Collective Molecular Activities of the Plant: Jaborosa Leucotricha
Plant ID: NPO26456
Plant Latin Name: Jaborosa Leucotricha
Taxonomy Genus: Jaborosa
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
1608011
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
68 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
58 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99321
Ingredient ID: NPC87466
Ingredient ID: NPC83546
Ingredient ID: NPC79027
Ingredient ID: NPC75485
Ingredient ID: NPC52214
Ingredient ID: NPC50488
Ingredient ID: NPC48919
Ingredient ID: NPC476163
Ingredient ID: NPC474342
Ingredient ID: NPC47294
Ingredient ID: NPC4509
Ingredient ID: NPC45083
Ingredient ID: NPC42564
Ingredient ID: NPC40175
Ingredient ID: NPC36002
Ingredient ID: NPC31409
Ingredient ID: NPC304429
Ingredient ID: NPC300098
Ingredient ID: NPC298410
Ingredient ID: NPC295038
Ingredient ID: NPC293427
Ingredient ID: NPC292952
Ingredient ID: NPC285802
Ingredient ID: NPC277907
Ingredient ID: NPC277525
Ingredient ID: NPC276466
Ingredient ID: NPC273965
Ingredient ID: NPC273069
Ingredient ID: NPC272471
Ingredient ID: NPC262094
Ingredient ID: NPC256040
Ingredient ID: NPC250667
Ingredient ID: NPC249122
Ingredient ID: NPC247945
Ingredient ID: NPC246392
Ingredient ID: NPC246224
Ingredient ID: NPC244942
Ingredient ID: NPC243728
Ingredient ID: NPC230301
Ingredient ID: NPC224224
Ingredient ID: NPC217727
Ingredient ID: NPC209451
Ingredient ID: NPC208094
Ingredient ID: NPC206276
Ingredient ID: NPC201767
Ingredient ID: NPC199703
Ingredient ID: NPC193142
Ingredient ID: NPC190358
Ingredient ID: NPC1898
Ingredient ID: NPC185556
Ingredient ID: NPC178464
Ingredient ID: NPC174362
Ingredient ID: NPC172193
Ingredient ID: NPC170084
Ingredient ID: NPC169275
Ingredient ID: NPC168990
Ingredient ID: NPC168248
Ingredient ID: NPC15702
Ingredient ID: NPC152506
Ingredient ID: NPC149496
Ingredient ID: NPC139954
Ingredient ID: NPC113733
Ingredient ID: NPC108758
Ingredient ID: NPC108292
Ingredient ID: NPC107712
Ingredient ID: NPC106508
Ingredient ID: NPC106021
Classification of Human Proteins Collectively Targeted by the Plant
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
