Plant ID: NPO28378
Plant Latin Name: Kokoona Ochracea
Taxonomy Genus: Kokoona
Taxonomy Family: Celastraceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
China
Ingredient ID: NPC95443
Ingredient ID: NPC94551
Ingredient ID: NPC91858
Ingredient ID: NPC88566
Ingredient ID: NPC87828
Ingredient ID: NPC83831
Ingredient ID: NPC76145
Ingredient ID: NPC70208
Ingredient ID: NPC65615
Ingredient ID: NPC62765
Ingredient ID: NPC62086
Ingredient ID: NPC483465
Ingredient ID: NPC483464
Ingredient ID: NPC475700
Ingredient ID: NPC475230
Ingredient ID: NPC474870
Ingredient ID: NPC3649
Ingredient ID: NPC35543
Ingredient ID: NPC35519
Ingredient ID: NPC312391
Ingredient ID: NPC30991
Ingredient ID: NPC309399
Ingredient ID: NPC299529
Ingredient ID: NPC287301
Ingredient ID: NPC287063
Ingredient ID: NPC283655
Ingredient ID: NPC280877
Ingredient ID: NPC271572
Ingredient ID: NPC2605
Ingredient ID: NPC246581
Ingredient ID: NPC243083
Ingredient ID: NPC228700
Ingredient ID: NPC225284
Ingredient ID: NPC221421
Ingredient ID: NPC219436
Ingredient ID: NPC216610
Ingredient ID: NPC206878
Ingredient ID: NPC205866
Ingredient ID: NPC202691
Ingredient ID: NPC188238
Ingredient ID: NPC18816
Ingredient ID: NPC172963
Ingredient ID: NPC170303
Ingredient ID: NPC161923
Ingredient ID: NPC159362
Ingredient ID: NPC150424
Ingredient ID: NPC149960
Ingredient ID: NPC14166
Ingredient ID: NPC139717
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC133253
Ingredient ID: NPC128248
Ingredient ID: NPC123290
Ingredient ID: NPC114239
Ingredient ID: NPC112454
Ingredient ID: NPC109854
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
Therapeutic Target | Transferase | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 6 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
NCT02059785 | Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke | Ischemic stroke | Pinocembrin (NPC243083) | NP level |
NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CYP19A1,TERT,CYP19A1,TERT
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CYP19A1,TERT,TERT
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP19A1,TERT
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01659580,NCT02029118
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CYP19A1,TERT
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1,TERT
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
TERT,NAPRT
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP19A1,TERT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TERT
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TERT
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
TERT
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TERT
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
TERT
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
TERT
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TERT
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TERT
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TERT
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
TERT
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
TERT
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TERT
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
TERT
|
ThrombocytosisDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B63 |
TERT
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
TERT
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
TERT
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
NCT02059785
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT05432284
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TERT
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
TERT
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CYP19A1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
TERT
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TERT
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TERT
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
CYP19A1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TERT
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
TERT
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TERT
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
TERT
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TERT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TERT
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
TERT
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
CYP19A1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
TERT
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP19A1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
TERT
|