Collective Molecular Activities of the Plant: Tamarix Gallica
Country/Region:
Thailand; China; Italy; India; AlgeriaTraditional Medicine System:
Indian Folk; TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Astringent; Detergent; Diuretic; Expectorant; Laxative
Brazil; Portugal; Italy; Bangladesh; Algeria; Trinidad and Tobago; Haiti; India; France; United Kingdom; Morocco; China; Thailand; Argentina; United States; Dominican Republic; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
45 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
36 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95443
Ingredient ID: NPC91858
Ingredient ID: NPC88566
Ingredient ID: NPC87828
Ingredient ID: NPC86412
Ingredient ID: NPC83831
Ingredient ID: NPC76145
Ingredient ID: NPC70208
Ingredient ID: NPC62765
Ingredient ID: NPC62086
Ingredient ID: NPC53028
Ingredient ID: NPC3649
Ingredient ID: NPC35519
Ingredient ID: NPC312391
Ingredient ID: NPC30991
Ingredient ID: NPC309399
Ingredient ID: NPC299529
Ingredient ID: NPC287301
Ingredient ID: NPC283655
Ingredient ID: NPC2605
Ingredient ID: NPC246581
Ingredient ID: NPC243083
Ingredient ID: NPC225284
Ingredient ID: NPC219436
Ingredient ID: NPC216610
Ingredient ID: NPC205866
Ingredient ID: NPC202691
Ingredient ID: NPC188238
Ingredient ID: NPC18816
Ingredient ID: NPC172963
Ingredient ID: NPC170303
Ingredient ID: NPC161923
Ingredient ID: NPC159362
Ingredient ID: NPC150424
Ingredient ID: NPC149960
Ingredient ID: NPC14166
Ingredient ID: NPC139717
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC133253
Ingredient ID: NPC128248
Ingredient ID: NPC123290
Ingredient ID: NPC118426
Ingredient ID: NPC114239
Ingredient ID: NPC109854
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 51 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00251056 | Mannitol Dose Response Study in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT03573999 | Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation | brain edema | Mannitol (NPC86412) | NP level |
| NCT01520207 | Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension | hypotension | Mannitol (NPC86412) | NP level |
| NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
| NCT01887197 | Repeatability and Response Study of Absorptive Clearance Scans | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
| NCT00669331 | Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT02570971 | Mannitol Versus Supportive Care in Ciguatera Fish Poisoning | ciguatera poisoning | Mannitol (NPC86412) | NP level |
| NCT01718964 | Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel) | opioid dependence | Mannitol (NPC86412) | NP level |
| NCT02861898 | Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma | brain cancer;glioblastoma multiforme | Mannitol (NPC86412) | NP level |
| NCT04217421 | Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass | congenital heart disease | Mannitol (NPC86412) | NP level |
| NCT00359697 | Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure | intracranial hypertension | Mannitol (NPC86412) | NP level |
| NCT04385264 | COVID-19 | Mannitol (NPC86412) | NP level | |
| NCT00113854 | Mannitol as Adjunct Therapy for Childhood Cerebral Malaria | malaria | Mannitol (NPC86412) | NP level |
| NCT02059785 | Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke | Ischemic stroke | Pinocembrin (NPC243083) | NP level |
| NCT01233492 | Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme | Central Nervous System Neoplasm | Mannitol (NPC86412) | NP level |
| NCT00730977 | A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT04534465 | Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements. | Constipation | Mannitol (NPC86412) | NP level |
| NCT00792714 | Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT04488874 | Sodium Lactate and Brain Relaxation (LSD) | intracranial hypertension | Mannitol (NPC86412) | NP level |
| NCT03747679 | Palatability (Taste) of Oral Formulations of Bosutinib | chronic myelogenous leukemia | Mannitol (NPC86412) | NP level |
| NCT01142505 | Wheeze and Intermittent Treatment | wheezing | Mannitol (NPC86412) | NP level |
| NCT00569088 | Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases | stroke | Mannitol (NPC86412) | NP level |
| NCT05129748 | Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy | hearing loss | Mannitol (NPC86412) | NP level |
| NCT02134353 | A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00446680 | Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00189007 | Antenatal Allopurinol During Fetal Hypoxia | fetal hypoxia | Mannitol (NPC86412) | NP level |
| NCT00810940 | Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury | injury | Mannitol (NPC86412) | NP level |
| NCT04870073 | Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery | coronary artery disease | Mannitol (NPC86412) | NP level |
| NCT01883531 | Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00303849 | Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors | anaplastic oligodendroglioma | Mannitol (NPC86412) | NP level |
| NCT03749408 | Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain | pulpitis | Mannitol (NPC86412) | NP level |
| NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
| NCT04394143 | Effect of AD128 to Treat Obstructive Sleep Apnea | obstructive sleep apnea | Mannitol (NPC86412) | NP level |
| NCT02037815 | Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy | brain edema | Mannitol (NPC86412) | NP level |
| NCT00446667 | A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD | chronic obstructive pulmonary disease | Mannitol (NPC86412) | NP level |
| NCT00455130 | A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT01843088 | Trial of Mannitol Cream for Pain Relief After a Long Run | pain | Mannitol (NPC86412) | NP level |
| NCT00117208 | Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT05305508 | Assessment of the Efficacy of Calcium Dobesilate vs. Placebo on SARS-CoV-2 Viral Load Amongst Outpatients With COVID-19. | COVID-19 | Mannitol (NPC86412) | NP level |
| NCT00277537 | Safety and Efficacy of Bronchitol in Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT01606787 | Mannitol Use During Partial Nephrectomy Prior to Renal Ischemia and Impact on Renal Function Outcomes | kidney cancer | Mannitol (NPC86412) | NP level |
| NCT02728687 | Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy | diabetic neuropathy | Mannitol (NPC86412) | NP level |
| NCT01485315 | Transfusion-requirements in Septic Shock Trial | septic shock | Mannitol (NPC86412) | NP level |
| NCT03636971 | Gait Analysis Following Knee Viscosupplementation | osteoarthritis | Mannitol (NPC86412) | NP level |
| NCT00630812 | Long Term Administration of Inhaled Mannitol in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT02484170 | Mannitol Cream for Post Herpetic Neuralgia | postherpetic neuralgia | Mannitol (NPC86412) | NP level |
| NCT01076491 | High Dose Inhaled Mannitol Study | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT01028339 | Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values | brain injury | Mannitol (NPC86412) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00117208,NCT00446680,NCT01887197,NCT00455130,NCT00630812,NCT00251056,NCT02134353,NCT00792714,NCT01883531
|
BronchiectasisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA24 |
NCT00730977,NCT00277537,NCT00669331,NCT01076491
|
Other specified increased intracranial pressureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.Y |
NCT00359697,NCT04488874
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04385264,NCT05305508
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01659580,NCT02029118
|
Cerebral oedemaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.1 |
NCT03573999,NCT02037815
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CYP19A1,CYP19A1
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP19A1
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT03636971
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT01233492
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
NCT00810940
|
Malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
NCT01606787
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
NCT00113854
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT02728687
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
NCT01718964
|
Chronic myeloid leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4XG8 |
NCT03747679
|
Structural developmental anomaly of heart or great vessels, unspecifiedDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA8Z |
NCT04217421
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT04392622
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT01028339
|
Hearing disorderDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB50-AB57 |
NCT05129748
|
Obstructive sleep apnoeaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A41 |
NCT04394143
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT00569088
|
Postherpetic polyneuropathyDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E91.5 |
NCT02484170
|
Maternal care for signs of fetal hypoxiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA86.2 |
NCT00189007
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT05432284
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT01843088
|
WheezingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.C |
NCT01142505
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT04870073
|
Oligodendroglioma, anaplasticDisease Category: X.Extension CodesDisease ICD-11 Code: XH8844 |
NCT00303849
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02861898
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
NCT01520207
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
NCT02861898
|
Exposure to or harmful effects of undetermined intent of other or unspecified substances chiefly nonmedicinal as to sourceDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PH56 |
NCT02570971
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT04534465
|
PulpitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA09.0 |
NCT03749408
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT00446667
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT01485315
|
Other specified non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.Y |
NCT04853082
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
NCT02059785
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CYP19A1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CYP19A1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CYP19A1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
CYP19A1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NAPRT
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
CYP19A1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP19A1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP19A1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
