Collective Molecular Activities of the Plant: Clausena Heptaphylla
Unknown.
Bangladesh; Myanmar; Indonesia; India; Vietnam; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
14 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
11 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
8 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC39616
Ingredient ID: NPC307739
Ingredient ID: NPC303951
Ingredient ID: NPC289883
Ingredient ID: NPC283975
Ingredient ID: NPC27682
Ingredient ID: NPC258231
Ingredient ID: NPC241503
Ingredient ID: NPC236176
Ingredient ID: NPC200964
Ingredient ID: NPC179365
Ingredient ID: NPC140231
Ingredient ID: NPC133771
Ingredient ID: NPC111930
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Metallo protease | METAP2 | Methionine aminopeptidase 2 | P50579 | CHEMBL3922 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 25 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02709044 | Fluid Resuscitation in Acute Pancreatitis | pancreatitis | D-Lactic Acid (NPC307739) | NP level |
| NCT04102371 | Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis | Shock | D-Lactic Acid (NPC307739) | NP level |
| NCT00529711 | The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients | heart failure | D-Lactic Acid (NPC307739) | NP level |
| NCT02782520 | Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Following Cardiac Surgery | Hypovolemia | D-Lactic Acid (NPC307739) | NP level |
| NCT02821546 | Aggressive Fluid Hydration for the Prevention of Post-ERCP Pancreatitis | pancreatitis | D-Lactic Acid (NPC307739) | NP level |
| NCT04858139 | Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism | stroke | D-Lactic Acid (NPC307739) | NP level |
| NCT01108601 | Transtympanic Ringer's Lactate for the Prevention of Cisplatin Ototoxicity | hearing loss | D-Lactic Acid (NPC307739) | NP level |
| NCT01236833 | Lactated Ringer's Solution in Neonates With Feeding Intolerance | intestinal disease | D-Lactic Acid (NPC307739) | NP level |
| NCT00801359 | BSSPlus Versus Lactated Ringer's for Phacoemulsification | cataract | D-Lactic Acid (NPC307739) | NP level |
| NCT02726308 | Dexamethasone With Super-hydration for Prevention of Postoperative Nausea and Vomiting | post operative nausea and vomiting | D-Lactic Acid (NPC307739) | NP level |
| NCT02467387 | A Study to Assess the Effect of Intravenous Dose of (aMBMC) to Subjects With Non-ischemic Heart Failure | heart failure | D-Lactic Acid (NPC307739) | NP level |
| NCT03629600 | Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis | acute pancreatitis | D-Lactic Acid (NPC307739) | NP level |
| NCT04381169 | Aggressive Versus Non-aggressive Goal-directed Fluid Resuscitation in Acute Pancreatitis | acute pancreatitis | D-Lactic Acid (NPC307739) | NP level |
| NCT02558543 | Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis | systemic scleroderma | D-Lactic Acid (NPC307739) | NP level |
| NCT00529490 | Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats | heart failure | D-Lactic Acid (NPC307739) | NP level |
| NCT02641561 | Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis | acute pancreatitis | D-Lactic Acid (NPC307739) | NP level |
| NCT00966628 | Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) | Dengue Hemorrhagic Fever | D-Lactic Acid (NPC307739) | NP level |
| NCT03340805 | Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study | septic shock | D-Lactic Acid (NPC307739) | NP level |
| NCT02866552 | SCLERoderma et Adipose-DErived Stroma Cells | systemic scleroderma | D-Lactic Acid (NPC307739) | NP level |
| NCT03478618 | Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia | hypotension | D-Lactic Acid (NPC307739) | NP level |
| NCT03679780 | The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction | cardiovascular disease | D-Lactic Acid (NPC307739) | NP level |
| NCT03118362 | Fluid Resuscitation in Burn Patients | burn | D-Lactic Acid (NPC307739) | NP level |
| NCT01433276 | Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients With Hemorrhagic Shock | Shock | D-Lactic Acid (NPC307739) | NP level |
| NCT02807727 | Cardiac REperfusion With Intralipid® at Reperfusion | ischemia reperfusion injury | D-Lactic Acid (NPC307739) | NP level |
| NCT00425334 | Safety Study of Hemospan® in Prostatectomy Patients | prostate cancer | D-Lactic Acid (NPC307739) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
NCT00529490,NCT02467387,NCT00529711
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02641561,NCT04381169,NCT03629600
|
PancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31-DC34 |
NCT02821546,NCT02709044
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
NCT02866552,NCT02558543
|
ShockDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG40 |
NCT04102371,NCT01433276
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
METAP2
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
METAP2
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
METAP2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
METAP2
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
NCT02726308
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
NCT00801359
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT03679780
|
Ischaemia reperfusion injury of liverDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB98.B |
NCT02807727
|
Dengue with warning signsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D21 |
NCT00966628
|
Diseases of the digestive system, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DE2Z |
NCT01236833
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT04858139
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
NCT03478618
|
Hearing disorderDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB50-AB57 |
NCT01108601
|
Burn and burn infectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND90-NE2Z |
NCT03118362
|
HypovolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C70.1 |
NCT02782520
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT03340805
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT00425334
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
METAP2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
