,HTR1D,LMNA,HTR7
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HTR7,HTR2C,HTR1B,HTR2A,HTR6,HTR1D
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
HTR2C,HTR1B,MPO,HTR7,HTR6,HTR2A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HTR1B,HTR2A,CNR2,HTR1D,LMNA,HTR7
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HTR2A,HTR2C,EIF4A1,CNR2,MPO,HTR7
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HTR7,HTR6,HTR2A,HTR2C,HTR1B
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
HTR2C,CNR2,HTR7,HTR1B,HTR2A
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HTR2C,HTR6,HTR1D,MPO,HTR7
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
HTR1B,HTR2A,HTR6,HTR1D,HTR7
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
HTR2A,HTR1B,HTR1D,HTR2C
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
HTR1D,HTR6,EIF4A1,HTR7
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
HTR6,HTR7,HTR1D,CNR2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
HTR1B,HTR2C,CNR2,HTR1D
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
HTR2C,HTR7,HTR2A
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
HTR2A,CNR2,HTR1D
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HTR2C,HTR2A,HTR6
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
HTR2C,HTR1D,HTR1B
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
HTR1D,HTR1B,HTR2A
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
HTR1B,HTR2A,HTR2C
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
HTR6,HTR2C,HTR1D
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
HTR1B,HTR1D,MPO
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
MPO,HTR7,CNR2
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
HTR2C,HTR7,HTR1D
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,EIF4A1,CNR2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
HTR2C,HTR1D,HTR1D
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
HTR2C,HTR1D,CNR2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HTR6,MPO,HTR2A
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C,HTR2A
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
HTR2C,HTR1B
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
HTR6,HTR7
|
Chronic insomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00 |
HTR2A,HTR2C
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HTR6,HTR2C
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
HTR2A,HTR1D
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
HTR2C,HTR2A
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
HTR2C,CNR2
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
HTR2A,HTR7
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
HTR2C,HTR1B
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT02029118,NCT01659580
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,HTR1D
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
HTR2C,HTR7
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
HTR2C,HTR1D
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
HTR2C,HTR1D
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
HTR2C,HTR1D
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HTR6,HTR2C
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
HTR2A
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
MPO
|
Psychoactive substances use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4G |
HTR2C
|
Social anxiety disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B04 |
HTR2A
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
HTR2A
|
Neurodegenerative disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20-8A23 |
HTR6
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CNR2
|
Cerebral ischaemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B1Z |
HTR2A
|
Epilepsy/seizureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A61-8A6Z |
HTR1D
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
HTR2A
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
CNR2
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
HTR2A
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
CNR2
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
HTR2A
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
MPO
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
HTR2A
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
HTR6
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
HTR2C
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
HTR2A
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
HTR2A
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
HTR2A
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
HTR2A
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT05432284
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
HTR7
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
HTR2A
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
HTR2C
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
HTR2C
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
HTR1D
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
HTR2C
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
HTR1D
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
HTR2A
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
CNR2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
HTR2C
|