Collective Molecular Activities of the Plant: Atalantia Buxifolia
Plant ID: NPO27785
Plant Latin Name: Atalantia Buxifolia
Taxonomy Genus: Atalantia
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
76974
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
74 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
46 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
39 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC88445
Ingredient ID: NPC79782
Ingredient ID: NPC74539
Ingredient ID: NPC68889
Ingredient ID: NPC60642
Ingredient ID: NPC479430
Ingredient ID: NPC479429
Ingredient ID: NPC479428
Ingredient ID: NPC479427
Ingredient ID: NPC479426
Ingredient ID: NPC479425
Ingredient ID: NPC479424
Ingredient ID: NPC479423
Ingredient ID: NPC479315
Ingredient ID: NPC47670
Ingredient ID: NPC462686
Ingredient ID: NPC45023
Ingredient ID: NPC35554
Ingredient ID: NPC33279
Ingredient ID: NPC313112
Ingredient ID: NPC312524
Ingredient ID: NPC309162
Ingredient ID: NPC308940
Ingredient ID: NPC30749
Ingredient ID: NPC30718
Ingredient ID: NPC301640
Ingredient ID: NPC301292
Ingredient ID: NPC29551
Ingredient ID: NPC293852
Ingredient ID: NPC293051
Ingredient ID: NPC2905
Ingredient ID: NPC28246
Ingredient ID: NPC280545
Ingredient ID: NPC276133
Ingredient ID: NPC265051
Ingredient ID: NPC264677
Ingredient ID: NPC264095
Ingredient ID: NPC263932
Ingredient ID: NPC263033
Ingredient ID: NPC262780
Ingredient ID: NPC261718
Ingredient ID: NPC261012
Ingredient ID: NPC260898
Ingredient ID: NPC256407
Ingredient ID: NPC250439
Ingredient ID: NPC246694
Ingredient ID: NPC246192
Ingredient ID: NPC243509
Ingredient ID: NPC241263
Ingredient ID: NPC222185
Ingredient ID: NPC220995
Ingredient ID: NPC218303
Ingredient ID: NPC212123
Ingredient ID: NPC196776
Ingredient ID: NPC193591
Ingredient ID: NPC180006
Ingredient ID: NPC176113
Ingredient ID: NPC17212
Ingredient ID: NPC172085
Ingredient ID: NPC171088
Ingredient ID: NPC161769
Ingredient ID: NPC161291
Ingredient ID: NPC153977
Ingredient ID: NPC152181
Ingredient ID: NPC137537
Ingredient ID: NPC131192
Ingredient ID: NPC130132
Ingredient ID: NPC13007
Ingredient ID: NPC123425
Ingredient ID: NPC122146
Ingredient ID: NPC121065
Ingredient ID: NPC114630
Ingredient ID: NPC106020
Ingredient ID: NPC103911
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Therapeutic Target | Transferase | PIK3CA | PI3-kinase p110-alpha subunit | P42336 | CHEMBL4005 |
| Therapeutic Target | Transferase | PIK3CB | PI3-kinase p110-beta subunit | P42338 | CHEMBL3145 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 887 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001300 | A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma | sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00001339 | A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection | carcinoma | Doxorubicin (NPC261012) | NP level |
| NCT00001384 | A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00001498 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00002105 | Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002318 | A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002557 | Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002565 | Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002707 | Chemotherapy in Treating Women With Breast Cancer That Can Be Surgically Removed | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00003150 | Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT02419755
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKA,TOP2A
NCT03059615,NCT03860844 |
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AURKA,CA12,TOP2A,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
PIK3CD,AURKA,CYP1B1,DHCR7,PIK3CG,ABCB1,CA7
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NCT02560051
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKA,TOP2A
NCT04047004 |
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT04852367
|
Adenoid cystic carcinomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH4302 |
NCT00581360
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
PIK3CG
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
