CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Serpocaulon Triseriale

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO27924
Plant Latin Name: Serpocaulon Triseriale
Taxonomy Genus: Serpocaulon
Taxonomy Family: Polypodiaceae

Plant External Links:

NCBI TaxonomyDB: 253793
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

136 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

112 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

58 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99968

Ingredient ID: NPC96572

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Ingredient ID: NPC103318

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Show entries

Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Therapeutic Target	Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Therapeutic Target	Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transcription factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Showing 1 to 6 of 6 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	568

Clinical trial details

Show entries

Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00000620	Action to Control Cardiovascular Risk in Diabetes (ACCORD)	atherosclerosis;coronary artery disease;Hypercholesterolemia;hypertension;type 2 diabetes mellitus	Metformin (NPC230775)	NP level
NCT00032487	Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)	type 2 diabetes mellitus	Metformin (NPC230775)	NP level
NCT00038727	Diabetes Prevention Program Outcomes Study	diabetes mellitus	Metformin (NPC230775)	NP level
NCT00046462	Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment	diabetes mellitus	Metformin (NPC230775)	NP level
NCT00063232	Treating Nonalcoholic Steatohepatitis (NASH) With Metformin	Hepatitis	Metformin (NPC230775)	NP level
NCT00063635	Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)	Hepatic steatosis	Metformin (NPC230775)	NP level
NCT00067951	A Study To Evaluate The Safety And Efficacy Of An Investigational Diabetes Drug In Poorly Controlled Type II Diabetics	type 2 diabetes mellitus	Metformin (NPC230775)	NP level
NCT00069836	Study Of AVANDAMET® With Or Without Insulin In Type II Diabetes Mellitus Patients. AVANDAMET® is a Registered Trademark of the GSK Group of Companies.	type 2 diabetes mellitus	Metformin (NPC230775)	NP level
NCT00081328	Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY)	type 2 diabetes mellitus	Metformin (NPC230775)	NP level
NCT00086502	Pioglitazone Add-on Study in Patients With Type 2 Diabetes Mellitus	type 2 diabetes mellitus	Metformin (NPC230775)	NP level

Showing 1 to 10 of 568 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute ischaemic heart disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA4Z	NCT05305898
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	NFKB1
Acute viral hepatitis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1E50	NCT00063232,NCT03000218
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	NFKB1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	LMNA,PTGS1,PDE4D,SNCA
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	NCT01996696,NCT01796028
Adenocarcinoma, endocervical type Disease Category: X.Extension Codes Disease ICD-11 Code: XH0GS9	NCT02394652
Adenocarcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D40	NCT01877564,NCT02186847,NCT01578551
Ageing associated decline in intrinsic capacity Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG2A	NCT04264897,NCT03072485,NCT02308228,NCT03861767,NCT03713801
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	SNCA,PDE4D,PTGS1

Showing 1 to 10 of 195 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Serpocaulon Triseriale

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

136 All known Ingredients in Total

112 Ingredients with Acceptable Bioavailablity

58 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute ischaemic heart disease, unspecified

Acute myeloid leukaemia

Acute viral hepatitis

Acute/subacute hepatic failure

Adenocarcinoma of pancreas

Adenocarcinoma of prostate

Adenocarcinoma, endocervical type

Adenocarcinoma

Ageing associated decline in intrinsic capacity

Alzheimer disease

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities