Collective Molecular Activities of the Plant: Tubocapsicum Anomalum
Plant ID: NPO28641
Plant Latin Name: Tubocapsicum Anomalum
Taxonomy Genus: Tubocapsicum
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
180580
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
86 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
67 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
39 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95676
Ingredient ID: NPC94304
Ingredient ID: NPC94218
Ingredient ID: NPC94045
Ingredient ID: NPC93033
Ingredient ID: NPC90787
Ingredient ID: NPC88326
Ingredient ID: NPC85813
Ingredient ID: NPC8374
Ingredient ID: NPC82648
Ingredient ID: NPC82363
Ingredient ID: NPC79527
Ingredient ID: NPC78540
Ingredient ID: NPC76145
Ingredient ID: NPC64318
Ingredient ID: NPC62086
Ingredient ID: NPC5708
Ingredient ID: NPC4827
Ingredient ID: NPC473396
Ingredient ID: NPC473274
Ingredient ID: NPC473270
Ingredient ID: NPC473265
Ingredient ID: NPC473256
Ingredient ID: NPC473255
Ingredient ID: NPC473253
Ingredient ID: NPC473233
Ingredient ID: NPC470882
Ingredient ID: NPC470880
Ingredient ID: NPC470878
Ingredient ID: NPC4125
Ingredient ID: NPC3922
Ingredient ID: NPC3649
Ingredient ID: NPC3190
Ingredient ID: NPC312391
Ingredient ID: NPC306616
Ingredient ID: NPC299529
Ingredient ID: NPC287903
Ingredient ID: NPC281994
Ingredient ID: NPC270074
Ingredient ID: NPC269806
Ingredient ID: NPC268862
Ingredient ID: NPC266021
Ingredient ID: NPC26583
Ingredient ID: NPC265513
Ingredient ID: NPC261831
Ingredient ID: NPC260623
Ingredient ID: NPC258723
Ingredient ID: NPC257522
Ingredient ID: NPC249018
Ingredient ID: NPC243601
Ingredient ID: NPC229403
Ingredient ID: NPC225406
Ingredient ID: NPC225284
Ingredient ID: NPC223417
Ingredient ID: NPC219573
Ingredient ID: NPC215702
Ingredient ID: NPC213322
Ingredient ID: NPC20892
Ingredient ID: NPC207869
Ingredient ID: NPC206380
Ingredient ID: NPC202691
Ingredient ID: NPC197378
Ingredient ID: NPC194801
Ingredient ID: NPC194383
Ingredient ID: NPC186525
Ingredient ID: NPC181582
Ingredient ID: NPC180612
Ingredient ID: NPC178859
Ingredient ID: NPC17458
Ingredient ID: NPC173658
Ingredient ID: NPC170070
Ingredient ID: NPC166894
Ingredient ID: NPC163424
Ingredient ID: NPC157923
Ingredient ID: NPC153700
Ingredient ID: NPC15292
Ingredient ID: NPC149570
Ingredient ID: NPC149203
Ingredient ID: NPC148677
Ingredient ID: NPC142871
Ingredient ID: NPC127447
Ingredient ID: NPC125962
Ingredient ID: NPC121270
Ingredient ID: NPC114239
Ingredient ID: NPC105380
Ingredient ID: NPC100178
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 11 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
| NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA,FFAR1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,XDH,CBR1,AKR1C3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,CA7,XDH,CBR1,LMNA,FFAR4,ALOX15,FABP3,AKR1C3,CYP2C19
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1,ALOX15
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CBR1,CA4
NCT00029679 |
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA4
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP19A1,CA4
NCT00908791 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA7,XDH,FABP5,CYP19A1,FFAR4,ALOX15,FFAR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
