Collective Molecular Activities of the Plant: Kadsura Ananosma
Plant ID: NPO27599
Plant Latin Name: Kadsura Ananosma
Taxonomy Genus: Kadsura
Taxonomy Family: Schisandraceae
Plant External Links:
NCBI TaxonomyDB:
133441
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
34 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
16 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
32 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC77633
Ingredient ID: NPC76415
Ingredient ID: NPC71680
Ingredient ID: NPC483384
Ingredient ID: NPC483383
Ingredient ID: NPC38232
Ingredient ID: NPC36531
Ingredient ID: NPC327651
Ingredient ID: NPC327352
Ingredient ID: NPC326144
Ingredient ID: NPC325720
Ingredient ID: NPC325122
Ingredient ID: NPC324962
Ingredient ID: NPC322426
Ingredient ID: NPC321958
Ingredient ID: NPC321696
Ingredient ID: NPC319749
Ingredient ID: NPC318286
Ingredient ID: NPC316989
Ingredient ID: NPC316676
Ingredient ID: NPC290802
Ingredient ID: NPC288679
Ingredient ID: NPC280566
Ingredient ID: NPC272632
Ingredient ID: NPC24562
Ingredient ID: NPC241477
Ingredient ID: NPC238850
Ingredient ID: NPC229172
Ingredient ID: NPC216665
Ingredient ID: NPC198129
Ingredient ID: NPC183570
Ingredient ID: NPC164600
Ingredient ID: NPC15551
Ingredient ID: NPC134018
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
